Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PRMT3 (protein arginine methyltransferase 3)

Identity

Alias_namesHRMT1L3
HMT1 hnRNP methyltransferase-like 3 (S. cerevisiae)
Other alias
HGNC (Hugo) PRMT3
LocusID (NCBI) 10196
Atlas_Id 46415
Location 11p15.1  [Link to chromosome band 11p15]
Location_base_pair Starts at 20387716 and ends at 20509338 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SBF2 (11p15.4) / PRMT3 (11p15.1)UPF3A (13q34) / PRMT3 (11p15.1)SBF2 11p15.4 / PRMT3 11p15.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  SBF2/PRMT3 (11p15)

External links

Nomenclature
HGNC (Hugo)PRMT3   30163
Cards
Entrez_Gene (NCBI)PRMT3  10196  protein arginine methyltransferase 3
AliasesHRMT1L3
GeneCards (Weizmann)PRMT3
Ensembl hg19 (Hinxton)ENSG00000185238 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185238 [Gene_View]  ENSG00000185238 [Sequence]  chr11:20387716-20509338 [Contig_View]  PRMT3 [Vega]
ICGC DataPortalENSG00000185238
TCGA cBioPortalPRMT3
AceView (NCBI)PRMT3
Genatlas (Paris)PRMT3
WikiGenes10196
SOURCE (Princeton)PRMT3
Genetics Home Reference (NIH)PRMT3
Genomic and cartography
GoldenPath hg38 (UCSC)PRMT3  -     chr11:20387716-20509338 +  11p15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRMT3  -     11p15.1   [Description]    (hg19-Feb_2009)
GoldenPathPRMT3 - 11p15.1 [CytoView hg19]  PRMT3 - 11p15.1 [CytoView hg38]
Genome Data Viewer NCBIPRMT3 [Mapview hg19]  
OMIM603190   
Gene and transcription
Genbank (Entrez)AF059531 AK125039 AK129984 AK298185 AK300591
RefSeq transcript (Entrez)NM_001145166 NM_001145167 NM_005788
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRMT3
Alternative Splicing GalleryENSG00000185238
Gene ExpressionPRMT3 [ NCBI-GEO ]   PRMT3 [ EBI - ARRAY_EXPRESS ]   PRMT3 [ SEEK ]   PRMT3 [ MEM ]
Gene Expression Viewer (FireBrowse)PRMT3 [ Firebrowse - Broad ]
GenevisibleExpression of PRMT3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10196
GTEX Portal (Tissue expression)PRMT3
Human Protein AtlasENSG00000185238-PRMT3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60678   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60678  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60678
Splice isoforms : SwissVarO60678
Catalytic activity : Enzyme2.1.1.- [ Enzyme-Expasy ]   2.1.1.-2.1.1.- [ IntEnz-EBI ]   2.1.1.- [ BRENDA ]   2.1.1.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusO60678
Domaine pattern : Prosite (Expaxy)SAM_MT_PRMT (PS51678)    ZINC_FINGER_C2H2_1 (PS00028)   
Domains : Interpro (EBI)Arg_MeTrfase    SAM-dependent_MTases    Znf_C2H2_sf    Znf_C2H2_type   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)PRMT3
DMDM Disease mutations10196
PDB (RSDB)2FYT    3SMQ    4HSG    4QQN    4RYL   
PDB Europe2FYT    3SMQ    4HSG    4QQN    4RYL   
PDB (PDBSum)2FYT    3SMQ    4HSG    4QQN    4RYL   
PDB (IMB)2FYT    3SMQ    4HSG    4QQN    4RYL   
Structural Biology KnowledgeBase2FYT    3SMQ    4HSG    4QQN    4RYL   
SCOP (Structural Classification of Proteins)2FYT    3SMQ    4HSG    4QQN    4RYL   
CATH (Classification of proteins structures)2FYT    3SMQ    4HSG    4QQN    4RYL   
SuperfamilyO60678
Human Protein Atlas [tissue]ENSG00000185238-PRMT3 [tissue]
Peptide AtlasO60678
HPRD11934
IPIIPI00401321   IPI00909714   IPI01012872   IPI00922411   IPI00973921   IPI00984385   
Protein Interaction databases
DIP (DOE-UCLA)O60678
IntAct (EBI)O60678
FunCoupENSG00000185238
BioGRIDPRMT3
STRING (EMBL)PRMT3
ZODIACPRMT3
Ontologies - Pathways
QuickGOO60678
Ontology : AmiGOnucleic acid binding  protein binding  cytoplasm  cytosol  protein methylation  methyltransferase activity  protein-arginine N-methyltransferase activity  protein-arginine N-methyltransferase activity  negative regulation of protein ubiquitination  peptidyl-arginine N-methylation  ribosome binding  metal ion binding  
Ontology : EGO-EBInucleic acid binding  protein binding  cytoplasm  cytosol  protein methylation  methyltransferase activity  protein-arginine N-methyltransferase activity  protein-arginine N-methyltransferase activity  negative regulation of protein ubiquitination  peptidyl-arginine N-methylation  ribosome binding  metal ion binding  
NDEx NetworkPRMT3
Atlas of Cancer Signalling NetworkPRMT3
Wikipedia pathwaysPRMT3
Orthology - Evolution
OrthoDB10196
GeneTree (enSembl)ENSG00000185238
Phylogenetic Trees/Animal Genes : TreeFamPRMT3
HOGENOMO60678
Homologs : HomoloGenePRMT3
Homology/Alignments : Family Browser (UCSC)PRMT3
Gene fusions - Rearrangements
Fusion : MitelmanSBF2/PRMT3 [11p15.4/11p15.1]  
Fusion PortalSBF2 11p15.4 PRMT3 11p15.1 LUSC
Fusion : QuiverPRMT3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRMT3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRMT3
dbVarPRMT3
ClinVarPRMT3
1000_GenomesPRMT3 
Exome Variant ServerPRMT3
GNOMAD BrowserENSG00000185238
Varsome BrowserPRMT3
Genetic variants : HAPMAP10196
Genomic Variants (DGV)PRMT3 [DGVbeta]
DECIPHERPRMT3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRMT3 
Mutations
ICGC Data PortalPRMT3 
TCGA Data PortalPRMT3 
Broad Tumor PortalPRMT3
OASIS PortalPRMT3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRMT3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPRMT3
Mutations and Diseases : HGMDPRMT3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect PRMT3
DgiDB (Drug Gene Interaction Database)PRMT3
DoCM (Curated mutations)PRMT3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRMT3 (select a term)
intoGenPRMT3
Cancer3DPRMT3 (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603190   
Orphanet
DisGeNETPRMT3
MedgenPRMT3
Genetic Testing Registry PRMT3
NextProtO60678 [Medical]
TSGene10196
GENETestsPRMT3
Open Targets GeneticsENSG00000185238  [validation]
snp3D : Map Gene to Disease10196
BioCentury BCIQPRMT3
ClinGenPRMT3
Clinical trials, drugs, therapy
Protein Interactions : CTD10196
Pharm GKB GenePA29462
Clinical trialPRMT3
Miscellaneous
canSAR (ICR)PRMT3 (select the gene name)
HarmonizomePRMT3
DataMed IndexPRMT3
Probes
Litterature
PubMed64 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRMT3
EVEXPRMT3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sat Jul 11 20:06:49 CEST 2020
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