Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PRMT5 (protein arginine methyltransferase 5)

Identity

Alias_namesHRMT1L5
SKB1
skb1 (S. pombe) homolog
SKB1 homolog (S. pombe)
Alias_symbol (synonym)SKB1Hs
Other aliasIBP72
JBP1
HGNC (Hugo) PRMT5
LocusID (NCBI) 10419
Atlas_Id 45521
Location 14q11.2  [Link to chromosome band 14q11]
Location_base_pair Starts at 22920511 and ends at 22929585 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HAUS4 (14q11.2) / PRMT5 (14q11.2)MYL12A (18p11.31) / PRMT5 (14q11.2)PRMT5 (14q11.2) / DLG2 (11q14.1)
PRMT5 (14q11.2) / PRMT5 (14q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRMT5   10894
Cards
Entrez_Gene (NCBI)PRMT5  10419  protein arginine methyltransferase 5
AliasesHRMT1L5; IBP72; JBP1; SKB1; 
SKB1Hs
GeneCards (Weizmann)PRMT5
Ensembl hg19 (Hinxton)ENSG00000100462 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100462 [Gene_View]  chr14:22920511-22929585 [Contig_View]  PRMT5 [Vega]
ICGC DataPortalENSG00000100462
TCGA cBioPortalPRMT5
AceView (NCBI)PRMT5
Genatlas (Paris)PRMT5
WikiGenes10419
SOURCE (Princeton)PRMT5
Genetics Home Reference (NIH)PRMT5
Genomic and cartography
GoldenPath hg38 (UCSC)PRMT5  -     chr14:22920511-22929585 -  14q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRMT5  -     14q11.2   [Description]    (hg19-Feb_2009)
EnsemblPRMT5 - 14q11.2 [CytoView hg19]  PRMT5 - 14q11.2 [CytoView hg38]
Mapping of homologs : NCBIPRMT5 [Mapview hg19]  PRMT5 [Mapview hg38]
OMIM604045   
Gene and transcription
Genbank (Entrez)AA496357 AB451246 AB451370 AF015913 AF167572
RefSeq transcript (Entrez)NM_001039619 NM_001282953 NM_001282954 NM_001282955 NM_001282956 NM_006109
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRMT5
Cluster EST : UnigeneHs.367854 [ NCBI ]
CGAP (NCI)Hs.367854
Alternative Splicing GalleryENSG00000100462
Gene ExpressionPRMT5 [ NCBI-GEO ]   PRMT5 [ EBI - ARRAY_EXPRESS ]   PRMT5 [ SEEK ]   PRMT5 [ MEM ]
Gene Expression Viewer (FireBrowse)PRMT5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10419
GTEX Portal (Tissue expression)PRMT5
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14744   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14744  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14744
Splice isoforms : SwissVarO14744
PhosPhoSitePlusO14744
Domaine pattern : Prosite (Expaxy)SAM_MT_PRMT (PS51678)   
Domains : Interpro (EBI)Arg_MeTrfase    Arg_MeTrfase_PRMT5    SAM-dependent_MTases   
Domain families : Pfam (Sanger)PRMT5 (PF05185)   
Domain families : Pfam (NCBI)pfam05185   
Conserved Domain (NCBI)PRMT5
DMDM Disease mutations10419
Blocks (Seattle)PRMT5
PDB (SRS)4GQB    4X60    4X61    4X63    5C9Z    5EMJ    5EMK    5EML    5EMM    5FA5   
PDB (PDBSum)4GQB    4X60    4X61    4X63    5C9Z    5EMJ    5EMK    5EML    5EMM    5FA5   
PDB (IMB)4GQB    4X60    4X61    4X63    5C9Z    5EMJ    5EMK    5EML    5EMM    5FA5   
PDB (RSDB)4GQB    4X60    4X61    4X63    5C9Z    5EMJ    5EMK    5EML    5EMM    5FA5   
Structural Biology KnowledgeBase4GQB    4X60    4X61    4X63    5C9Z    5EMJ    5EMK    5EML    5EMM    5FA5   
SCOP (Structural Classification of Proteins)4GQB    4X60    4X61    4X63    5C9Z    5EMJ    5EMK    5EML    5EMM    5FA5   
CATH (Classification of proteins structures)4GQB    4X60    4X61    4X63    5C9Z    5EMJ    5EMK    5EML    5EMM    5FA5   
SuperfamilyO14744
Human Protein AtlasENSG00000100462
Peptide AtlasO14744
HPRD04955
IPIIPI00441473   IPI01014354   IPI01025861   IPI00794580   IPI01024830   IPI01026356   IPI01026489   IPI01026157   IPI01025997   IPI01026107   IPI01025770   IPI01025850   IPI01025856   IPI01025520   IPI01025227   IPI01025348   IPI00064328   IPI00793983   IPI00792693   
Protein Interaction databases
DIP (DOE-UCLA)O14744
IntAct (EBI)O14744
FunCoupENSG00000100462
BioGRIDPRMT5
STRING (EMBL)PRMT5
ZODIACPRMT5
Ontologies - Pathways
QuickGOO14744
