PRKG2 (protein kinase cGMP-dependent 2)

2003-11-01  

Identity

HGNC
LOCATION
4q21.21
LOCUSID
ALIAS
PKG2,PRKGR2,cGK2,cGKII
FUSION GENES

Other Information

Locus ID:

NCBI: 5593
MIM: 601591
HGNC: 9416
Ensembl: ENSG00000138669

Variants:

dbSNP: 5593
ClinVar: 5593
TCGA: ENSG00000138669
COSMIC: PRKG2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138669ENST00000264399Q13237
ENSG00000138669ENST00000264399A0A140VJM3
ENSG00000138669ENST00000395578Q13237
ENSG00000138669ENST00000395578A0A140VJM3
ENSG00000138669ENST00000545647B7ZA25
ENSG00000138669ENST00000628926Q13237

Expression (GTEx)

0
1
2
3
4
5
6

Pathways

PathwaySourceExternal ID
Gap junctionKEGGko04540
Long-term depressionKEGGko04730
Olfactory transductionKEGGko04740
Gap junctionKEGGhsa04540
Long-term depressionKEGGhsa04730
Olfactory transductionKEGGhsa04740
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
Circadian entrainmentKEGGhsa04713
Circadian entrainmentKEGGko04713
Platelet activationKEGGhsa04611
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Regulation of lipolysis in adipocytesKEGGhsa04923
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Nitric oxide stimulates guanylate cyclaseREACTOMER-HSA-392154
cGMP effectsREACTOMER-HSA-418457
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
Ca2+ pathwayREACTOMER-HSA-4086398
MetabolismREACTOMER-HSA-1430728
Metabolism of nitric oxideREACTOMER-HSA-202131
eNOS activation and regulationREACTOMER-HSA-203765
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulationREACTOMER-HSA-1474151

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
193431782009Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.112
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
186069552008Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior.55
195433192009Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines.34
193593702009Regulation of epithelial sodium channels by cGMP/PKGII.24
225561462012Type 2 cGMP-dependent protein kinase regulates proliferation and differentiation in the colonic mucosa.18
220122472012Type II cGMP-dependent protein kinase inhibits EGF-triggered signal transduction of the MAPK/ERK-mediated pathway in gastric cancer cells.15
224270122012Type II cGMP-dependent protein kinase inhibits EGF-induced MAPK/JNK signal transduction in breast cancer cells.11
250708902014Crystal structure of the cGMP-dependent protein kinase II leucine zipper and Rab11b protein complex reveals molecular details of G-kinase-specific interactions.10
182620532008Fusion of PRKG2 and SPTBN1 to the platelet-derived growth factor receptor beta gene (PDGFRB) in imatinib-responsive atypical myeloproliferative disorders.8

Citation

Dessen P

PRKG2 (protein kinase cGMP-dependent 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41865/prkg2