Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PRL (prolactin)

Identity

HGNC (Hugo) PRL
LocusID (NCBI) 5617
Atlas_Id 41868
Location 6p22.3
Location_base_pair Starts at 22287473 and ends at 22297730 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PRL   9445
Cards
Entrez_Gene (NCBI)PRL  5617  prolactin
GeneCards (Weizmann)PRL
Ensembl hg19 (Hinxton)ENSG00000172179 [Gene_View]  chr6:22287473-22297730 [Contig_View]  PRL [Vega]
Ensembl hg38 (Hinxton)ENSG00000172179 [Gene_View]  chr6:22287473-22297730 [Contig_View]  PRL [Vega]
ICGC DataPortalENSG00000172179
TCGA cBioPortalPRL
AceView (NCBI)PRL
Genatlas (Paris)PRL
WikiGenes5617
SOURCE (Princeton)PRL
Genomic and cartography
GoldenPath hg19 (UCSC)PRL  -     chr6:22287473-22297730 -  6p22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PRL  -     6p22.3   [Description]    (hg38-Dec_2013)
EnsemblPRL - 6p22.3 [CytoView hg19]  PRL - 6p22.3 [CytoView hg38]
Mapping of homologs : NCBIPRL [Mapview hg19]  PRL [Mapview hg38]
OMIM176760   
Gene and transcription
Genbank (Entrez)BC015850 BC088370 CD106243 D00411 DQ839492
RefSeq transcript (Entrez)NM_000948 NM_001163558
RefSeq genomic (Entrez)NC_000006 NC_018917 NG_029819 NT_007592 NW_004929326
Consensus coding sequences : CCDS (NCBI)PRL
Cluster EST : UnigeneHs.735971 [ NCBI ]
CGAP (NCI)Hs.735971
Alternative Splicing : Fast-db (Paris)GSHG0026347
Alternative Splicing GalleryENSG00000172179
Gene ExpressionPRL [ NCBI-GEO ]     PRL [ SEEK ]   PRL [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01236 (Uniprot)
NextProtP01236  [Medical]  [Publications]
With graphics : InterProP01236
Splice isoforms : SwissVarP01236 (Swissvar)
Domaine pattern : Prosite (Expaxy)SOMATOTROPIN_1 (PS00266)    SOMATOTROPIN_2 (PS00338)   
Domains : Interpro (EBI)4_helix_cytokine-like_core    4_helix_cytokine_core    Somatotropin    Somatotropin_CS   
Related proteins : CluSTrP01236
Domain families : Pfam (Sanger)Hormone_1 (PF00103)   
Domain families : Pfam (NCBI)pfam00103   
DMDM Disease mutations5617
Blocks (Seattle)P01236
PDB (SRS)1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
PDB (PDBSum)1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
PDB (IMB)1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
PDB (RSDB)1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
Human Protein AtlasENSG00000172179
Peptide AtlasP01236
HPRD07180
IPIIPI00855965   IPI00000871   
Protein Interaction databases
DIP (DOE-UCLA)P01236
IntAct (EBI)P01236
FunCoupENSG00000172179
BioGRIDPRL
IntegromeDBPRL
STRING (EMBL)PRL
Ontologies - Pathways
QuickGOP01236
Ontology : AmiGOprolactin receptor binding  hormone activity  protein binding  extracellular region  intracellular  cell surface receptor signaling pathway  female pregnancy  lactation  cell proliferation  regulation of multicellular organism growth  positive regulation of JAK-STAT cascade  JAK-STAT cascade involved in growth hormone signaling pathway  
Ontology : EGO-EBIprolactin receptor binding  hormone activity  protein binding  extracellular region  intracellular  cell surface receptor signaling pathway  female pregnancy  lactation  cell proliferation  regulation of multicellular organism growth  positive regulation of JAK-STAT cascade  JAK-STAT cascade involved in growth hormone signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction    Neuroactive ligand-receptor interaction    PI3K-Akt signaling pathway    Jak-STAT signaling pathway    Prolactin signaling pathway   
Protein Interaction DatabasePRL
DoCM (Curated mutations)PRL
Wikipedia pathwaysPRL
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerPRL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRL
dbVarPRL
ClinVarPRL
1000_GenomesPRL 
Exome Variant ServerPRL
SNP (GeneSNP Utah)PRL
SNP : HGBasePRL
Genetic variants : HAPMAPPRL
Genomic Variants (DGV)PRL [DGVbeta]
Mutations
ICGC Data PortalPRL 
TCGA Data PortalPRL 
Tumor PortalPRL
Somatic Mutations in Cancer : COSMICPRL 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)6:22287473-22297730
CONAN: Copy Number AnalysisPRL 
Mutations and Diseases : HGMDPRL
OMIM176760   
MedgenPRL
NextProtP01236 [Medical]
GENETestsPRL
Disease Genetic AssociationPRL
Huge Navigator PRL [HugePedia]  PRL [HugeCancerGEM]
snp3D : Map Gene to Disease5617
DGIdb (Drug Gene Interaction db)PRL
BioCentury BCIQPRL
General knowledge
Homologs : HomoloGenePRL
Homology/Alignments : Family Browser (UCSC)PRL
Phylogenetic Trees/Animal Genes : TreeFamPRL
Chemical/Protein Interactions : CTD5617
Chemical/Pharm GKB GenePA33790
Clinical trialPRL
Cancer Resource (Charite)ENSG00000172179
Other databases
Probes
Litterature
PubMed230 Pubmed reference(s) in Entrez
CoreMinePRL
GoPubMedPRL
iHOPPRL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jun 27 12:07:58 CEST 2015

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.