Ontology : AmiGOspliceosomal snRNP assembly  spliceosomal snRNP assembly  core promoter sequence-specific DNA binding  transcription corepressor activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  cytosol  cytosol  DNA-templated transcription, termination  regulation of transcription, DNA-templated  regulation of mitotic nuclear division  methyltransferase activity  cell proliferation  methyl-CpG binding  histone-arginine N-methyltransferase activity  protein-arginine N-methyltransferase activity  protein-arginine N-methyltransferase activity  peptidyl-arginine methylation  peptidyl-arginine methylation, to symmetrical-dimethyl arginine  protein complex binding  circadian regulation of gene expression  methylosome  histone methyltransferase complex  protein-arginine omega-N symmetric methyltransferase activity  protein-arginine omega-N symmetric methyltransferase activity  peptidyl-arginine N-methylation  endothelial cell activation  ribonucleoprotein complex binding  protein complex  histone H4-R3 methylation  histone H4-R3 methylation  histone methyltransferase activity (H4-R3 specific)  regulation of DNA methylation  negative regulation of cell differentiation  protein heterodimerization activity  positive regulation of oligodendrocyte differentiation  regulation of ERK1 and ERK2 cascade  Golgi ribbon formation  liver regeneration  regulation of signal transduction by p53 class mediator  negative regulation of nucleic acid-templated transcription  positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway  
Ontology : EGO-EBIspliceosomal snRNP assembly  spliceosomal snRNP assembly  core promoter sequence-specific DNA binding  transcription corepressor activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  cytosol  cytosol  DNA-templated transcription, termination  regulation of transcription, DNA-templated  regulation of mitotic nuclear division  methyltransferase activity  cell proliferation  methyl-CpG binding  histone-arginine N-methyltransferase activity  protein-arginine N-methyltransferase activity  protein-arginine N-methyltransferase activity  peptidyl-arginine methylation  peptidyl-arginine methylation, to symmetrical-dimethyl arginine  protein complex binding  circadian regulation of gene expression  methylosome  histone methyltransferase complex  protein-arginine omega-N symmetric methyltransferase activity  protein-arginine omega-N symmetric methyltransferase activity  peptidyl-arginine N-methylation  endothelial cell activation  ribonucleoprotein complex binding  protein complex  histone H4-R3 methylation  histone H4-R3 methylation  histone methyltransferase activity (H4-R3 specific)  regulation of DNA methylation  negative regulation of cell differentiation  protein heterodimerization activity  positive regulation of oligodendrocyte differentiation  regulation of ERK1 and ERK2 cascade  Golgi ribbon formation  liver regeneration  regulation of signal transduction by p53 class mediator  negative regulation of nucleic acid-templated transcription  positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway  
Pathways : KEGGRNA transport   
NDEx NetworkPRMT5
Atlas of Cancer Signalling NetworkPRMT5
Wikipedia pathwaysPRMT5
Orthology - Evolution
OrthoDB10419
GeneTree (enSembl)ENSG00000100462
Phylogenetic Trees/Animal Genes : TreeFamPRMT5
HOVERGENO14744
HOGENOMO14744
Homologs : HomoloGenePRMT5
Homology/Alignments : Family Browser (UCSC)PRMT5
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRMT5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRMT5
dbVarPRMT5
ClinVarPRMT5
1000_GenomesPRMT5 
Exome Variant ServerPRMT5
ExAC (Exome Aggregation Consortium)PRMT5 (select the gene name)
Genetic variants : HAPMAP10419
Genomic Variants (DGV)PRMT5 [DGVbeta]
DECIPHERPRMT5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRMT5 
Mutations
ICGC Data PortalPRMT5 
TCGA Data PortalPRMT5 
Broad Tumor PortalPRMT5
OASIS PortalPRMT5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRMT5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRMT5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRMT5
DgiDB (Drug Gene Interaction Database)PRMT5
DoCM (Curated mutations)PRMT5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRMT5 (select a term)
intoGenPRMT5
Cancer3DPRMT5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604045   
Orphanet
MedgenPRMT5
Genetic Testing Registry PRMT5
NextProtO14744 [Medical]
TSGene10419
GENETestsPRMT5
Target ValidationPRMT5
Huge Navigator PRMT5 [HugePedia]
snp3D : Map Gene to Disease10419
BioCentury BCIQPRMT5
ClinGenPRMT5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10419
Chemical/Pharm GKB GenePA35794
Clinical trialPRMT5
Miscellaneous
canSAR (ICR)PRMT5 (select the gene name)
Probes
Litterature
PubMed191 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRMT5
EVEXPRMT5
GoPubMedPRMT5
iHOPPRMT5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:51:10 CEST 2017

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