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PRKDC (protein kinase, DNA-activated, catalytic polypeptide)

Identity

Other namesDNA-PKcs
DNAPK
DNPK1
HYRC
HYRC1
XRCC7
p350
HGNC (Hugo) PRKDC
LocusID (NCBI) 5591
Location 8q11.21
Location_base_pair Starts at 48685669 and ends at 48872743 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PRKDC   9413
Entrez_Gene (NCBI)PRKDC  5591  protein kinase, DNA-activated, catalytic polypeptide
Cards
GeneCards (Weizmann)PRKDC
Ensembl (Hinxton)ENSG00000253729 [Gene_View]  chr8:48685669-48872743 [Contig_View]  PRKDC [Vega]
AceView (NCBI)PRKDC
Genatlas (Paris)PRKDC
SOURCE (Stanford)NM_001081640 NM_006904
Genomic and cartography
GoldenPath (UCSC)PRKDC  -  8q11.21   chr8:48685669-48872743 -  8q11.21   [Description]    (hg19-Feb_2009)
EnsemblPRKDC - 8q11.21 [CytoView]
Mapping of homologs : NCBIPRKDC [Mapview]
OMIM600899   
Gene and transcription
Genbank (Entrez)AB208860 AK296833 BC017494 BC024963 BC037968
RefSeq transcript (SRS)NM_001081640 NM_006904
RefSeq transcript (Entrez)NM_001081640 NM_006904
RefSeq genomic (SRS)AC_000140 NC_000008 NC_018919 NG_023435 NT_008183 NW_001839132 NW_004078036
RefSeq genomic (Entrez)AC_000140 NC_000008 NC_018919 NG_023435 NT_008183 NW_001839132 NW_004078036
Consensus coding sequences : CCDS (NCBI)PRKDC
Cluster EST : UnigeneHs.491682 [ SRS ] Hs.491682 [ NCBI ]
CGAP (NCI)Hs.491682
Alternative Splicing : Fast-db (Paris)GSHG0029561
Alternative Splicing GalleryENSG00000253729
Gene ExpressionPRKDC [ NCBI-GEO ]   PRKDC [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78527 (SRS) P78527 (Uniprot)
NextProtP78527
With graphics : InterProP78527
Splice isoforms : SwissVarP78527(Swissvar)
Domaine pattern : Prosite (SRS)FAT (PS51189)    FATC (PS51190)    HEAT_REPEAT (PS50077)    PI3_4_KINASE_1 (PS00915)    PI3_4_KINASE_2 (PS00916)    PI3_4_KINASE_3 (PS50290)    TPR (PS50005)    TPR_REGION (PS50293)   
Domaine pattern : Prosite (Expaxy)FAT (PS51189)    FATC (PS51190)    HEAT_REPEAT (PS50077)    PI3_4_KINASE_1 (PS00915)    PI3_4_KINASE_2 (PS00916)    PI3_4_KINASE_3 (PS50290)    TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (SRS)ARM-like    ARM-type_fold    FATC    Kinase-like_dom    NUC194    PI3/4_kinase_cat_dom    PI3/4_kinase_CS    PIK-rel_kinase_FAT    PIK_FAT   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    FATC    Kinase-like_dom    NUC194    PI3/4_kinase_cat_dom    PI3/4_kinase_CS    PIK-rel_kinase_FAT    PIK_FAT   
Related proteins : CluSTrP78527
Domain families : Pfam (SRS)FAT (PF02259)    FATC (PF02260)    NUC194 (PF08163)    PI3_PI4_kinase (PF00454)   
Domain families : Pfam (Sanger)FAT (PF02259)    FATC (PF02260)    NUC194 (PF08163)    PI3_PI4_kinase (PF00454)   
Domain families : Pfam (NCBI)pfam02259    pfam02260    pfam08163    pfam00454   
Domain families : Smart (EMBL)PI3Kc (SM00146)  
DMDM5591
Blocks (Seattle)P78527
Human Protein AtlasENSG00000253729
HPRD02941
IPIIPI00296337   IPI00376215   
Protein Interaction databases
DIP (DOE-UCLA)P78527
IntAct (EBI)P78527
FunCoupENSG00000253729
REACTOMEPRKDC
Protein Interaction Database5591
BioGRIDPRKDC
InParanoidP78527
Interologous Interaction database P78527
IntegromeDBPRKDC
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PRKDC
SNP (GeneSNP Utah)PRKDC
SNP : HGBasePRKDC
Genetic variants : HAPMAPPRKDC
Somatic Mutations in Cancer : COSMICPRKDC 
CONAN: Copy Number AnalysisPRKDC 
Mutations and Diseases : HGMDPRKDC
OMIM600899   
GENETests600899   
Disease Genetic AssociationPRKDC
Huge Navigator PRKDC [HugePedia]  PRKDC [HugeCancerGEM]
Genomic VariantsPRKDC  PRKDC [DGVbeta]
snp3D : Map Gene to Disease5591
General knowledge
Homologs : HomoloGenePRKDC
Homology/Alignments : Family Browser (UCSC)PRKDC
Phylogenetic Trees/Animal Genes : TreeFamPRKDC
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.1 [ Enzyme-SRS ]   2.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
Chemical/Protein Interactions : CTD5591
Chemical/Pharm GKB GenePA33776
Clinical trialPRKDC
Cancer Resource (Charite)ENSG00000253729
Ontology : AmiGOtelomere maintenance  somitogenesis  B cell lineage commitment  pro-B cell differentiation  T cell lineage commitment  DNA binding  protein kinase activity  protein serine/threonine kinase activity  DNA-dependent protein kinase activity  protein binding  ATP binding  nucleoplasm  transcription factor complex  nucleolus  DNA-dependent protein kinase-DNA ligase 4 complex  DNA repair  double-strand break repair  double-strand break repair via nonhomologous end joining  cellular protein modification process  apoptotic process  brain development  heart development  transcription factor binding  response to gamma radiation  peptidyl-serine phosphorylation  enzyme binding  protein destabilization  cellular response to insulin stimulus  T cell differentiation in thymus  immunoglobulin V(D)J recombination  T cell receptor V(D)J recombination  germ cell programmed cell death  positive regulation of apoptotic process  positive regulation of transcription from RNA polymerase II promoter  nonhomologous end joining complex  
Ontology : EGO-EBItelomere maintenance  somitogenesis  B cell lineage commitment  pro-B cell differentiation  T cell lineage commitment  DNA binding  protein kinase activity  protein serine/threonine kinase activity  DNA-dependent protein kinase activity  protein binding  ATP binding  nucleoplasm  transcription factor complex  nucleolus  DNA-dependent protein kinase-DNA ligase 4 complex  DNA repair  double-strand break repair  double-strand break repair via nonhomologous end joining  cellular protein modification process  apoptotic process  brain development  heart development  transcription factor binding  response to gamma radiation  peptidyl-serine phosphorylation  enzyme binding  protein destabilization  cellular response to insulin stimulus  T cell differentiation in thymus  immunoglobulin V(D)J recombination  T cell receptor V(D)J recombination  germ cell programmed cell death  positive regulation of apoptotic process  positive regulation of transcription from RNA polymerase II promoter  nonhomologous end joining complex  
Pathways : BIOCARTAFAS signaling pathway ( CD95 ) [Genes]    Cell Cycle: G2/M Checkpoint [Genes]    TNFR1 Signaling Pathway [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]   
Pathways : KEGGCell cycle
Other databases
Probes
Litterature
PubMed354 Pubmed reference(s) in Entrez
PubGenePRKDC
iHOPPRKDC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:19:53 CEST 2013
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