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PRMT2 (protein arginine methyltransferase 2)

Identity

Other namesHRMT1L1
HGNC (Hugo) PRMT2
LocusID (NCBI) 3275
Location 21q22.3
Location_base_pair Starts at 48055507 and ends at 48085155 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PRMT2   5186
Entrez_Gene (NCBI)PRMT2  3275  protein arginine methyltransferase 2
Cards
GeneCards (Weizmann)PRMT2
Ensembl (Hinxton)ENSG00000160310 [Gene_View]  chr21:48055507-48085155 [Contig_View]  PRMT2 [Vega]
AceView (NCBI)PRMT2
Genatlas (Paris)PRMT2
SOURCE (Stanford)NM_001242864 NM_001242865 NM_001242866 NM_001535 NM_206962
Genomic and cartography
GoldenPath (UCSC)PRMT2  -  21q22.3   chr21:48055507-48085155 +  21q22.3   [Description]    (hg19-Feb_2009)
EnsemblPRMT2 - 21q22.3 [CytoView]
Mapping of homologs : NCBIPRMT2 [Mapview]
OMIM601961   
Gene and transcription
Genbank (Entrez)AF059319 AK055950 AK095641 AK123352 AK123650
RefSeq transcript (SRS)NM_001242864 NM_001242865 NM_001242866 NM_001535 NM_206962
RefSeq transcript (Entrez)NM_001242864 NM_001242865 NM_001242866 NM_001535 NM_206962
RefSeq genomic (SRS)AC_000153 NC_000021 NC_018932 NT_011515 NW_001838717 NW_004078109
RefSeq genomic (Entrez)AC_000153 NC_000021 NC_018932 NT_011515 NW_001838717 NW_004078109
Consensus coding sequences : CCDS (NCBI)PRMT2
Cluster EST : UnigeneHs.154163 [ SRS ] Hs.154163 [ NCBI ]
CGAP (NCI)Hs.154163
Alternative Splicing : Fast-db (Paris)GSHG0019573
Alternative Splicing GalleryENSG00000160310
Gene ExpressionPRMT2 [ NCBI-GEO ]   PRMT2 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55345 (SRS) P55345 (Uniprot)
NextProtP55345
With graphics : InterProP55345
Splice isoforms : SwissVarP55345(Swissvar)
Domaine pattern : Prosite (SRS)SH3 (PS50002)   
Domaine pattern : Prosite (Expaxy)SH3 (PS50002)   
Domains : Interpro (SRS)Arg_MeTrfase    Arg_MeTrfase_PMTR2    SH3_domain   
Domains : Interpro (EBI)Arg_MeTrfase    Arg_MeTrfase_PMTR2    SH3_domain   
Related proteins : CluSTrP55345
Domain families : Pfam (SRS)PRMT5 (PF05185)    SH3_1 (PF00018)   
Domain families : Pfam (Sanger)PRMT5 (PF05185)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam05185    pfam00018   
Domain families : Smart (EMBL)SH3 (SM00326)  
DMDM3275
Blocks (Seattle)P55345
PDB (SRS)1X2P   
PDB (PDBSum)1X2P   
PDB (IMB)1X2P   
PDB (RSDB)1X2P   
Human Protein AtlasENSG00000160310
HPRD09060
IPIIPI00297265   IPI01013409   IPI00921015   IPI00385972   IPI00383618   IPI00792684   IPI00793540   IPI00642559   
Protein Interaction databases
DIP (DOE-UCLA)P55345
IntAct (EBI)P55345
FunCoupENSG00000160310
REACTOMEPRMT2
Protein Interaction Database3275
BioGRIDPRMT2
InParanoidP55345
Interologous Interaction database P55345
IntegromeDBPRMT2
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PRMT2
SNP (GeneSNP Utah)PRMT2
SNP : HGBasePRMT2
Genetic variants : HAPMAPPRMT2
Somatic Mutations in Cancer : COSMICPRMT2 
CONAN: Copy Number AnalysisPRMT2 
Mutations and Diseases : HGMDPRMT2
OMIM601961   
GENETests601961   
Disease Genetic AssociationPRMT2
Huge Navigator PRMT2 [HugePedia]  PRMT2 [HugeCancerGEM]
Genomic VariantsPRMT2  PRMT2 [DGVbeta]
ClinVarPRMT2
snp3D : Map Gene to Disease3275
General knowledge
Homologs : HomoloGenePRMT2
Homology/Alignments : Family Browser (UCSC)PRMT2
Phylogenetic Trees/Animal Genes : TreeFamPRMT2
Catalytic activity : Enzyme2.1.1.- [ Enzyme-Expasy ]   2.1.1.- [ Enzyme-SRS ]   2.1.1.- [ IntEnz-EBI ]   2.1.1.- [ BRENDA ]   2.1.1.- [ KEGG ]   
Chemical/Protein Interactions : CTD3275
Chemical/Pharm GKB GenePA29460
Clinical trialPRMT2
Cancer Resource (Charite)ENSG00000160310
Ontology : AmiGOtranscription coactivator activity  signal transducer activity  protein binding  nucleus  cytoplasm  cytosol  protein methylation  induction of apoptosis  signal transduction  histone-arginine N-methyltransferase activity  protein-arginine N-methyltransferase activity  histone methylation  histone methylation  estrogen receptor binding  estrogen receptor binding  negative regulation of NF-kappaB transcription factor activity  progesterone receptor binding  histone arginine methylation  Rb-E2F complex  peptidyl-arginine N-methylation  histone methyltransferase activity  protein homodimerization activity  retinoic acid receptor binding  peroxisome proliferator activated receptor binding  negative regulation of transcription, DNA-dependent  positive regulation of transcription, DNA-dependent  thyroid hormone receptor binding  developmental cell growth  androgen receptor binding  regulation of androgen receptor signaling pathway  negative regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBItranscription coactivator activity  signal transducer activity  protein binding  nucleus  cytoplasm  cytosol  protein methylation  induction of apoptosis  signal transduction  histone-arginine N-methyltransferase activity  protein-arginine N-methyltransferase activity  histone methylation  histone methylation  estrogen receptor binding  estrogen receptor binding  negative regulation of NF-kappaB transcription factor activity  progesterone receptor binding  histone arginine methylation  Rb-E2F complex  peptidyl-arginine N-methylation  histone methyltransferase activity  protein homodimerization activity  retinoic acid receptor binding  peroxisome proliferator activated receptor binding  negative regulation of transcription, DNA-dependent  positive regulation of transcription, DNA-dependent  thyroid hormone receptor binding  developmental cell growth  androgen receptor binding  regulation of androgen receptor signaling pathway  negative regulation of G1/S transition of mitotic cell cycle  
Pathways : KEGGAminophosphonate metabolismAndrogen and estrogen metabolismNitrobenzene degradationSelenoamino acid metabolismHistidine metabolismTyrosine metabolismTryptophan metabolism
Other databases
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
PubGenePRMT2
iHOPPRMT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 14 17:43:54 CEST 2013
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