PRKDC (protein kinase, DNA-activated, catalytic subunit)

2003-02-01  

Identity

HGNC
LOCATION
8q11.21
LOCUSID
ALIAS
DNA-PKC,DNA-PKcs,DNAPK,DNAPKc,DNPK1,HYRC,HYRC1,IMD26,XRCC7,p350
FUSION GENES

Other Information

Locus ID:

NCBI: 5591
MIM: 600899
HGNC: 9413
Ensembl: ENSG00000253729

Variants:

dbSNP: 5591
ClinVar: 5591
TCGA: ENSG00000253729
COSMIC: PRKDC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000253729ENST00000314191P78527
ENSG00000253729ENST00000338368P78527
ENSG00000253729ENST00000536429H0YG84
ENSG00000253729ENST00000540819F5GX40

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Non-homologous end-joiningKEGGko03450
Cell cycleKEGGko04110
Non-homologous end-joiningKEGGhsa03450
Cell cycleKEGGhsa04110
DNA-PK complexKEGGhsa_M00297
DNA-PK complexKEGGM00297
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
STING mediated induction of host immune responsesREACTOMER-HSA-1834941
IRF3-mediated induction of type I IFNREACTOMER-HSA-3270619
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Nonhomologous End-Joining (NHEJ)REACTOMER-HSA-5693571
Protein ubiquitinationREACTOMER-HSA-8852135
E3 ubiquitin ligases ubiquitinate target proteinsREACTOMER-HSA-8866654

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA29116H2AFXGenePathwayassociated

References

Pubmed IDYearTitleCitations
157589532005Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.456
122316222002Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks.175
160002982005Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase.163
156774762005Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks.156
152629622004Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase.155
209724252010GAPDH mediates nitrosylation of nuclear proteins.150
171892552007Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.142
128971532003Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.123
201575942009SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair.123
168742982006DNA-PK autophosphorylation facilitates Artemis endonuclease activity.114

Citation

Dessen P

PRKDC (protein kinase, DNA-activated, catalytic subunit)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/338/prkdc