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PRKG1 (protein kinase, cGMP-dependent, type I)

Identity

Alias_namesPRKGR1B
PRKG1B
Alias_symbol (synonym)PGK
PKG
Other aliasAAT8
cGK
cGK 1
cGK1
cGKI
cGKI-BETA
cGKI-alpha
HGNC (Hugo) PRKG1
LocusID (NCBI) 5592
Atlas_Id 41864
Location 10q11.23  [Link to chromosome band 10q11]
Location_base_pair Starts at 50991151 and ends at 52298350 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDC42BPA (1q42.13) / PRKG1 (10q11.23)MARCH8 (10q11.21) / PRKG1 (10q11.23)PRKG1 (10q11.23) / RASL11B (4q12)
PRKG1 (10q11.23) / VDAC3 (8p11.21)SUPV3L1 (10q22.1) / PRKG1 (10q11.23)VGLL4 (3p25.3) / PRKG1 (10q11.23)
CDC42BPA 1q42.13 / PRKG1 10q11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)PRKG1   9414
Cards
Entrez_Gene (NCBI)PRKG1  5592  protein kinase, cGMP-dependent, type I
AliasesAAT8; PKG; PRKG1B; PRKGR1B; 
cGK; cGK; cGK1; cGKI; cGKI-BETA; cGKI-alpha
GeneCards (Weizmann)PRKG1
Ensembl hg19 (Hinxton)ENSG00000185532 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185532 [Gene_View]  chr10:50991151-52298350 [Contig_View]  PRKG1 [Vega]
ICGC DataPortalENSG00000185532
TCGA cBioPortalPRKG1
AceView (NCBI)PRKG1
Genatlas (Paris)PRKG1
WikiGenes5592
SOURCE (Princeton)PRKG1
Genetics Home Reference (NIH)PRKG1
Genomic and cartography
GoldenPath hg38 (UCSC)PRKG1  -     chr10:50991151-52298350 +  10q11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRKG1  -     10q11.23   [Description]    (hg19-Feb_2009)
EnsemblPRKG1 - 10q11.23 [CytoView hg19]  PRKG1 - 10q11.23 [CytoView hg38]
Mapping of homologs : NCBIPRKG1 [Mapview hg19]  PRKG1 [Mapview hg38]
OMIM176894   615436   
Gene and transcription
Genbank (Entrez)AK093436 AK300110 AK313416 AL599933 BC062688
RefSeq transcript (Entrez)NM_001098512 NM_006258
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRKG1
Cluster EST : UnigeneHs.407535 [ NCBI ]
CGAP (NCI)Hs.407535
Alternative Splicing GalleryENSG00000185532
Gene ExpressionPRKG1 [ NCBI-GEO ]   PRKG1 [ EBI - ARRAY_EXPRESS ]   PRKG1 [ SEEK ]   PRKG1 [ MEM ]
Gene Expression Viewer (FireBrowse)PRKG1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5592
GTEX Portal (Tissue expression)PRKG1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13976   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13976  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13976
Splice isoforms : SwissVarQ13976
Catalytic activity : Enzyme2.7.11.12 [ Enzyme-Expasy ]   2.7.11.122.7.11.12 [ IntEnz-EBI ]   2.7.11.12 [ BRENDA ]   2.7.11.12 [ KEGG ]   
PhosPhoSitePlusQ13976
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    CNMP_BINDING_1 (PS00888)    CNMP_BINDING_2 (PS00889)    CNMP_BINDING_3 (PS50042)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AGC-kinase_C    cGMP_dep_kinase    cNMP-bd-like    cNMP-bd_CS    cNMP-bd_dom    Kinase-like_dom    PKcGMP_CC    Prot_kinase_dom    Protein_kinase_ATP_BS    RmlC-like_jellyroll    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)cNMP_binding (PF00027)    PKcGMP_CC (PF16808)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00027    pfam16808    pfam00069   
Domain families : Smart (EMBL)cNMP (SM00100)  S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)PRKG1
DMDM Disease mutations5592
Blocks (Seattle)PRKG1
PDB (SRS)1ZXA    3NMD    3OCP    3OD0    3OGJ    4KU7    4KU8    4QX5    4QXK    4R4L    4R4M    4Z07   
PDB (PDBSum)1ZXA    3NMD    3OCP    3OD0    3OGJ    4KU7    4KU8    4QX5    4QXK    4R4L    4R4M    4Z07   
PDB (IMB)1ZXA    3NMD    3OCP    3OD0    3OGJ    4KU7    4KU8    4QX5    4QXK    4R4L    4R4M    4Z07   
PDB (RSDB)1ZXA    3NMD    3OCP    3OD0    3OGJ    4KU7    4KU8    4QX5    4QXK    4R4L    4R4M    4Z07   
Structural Biology KnowledgeBase1ZXA    3NMD    3OCP    3OD0    3OGJ    4KU7    4KU8    4QX5    4QXK    4R4L    4R4M    4Z07   
SCOP (Structural Classification of Proteins)1ZXA    3NMD    3OCP    3OD0    3OGJ    4KU7    4KU8    4QX5    4QXK    4R4L    4R4M    4Z07   
