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PRMT8 (protein arginine methyltransferase 8)

Identity

Alias_namesHRMT1L3
HRMT1L4
HMT1 hnRNP methyltransferase-like 3 (S. cerevisiae)
HMT1 hnRNP methyltransferase-like 4 (S. cerevisiae)
Other alias
HGNC (Hugo) PRMT8
LocusID (NCBI) 56341
Atlas_Id 72221
Location 12p13.32  [Link to chromosome band 12p13]
Location_base_pair Starts at 3490515 and ends at 3703138 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GALNT8 (12p13.32) / PRMT8 (12p13.32)PRMT8 (12p13.32) / AGAP3 (7q36.1)WNK1 (12p13.33) / PRMT8 (12p13.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRMT8   5188
Cards
Entrez_Gene (NCBI)PRMT8  56341  protein arginine methyltransferase 8
AliasesHRMT1L3; HRMT1L4
GeneCards (Weizmann)PRMT8
Ensembl hg19 (Hinxton)ENSG00000111218 [Gene_View]  chr12:3490515-3703138 [Contig_View]  PRMT8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000111218 [Gene_View]  chr12:3490515-3703138 [Contig_View]  PRMT8 [Vega]
ICGC DataPortalENSG00000111218
TCGA cBioPortalPRMT8
AceView (NCBI)PRMT8
Genatlas (Paris)PRMT8
WikiGenes56341
SOURCE (Princeton)PRMT8
Genetics Home Reference (NIH)PRMT8
Genomic and cartography
GoldenPath hg19 (UCSC)PRMT8  -     chr12:3490515-3703138 +  12p13.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PRMT8  -     12p13.32   [Description]    (hg38-Dec_2013)
EnsemblPRMT8 - 12p13.32 [CytoView hg19]  PRMT8 - 12p13.32 [CytoView hg38]
Mapping of homologs : NCBIPRMT8 [Mapview hg19]  PRMT8 [Mapview hg38]
OMIM610086   
Gene and transcription
Genbank (Entrez)AB209027 AF263539 AK026786 AK093651 AK315619
RefSeq transcript (Entrez)NM_001256536 NM_001256537 NM_019854
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_009759 NW_004929382
Consensus coding sequences : CCDS (NCBI)PRMT8
Cluster EST : UnigeneHs.504530 [ NCBI ]
CGAP (NCI)Hs.504530
Alternative Splicing GalleryENSG00000111218
Gene ExpressionPRMT8 [ NCBI-GEO ]   PRMT8 [ EBI - ARRAY_EXPRESS ]   PRMT8 [ SEEK ]   PRMT8 [ MEM ]
Gene Expression Viewer (FireBrowse)PRMT8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56341
GTEX Portal (Tissue expression)PRMT8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NR22   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NR22  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NR22
Splice isoforms : SwissVarQ9NR22
Catalytic activity : Enzyme2.1.1.- [ Enzyme-Expasy ]   2.1.1.-2.1.1.- [ IntEnz-EBI ]   2.1.1.- [ BRENDA ]   2.1.1.- [ KEGG ]   
PhosPhoSitePlusQ9NR22
Domaine pattern : Prosite (Expaxy)SAM_MT_PRMT (PS51678)   
Domains : Interpro (EBI)Arg_MeTrfase    SAM-dependent_MTases   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)PRMT8
DMDM Disease mutations56341
Blocks (Seattle)PRMT8
SuperfamilyQ9NR22
Human Protein AtlasENSG00000111218
Peptide AtlasQ9NR22
HPRD11029
IPIIPI00549813   IPI00747005   IPI00013578   
Protein Interaction databases
DIP (DOE-UCLA)Q9NR22
IntAct (EBI)Q9NR22
FunCoupENSG00000111218
BioGRIDPRMT8
STRING (EMBL)PRMT8
ZODIACPRMT8
Ontologies - Pathways
QuickGOQ9NR22
Ontology : AmiGOprotein binding  nucleus  cytosol  plasma membrane  regulation of transcription, DNA-templated  histone-arginine N-methyltransferase activity  S-adenosylmethionine-dependent methyltransferase activity  histone methylation  peptidyl-arginine methylation  peptidyl-arginine methylation, to asymmetrical-dimethyl arginine  histone arginine methylation  protein-arginine omega-N monomethyltransferase activity  protein-arginine omega-N asymmetric methyltransferase activity  identical protein binding  protein homodimerization activity  regulation of protein binding  histone H4-R3 methylation  histone methyltransferase activity (H4-R3 specific)  protein heterodimerization activity  
Ontology : EGO-EBIprotein binding  nucleus  cytosol  plasma membrane  regulation of transcription, DNA-templated  histone-arginine N-methyltransferase activity  S-adenosylmethionine-dependent methyltransferase activity  histone methylation  peptidyl-arginine methylation  peptidyl-arginine methylation, to asymmetrical-dimethyl arginine  histone arginine methylation  protein-arginine omega-N monomethyltransferase activity  protein-arginine omega-N asymmetric methyltransferase activity  identical protein binding  protein homodimerization activity  regulation of protein binding  histone H4-R3 methylation  histone methyltransferase activity (H4-R3 specific)  protein heterodimerization activity  
NDEx NetworkPRMT8
Atlas of Cancer Signalling NetworkPRMT8
Wikipedia pathwaysPRMT8
Orthology - Evolution
OrthoDB56341
GeneTree (enSembl)ENSG00000111218
Phylogenetic Trees/Animal Genes : TreeFamPRMT8
HOVERGENQ9NR22
HOGENOMQ9NR22
Homologs : HomoloGenePRMT8
Homology/Alignments : Family Browser (UCSC)PRMT8
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRMT8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRMT8
dbVarPRMT8
ClinVarPRMT8
1000_GenomesPRMT8 
Exome Variant ServerPRMT8
ExAC (Exome Aggregation Consortium)PRMT8 (select the gene name)
Genetic variants : HAPMAP56341
Genomic Variants (DGV)PRMT8 [DGVbeta]
DECIPHER (Syndromes)12:3490515-3703138  ENSG00000111218
CONAN: Copy Number AnalysisPRMT8 
Mutations
ICGC Data PortalPRMT8 
TCGA Data PortalPRMT8 
Broad Tumor PortalPRMT8
OASIS PortalPRMT8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRMT8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRMT8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRMT8
DgiDB (Drug Gene Interaction Database)PRMT8
DoCM (Curated mutations)PRMT8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRMT8 (select a term)
intoGenPRMT8
Cancer3DPRMT8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610086   
Orphanet
MedgenPRMT8
Genetic Testing Registry PRMT8
NextProtQ9NR22 [Medical]
TSGene56341
GENETestsPRMT8
Huge Navigator PRMT8 [HugePedia]
snp3D : Map Gene to Disease56341
BioCentury BCIQPRMT8
ClinGenPRMT8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD56341
Chemical/Pharm GKB GenePA134903406
Clinical trialPRMT8
Miscellaneous
canSAR (ICR)PRMT8 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRMT8
EVEXPRMT8
GoPubMedPRMT8
iHOPPRMT8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:39:40 CET 2017

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