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PRMT2 (protein arginine methyltransferase 2)

Identity

Alias_namesHRMT1L1
HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1
HMT1 hnRNP methyltransferase-like 1 (S. cerevisiae)
Alias_symbol (synonym)MGC111373
Other alias
HGNC (Hugo) PRMT2
LocusID (NCBI) 3275
Atlas_Id 49971
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 46635595 and ends at 46665124 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PRMT2 (21q22.3) / ARHGEF9 (Xq11.1)PRMT2 (21q22.3) / DIP2A (21q22.3)PRMT2 (21q22.3) / GAPDH (12p13.31)
PRMT2 (21q22.3) / PRMT2 (21q22.3)PRMT2 (21q22.3) / SNX5 (20p11.23)PRMT2 (21q22.3) / STX18 (4p16.3)
TNNC2 (20q13.12) / PRMT2 (21q22.3)PRMT2 21q22.3 / DIP2A 21q22.3PRMT2 21q22.3 / STX18 4p16.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRMT2   5186
Cards
Entrez_Gene (NCBI)PRMT2  3275  protein arginine methyltransferase 2
AliasesHRMT1L1
GeneCards (Weizmann)PRMT2
Ensembl hg19 (Hinxton)ENSG00000160310 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160310 [Gene_View]  chr21:46635595-46665124 [Contig_View]  PRMT2 [Vega]
ICGC DataPortalENSG00000160310
TCGA cBioPortalPRMT2
AceView (NCBI)PRMT2
Genatlas (Paris)PRMT2
WikiGenes3275
SOURCE (Princeton)PRMT2
Genetics Home Reference (NIH)PRMT2
Genomic and cartography
GoldenPath hg38 (UCSC)PRMT2  -     chr21:46635595-46665124 +  21q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRMT2  -     21q22.3   [Description]    (hg19-Feb_2009)
EnsemblPRMT2 - 21q22.3 [CytoView hg19]  PRMT2 - 21q22.3 [CytoView hg38]
Mapping of homologs : NCBIPRMT2 [Mapview hg19]  PRMT2 [Mapview hg38]
OMIM601961   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001242864 NM_001242865 NM_001242866 NM_001286676 NM_001286677 NM_001286678 NM_001535 NM_206962
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRMT2
Cluster EST : UnigeneHs.661229 [ NCBI ]
CGAP (NCI)Hs.661229
Alternative Splicing GalleryENSG00000160310
Gene ExpressionPRMT2 [ NCBI-GEO ]   PRMT2 [ EBI - ARRAY_EXPRESS ]   PRMT2 [ SEEK ]   PRMT2 [ MEM ]
Gene Expression Viewer (FireBrowse)PRMT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3275
GTEX Portal (Tissue expression)PRMT2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55345   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP55345  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55345
Splice isoforms : SwissVarP55345
PhosPhoSitePlusP55345
Domaine pattern : Prosite (Expaxy)SAM_MT_PRMT (PS51678)    SH3 (PS50002)   
Domains : Interpro (EBI)Arg_MeTrfase    SAM-dependent_MTases    SH3_domain   
Domain families : Pfam (Sanger)PRMT5 (PF05185)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam05185    pfam14604   
Domain families : Smart (EMBL)SH3 (SM00326)  
Conserved Domain (NCBI)PRMT2
DMDM Disease mutations3275
Blocks (Seattle)PRMT2
PDB (SRS)1X2P   
PDB (PDBSum)1X2P   
PDB (IMB)1X2P   
PDB (RSDB)1X2P   
Structural Biology KnowledgeBase1X2P   
SCOP (Structural Classification of Proteins)1X2P   
CATH (Classification of proteins structures)1X2P   
SuperfamilyP55345
Human Protein AtlasENSG00000160310
Peptide AtlasP55345
HPRD09060
IPIIPI00297265   IPI01013409   IPI00921015   IPI00385972   IPI00383618   IPI00792684   IPI00793540   IPI00642559   
Protein Interaction databases
DIP (DOE-UCLA)P55345
IntAct (EBI)P55345
FunCoupENSG00000160310
BioGRIDPRMT2
STRING (EMBL)PRMT2
ZODIACPRMT2
Ontologies - Pathways
QuickGOP55345