CATH (Classification of proteins structures)1ZXA    3NMD    3OCP    3OD0    3OGJ    4KU7    4KU8    4QX5    4QXK    4R4L    4R4M    4Z07   
SuperfamilyQ13976
Human Protein AtlasENSG00000185532
Peptide AtlasQ13976
HPRD08910
IPIIPI00427586   IPI00436355   IPI00647138   IPI00552517   
Protein Interaction databases
DIP (DOE-UCLA)Q13976
IntAct (EBI)Q13976
FunCoupENSG00000185532
BioGRIDPRKG1
STRING (EMBL)PRKG1
ZODIACPRKG1
Ontologies - Pathways
QuickGOQ13976
Ontology : AmiGOneuron migration  protein serine/threonine kinase activity  cGMP-dependent protein kinase activity  cGMP-dependent protein kinase activity  calcium channel regulator activity  protein binding  ATP binding  cytoplasm  Golgi apparatus  cytosol  plasma membrane  protein phosphorylation  signal transduction  dendrite development  cGMP-mediated signaling  actin cytoskeleton organization  cGMP binding  forebrain development  regulation of GTPase activity  relaxation of vascular smooth muscle  negative regulation of platelet aggregation  
Ontology : EGO-EBIneuron migration  protein serine/threonine kinase activity  cGMP-dependent protein kinase activity  cGMP-dependent protein kinase activity  calcium channel regulator activity  protein binding  ATP binding  cytoplasm  Golgi apparatus  cytosol  plasma membrane  protein phosphorylation  signal transduction  dendrite development  cGMP-mediated signaling  actin cytoskeleton organization  cGMP binding  forebrain development  regulation of GTPase activity  relaxation of vascular smooth muscle  negative regulation of platelet aggregation  
Pathways : KEGGVascular smooth muscle contraction    Gap junction    Circadian entrainment    Long-term depression    Olfactory transduction    Salivary secretion   
NDEx NetworkPRKG1
Atlas of Cancer Signalling NetworkPRKG1
Wikipedia pathwaysPRKG1
Orthology - Evolution
OrthoDB5592
GeneTree (enSembl)ENSG00000185532
Phylogenetic Trees/Animal Genes : TreeFamPRKG1
HOVERGENQ13976
HOGENOMQ13976
Homologs : HomoloGenePRKG1
Homology/Alignments : Family Browser (UCSC)PRKG1
Gene fusions - Rearrangements
Fusion : MitelmanCDC42BPA/PRKG1 [1q42.13/10q11.23]  [t(1;10)(q42;q11)]  
Fusion : MitelmanMARCH8/PRKG1 [10q11.21/10q11.23]  [t(10;10)(q11;q11)]  
Fusion: TCGACDC42BPA 1q42.13 PRKG1 10q11.23 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRKG1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKG1
dbVarPRKG1
ClinVarPRKG1
1000_GenomesPRKG1 
Exome Variant ServerPRKG1
ExAC (Exome Aggregation Consortium)PRKG1 (select the gene name)
Genetic variants : HAPMAP5592
Genomic Variants (DGV)PRKG1 [DGVbeta]
DECIPHERPRKG1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRKG1 
Mutations
ICGC Data PortalPRKG1 
TCGA Data PortalPRKG1 
Broad Tumor PortalPRKG1
OASIS PortalPRKG1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRKG1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRKG1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRKG1
DgiDB (Drug Gene Interaction Database)PRKG1
DoCM (Curated mutations)PRKG1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRKG1 (select a term)
intoGenPRKG1
Cancer3DPRKG1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176894    615436   
Orphanet12138   
MedgenPRKG1
Genetic Testing Registry PRKG1
NextProtQ13976 [Medical]
TSGene5592
GENETestsPRKG1
Target ValidationPRKG1
Huge Navigator PRKG1 [HugePedia]
snp3D : Map Gene to Disease5592
BioCentury BCIQPRKG1
ClinGenPRKG1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5592
Chemical/Pharm GKB GenePA33777
Clinical trialPRKG1
Miscellaneous
canSAR (ICR)PRKG1 (select the gene name)
Probes
Litterature
PubMed150 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRKG1
EVEXPRKG1
GoPubMedPRKG1
iHOPPRKG1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:51:07 CEST 2017

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