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PRODH (proline dehydrogenase (oxidase) 1)

Identity

Other namesHSPOX2
PIG6
POX
PRODH1
PRODH2
TP53I6
HGNC (Hugo) PRODH
LocusID (NCBI) 5625
Atlas_Id 41873
Location 22q11.21
Location_base_pair Starts at 18900287 and ends at 18923964 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PI4KA (22q11.21) / PRODH (22q11.21)ST5 (11p15.4) / PRODH (22q11.21)THAP7 (22q11.21) / PRODH (22q11.21)
USP11 (Xp11.23) / PRODH (22q11.21)PI4KA 22q11.21 / PRODH 22q11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Lung: Translocations in Squamous Cell Carcinoma

External links

Nomenclature
HGNC (Hugo)PRODH   9453
Cards
Entrez_Gene (NCBI)PRODH  5625  proline dehydrogenase (oxidase) 1
GeneCards (Weizmann)PRODH
Ensembl hg19 (Hinxton)ENSG00000100033 [Gene_View]  chr22:18900287-18923964 [Contig_View]  PRODH [Vega]
Ensembl hg38 (Hinxton)ENSG00000100033 [Gene_View]  chr22:18900287-18923964 [Contig_View]  PRODH [Vega]
ICGC DataPortalENSG00000100033
TCGA cBioPortalPRODH
AceView (NCBI)PRODH
Genatlas (Paris)PRODH
WikiGenes5625
SOURCE (Princeton)PRODH
Genomic and cartography
GoldenPath hg19 (UCSC)PRODH  -     chr22:18900287-18923964 -  22q11.21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PRODH  -     22q11.21   [Description]    (hg38-Dec_2013)
EnsemblPRODH - 22q11.21 [CytoView hg19]  PRODH - 22q11.21 [CytoView hg38]
Mapping of homologs : NCBIPRODH [Mapview hg19]  PRODH [Mapview hg38]
OMIM239500   600850   606810   
Gene and transcription
Genbank (Entrez)AA322439 AB209472 AF010310 AK001359 AK091063
RefSeq transcript (Entrez)NM_001195226 NM_016335
RefSeq genomic (Entrez)NC_000022 NC_018933 NG_008226 NT_011520 NW_004929429
Consensus coding sequences : CCDS (NCBI)PRODH
Cluster EST : UnigeneHs.517352 [ NCBI ]
CGAP (NCI)Hs.517352
Alternative Splicing GalleryENSG00000100033
Gene ExpressionPRODH [ NCBI-GEO ]   PRODH [ EBI - ARRAY_EXPRESS ]   PRODH [ SEEK ]   PRODH [ MEM ]
Gene Expression Viewer (FireBrowse)PRODH [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5625
GTEX Portal (Tissue expression)PRODH
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43272 (Uniprot)
NextProtO43272  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43272
Splice isoforms : SwissVarO43272 (Swissvar)
Catalytic activity : Enzyme1.5.5.2 [ Enzyme-Expasy ]   1.5.5.21.5.5.2 [ IntEnz-EBI ]   1.5.5.2 [ BRENDA ]   1.5.5.2 [ KEGG ]   
PhosPhoSitePlusO43272
Domains : Interpro (EBI)FAD-linked_oxidoreductase-like    Proline_DH_dom    Proline_oxidase   
Domain families : Pfam (Sanger)Pro_dh (PF01619)   
Domain families : Pfam (NCBI)pfam01619   
DMDM Disease mutations5625
Blocks (Seattle)PRODH
SuperfamilyO43272
Human Protein AtlasENSG00000100033
Peptide AtlasO43272
HPRD08433
IPIIPI00816398   IPI00816668   IPI00383798   IPI00853430   IPI00177725   IPI00797839   IPI00853114   IPI00953330   IPI00798307   IPI00797607   
Protein Interaction databases
DIP (DOE-UCLA)O43272
IntAct (EBI)O43272
FunCoupENSG00000100033
BioGRIDPRODH
STRING (EMBL)PRODH
ZODIACPRODH
Ontologies - Pathways
QuickGOO43272
Ontology : AmiGOproline dehydrogenase activity  proline dehydrogenase activity  mitochondrial inner membrane  mitochondrial matrix  proline metabolic process  proline catabolic process  intrinsic apoptotic signaling pathway in response to oxidative stress  proline catabolic process to glutamate  positive regulation of cell death  4-hydroxyproline catabolic process  oxidation-reduction process  FAD binding  
Ontology : EGO-EBIproline dehydrogenase activity  proline dehydrogenase activity  mitochondrial inner membrane  mitochondrial matrix  proline metabolic process  proline catabolic process  intrinsic apoptotic signaling pathway in response to oxidative stress  proline catabolic process to glutamate  positive regulation of cell death  4-hydroxyproline catabolic process  oxidation-reduction process  FAD binding  
Pathways : KEGGArginine and proline metabolism   
NDEx Network
Atlas of Cancer Signalling NetworkPRODH
Wikipedia pathwaysPRODH
Orthology - Evolution
OrthoDB5625
GeneTree (enSembl)ENSG00000100033
Phylogenetic Trees/Animal Genes : TreeFamPRODH
Homologs : HomoloGenePRODH
Homology/Alignments : Family Browser (UCSC)PRODH
Gene fusions - Rearrangements
Fusion: TCGAPI4KA 22q11.21 PRODH 22q11.21 LUSC
Polymorphisms : SNP, variants
NCBI Variation ViewerPRODH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRODH
dbVarPRODH
ClinVarPRODH
1000_GenomesPRODH 
Exome Variant ServerPRODH
ExAC (Exome Aggregation Consortium)PRODH (select the gene name)
Genetic variants : HAPMAP5625
Genomic Variants (DGV)PRODH [DGVbeta]
Mutations
ICGC Data PortalPRODH 
TCGA Data PortalPRODH 
Broad Tumor PortalPRODH
OASIS PortalPRODH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRODH 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PRODH
DgiDB (Drug Gene Interaction Database)PRODH
DoCM (Curated mutations)PRODH (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRODH (select a term)
intoGenPRODH
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)22:18900287-18923964  ENSG00000100033
CONAN: Copy Number AnalysisPRODH 
Mutations and Diseases : HGMDPRODH
OMIM239500    600850    606810   
MedgenPRODH
Genetic Testing Registry PRODH
NextProtO43272 [Medical]
TSGene5625
GENETestsPRODH
Huge Navigator PRODH [HugePedia]
snp3D : Map Gene to Disease5625
BioCentury BCIQPRODH
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5625
Chemical/Pharm GKB GenePA33801
Clinical trialPRODH
Miscellaneous
canSAR (ICR)PRODH (select the gene name)
Probes
Litterature
PubMed76 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRODH
EVEXPRODH
GoPubMedPRODH
iHOPPRODH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun May 8 19:01:57 CEST 2016

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