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PRL (prolactin)

Identity

Alias (NCBI)GHA1
HGNC (Hugo) PRL
LocusID (NCBI) 5617
Atlas_Id 41868
Location 6p22.3  [Link to chromosome band 6p22]
Location_base_pair Starts at 22287248 and ends at 22302835 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LOC100507412 (-) / PRL (6p22.3)NEBL (10p12.31) / PRL (6p22.3)ZC3H4 (19q13.32) / PRL (6p22.3)
NEBL 10p12.31 / PRL 6p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PRL   9445
Cards
Entrez_Gene (NCBI)PRL    prolactin
AliasesGHA1
GeneCards (Weizmann)PRL
Ensembl hg19 (Hinxton)ENSG00000172179 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172179 [Gene_View]  ENSG00000172179 [Sequence]  chr6:22287248-22302835 [Contig_View]  PRL [Vega]
ICGC DataPortalENSG00000172179
TCGA cBioPortalPRL
AceView (NCBI)PRL
Genatlas (Paris)PRL
SOURCE (Princeton)PRL
Genetics Home Reference (NIH)PRL
Genomic and cartography
GoldenPath hg38 (UCSC)PRL  -     chr6:22287248-22302835 -  6p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRL  -     6p22.3   [Description]    (hg19-Feb_2009)
GoldenPathPRL - 6p22.3 [CytoView hg19]  PRL - 6p22.3 [CytoView hg38]
ImmunoBaseENSG00000172179
Genome Data Viewer NCBIPRL [Mapview hg19]  
OMIM176760   
Gene and transcription
Genbank (Entrez)BC015850 BC088370 CD106243 D00411 DQ839492
RefSeq transcript (Entrez)NM_000948 NM_001163558
Consensus coding sequences : CCDS (NCBI)PRL
Gene ExpressionPRL [ NCBI-GEO ]   PRL [ EBI - ARRAY_EXPRESS ]   PRL [ SEEK ]   PRL [ MEM ]
Gene Expression Viewer (FireBrowse)PRL [ Firebrowse - Broad ]
GenevisibleExpression of PRL in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5617
GTEX Portal (Tissue expression)PRL
Human Protein AtlasENSG00000172179-PRL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01236   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01236  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01236
PhosPhoSitePlusP01236
Domaine pattern : Prosite (Expaxy)SOMATOTROPIN_1 (PS00266)    SOMATOTROPIN_2 (PS00338)   
Domains : Interpro (EBI)4_helix_cytokine-like_core    Somatotropin/Prolactin    Somatotropin_CS   
Domain families : Pfam (Sanger)Hormone_1 (PF00103)   
Domain families : Pfam (NCBI)pfam00103   
Conserved Domain (NCBI)PRL
PDB (RSDB)1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
PDB Europe1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
PDB (PDBSum)1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
PDB (IMB)1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
Structural Biology KnowledgeBase1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
SCOP (Structural Classification of Proteins)1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
CATH (Classification of proteins structures)1RW5    2Q98    3D48    3EW3    3MZG    3N06    3N0P    3NCB    3NCC    3NCE    3NCF    3NPZ   
SuperfamilyP01236
AlphaFold pdb e-kbP01236   
Human Protein Atlas [tissue]ENSG00000172179-PRL [tissue]
HPRD07180
Protein Interaction databases
DIP (DOE-UCLA)P01236
IntAct (EBI)P01236
BioGRIDPRL
STRING (EMBL)PRL
ZODIACPRL
Ontologies - Pathways
QuickGOP01236
Ontology : AmiGOnegative regulation of endothelial cell proliferation  prolactin receptor binding  hormone activity  protein binding  extracellular region  extracellular space  cell surface receptor signaling pathway  female pregnancy  lactation  positive regulation of cell population proliferation  negative regulation of angiogenesis  mammary gland development  response to nutrient levels  endosome lumen  regulation of multicellular organism growth  positive regulation of receptor signaling pathway via JAK-STAT  positive regulation of receptor signaling pathway via JAK-STAT  growth hormone receptor signaling pathway via JAK-STAT  positive regulation of pri-miRNA transcription by RNA polymerase II  positive regulation of lactation  amyloid fibril formation  
Ontology : EGO-EBInegative regulation of endothelial cell proliferation  prolactin receptor binding  hormone activity  protein binding  extracellular region  extracellular space  cell surface receptor signaling pathway  female pregnancy  lactation  positive regulation of cell population proliferation  negative regulation of angiogenesis  mammary gland development  response to nutrient levels  endosome lumen  regulation of multicellular organism growth  positive regulation of receptor signaling pathway via JAK-STAT  positive regulation of receptor signaling pathway via JAK-STAT  growth hormone receptor signaling pathway via JAK-STAT  positive regulation of pri-miRNA transcription by RNA polymerase II  positive regulation of lactation  amyloid fibril formation  
Pathways : KEGGCytokine-cytokine receptor interaction    Neuroactive ligand-receptor interaction    PI3K-Akt signaling pathway    Jak-STAT signaling pathway    Prolactin signaling pathway   
NDEx NetworkPRL
Atlas of Cancer Signalling NetworkPRL
Wikipedia pathwaysPRL
Orthology - Evolution
OrthoDB5617
GeneTree (enSembl)ENSG00000172179
Phylogenetic Trees/Animal Genes : TreeFamPRL
Homologs : HomoloGenePRL
Homology/Alignments : Family Browser (UCSC)PRL
Gene fusions - Rearrangements
Fusion : MitelmanNEBL/PRL [10p12.31/6p22.3]  
Fusion : QuiverPRL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRL
dbVarPRL
ClinVarPRL
MonarchPRL
1000_GenomesPRL 
Exome Variant ServerPRL
GNOMAD BrowserENSG00000172179
Varsome BrowserPRL
ACMGPRL variants
VarityP01236
Genomic Variants (DGV)PRL [DGVbeta]
DECIPHERPRL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRL 
Mutations
ICGC Data PortalPRL 
TCGA Data PortalPRL 
Broad Tumor PortalPRL
OASIS PortalPRL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRL  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPRL
Mutations and Diseases : HGMDPRL
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPRL
DgiDB (Drug Gene Interaction Database)PRL
DoCM (Curated mutations)PRL
CIViC (Clinical Interpretations of Variants in Cancer)PRL
Cancer3DPRL
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176760   
Orphanet
DisGeNETPRL
MedgenPRL
Genetic Testing Registry PRL
NextProtP01236 [Medical]
GENETestsPRL
Target ValidationPRL
Huge Navigator PRL [HugePedia]
ClinGenPRL
Clinical trials, drugs, therapy
MyCancerGenomePRL
Protein Interactions : CTDPRL
Pharm GKB GenePA33790
PharosP01236
Clinical trialPRL
Miscellaneous
canSAR (ICR)PRL
HarmonizomePRL
DataMed IndexPRL
Probes
Litterature
PubMed295 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPRL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:26:54 CEST 2021

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