PRMT3 (protein arginine methyltransferase 3)

2007-02-01  

Identity

HGNC
PRMT3
LOCATION
11p15.1
LOCUSID
10196
ALIAS
HRMT1L3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10196
MIM: 603190
HGNC: 30163
Ensembl: ENSG00000185238

Variants:

dbSNP: 10196
ClinVar: 10196
TCGA: ENSG00000185238
COSMIC: PRMT3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185238ENST00000330796E9PLF6
ENSG00000185238ENST00000331079O60678
ENSG00000185238ENST00000437750O60678
ENSG00000185238ENST00000525188E9PLF6
ENSG00000185238ENST00000526583E9PRB4

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
RMTs methylate histone argininesREACTOMER-HSA-3214858
Protein methylationREACTOMER-HSA-8876725

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
151756572004PRMT3 is a ribosomal protein methyltransferase that affects the cellular levels of ribosomal subunits.52
227950842012An allosteric inhibitor of protein arginine methyltransferase 3.37
153340602004DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo.31
196416052009Hsp70 chaperones and type I PRMTs are sequestered at intranuclear inclusions caused by polyalanine expansions in PABPN1.19
219427152011Proteomic dissection of the von Hippel-Lindau (VHL) interactome.17
243201602014Profiling substrates of protein arginine N-methyltransferase 3 with S-adenosyl-L-methionine analogues.16
191580822009Type I Arginine Methyltransferases PRMT1 and PRMT-3 Act Distributively.13
251873712015PRMT3 regulates hepatic lipogenesis through direct interaction with LXRα.12
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11

Citation

Dessen P

PRMT3 (protein arginine methyltransferase 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46415/prmt3