Atlas of Genetics and Cytogenetics in Oncology and Haematology


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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars

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PRL (prolactin)

Identity

Other names-
HGNC (Hugo) PRL
LocusID (NCBI) 5617
Location 6p22.3
Location_base_pair Starts at 22287473 and ends at 22297730 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors AmeloblastomID5945

External links

Nomenclature
HGNC (Hugo)PRL   9445
Cards
Entrez_Gene (NCBI)PRL  5617  prolactin
GeneCards (Weizmann)PRL
Ensembl hg19 (Hinxton)ENSG00000172179 [Gene_View]  chr6:22287473-22297730 [Contig_View]  PRL [Vega]
Ensembl hg38 (Hinxton)ENSG00000172179 [Gene_View]  chr6:22287473-22297730 [Contig_View]  PRL [Vega]
ICGC DataPortalENSG00000172179
cBioPortalPRL
AceView (NCBI)PRL
Genatlas (Paris)PRL
WikiGenes5617
SOURCE (Princeton)PRL
Genomic and cartography
GoldenPath hg19 (UCSC)PRL  -     chr6:22287473-22297730 -  6p22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PRL  -     6p22.3   [Description]    (hg38-Dec_2013)
EnsemblPRL - 6p22.3 [CytoView hg19]  PRL - 6p22.3 [CytoView hg38]
Mapping of homologs : NCBIPRL [Mapview hg19]  PRL [Mapview hg38]
OMIM176760   
Gene and transcription
Genbank (Entrez)BC015850 BC088370 CD106243 D00411 DQ839492
RefSeq transcript (Entrez)NM_000948 NM_001163558
RefSeq genomic (Entrez)NC_000006 NC_018917 NG_029819 NT_007592 NW_004929326
Consensus coding sequences : CCDS (NCBI)PRL
Cluster EST : UnigeneHs.735971 [ NCBI ]
CGAP (NCI)Hs.735971
Alternative Splicing : Fast-db (Paris)GSHG0026347
Alternative Splicing GalleryENSG00000172179
Gene ExpressionPRL [ NCBI-GEO ]     PRL [ SEEK ]   PRL [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01236 (Uniprot)
NextProtP01236  [Medical]
With graphics : InterProP01236
Splice isoforms : SwissVarP01236 (Swissvar)
Domaine pattern : Prosite (Expaxy)SOMATOTROPIN_1 (PS00266)    SOMATOTROPIN_2 (PS00338)   
Domains : Interpro (EBI)4_helix_cytokine-like_core    4_helix_cytokine_core    Somatotropin    Somatotropin_CS   
Related proteins : CluSTrP01236
Domain families : Pfam (Sanger)Hormone_1 (PF00103)   
Domain families : Pfam (NCBI)pfam00103   
DMDM Disease mutations5617
Blocks (Seattle)P01236
PDB (SRS)1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
PDB (PDBSum)1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
PDB (IMB)1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
PDB (RSDB)1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
Human Protein AtlasENSG00000172179
Peptide AtlasP01236
HPRD07180
IPIIPI00855965   IPI00000871   
Protein Interaction databases
DIP (DOE-UCLA)P01236
IntAct (EBI)P01236
FunCoupENSG00000172179
BioGRIDPRL
IntegromeDBPRL
STRING (EMBL)PRL
Ontologies - Pathways
QuickGOP01236
Ontology : AmiGOprolactin receptor binding  hormone activity  protein binding  extracellular region  cell surface receptor signaling pathway  female pregnancy  lactation  cell proliferation  regulation of multicellular organism growth  positive regulation of JAK-STAT cascade  JAK-STAT cascade involved in growth hormone signaling pathway  
Ontology : EGO-EBIprolactin receptor binding  hormone activity  protein binding  extracellular region  cell surface receptor signaling pathway  female pregnancy  lactation  cell proliferation  regulation of multicellular organism growth  positive regulation of JAK-STAT cascade  JAK-STAT cascade involved in growth hormone signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction    Neuroactive ligand-receptor interaction    PI3K-Akt signaling pathway    Jak-STAT signaling pathway    Prolactin signaling pathway   
Protein Interaction DatabasePRL
DoCM (Curated mutations)PRL
Wikipedia pathwaysPRL
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPRL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRL
dbVarPRL
ClinVarPRL
1000_GenomesPRL 
Exome Variant ServerPRL
SNP (GeneSNP Utah)PRL
SNP : HGBasePRL
Genetic variants : HAPMAPPRL
Genomic Variants (DGV)PRL [DGVbeta]
Mutations
ICGC Data PortalENSG00000172179 
Somatic Mutations in Cancer : COSMICPRL 
CONAN: Copy Number AnalysisPRL 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)6:22287473-22297730
Mutations and Diseases : HGMDPRL
OMIM176760   
MedgenPRL
NextProtP01236 [Medical]
GENETestsPRL
Disease Genetic AssociationPRL
Huge Navigator PRL [HugePedia]  PRL [HugeCancerGEM]
snp3D : Map Gene to Disease5617
DGIdb (Drug Gene Interaction db)PRL
General knowledge
Homologs : HomoloGenePRL
Homology/Alignments : Family Browser (UCSC)PRL
Phylogenetic Trees/Animal Genes : TreeFamPRL
Chemical/Protein Interactions : CTD5617
Chemical/Pharm GKB GenePA33790
Clinical trialPRL
Cancer Resource (Charite)ENSG00000172179
Other databases
Probes
Litterature
PubMed227 Pubmed reference(s) in Entrez
CoreMinePRL
GoPubMedPRL
iHOPPRL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 17:01:06 CET 2015

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.