PRMT8 (protein arginine methyltransferase 8)

2014-11-01  

Identity

HGNC
LOCATION
12p13.32
LOCUSID
ALIAS
HRMT1L3,HRMT1L4
FUSION GENES

Other Information

Locus ID:

NCBI: 56341
MIM: 610086
HGNC: 5188
Ensembl: ENSG00000111218

Variants:

dbSNP: 56341
ClinVar: 56341
TCGA: ENSG00000111218
COSMIC: PRMT8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111218ENST00000382622Q9NR22
ENSG00000111218ENST00000452611Q9NR22

Expression (GTEx)

0
5
10
15
20
25

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
190609112009Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.392
160516122005PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family.77
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
179254052007Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain.38
236207692013Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo.31
183205852008Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.24
186984892008EWS is a substrate of type I protein arginine methyltransferase, PRMT8.12
239464802013Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity.12
285438632017PRMT8 Controls the Pluripotency and Mesodermal Fate of Human Embryonic Stem Cells By Enhancing the PI3K/AKT/SOX2 Axis.8
268766022016Novel helical assembly in arginine methyltransferase 8.7

Citation

Dessen P

PRMT8 (protein arginine methyltransferase 8)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72221/prmt8