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PRKRIR (protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor))

Identity

Other aliasDAP4
P52rIPK
THAP0
THAP12
HGNC (Hugo) PRKRIR
LocusID (NCBI) 5612
Atlas_Id 72215
Location 11q13.5  [Link to chromosome band 11q13]
Location_base_pair Starts at 76061001 and ends at 76092009 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PRKRIR MARK4PRKRIR POLD4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRKRIR   9440
Cards
Entrez_Gene (NCBI)PRKRIR  5612  protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
AliasesDAP4; P52rIPK; THAP0; THAP12
GeneCards (Weizmann)PRKRIR
Ensembl hg19 (Hinxton)ENSG00000137492 [Gene_View]  chr11:76061001-76092009 [Contig_View]  PRKRIR [Vega]
Ensembl hg38 (Hinxton)ENSG00000137492 [Gene_View]  chr11:76061001-76092009 [Contig_View]  PRKRIR [Vega]
ICGC DataPortalENSG00000137492
TCGA cBioPortalPRKRIR
AceView (NCBI)PRKRIR
Genatlas (Paris)PRKRIR
WikiGenes5612
SOURCE (Princeton)PRKRIR
Genetics Home Reference (NIH)PRKRIR
Genomic and cartography
GoldenPath hg19 (UCSC)PRKRIR  -     chr11:76061001-76092009 -  11q13.5   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PRKRIR  -     11q13.5   [Description]    (hg38-Dec_2013)
EnsemblPRKRIR - 11q13.5 [CytoView hg19]  PRKRIR - 11q13.5 [CytoView hg38]
Mapping of homologs : NCBIPRKRIR [Mapview hg19]  PRKRIR [Mapview hg38]
OMIM607374   
Gene and transcription
Genbank (Entrez)AA765102 AF007393 AF081567 AK001522 AK291843
RefSeq transcript (Entrez)NM_004705
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_167190 NW_004929380
Consensus coding sequences : CCDS (NCBI)PRKRIR
Cluster EST : UnigeneHs.503315 [ NCBI ]
CGAP (NCI)Hs.503315
Alternative Splicing GalleryENSG00000137492
Gene ExpressionPRKRIR [ NCBI-GEO ]   PRKRIR [ EBI - ARRAY_EXPRESS ]   PRKRIR [ SEEK ]   PRKRIR [ MEM ]
Gene Expression Viewer (FireBrowse)PRKRIR [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5612
GTEX Portal (Tissue expression)PRKRIR
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43422   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43422  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43422
Splice isoforms : SwissVarO43422
PhosPhoSitePlusO43422
Domaine pattern : Prosite (Expaxy)ZF_THAP (PS50950)   
Domains : Interpro (EBI)DUF4371    HATC_dom_C    RNaseH-like_dom    Znf_C2CH   
Domain families : Pfam (Sanger)Dimer_Tnp_hAT (PF05699)    DUF4371 (PF14291)    THAP (PF05485)   
Domain families : Pfam (NCBI)pfam05699    pfam14291    pfam05485   
Domain families : Smart (EMBL)DM3 (SM00692)  THAP (SM00980)  
Conserved Domain (NCBI)PRKRIR
DMDM Disease mutations5612
Blocks (Seattle)PRKRIR
SuperfamilyO43422
Human Protein AtlasENSG00000137492
Peptide AtlasO43422
HPRD09567
IPIIPI00012438   IPI00219175   IPI00981277   IPI00978056   
Protein Interaction databases
DIP (DOE-UCLA)O43422
IntAct (EBI)O43422
FunCoupENSG00000137492
BioGRIDPRKRIR
STRING (EMBL)PRKRIR
ZODIACPRKRIR
Ontologies - Pathways
QuickGOO43422
Ontology : AmiGODNA binding  protein binding  nucleus  response to stress  signal transduction  negative regulation of cell proliferation  metal ion binding  protein dimerization activity  
Ontology : EGO-EBIDNA binding  protein binding  nucleus  response to stress  signal transduction  negative regulation of cell proliferation  metal ion binding  protein dimerization activity  
NDEx NetworkPRKRIR
Atlas of Cancer Signalling NetworkPRKRIR
Wikipedia pathwaysPRKRIR
Orthology - Evolution
OrthoDB5612
GeneTree (enSembl)ENSG00000137492
Phylogenetic Trees/Animal Genes : TreeFamPRKRIR
HOVERGENO43422
HOGENOMO43422
Homologs : HomoloGenePRKRIR
Homology/Alignments : Family Browser (UCSC)PRKRIR
Gene fusions - Rearrangements
Fusion: TCGAPRKRIR MARK4
Fusion: TCGAPRKRIR POLD4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRKRIR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKRIR
dbVarPRKRIR
ClinVarPRKRIR
1000_GenomesPRKRIR 
Exome Variant ServerPRKRIR
ExAC (Exome Aggregation Consortium)PRKRIR (select the gene name)
Genetic variants : HAPMAP5612
Genomic Variants (DGV)PRKRIR [DGVbeta]
DECIPHER (Syndromes)11:76061001-76092009  ENSG00000137492
CONAN: Copy Number AnalysisPRKRIR 
Mutations
ICGC Data PortalPRKRIR 
TCGA Data PortalPRKRIR 
Broad Tumor PortalPRKRIR
OASIS PortalPRKRIR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRKRIR  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRKRIR
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRKRIR
DgiDB (Drug Gene Interaction Database)PRKRIR
DoCM (Curated mutations)PRKRIR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRKRIR (select a term)
intoGenPRKRIR
Cancer3DPRKRIR(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607374   
Orphanet
MedgenPRKRIR
Genetic Testing Registry PRKRIR
NextProtO43422 [Medical]
TSGene5612
GENETestsPRKRIR
Huge Navigator PRKRIR [HugePedia]
snp3D : Map Gene to Disease5612
BioCentury BCIQPRKRIR
ClinGenPRKRIR
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5612
Chemical/Pharm GKB GenePA33781
Clinical trialPRKRIR
Miscellaneous
canSAR (ICR)PRKRIR (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRKRIR
EVEXPRKRIR
GoPubMedPRKRIR
iHOPPRKRIR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:39:39 CET 2017

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