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PROC (protein C, inactivator of coagulation factors Va and VIIIa)

Identity

Alias (NCBI)APC
PC
PROC1
THPH3
THPH4
HGNC (Hugo) PROC
HGNC Alias nameprepro-protein C
HGNC Previous nameprotein C (inactivator of coagulation factors Va and VIIIa)
LocusID (NCBI) 5624
Atlas_Id 46329
Location 2q14.3  [Link to chromosome band 2q14]
Location_base_pair Starts at 127419697 and ends at 127429242 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PROC   9451
LRG (Locus Reference Genomic)LRG_599
Cards
Entrez_Gene (NCBI)PROC    protein C, inactivator of coagulation factors Va and VIIIa
AliasesAPC; PC; PROC1; THPH3; 
THPH4
GeneCards (Weizmann)PROC
Ensembl hg19 (Hinxton)ENSG00000115718 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115718 [Gene_View]  ENSG00000115718 [Sequence]  chr2:127419697-127429242 [Contig_View]  PROC [Vega]
ICGC DataPortalENSG00000115718
TCGA cBioPortalPROC
AceView (NCBI)PROC
Genatlas (Paris)PROC
SOURCE (Princeton)PROC
Genetics Home Reference (NIH)PROC
Genomic and cartography
GoldenPath hg38 (UCSC)PROC  -     chr2:127419697-127429242 +  2q14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PROC  -     2q14.3   [Description]    (hg19-Feb_2009)
GoldenPathPROC - 2q14.3 [CytoView hg19]  PROC - 2q14.3 [CytoView hg38]
ImmunoBaseENSG00000115718
Genome Data Viewer NCBIPROC [Mapview hg19]  
OMIM176860   612283   612304   
Gene and transcription
Genbank (Entrez)AK298280 AK298449 AK298454 AK303773 BC034377
RefSeq transcript (Entrez)NM_000312 NM_001375602 NM_001375603 NM_001375604 NM_001375605 NM_001375606 NM_001375607 NM_001375608 NM_001375609 NM_001375610 NM_001375611 NM_001375613
Consensus coding sequences : CCDS (NCBI)PROC
Gene ExpressionPROC [ NCBI-GEO ]   PROC [ EBI - ARRAY_EXPRESS ]   PROC [ SEEK ]   PROC [ MEM ]
Gene Expression Viewer (FireBrowse)PROC [ Firebrowse - Broad ]
GenevisibleExpression of PROC in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5624
GTEX Portal (Tissue expression)PROC
Human Protein AtlasENSG00000115718-PROC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04070   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP04070  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP04070
Catalytic activity : Enzyme3.4.21.69 [ Enzyme-Expasy ]   3.4.21.693.4.21.69 [ IntEnz-EBI ]   3.4.21.69 [ BRENDA ]   3.4.21.69 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP04070
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    GLA_1 (PS00011)    GLA_2 (PS50998)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Coagulation_fac-like_Gla_dom    EGF-like_Ca-bd_dom    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    GLA-like_dom_SF    GLA_domain    Pept_S1A_FX    Peptidase_S1_PA    Peptidase_S1_PA_chymotrypsin    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)EGF (PF00008)    Gla (PF00594)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00008    pfam00594    pfam00089   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  GLA (SM00069)  Tryp_SPc (SM00020)  
Conserved Domain (NCBI)PROC
PDB (RSDB)1AUT    1LQV    1PCU    2PCT    3F6U    3JTC    4DT7    6M3B    6M3C   
PDB Europe1AUT    1LQV    1PCU    2PCT    3F6U    3JTC    4DT7    6M3B    6M3C   
PDB (PDBSum)1AUT    1LQV    1PCU    2PCT    3F6U    3JTC    4DT7    6M3B    6M3C   
PDB (IMB)1AUT    1LQV    1PCU    2PCT    3F6U    3JTC    4DT7    6M3B    6M3C   
Structural Biology KnowledgeBase1AUT    1LQV    1PCU    2PCT    3F6U    3JTC    4DT7    6M3B    6M3C   
SCOP (Structural Classification of Proteins)1AUT    1LQV    1PCU    2PCT    3F6U    3JTC    4DT7    6M3B    6M3C   
CATH (Classification of proteins structures)1AUT    1LQV    1PCU    2PCT    3F6U    3JTC    4DT7    6M3B    6M3C   
SuperfamilyP04070
AlphaFold pdb e-kbP04070   
