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PRL (prolactin)

Identity

Other namesGHA1
HGNC (Hugo) PRL
LocusID (NCBI) 5617
Atlas_Id 41868
Location 6p22.3  [Link to chromosome band 6p22]
Location_base_pair Starts at 22287473 and ends at 22297730 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LOC100507412 (-) / PRL (6p22.3)NEBL (10p12.31) / PRL (6p22.3)ZC3H4 (19q13.32) / PRL (6p22.3)
NEBL 10p12.31 / PRL 6p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Uterus: Leiomyoma

External links

Nomenclature
HGNC (Hugo)PRL   9445
Cards
Entrez_Gene (NCBI)PRL  5617  prolactin
AliasesGHA1
GeneCards (Weizmann)PRL
Ensembl hg19 (Hinxton)ENSG00000172179 [Gene_View]  chr6:22287473-22297730 [Contig_View]  PRL [Vega]
Ensembl hg38 (Hinxton)ENSG00000172179 [Gene_View]  chr6:22287473-22297730 [Contig_View]  PRL [Vega]
ICGC DataPortalENSG00000172179
TCGA cBioPortalPRL
AceView (NCBI)PRL
Genatlas (Paris)PRL
WikiGenes5617
SOURCE (Princeton)PRL
Genomic and cartography
GoldenPath hg19 (UCSC)PRL  -     chr6:22287473-22297730 -  6p22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PRL  -     6p22.3   [Description]    (hg38-Dec_2013)
EnsemblPRL - 6p22.3 [CytoView hg19]  PRL - 6p22.3 [CytoView hg38]
Mapping of homologs : NCBIPRL [Mapview hg19]  PRL [Mapview hg38]
OMIM176760   
Gene and transcription
Genbank (Entrez)BC015850 BC088370 CD106243 D00411 DQ839492
RefSeq transcript (Entrez)NM_000948 NM_001163558
RefSeq genomic (Entrez)NC_000006 NC_018917 NG_029819 NT_007592 NW_004929326
Consensus coding sequences : CCDS (NCBI)PRL
Cluster EST : UnigeneHs.735971 [ NCBI ]
CGAP (NCI)Hs.735971
Alternative Splicing GalleryENSG00000172179
Gene ExpressionPRL [ NCBI-GEO ]   PRL [ EBI - ARRAY_EXPRESS ]   PRL [ SEEK ]   PRL [ MEM ]
Gene Expression Viewer (FireBrowse)PRL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5617
GTEX Portal (Tissue expression)PRL
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01236 (Uniprot)
NextProtP01236  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01236
Splice isoforms : SwissVarP01236 (Swissvar)
PhosPhoSitePlusP01236
Domaine pattern : Prosite (Expaxy)SOMATOTROPIN_1 (PS00266)    SOMATOTROPIN_2 (PS00338)   
Domains : Interpro (EBI)4_helix_cytokine-like_core    4_helix_cytokine_core    Somatotropin    Somatotropin_CS   
Domain families : Pfam (Sanger)Hormone_1 (PF00103)   
Domain families : Pfam (NCBI)pfam00103   
DMDM Disease mutations5617
Blocks (Seattle)PRL
PDB (SRS)1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
PDB (PDBSum)1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
PDB (IMB)1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
PDB (RSDB)1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
Structural Biology KnowledgeBase1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
SCOP (Structural Classification of Proteins)1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
CATH (Classification of proteins structures)1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
SuperfamilyP01236
Human Protein AtlasENSG00000172179
Peptide AtlasP01236
HPRD07180
IPIIPI00855965   IPI00000871   
Protein Interaction databases
DIP (DOE-UCLA)P01236
IntAct (EBI)P01236
FunCoupENSG00000172179
BioGRIDPRL
STRING (EMBL)PRL
ZODIACPRL
Ontologies - Pathways
QuickGOP01236
Ontology : AmiGOprolactin receptor binding  hormone activity  protein binding  extracellular region  intracellular  cell surface receptor signaling pathway  female pregnancy  lactation  cell proliferation  regulation of multicellular organism growth  cellular protein metabolic process  positive regulation of JAK-STAT cascade  JAK-STAT cascade involved in growth hormone signaling pathway  
Ontology : EGO-EBIprolactin receptor binding  hormone activity  protein binding  extracellular region  intracellular  cell surface receptor signaling pathway  female pregnancy  lactation  cell proliferation  regulation of multicellular organism growth  cellular protein metabolic process  positive regulation of JAK-STAT cascade  JAK-STAT cascade involved in growth hormone signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction    Neuroactive ligand-receptor interaction    PI3K-Akt signaling pathway    Jak-STAT signaling pathway    Prolactin signaling pathway   
NDEx NetworkPRL
Atlas of Cancer Signalling NetworkPRL
Wikipedia pathwaysPRL
Orthology - Evolution
OrthoDB5617
GeneTree (enSembl)ENSG00000172179
Phylogenetic Trees/Animal Genes : TreeFamPRL
Homologs : HomoloGenePRL
Homology/Alignments : Family Browser (UCSC)PRL
Gene fusions - Rearrangements
Fusion: TCGANEBL 10p12.31 PRL 6p22.3 BLCA
Polymorphisms : SNP, variants
NCBI Variation ViewerPRL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRL
dbVarPRL
ClinVarPRL
1000_GenomesPRL 
Exome Variant ServerPRL
ExAC (Exome Aggregation Consortium)PRL (select the gene name)
Genetic variants : HAPMAP5617
Genomic Variants (DGV)PRL [DGVbeta]
Mutations
ICGC Data PortalPRL 
TCGA Data PortalPRL 
Broad Tumor PortalPRL
OASIS PortalPRL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRL 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRL
DgiDB (Drug Gene Interaction Database)PRL
DoCM (Curated mutations)PRL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRL (select a term)
intoGenPRL
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)6:22287473-22297730  ENSG00000172179
CONAN: Copy Number AnalysisPRL 
Mutations and Diseases : HGMDPRL
OMIM176760   
MedgenPRL
Genetic Testing Registry PRL
NextProtP01236 [Medical]
TSGene5617
GENETestsPRL
Huge Navigator PRL [HugePedia]
snp3D : Map Gene to Disease5617
BioCentury BCIQPRL
ClinGenPRL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5617
Chemical/Pharm GKB GenePA33790
Clinical trialPRL
Miscellaneous
canSAR (ICR)PRL (select the gene name)
Probes
Litterature
PubMed246 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRL
EVEXPRL
GoPubMedPRL
iHOPPRL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 19 19:08:38 CEST 2016

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