Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PROC (protein C (inactivator of coagulation factors Va and VIIIa))

Identity

Other namesAPC
PC
PROC1
THPH3
THPH4
HGNC (Hugo) PROC
LocusID (NCBI) 5624
Location 2q14.3
Location_base_pair Starts at 128175996 and ends at 128186822 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PROC   9451
Cards
Entrez_Gene (NCBI)PROC  5624  protein C (inactivator of coagulation factors Va and VIIIa)
GeneCards (Weizmann)PROC
Ensembl hg19 (Hinxton)ENSG00000115718 [Gene_View]  chr2:128175996-128186822 [Contig_View]  PROC [Vega]
Ensembl hg38 (Hinxton)ENSG00000115718 [Gene_View]  chr2:128175996-128186822 [Contig_View]  PROC [Vega]
ICGC DataPortalENSG00000115718
cBioPortalPROC
AceView (NCBI)PROC
Genatlas (Paris)PROC
WikiGenes5624
SOURCE (Princeton)PROC
Genomic and cartography
GoldenPath hg19 (UCSC)PROC  -     chr2:128175996-128186822 +  2q14.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PROC  -     2q14.3   [Description]    (hg38-Dec_2013)
EnsemblPROC - 2q14.3 [CytoView hg19]  PROC - 2q14.3 [CytoView hg38]
Mapping of homologs : NCBIPROC [Mapview hg19]  PROC [Mapview hg38]
OMIM176860   612283   612304   
Gene and transcription
Genbank (Entrez)AK298280 AK298449 AK298454 AK303773 BC034377
RefSeq transcript (Entrez)NM_000312
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_016323 NT_005403 NW_001838849 NW_004929304
Consensus coding sequences : CCDS (NCBI)PROC
Cluster EST : UnigeneHs.224698 [ NCBI ]
CGAP (NCI)Hs.224698
Alternative Splicing : Fast-db (Paris)GSHG0016836
Alternative Splicing GalleryENSG00000115718
Gene ExpressionPROC [ NCBI-GEO ]     PROC [ SEEK ]   PROC [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04070 (Uniprot)
NextProtP04070  [Medical]
With graphics : InterProP04070
Splice isoforms : SwissVarP04070 (Swissvar)
Catalytic activity : Enzyme3.4.21.69 [ Enzyme-Expasy ]   3.4.21.693.4.21.69 [ IntEnz-EBI ]   3.4.21.69 [ BRENDA ]   3.4.21.69 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    GLA_1 (PS00011)    GLA_2 (PS50998)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Coagulation_fac_subgr_Gla_dom    EG-like_dom    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    GLA_domain    Pept_S1A_FX    Peptidase_S1    Peptidase_S1_AS    Peptidase_S1A    Trypsin-like_Pept_dom   
Related proteins : CluSTrP04070
Domain families : Pfam (Sanger)Gla (PF00594)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00594    pfam00089   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  GLA (SM00069)  Tryp_SPc (SM00020)  
DMDM Disease mutations5624
Blocks (Seattle)P04070
PDB (SRS)1AUT    1LQV    1PCU    2PCT    3F6U    3JTC    4DT7   
PDB (PDBSum)1AUT    1LQV    1PCU    2PCT    3F6U    3JTC    4DT7   
PDB (IMB)1AUT    1LQV    1PCU    2PCT    3F6U    3JTC    4DT7   
PDB (RSDB)1AUT    1LQV    1PCU    2PCT    3F6U    3JTC    4DT7   
Human Protein AtlasENSG00000115718
Peptide AtlasP04070
HPRD01466
IPIIPI00021817   IPI00911093   IPI00908685   IPI00940493   IPI00816176   IPI01018032   IPI00916433   IPI00916520   IPI00917138   IPI00917472   
Protein Interaction databases
DIP (DOE-UCLA)P04070
IntAct (EBI)P04070
FunCoupENSG00000115718
BioGRIDPROC
IntegromeDBPROC
STRING (EMBL)PROC
Ontologies - Pathways
QuickGOP04070
Ontology : AmiGOserine-type endopeptidase activity  calcium ion binding  protein binding  extracellular region  extracellular region  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  proteolysis  proteolysis  blood coagulation  peptidyl-glutamic acid carboxylation  negative regulation of blood coagulation  negative regulation of apoptotic process  post-translational protein modification  cellular protein metabolic process  leukocyte migration  
Ontology : EGO-EBIserine-type endopeptidase activity  calcium ion binding  protein binding  extracellular region  extracellular region  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  proteolysis  proteolysis  blood coagulation  peptidyl-glutamic acid carboxylation  negative regulation of blood coagulation  negative regulation of apoptotic process  post-translational protein modification  cellular protein metabolic process  leukocyte migration  
Pathways : BIOCARTAAcute Myocardial Infarction [Genes]    Extrinsic Prothrombin Activation Pathway [Genes]    Intrinsic Prothrombin Activation Pathway [Genes]   
Pathways : KEGGComplement and coagulation cascades   
Protein Interaction DatabasePROC
DoCM (Curated mutations)PROC
Wikipedia pathwaysPROC
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPROC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PROC
dbVarPROC
ClinVarPROC
1000_GenomesPROC 
Exome Variant ServerPROC
SNP (GeneSNP Utah)PROC
SNP : HGBasePROC
Genetic variants : HAPMAPPROC
Genomic VariantsPROC  PROC [DGVbeta]
Mutations
ICGC Data PortalENSG00000115718 
Somatic Mutations in Cancer : COSMICPROC 
CONAN: Copy Number AnalysisPROC 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)2:128175996-128186822
Mutations and Diseases : HGMDPROC
OMIM176860    612283    612304   
MedgenPROC
NextProtP04070 [Medical]
GENETestsPROC
Disease Genetic AssociationPROC
Huge Navigator PROC [HugePedia]  PROC [HugeCancerGEM]
snp3D : Map Gene to Disease5624
DGIdb (Drug Gene Interaction db)PROC
General knowledge
Homologs : HomoloGenePROC
Homology/Alignments : Family Browser (UCSC)PROC
Phylogenetic Trees/Animal Genes : TreeFamPROC
Chemical/Protein Interactions : CTD5624
Chemical/Pharm GKB GenePA33799
Clinical trialPROC
Cancer Resource (Charite)ENSG00000115718
Other databases
Probes
Litterature
PubMed309 Pubmed reference(s) in Entrez
CoreMinePROC
GoPubMedPROC
iHOPPROC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Dec 21 00:59:01 CET 2014

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