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PROC (protein C, inactivator of coagulation factors Va and VIIIa)

Identity

Other namesAPC
PC
PROC1
THPH3
THPH4
HGNC (Hugo) PROC
LocusID (NCBI) 5624
Atlas_Id 46329
Location 2q14.3
Location_base_pair Starts at 128175996 and ends at 128186822 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PROC   9451
Cards
Entrez_Gene (NCBI)PROC  5624  protein C, inactivator of coagulation factors Va and VIIIa
AliasesAPC; PC; PROC1; THPH3; 
THPH4
GeneCards (Weizmann)PROC
Ensembl hg19 (Hinxton)ENSG00000115718 [Gene_View]  chr2:128175996-128186822 [Contig_View]  PROC [Vega]
Ensembl hg38 (Hinxton)ENSG00000115718 [Gene_View]  chr2:128175996-128186822 [Contig_View]  PROC [Vega]
ICGC DataPortalENSG00000115718
TCGA cBioPortalPROC
AceView (NCBI)PROC
Genatlas (Paris)PROC
WikiGenes5624
SOURCE (Princeton)PROC
Genomic and cartography
GoldenPath hg19 (UCSC)PROC  -     chr2:128175996-128186822 +  2q14.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PROC  -     2q14.3   [Description]    (hg38-Dec_2013)
EnsemblPROC - 2q14.3 [CytoView hg19]  PROC - 2q14.3 [CytoView hg38]
Mapping of homologs : NCBIPROC [Mapview hg19]  PROC [Mapview hg38]
OMIM176860   612283   612304   
Gene and transcription
Genbank (Entrez)AK298280 AK298449 AK298454 AK303773 BC034377
RefSeq transcript (Entrez)NM_000312
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_016323 NT_005403 NW_004929304
Consensus coding sequences : CCDS (NCBI)PROC
Cluster EST : UnigeneHs.224698 [ NCBI ]
CGAP (NCI)Hs.224698
Alternative Splicing GalleryENSG00000115718
Gene ExpressionPROC [ NCBI-GEO ]   PROC [ EBI - ARRAY_EXPRESS ]   PROC [ SEEK ]   PROC [ MEM ]
Gene Expression Viewer (FireBrowse)PROC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5624
GTEX Portal (Tissue expression)PROC
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04070 (Uniprot)
NextProtP04070  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP04070
Splice isoforms : SwissVarP04070 (Swissvar)
Catalytic activity : Enzyme3.4.21.69 [ Enzyme-Expasy ]   3.4.21.693.4.21.69 [ IntEnz-EBI ]   3.4.21.69 [ BRENDA ]   3.4.21.69 [ KEGG ]   
PhosPhoSitePlusP04070
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    GLA_1 (PS00011)    GLA_2 (PS50998)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Coagulation_fac_subgr_Gla_dom    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    GLA_domain    Pept_S1A_FX    Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)EGF (PF00008)    Gla (PF00594)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00008    pfam00594    pfam00089   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  GLA (SM00069)  Tryp_SPc (SM00020)  
DMDM Disease mutations5624
Blocks (Seattle)PROC
PDB (SRS)1AUT    1LQV    1PCU    2PCT    3F6U    3JTC    4DT7   
PDB (PDBSum)1AUT    1LQV    1PCU    2PCT    3F6U    3JTC    4DT7   
PDB (IMB)1AUT    1LQV    1PCU    2PCT    3F6U    3JTC    4DT7   
PDB (RSDB)1AUT    1LQV    1PCU    2PCT    3F6U    3JTC    4DT7   
Structural Biology KnowledgeBase1AUT    1LQV    1PCU    2PCT    3F6U    3JTC    4DT7   
SCOP (Structural Classification of Proteins)1AUT    1LQV    1PCU    2PCT    3F6U    3JTC    4DT7   
CATH (Classification of proteins structures)1AUT    1LQV    1PCU    2PCT    3F6U    3JTC    4DT7   
SuperfamilyP04070
Human Protein AtlasENSG00000115718
Peptide AtlasP04070
HPRD01466
IPIIPI00021817   IPI00911093   IPI00908685   IPI00940493   IPI00816176   IPI01018032   IPI00916433   IPI00916520   IPI00917138   IPI00917472   
