PROCR (protein C receptor)

2007-02-01  

Identity

HGNC
LOCATION
20q11.22
LOCUSID
ALIAS
CCCA,CCD41,EPCR

Other Information

Locus ID:

NCBI: 10544
MIM: 600646
HGNC: 9452
Ensembl: ENSG00000101000

Variants:

dbSNP: 10544
ClinVar: 10544
TCGA: ENSG00000101000
COSMIC: PROCR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101000ENST00000216968Q9UNN8
ENSG00000101000ENST00000634509A0A0U1RRC4
ENSG00000101000ENST00000635377A0A0U1RQQ4

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
HemostasisREACTOMER-HSA-109582
Formation of Fibrin Clot (Clotting Cascade)REACTOMER-HSA-140877
Common Pathway of Fibrin Clot FormationREACTOMER-HSA-140875
Cell surface interactions at the vascular wallREACTOMER-HSA-202733

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
237393252013Severe malaria is associated with parasite binding to endothelial protein C receptor.209
157106222005Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation.153
228859852012Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor.104
237410072013Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children.96
178233082007The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells.93
151785542004Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation.92
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
173272342007Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium.58
212520882011Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection.44
125866112003Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1.40

Citation

Dessen P

PROCR (protein C receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43779/procr