Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PRKX (protein kinase, X-linked)

Identity

Alias_symbol (synonym)PKX1
Other alias
HGNC (Hugo) PRKX
LocusID (NCBI) 5613
Atlas_Id 43429
Location Xp22.33  [Link to chromosome band Xp22]
Location_base_pair Starts at 3604343 and ends at 3713634 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PRKX (Xp22.33) / CLCN4 (Xp22.2)PRKX Xp22.33 / CLCN4 Xp22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRKX   9441
Cards
Entrez_Gene (NCBI)PRKX  5613  protein kinase, X-linked
AliasesPKX1
GeneCards (Weizmann)PRKX
Ensembl hg19 (Hinxton)ENSG00000183943 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000183943 [Gene_View]  chrX:3604343-3713634 [Contig_View]  PRKX [Vega]
ICGC DataPortalENSG00000183943
TCGA cBioPortalPRKX
AceView (NCBI)PRKX
Genatlas (Paris)PRKX
WikiGenes5613
SOURCE (Princeton)PRKX
Genetics Home Reference (NIH)PRKX
Genomic and cartography
GoldenPath hg38 (UCSC)PRKX  -     chrX:3604343-3713634 -  Xp22.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRKX  -     Xp22.33   [Description]    (hg19-Feb_2009)
EnsemblPRKX - Xp22.33 [CytoView hg19]  PRKX - Xp22.33 [CytoView hg38]
Mapping of homologs : NCBIPRKX [Mapview hg19]  PRKX [Mapview hg38]
OMIM300083   
Gene and transcription
Genbank (Entrez)BC041073 BE675757 DN996851 DN997580 EU832357
RefSeq transcript (Entrez)NM_005044
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRKX
Cluster EST : UnigeneHs.390788 [ NCBI ]
CGAP (NCI)Hs.390788
Alternative Splicing GalleryENSG00000183943
Gene ExpressionPRKX [ NCBI-GEO ]   PRKX [ EBI - ARRAY_EXPRESS ]   PRKX [ SEEK ]   PRKX [ MEM ]
Gene Expression Viewer (FireBrowse)PRKX [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5613
GTEX Portal (Tissue expression)PRKX
Human Protein AtlasENSG00000183943-PRKX [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51817   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51817  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51817
Splice isoforms : SwissVarP51817
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusP51817
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AGC-kinase_C    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)PRKX
DMDM Disease mutations5613
Blocks (Seattle)PRKX
SuperfamilyP51817
Human Protein Atlas [tissue]ENSG00000183943-PRKX [tissue]
Peptide AtlasP51817
HPRD02097
IPIIPI00020904   
Protein Interaction databases
DIP (DOE-UCLA)P51817
IntAct (EBI)P51817
FunCoupENSG00000183943
BioGRIDPRKX
STRING (EMBL)PRKX
ZODIACPRKX
Ontologies - Pathways
QuickGOP51817
Ontology : AmiGOangiogenesis  endothelial cell proliferation  cAMP-dependent protein kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cell adhesion  peptidyl-serine phosphorylation  myeloid cell differentiation  regulation of cell adhesion  regulation of cell migration  cell-substrate adhesion  endothelial cell migration  protein autophosphorylation  epithelial tube morphogenesis  kidney morphogenesis  regulation of epithelial cell differentiation involved in kidney development  
Ontology : EGO-EBIangiogenesis  endothelial cell proliferation  cAMP-dependent protein kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cell adhesion  peptidyl-serine phosphorylation  myeloid cell differentiation  regulation of cell adhesion  regulation of cell migration  cell-substrate adhesion  endothelial cell migration  protein autophosphorylation  epithelial tube morphogenesis  kidney morphogenesis  regulation of epithelial cell differentiation involved in kidney development  
Pathways : KEGG   
NDEx NetworkPRKX
Atlas of Cancer Signalling NetworkPRKX
Wikipedia pathwaysPRKX
Orthology - Evolution
OrthoDB5613
GeneTree (enSembl)ENSG00000183943
Phylogenetic Trees/Animal Genes : TreeFamPRKX
HOVERGENP51817
HOGENOMP51817
Homologs : HomoloGenePRKX
Homology/Alignments : Family Browser (UCSC)PRKX
Gene fusions - Rearrangements
Fusion : MitelmanPRKX/CLCN4 [Xp22.33/Xp22.2]  
Fusion: TCGA_MDACCPRKX Xp22.33 CLCN4 Xp22.2 LGG
Tumor Fusion PortalPRKX
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRKX [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKX
dbVarPRKX
ClinVarPRKX
1000_GenomesPRKX 
Exome Variant ServerPRKX
ExAC (Exome Aggregation Consortium)ENSG00000183943
GNOMAD BrowserENSG00000183943
Genetic variants : HAPMAP5613
Genomic Variants (DGV)PRKX [DGVbeta]
DECIPHERPRKX [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRKX 
Mutations
ICGC Data PortalPRKX 
TCGA Data PortalPRKX 
Broad Tumor PortalPRKX
OASIS PortalPRKX [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRKX  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRKX
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch PRKX
DgiDB (Drug Gene Interaction Database)PRKX
DoCM (Curated mutations)PRKX (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRKX (select a term)
intoGenPRKX
Cancer3DPRKX(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300083   
Orphanet
DisGeNETPRKX
MedgenPRKX
Genetic Testing Registry PRKX
NextProtP51817 [Medical]
TSGene5613
GENETestsPRKX
Target ValidationPRKX
Huge Navigator PRKX [HugePedia]
snp3D : Map Gene to Disease5613
BioCentury BCIQPRKX
ClinGenPRKX
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5613
Chemical/Pharm GKB GenePA33786
Clinical trialPRKX
Miscellaneous
canSAR (ICR)PRKX (select dhe gmn% name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRKX
EVEXPRKX
GoPubMedPRKX
iHOPPRKX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:30:23 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.