Ontology : AmiGOtranscription coactivator activity  signal transducer activity  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  protein methylation  signal transduction  histone-arginine N-methyltransferase activity  protein-arginine N-methyltransferase activity  histone methylation  histone methylation  estrogen receptor binding  estrogen receptor binding  negative regulation of NF-kappaB transcription factor activity  progesterone receptor binding  histone arginine methylation  Rb-E2F complex  peptidyl-arginine N-methylation  histone methyltransferase activity  protein homodimerization activity  retinoic acid receptor binding  peroxisome proliferator activated receptor binding  positive regulation of apoptotic process  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  thyroid hormone receptor binding  developmental cell growth  androgen receptor binding  regulation of androgen receptor signaling pathway  negative regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBItranscription coactivator activity  signal transducer activity  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  protein methylation  signal transduction  histone-arginine N-methyltransferase activity  protein-arginine N-methyltransferase activity  histone methylation  histone methylation  estrogen receptor binding  estrogen receptor binding  negative regulation of NF-kappaB transcription factor activity  progesterone receptor binding  histone arginine methylation  Rb-E2F complex  peptidyl-arginine N-methylation  histone methyltransferase activity  protein homodimerization activity  retinoic acid receptor binding  peroxisome proliferator activated receptor binding  positive regulation of apoptotic process  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  thyroid hormone receptor binding  developmental cell growth  androgen receptor binding  regulation of androgen receptor signaling pathway  negative regulation of G1/S transition of mitotic cell cycle  
NDEx NetworkPRMT2
Atlas of Cancer Signalling NetworkPRMT2
Wikipedia pathwaysPRMT2
Orthology - Evolution
OrthoDB3275
GeneTree (enSembl)ENSG00000160310
Phylogenetic Trees/Animal Genes : TreeFamPRMT2
HOVERGENP55345
HOGENOMP55345
Homologs : HomoloGenePRMT2
Homology/Alignments : Family Browser (UCSC)PRMT2
Gene fusions - Rearrangements
Fusion : MitelmanPRMT2/DIP2A [21q22.3/21q22.3]  
Fusion : MitelmanPRMT2/STX18 [21q22.3/4p16.3]  [t(4;21)(p16;q22)]  
Fusion: TCGAPRMT2 21q22.3 DIP2A 21q22.3 BRCA
Fusion: TCGAPRMT2 21q22.3 STX18 4p16.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRMT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRMT2
dbVarPRMT2
ClinVarPRMT2
1000_GenomesPRMT2 
Exome Variant ServerPRMT2
ExAC (Exome Aggregation Consortium)PRMT2 (select the gene name)
Genetic variants : HAPMAP3275
Genomic Variants (DGV)PRMT2 [DGVbeta]
DECIPHERPRMT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRMT2 
Mutations
ICGC Data PortalPRMT2 
TCGA Data PortalPRMT2 
Broad Tumor PortalPRMT2
OASIS PortalPRMT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRMT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRMT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRMT2
DgiDB (Drug Gene Interaction Database)PRMT2
DoCM (Curated mutations)PRMT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRMT2 (select a term)
intoGenPRMT2
Cancer3DPRMT2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601961   
Orphanet
MedgenPRMT2
Genetic Testing Registry PRMT2
NextProtP55345 [Medical]
TSGene3275
GENETestsPRMT2
Huge Navigator PRMT2 [HugePedia]
snp3D : Map Gene to Disease3275
BioCentury BCIQPRMT2
ClinGenPRMT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3275
Chemical/Pharm GKB GenePA29460
Clinical trialPRMT2
Miscellaneous
canSAR (ICR)PRMT2 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRMT2
EVEXPRMT2
GoPubMedPRMT2
iHOPPRMT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:32:54 CEST 2017

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