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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

Donate (in Euros)

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PRODH (proline dehydrogenase (oxidase) 1)

Identity

Other namesHSPOX2
PIG6
POX
PRODH1
PRODH2
TP53I6
HGNC (Hugo) PRODH
LocusID (NCBI) 5625
Location 22q11.21
Location_base_pair Starts at 18900287 and ends at 18923964 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors AmeloblastomID5945

External links

Nomenclature
HGNC (Hugo)PRODH   9453
Cards
Entrez_Gene (NCBI)PRODH  5625  proline dehydrogenase (oxidase) 1
GeneCards (Weizmann)PRODH
Ensembl hg19 (Hinxton)ENSG00000100033 [Gene_View]  chr22:18900287-18923964 [Contig_View]  PRODH [Vega]
Ensembl hg38 (Hinxton)ENSG00000100033 [Gene_View]  chr22:18900287-18923964 [Contig_View]  PRODH [Vega]
ICGC DataPortalENSG00000100033
cBioPortalPRODH
AceView (NCBI)PRODH
Genatlas (Paris)PRODH
WikiGenes5625
SOURCE (Princeton)PRODH
Genomic and cartography
GoldenPath hg19 (UCSC)PRODH  -     chr22:18900287-18923964 -  22q11.21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PRODH  -     22q11.21   [Description]    (hg38-Dec_2013)
EnsemblPRODH - 22q11.21 [CytoView hg19]  PRODH - 22q11.21 [CytoView hg38]
Mapping of homologs : NCBIPRODH [Mapview hg19]  PRODH [Mapview hg38]
OMIM239500   600850   606810   
Gene and transcription
Genbank (Entrez)AA322439 AB209472 AF010310 AK001359 AK091063
RefSeq transcript (Entrez)NM_001195226 NM_016335
RefSeq genomic (Entrez)AC_000154 NC_000022 NC_018933 NG_008226 NT_011520 NW_001838737 NW_004929429
Consensus coding sequences : CCDS (NCBI)PRODH
Cluster EST : UnigeneHs.517352 [ NCBI ]
CGAP (NCI)Hs.517352
Alternative Splicing : Fast-db (Paris)GSHG0020177
Alternative Splicing GalleryENSG00000100033
Gene ExpressionPRODH [ NCBI-GEO ]     PRODH [ SEEK ]   PRODH [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43272 (Uniprot)
NextProtO43272  [Medical]
With graphics : InterProO43272
Splice isoforms : SwissVarO43272 (Swissvar)
Catalytic activity : Enzyme1.5.5.2 [ Enzyme-Expasy ]   1.5.5.21.5.5.2 [ IntEnz-EBI ]   1.5.5.2 [ BRENDA ]   1.5.5.2 [ KEGG ]   
Domains : Interpro (EBI)FAD-linked_oxidoreductase-like    Proline_DH    Proline_oxidase   
Related proteins : CluSTrO43272
Domain families : Pfam (Sanger)Pro_dh (PF01619)   
Domain families : Pfam (NCBI)pfam01619   
DMDM Disease mutations5625
Blocks (Seattle)O43272
Human Protein AtlasENSG00000100033
Peptide AtlasO43272
HPRD08433
IPIIPI00816398   IPI00816668   IPI00383798   IPI00853430   IPI00177725   IPI00797839   IPI00853114   IPI00953330   IPI00798307   IPI00797607   
Protein Interaction databases
DIP (DOE-UCLA)O43272
IntAct (EBI)O43272
FunCoupENSG00000100033
BioGRIDPRODH
IntegromeDBPRODH
STRING (EMBL)PRODH
Ontologies - Pathways
QuickGOO43272
Ontology : AmiGOproline dehydrogenase activity  mitochondrial inner membrane  mitochondrial matrix  glutamate biosynthetic process  proline metabolic process  proline catabolic process  intrinsic apoptotic signaling pathway in response to oxidative stress  proline catabolic process to glutamate  amino acid binding  4-hydroxyproline catabolic process  cellular nitrogen compound metabolic process  small molecule metabolic process  oxidation-reduction process  FAD binding  
Ontology : EGO-EBIproline dehydrogenase activity  mitochondrial inner membrane  mitochondrial matrix  glutamate biosynthetic process  proline metabolic process  proline catabolic process  intrinsic apoptotic signaling pathway in response to oxidative stress  proline catabolic process to glutamate  amino acid binding  4-hydroxyproline catabolic process  cellular nitrogen compound metabolic process  small molecule metabolic process  oxidation-reduction process  FAD binding  
Pathways : KEGGArginine and proline metabolism   
Protein Interaction DatabasePRODH
DoCM (Curated mutations)PRODH
Wikipedia pathwaysPRODH
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPRODH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRODH
dbVarPRODH
ClinVarPRODH
1000_GenomesPRODH 
Exome Variant ServerPRODH
SNP (GeneSNP Utah)PRODH
SNP : HGBasePRODH
Genetic variants : HAPMAPPRODH
Genomic Variants (DGV)PRODH [DGVbeta]
Mutations
ICGC Data PortalENSG00000100033 
Somatic Mutations in Cancer : COSMICPRODH 
CONAN: Copy Number AnalysisPRODH 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)22:18900287-18923964
Mutations and Diseases : HGMDPRODH
OMIM239500    600850    606810   
MedgenPRODH
NextProtO43272 [Medical]
GENETestsPRODH
Disease Genetic AssociationPRODH
Huge Navigator PRODH [HugePedia]  PRODH [HugeCancerGEM]
snp3D : Map Gene to Disease5625
DGIdb (Drug Gene Interaction db)PRODH
General knowledge
Homologs : HomoloGenePRODH
Homology/Alignments : Family Browser (UCSC)PRODH
Phylogenetic Trees/Animal Genes : TreeFamPRODH
Chemical/Protein Interactions : CTD5625
Chemical/Pharm GKB GenePA33801
Clinical trialPRODH
Cancer Resource (Charite)ENSG00000100033
Other databases
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
CoreMinePRODH
GoPubMedPRODH
iHOPPRODH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 14 18:08:20 CET 2015

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.