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PRL (prolactin)

Identity

Other names-
HGNC (Hugo) PRL
LocusID (NCBI) 5617
Location 6p22.3
Location_base_pair Starts at 22287473 and ends at 22297730 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors AmeloblastomID5945

External links

Nomenclature
HGNC (Hugo)PRL   9445
Cards
Entrez_Gene (NCBI)PRL  5617  prolactin
GeneCards (Weizmann)PRL
Ensembl (Hinxton)ENSG00000172179 [Gene_View]  chr6:22287473-22297730 [Contig_View]  PRL [Vega]
ICGC DataPortalENSG00000172179
cBioPortalPRL
AceView (NCBI)PRL
Genatlas (Paris)PRL
WikiGenes5617
SOURCE (Princeton)NM_000948 NM_001163558
Genomic and cartography
GoldenPath (UCSC)PRL  -  6p22.3   chr6:22287473-22297730 -  6p22.3   [Description]    (hg19-Feb_2009)
EnsemblPRL - 6p22.3 [CytoView]
Mapping of homologs : NCBIPRL [Mapview]
OMIM176760   
Gene and transcription
Genbank (Entrez)BC015850 BC088370 CD106243 D00411 DQ839492
RefSeq transcript (Entrez)NM_000948 NM_001163558
RefSeq genomic (Entrez)AC_000138 NC_000006 NC_018917 NG_029819 NT_007592 NW_001838973 NW_004929326
Consensus coding sequences : CCDS (NCBI)PRL
Cluster EST : UnigeneHs.735971 [ NCBI ]
CGAP (NCI)Hs.735971
Alternative Splicing : Fast-db (Paris)GSHG0026347
Alternative Splicing GalleryENSG00000172179
Gene ExpressionPRL [ NCBI-GEO ]     PRL [ SEEK ]   PRL [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01236 (Uniprot)
NextProtP01236  [Medical]
With graphics : InterProP01236
Splice isoforms : SwissVarP01236 (Swissvar)
Domaine pattern : Prosite (Expaxy)SOMATOTROPIN_1 (PS00266)    SOMATOTROPIN_2 (PS00338)   
Domains : Interpro (EBI)4_helix_cytokine-like_core [organisation]   4_helix_cytokine_core [organisation]   Somatotropin [organisation]   Somatotropin_CS [organisation]  
Related proteins : CluSTrP01236
Domain families : Pfam (Sanger)Hormone_1 (PF00103)   
Domain families : Pfam (NCBI)pfam00103   
DMDM Disease mutations5617
Blocks (Seattle)P01236
PDB (SRS)1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
PDB (PDBSum)1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
PDB (IMB)1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
PDB (RSDB)1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
Human Protein AtlasENSG00000172179 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP01236
HPRD07180
IPIIPI00855965   IPI00000871   
Protein Interaction databases
DIP (DOE-UCLA)P01236
IntAct (EBI)P01236
FunCoupENSG00000172179
BioGRIDPRL
InParanoidP01236
Interologous Interaction database P01236
IntegromeDBPRL
STRING (EMBL)PRL
Ontologies - Pathways
Ontology : AmiGOprolactin receptor binding  hormone activity  protein binding  extracellular region  cell surface receptor signaling pathway  female pregnancy  lactation  cell proliferation  regulation of multicellular organism growth  positive regulation of JAK-STAT cascade  JAK-STAT cascade involved in growth hormone signaling pathway  
Ontology : EGO-EBIprolactin receptor binding  hormone activity  protein binding  extracellular region  cell surface receptor signaling pathway  female pregnancy  lactation  cell proliferation  regulation of multicellular organism growth  positive regulation of JAK-STAT cascade  JAK-STAT cascade involved in growth hormone signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction    Neuroactive ligand-receptor interaction    PI3K-Akt signaling pathway    Jak-STAT signaling pathway    Prolactin signaling pathway   
Protein Interaction DatabasePRL
Wikipedia pathwaysPRL
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PRL
snp3D : Map Gene to Disease5617
SNP (GeneSNP Utah)PRL
SNP : HGBasePRL
Genetic variants : HAPMAPPRL
Exome VariantPRL
1000_GenomesPRL 
ICGC programENSG00000172179 
Somatic Mutations in Cancer : COSMICPRL 
CONAN: Copy Number AnalysisPRL 
Mutations and Diseases : HGMDPRL
Mutations and Diseases : intOGenPRL
Genomic VariantsPRL  PRL [DGVbeta]
dbVarPRL
ClinVarPRL
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM176760   
MedgenPRL
GENETestsPRL
Disease Genetic AssociationPRL
Huge Navigator PRL [HugePedia]  PRL [HugeCancerGEM]
General knowledge
Homologs : HomoloGenePRL
Homology/Alignments : Family Browser (UCSC)PRL
Phylogenetic Trees/Animal Genes : TreeFamPRL
Chemical/Protein Interactions : CTD5617
Chemical/Pharm GKB GenePA33790
Clinical trialPRL
Cancer Resource (Charite)ENSG00000172179
Other databases
Probes
Litterature
PubMed219 Pubmed reference(s) in Entrez
CoreMinePRL
iHOPPRL
OncoSearchPRL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 17:01:13 CEST 2014

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