Human Protein Atlas [tissue]ENSG00000115718-PROC [tissue]
HPRD01466
Protein Interaction databases
DIP (DOE-UCLA)P04070
IntAct (EBI)P04070
BioGRIDPROC
STRING (EMBL)PROC
ZODIACPROC
Ontologies - Pathways
QuickGOP04070
Ontology : AmiGOserine-type endopeptidase activity  serine-type endopeptidase activity  serine-type endopeptidase activity  calcium ion binding  protein binding  extracellular region  extracellular region  extracellular space  endoplasmic reticulum  endoplasmic reticulum lumen  Golgi apparatus  Golgi lumen  proteolysis  endoplasmic reticulum to Golgi vesicle-mediated transport  blood coagulation  negative regulation of blood coagulation  negative regulation of blood coagulation  negative regulation of apoptotic process  post-translational protein modification  cellular protein metabolic process  negative regulation of inflammatory response  negative regulation of coagulation  positive regulation of establishment of endothelial barrier  
Ontology : EGO-EBIserine-type endopeptidase activity  serine-type endopeptidase activity  serine-type endopeptidase activity  calcium ion binding  protein binding  extracellular region  extracellular region  extracellular space  endoplasmic reticulum  endoplasmic reticulum lumen  Golgi apparatus  Golgi lumen  proteolysis  endoplasmic reticulum to Golgi vesicle-mediated transport  blood coagulation  negative regulation of blood coagulation  negative regulation of blood coagulation  negative regulation of apoptotic process  post-translational protein modification  cellular protein metabolic process  negative regulation of inflammatory response  negative regulation of coagulation  positive regulation of establishment of endothelial barrier  
Pathways : BIOCARTAAcute Myocardial Infarction [Genes]    Extrinsic Prothrombin Activation Pathway [Genes]    Intrinsic Prothrombin Activation Pathway [Genes]   
Pathways : KEGGComplement and coagulation cascades   
NDEx NetworkPROC
Atlas of Cancer Signalling NetworkPROC
Wikipedia pathwaysPROC
Orthology - Evolution
OrthoDB5624
GeneTree (enSembl)ENSG00000115718
Phylogenetic Trees/Animal Genes : TreeFamPROC
Homologs : HomoloGenePROC
Homology/Alignments : Family Browser (UCSC)PROC
Gene fusions - Rearrangements
Fusion : QuiverPROC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPROC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PROC
dbVarPROC
ClinVarPROC
MonarchPROC
1000_GenomesPROC 
Exome Variant ServerPROC
GNOMAD BrowserENSG00000115718
Varsome BrowserPROC
ACMGPROC variants
VarityP04070
Genomic Variants (DGV)PROC [DGVbeta]
DECIPHERPROC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPROC 
Mutations
ICGC Data PortalPROC 
TCGA Data PortalPROC 
Broad Tumor PortalPROC
OASIS PortalPROC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPROC  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPROC
Mutations and Diseases : HGMDPROC
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPROC
DgiDB (Drug Gene Interaction Database)PROC
DoCM (Curated mutations)PROC
CIViC (Clinical Interpretations of Variants in Cancer)PROC
Cancer3DPROC
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176860    612283    612304   
Orphanet3383   
DisGeNETPROC
MedgenPROC
Genetic Testing Registry PROC
NextProtP04070 [Medical]
GENETestsPROC
Target ValidationPROC
Huge Navigator PROC [HugePedia]
ClinGenPROC
Clinical trials, drugs, therapy
MyCancerGenomePROC
Protein Interactions : CTDPROC
Pharm GKB GenePA33799
Pharm GKB PathwaysPA145011114   
PharosP04070
Clinical trialPROC
Miscellaneous
canSAR (ICR)PROC
HarmonizomePROC
DataMed IndexPROC
Probes
Litterature
PubMed379 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPROC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:26:57 CEST 2021

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