Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PRKG2 (protein kinase, cGMP-dependent, type II)

Identity

Alias_symbol (synonym)cGKII
PRKGR2
Other aliascGK2
HGNC (Hugo) PRKG2
LocusID (NCBI) 5593
Atlas_Id 41865
Location 4q21.21  [Link to chromosome band 4q21]
Location_base_pair Starts at 81087370 and ends at 81154157 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PRKG2 (4q21.21) / PDGFRB (5q32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(4;5)(q21;q33) PRKG2/PDGFRB


External links

Nomenclature
HGNC (Hugo)PRKG2   9416
Cards
Entrez_Gene (NCBI)PRKG2  5593  protein kinase, cGMP-dependent, type II
AliasesPRKGR2; cGK2; cGKII
GeneCards (Weizmann)PRKG2
Ensembl hg19 (Hinxton)ENSG00000138669 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138669 [Gene_View]  chr4:81087370-81154157 [Contig_View]  PRKG2 [Vega]
ICGC DataPortalENSG00000138669
TCGA cBioPortalPRKG2
AceView (NCBI)PRKG2
Genatlas (Paris)PRKG2
WikiGenes5593
SOURCE (Princeton)PRKG2
Genetics Home Reference (NIH)PRKG2
Genomic and cartography
GoldenPath hg38 (UCSC)PRKG2  -     chr4:81087370-81154157 -  4q21.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRKG2  -     4q21.21   [Description]    (hg19-Feb_2009)
EnsemblPRKG2 - 4q21.21 [CytoView hg19]  PRKG2 - 4q21.21 [CytoView hg38]
Mapping of homologs : NCBIPRKG2 [Mapview hg19]  PRKG2 [Mapview hg38]
OMIM601591   
Gene and transcription
Genbank (Entrez)AK296979 AK297673 AK316140 BC111597 BF508892
RefSeq transcript (Entrez)NM_001282480 NM_001282481 NM_001282482 NM_001282483 NM_001282485 NM_006259
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRKG2
Cluster EST : UnigeneHs.739943 [ NCBI ]
CGAP (NCI)Hs.739943
Alternative Splicing GalleryENSG00000138669
Gene ExpressionPRKG2 [ NCBI-GEO ]   PRKG2 [ EBI - ARRAY_EXPRESS ]   PRKG2 [ SEEK ]   PRKG2 [ MEM ]
Gene Expression Viewer (FireBrowse)PRKG2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5593
GTEX Portal (Tissue expression)PRKG2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13237   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13237  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13237
Splice isoforms : SwissVarQ13237
Catalytic activity : Enzyme2.7.11.12 [ Enzyme-Expasy ]   2.7.11.122.7.11.12 [ IntEnz-EBI ]   2.7.11.12 [ BRENDA ]   2.7.11.12 [ KEGG ]   
PhosPhoSitePlusQ13237
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    CNMP_BINDING_1 (PS00888)    CNMP_BINDING_2 (PS00889)    CNMP_BINDING_3 (PS50042)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AGC-kinase_C    cGMP_dep_kinase    cNMP-bd-like    cNMP-bd_CS    cNMP-bd_dom    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    RmlC-like_jellyroll    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)cNMP_binding (PF00027)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00027    pfam00069   
Domain families : Smart (EMBL)cNMP (SM00100)  S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)PRKG2
DMDM Disease mutations5593
Blocks (Seattle)PRKG2
PDB (SRS)5BV6    5C6C    5C8W   
PDB (PDBSum)5BV6    5C6C    5C8W   
PDB (IMB)5BV6    5C6C    5C8W   
PDB (RSDB)5BV6    5C6C    5C8W   
Structural Biology KnowledgeBase5BV6    5C6C    5C8W   
SCOP (Structural Classification of Proteins)5BV6    5C6C    5C8W   
CATH (Classification of proteins structures)5BV6    5C6C    5C8W   
SuperfamilyQ13237
Human Protein AtlasENSG00000138669
Peptide AtlasQ13237
HPRD09034
IPIIPI00012322   IPI00909824   IPI01013942   
Protein Interaction databases
DIP (DOE-UCLA)Q13237
IntAct (EBI)Q13237
FunCoupENSG00000138669
BioGRIDPRKG2
STRING (EMBL)PRKG2
ZODIACPRKG2
Ontologies - Pathways
QuickGOQ13237
Ontology : AmiGOprotein kinase activity  cGMP-dependent protein kinase activity  ATP binding  cytosol  protein phosphorylation  signal transduction  apical plasma membrane  cGMP binding  nuclear membrane  peptidyl-serine autophosphorylation  protein homodimerization activity  regulation of nitric-oxide synthase activity  protein targeting to plasma membrane  negative regulation of chloride transport  
Ontology : EGO-EBIprotein kinase activity  cGMP-dependent protein kinase activity  ATP binding  cytosol  protein phosphorylation  signal transduction  apical plasma membrane  cGMP binding  nuclear membrane  peptidyl-serine autophosphorylation  protein homodimerization activity  regulation of nitric-oxide synthase activity  protein targeting to plasma membrane  negative regulation of chloride transport  
Pathways : KEGGGap junction    Circadian entrainment    Long-term depression    Olfactory transduction    Salivary secretion   
NDEx NetworkPRKG2
Atlas of Cancer Signalling NetworkPRKG2
Wikipedia pathwaysPRKG2
Orthology - Evolution
OrthoDB5593
GeneTree (enSembl)ENSG00000138669
Phylogenetic Trees/Animal Genes : TreeFamPRKG2
HOVERGENQ13237
HOGENOMQ13237
Homologs : HomoloGenePRKG2
Homology/Alignments : Family Browser (UCSC)PRKG2
Gene fusions - Rearrangements
Fusion : MitelmanPRKG2/PDGFRB [4q21.21/5q32]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRKG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKG2
dbVarPRKG2
ClinVarPRKG2
1000_GenomesPRKG2 
Exome Variant ServerPRKG2
ExAC (Exome Aggregation Consortium)PRKG2 (select the gene name)
Genetic variants : HAPMAP5593
Genomic Variants (DGV)PRKG2 [DGVbeta]
DECIPHERPRKG2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRKG2 
Mutations
ICGC Data PortalPRKG2 
TCGA Data PortalPRKG2 
Broad Tumor PortalPRKG2
OASIS PortalPRKG2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDPRKG2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRKG2
DgiDB (Drug Gene Interaction Database)PRKG2
DoCM (Curated mutations)PRKG2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRKG2 (select a term)
intoGenPRKG2
Cancer3DPRKG2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601591   
Orphanet
MedgenPRKG2
Genetic Testing Registry PRKG2
NextProtQ13237 [Medical]
TSGene5593
GENETestsPRKG2
Target ValidationPRKG2
Huge Navigator PRKG2 [HugePedia]
snp3D : Map Gene to Disease5593
BioCentury BCIQPRKG2
ClinGenPRKG2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5593
Chemical/Pharm GKB GenePA33778
Clinical trialPRKG2
Miscellaneous
canSAR (ICR)PRKG2 (select the gene name)
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRKG2
EVEXPRKG2
GoPubMedPRKG2
iHOPPRKG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:51:07 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.