Protein Interaction databases
DIP (DOE-UCLA)P04070
IntAct (EBI)P04070
FunCoupENSG00000115718
BioGRIDPROC
STRING (EMBL)PROC
ZODIACPROC
Ontologies - Pathways
QuickGOP04070
Ontology : AmiGOserine-type endopeptidase activity  serine-type endopeptidase activity  calcium ion binding  protein binding  extracellular region  extracellular region  extracellular space  endoplasmic reticulum  endoplasmic reticulum lumen  Golgi apparatus  Golgi lumen  signal peptide processing  proteolysis  ER to Golgi vesicle-mediated transport  blood coagulation  peptidyl-glutamic acid carboxylation  negative regulation of blood coagulation  negative regulation of apoptotic process  negative regulation of inflammatory response  negative regulation of coagulation  leukocyte migration  positive regulation of establishment of endothelial barrier  
Ontology : EGO-EBIserine-type endopeptidase activity  serine-type endopeptidase activity  calcium ion binding  protein binding  extracellular region  extracellular region  extracellular space  endoplasmic reticulum  endoplasmic reticulum lumen  Golgi apparatus  Golgi lumen  signal peptide processing  proteolysis  ER to Golgi vesicle-mediated transport  blood coagulation  peptidyl-glutamic acid carboxylation  negative regulation of blood coagulation  negative regulation of apoptotic process  negative regulation of inflammatory response  negative regulation of coagulation  leukocyte migration  positive regulation of establishment of endothelial barrier  
Pathways : BIOCARTAAcute Myocardial Infarction [Genes]    Extrinsic Prothrombin Activation Pathway [Genes]    Intrinsic Prothrombin Activation Pathway [Genes]   
Pathways : KEGGComplement and coagulation cascades   
NDEx Network
Atlas of Cancer Signalling NetworkPROC
Wikipedia pathwaysPROC
Orthology - Evolution
OrthoDB5624
GeneTree (enSembl)ENSG00000115718
Phylogenetic Trees/Animal Genes : TreeFamPROC
Homologs : HomoloGenePROC
Homology/Alignments : Family Browser (UCSC)PROC
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPROC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PROC
dbVarPROC
ClinVarPROC
1000_GenomesPROC 
Exome Variant ServerPROC
ExAC (Exome Aggregation Consortium)PROC (select the gene name)
Genetic variants : HAPMAP5624
Genomic Variants (DGV)PROC [DGVbeta]
Mutations
ICGC Data PortalPROC 
TCGA Data PortalPROC 
Broad Tumor PortalPROC
OASIS PortalPROC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPROC 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PROC
DgiDB (Drug Gene Interaction Database)PROC
DoCM (Curated mutations)PROC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PROC (select a term)
intoGenPROC
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)2:128175996-128186822  ENSG00000115718
CONAN: Copy Number AnalysisPROC 
Mutations and Diseases : HGMDPROC
OMIM176860    612283    612304   
MedgenPROC
Genetic Testing Registry PROC
NextProtP04070 [Medical]
TSGene5624
GENETestsPROC
Huge Navigator PROC [HugePedia]
snp3D : Map Gene to Disease5624
BioCentury BCIQPROC
ClinGenPROC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5624
Chemical/Pharm GKB GenePA33799
Clinical trialPROC
Miscellaneous
canSAR (ICR)PROC (select the gene name)
Probes
Litterature
PubMed331 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePROC
EVEXPROC
GoPubMedPROC
iHOPPROC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat May 28 11:17:10 CEST 2016

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