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PRMT1 (protein arginine methyltransferase 1)

Identity

Alias_namesHRMT1L2
HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2
HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae)
Alias_symbol (synonym)HCP1
ANM1
Other aliasIR1B4
HGNC (Hugo) PRMT1
LocusID (NCBI) 3276
Atlas_Id 49941
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 50180409 and ends at 50191707 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
BCL2L12 (19q13.33) / PRMT1 (19q13.33)PRMT1 (19q13.33) / BCL2L12 (19q13.33)PRMT1 (19q13.33) / CCDC186 (10q25.3)
PRMT1 (19q13.33) / FLT3LG (19q13.33)PRMT1 (19q13.33) / TLE6 (19p13.3)SH3D21 (1p34.3) / PRMT1 (19q13.33)
PRMT1 19q13.33 / TLE6 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Soft Tissues: Angiofibroma


External links

Nomenclature
HGNC (Hugo)PRMT1   5187
Cards
Entrez_Gene (NCBI)PRMT1  3276  protein arginine methyltransferase 1
AliasesANM1; HCP1; HRMT1L2; IR1B4
GeneCards (Weizmann)PRMT1
Ensembl hg19 (Hinxton)ENSG00000126457 [Gene_View]  chr19:50180409-50191707 [Contig_View]  PRMT1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000126457 [Gene_View]  chr19:50180409-50191707 [Contig_View]  PRMT1 [Vega]
ICGC DataPortalENSG00000126457
TCGA cBioPortalPRMT1
AceView (NCBI)PRMT1
Genatlas (Paris)PRMT1
WikiGenes3276
SOURCE (Princeton)PRMT1
Genetics Home Reference (NIH)PRMT1
Genomic and cartography
GoldenPath hg19 (UCSC)PRMT1  -     chr19:50180409-50191707 +  19q13.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PRMT1  -     19q13.33   [Description]    (hg38-Dec_2013)
EnsemblPRMT1 - 19q13.33 [CytoView hg19]  PRMT1 - 19q13.33 [CytoView hg38]
Mapping of homologs : NCBIPRMT1 [Mapview hg19]  PRMT1 [Mapview hg38]
OMIM602950   
Gene and transcription
Genbank (Entrez)AF085918 AI193116 AK295973 AK301038 AK304660
RefSeq transcript (Entrez)NM_001207042 NM_001536 NM_198318 NM_198319
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_031846 NT_011109 NW_004929415
Consensus coding sequences : CCDS (NCBI)PRMT1
Cluster EST : UnigeneHs.20521 [ NCBI ]
CGAP (NCI)Hs.20521
Alternative Splicing GalleryENSG00000126457
Gene ExpressionPRMT1 [ NCBI-GEO ]   PRMT1 [ EBI - ARRAY_EXPRESS ]   PRMT1 [ SEEK ]   PRMT1 [ MEM ]
Gene Expression Viewer (FireBrowse)PRMT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3276
GTEX Portal (Tissue expression)PRMT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99873   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99873  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99873
Splice isoforms : SwissVarQ99873
PhosPhoSitePlusQ99873
Domaine pattern : Prosite (Expaxy)SAM_MT_PRMT (PS51678)   
Domains : Interpro (EBI)Arg_MeTrfase    Methyltranfer_dom    SAM-dependent_MTases   
Domain families : Pfam (Sanger)Methyltransf_31 (PF13847)   
Domain families : Pfam (NCBI)pfam13847   
Conserved Domain (NCBI)PRMT1
DMDM Disease mutations3276
Blocks (Seattle)PRMT1
SuperfamilyQ99873
Human Protein AtlasENSG00000126457
Peptide AtlasQ99873
HPRD04257
IPIIPI01018101   IPI00909470   IPI00978434   IPI00984352   IPI00982604   IPI00984969   IPI00382516   IPI00976691   IPI01014546   IPI00979045   IPI00981445   IPI00980839   
Protein Interaction databases
DIP (DOE-UCLA)Q99873
IntAct (EBI)Q99873
FunCoupENSG00000126457
BioGRIDPRMT1
STRING (EMBL)PRMT1
ZODIACPRMT1
Ontologies - Pathways
QuickGOQ99873
Ontology : AmiGOprotein binding  nucleus  nucleoplasm  cytoplasm  cytosol  regulation of transcription, DNA-templated  protein methylation  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  cell surface receptor signaling pathway  methyltransferase activity  N-methyltransferase activity  N-methyltransferase activity  protein methyltransferase activity  methyl-CpG binding  protein-arginine N-methyltransferase activity  protein-arginine N-methyltransferase activity  histone methylation  peptidyl-arginine methylation  enzyme binding  peptidyl-arginine methylation, to asymmetrical-dimethyl arginine  neuron projection development  methylosome  protein-arginine omega-N asymmetric methyltransferase activity  peptidyl-arginine N-methylation  peptidyl-arginine N-methylation  histone methyltransferase activity  identical protein binding  histone H4-R3 methylation  histone methyltransferase activity (H4-R3 specific)  histone methyltransferase activity (H4-R3 specific)  poly(A) RNA binding  positive regulation of erythrocyte differentiation  negative regulation of megakaryocyte differentiation  positive regulation of hemoglobin biosynthetic process  mitogen-activated protein kinase p38 binding  positive regulation of p38MAPK cascade  
Ontology : EGO-EBIprotein binding  nucleus  nucleoplasm  cytoplasm  cytosol  regulation of transcription, DNA-templated  protein methylation  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  cell surface receptor signaling pathway  methyltransferase activity  N-methyltransferase activity  N-methyltransferase activity  protein methyltransferase activity  methyl-CpG binding  protein-arginine N-methyltransferase activity  protein-arginine N-methyltransferase activity  histone methylation  peptidyl-arginine methylation  enzyme binding  peptidyl-arginine methylation, to asymmetrical-dimethyl arginine  neuron projection development  methylosome  protein-arginine omega-N asymmetric methyltransferase activity  peptidyl-arginine N-methylation  peptidyl-arginine N-methylation  histone methyltransferase activity  identical protein binding  histone H4-R3 methylation  histone methyltransferase activity (H4-R3 specific)  histone methyltransferase activity (H4-R3 specific)  poly(A) RNA binding  positive regulation of erythrocyte differentiation  negative regulation of megakaryocyte differentiation  positive regulation of hemoglobin biosynthetic process  mitogen-activated protein kinase p38 binding  positive regulation of p38MAPK cascade  
Pathways : BIOCARTABTG family proteins and cell cycle regulation [Genes]    Control of Gene Expression by Vitamin D Receptor [Genes]   
Pathways : KEGGFoxO signaling pathway   
NDEx NetworkPRMT1
Atlas of Cancer Signalling NetworkPRMT1
Wikipedia pathwaysPRMT1
Orthology - Evolution
OrthoDB3276
GeneTree (enSembl)ENSG00000126457
Phylogenetic Trees/Animal Genes : TreeFamPRMT1
HOVERGENQ99873
HOGENOMQ99873
Homologs : HomoloGenePRMT1
Homology/Alignments : Family Browser (UCSC)PRMT1
Gene fusions - Rearrangements
Fusion : MitelmanBCL2L12/PRMT1 [19q13.33/19q13.33]  [t(19;19)(q13;q13)]  
Fusion : MitelmanPRMT1/FLT3LG [19q13.33/19q13.33]  [t(19;19)(q13;q13)]  
Fusion : MitelmanPRMT1/TLE6 [19q13.33/19p13.3]  [t(19;19)(p13;q13)]  
Fusion: TCGAPRMT1 19q13.33 TLE6 19p13.3 LAML
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRMT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRMT1
dbVarPRMT1
ClinVarPRMT1
1000_GenomesPRMT1 
Exome Variant ServerPRMT1
ExAC (Exome Aggregation Consortium)PRMT1 (select the gene name)
Genetic variants : HAPMAP3276
Genomic Variants (DGV)PRMT1 [DGVbeta]
DECIPHER (Syndromes)19:50180409-50191707  ENSG00000126457
CONAN: Copy Number AnalysisPRMT1 
Mutations
ICGC Data PortalPRMT1 
TCGA Data PortalPRMT1 
Broad Tumor PortalPRMT1
OASIS PortalPRMT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRMT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRMT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRMT1
DgiDB (Drug Gene Interaction Database)PRMT1
DoCM (Curated mutations)PRMT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRMT1 (select a term)
intoGenPRMT1
Cancer3DPRMT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602950   
Orphanet
MedgenPRMT1
Genetic Testing Registry PRMT1
NextProtQ99873 [Medical]
TSGene3276
GENETestsPRMT1
Huge Navigator PRMT1 [HugePedia]
snp3D : Map Gene to Disease3276
BioCentury BCIQPRMT1
ClinGenPRMT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3276
Chemical/Pharm GKB GenePA29461
Clinical trialPRMT1
Miscellaneous
canSAR (ICR)PRMT1 (select the gene name)
Probes
Litterature
PubMed180 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRMT1
EVEXPRMT1
GoPubMedPRMT1
iHOPPRMT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:23:01 CET 2017

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