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PRODH (proline dehydrogenase 1)

Identity

Alias (NCBI)HSPOX2
PIG6
POX
PRODH1
PRODH2
TP53I6
HGNC (Hugo) PRODH
HGNC Alias symbHSPOX2
PRODH1
PIG6
PRODH2
TP53I6
HGNC Alias nameproline oxidase
HGNC Previous nameproline dehydrogenase (proline oxidase )
LocusID (NCBI) 5625
Atlas_Id 41873
Location 22q11.21  [Link to chromosome band 22q11]
Location_base_pair Starts at 18912781 and ends at 18936553 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PI4KA (22q11.21) / PRODH (22q11.21)ST5 (11p15.4) / PRODH (22q11.21)THAP7 (22q11.21) / PRODH (22q11.21)
USP11 (Xp11.23) / PRODH (22q11.21)PI4KA 22q11.21 / PRODH 22q11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PRODH   9453
Cards
Entrez_Gene (NCBI)PRODH    proline dehydrogenase 1
AliasesHSPOX2; PIG6; POX; PRODH1; 
PRODH2; TP53I6
GeneCards (Weizmann)PRODH
Ensembl hg19 (Hinxton)ENSG00000100033 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100033 [Gene_View]  ENSG00000100033 [Sequence]  chr22:18912781-18936553 [Contig_View]  PRODH [Vega]
ICGC DataPortalENSG00000100033
TCGA cBioPortalPRODH
AceView (NCBI)PRODH
Genatlas (Paris)PRODH
SOURCE (Princeton)PRODH
Genetics Home Reference (NIH)PRODH
Genomic and cartography
GoldenPath hg38 (UCSC)PRODH  -     chr22:18912781-18936553 -  22q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRODH  -     22q11.21   [Description]    (hg19-Feb_2009)
GoldenPathPRODH - 22q11.21 [CytoView hg19]  PRODH - 22q11.21 [CytoView hg38]
ImmunoBaseENSG00000100033
Genome Data Viewer NCBIPRODH [Mapview hg19]  
OMIM239500   600850   606810   
Gene and transcription
Genbank (Entrez)AA322439 AF010310 BC036534 BC118597 BU730461
RefSeq transcript (Entrez)NM_001195226 NM_016335
Consensus coding sequences : CCDS (NCBI)PRODH
Gene ExpressionPRODH [ NCBI-GEO ]   PRODH [ EBI - ARRAY_EXPRESS ]   PRODH [ SEEK ]   PRODH [ MEM ]
Gene Expression Viewer (FireBrowse)PRODH [ Firebrowse - Broad ]
GenevisibleExpression of PRODH in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5625
GTEX Portal (Tissue expression)PRODH
Human Protein AtlasENSG00000100033-PRODH [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43272   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43272  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43272
PhosPhoSitePlusO43272
Domains : Interpro (EBI)FAD-linked_oxidoreductase-like    Proline_DH_dom    Proline_oxidase   
Domain families : Pfam (Sanger)Pro_dh (PF01619)   
Domain families : Pfam (NCBI)pfam01619   
Conserved Domain (NCBI)PRODH
SuperfamilyO43272
AlphaFold pdb e-kbO43272   
Human Protein Atlas [tissue]ENSG00000100033-PRODH [tissue]
HPRD08433
Protein Interaction databases
DIP (DOE-UCLA)O43272
IntAct (EBI)O43272
BioGRIDPRODH
STRING (EMBL)PRODH
ZODIACPRODH
Ontologies - Pathways
QuickGOO43272
Ontology : AmiGOproline dehydrogenase activity  proline dehydrogenase activity  proline dehydrogenase activity  nucleoplasm  mitochondrion  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  proline metabolic process  proline catabolic process  intrinsic apoptotic signaling pathway in response to oxidative stress  proline catabolic process to glutamate  proline catabolic process to glutamate  positive regulation of cell death  4-hydroxyproline catabolic process  intracellular membrane-bounded organelle  FAD binding  FAD binding  
Ontology : EGO-EBIproline dehydrogenase activity  proline dehydrogenase activity  proline dehydrogenase activity  nucleoplasm  mitochondrion  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  proline metabolic process  proline catabolic process  intrinsic apoptotic signaling pathway in response to oxidative stress  proline catabolic process to glutamate  proline catabolic process to glutamate  positive regulation of cell death  4-hydroxyproline catabolic process  intracellular membrane-bounded organelle  FAD binding  FAD binding  
Pathways : KEGGArginine and proline metabolism   
NDEx NetworkPRODH
Atlas of Cancer Signalling NetworkPRODH
Wikipedia pathwaysPRODH
Orthology - Evolution
OrthoDB5625
GeneTree (enSembl)ENSG00000100033
Phylogenetic Trees/Animal Genes : TreeFamPRODH
Homologs : HomoloGenePRODH
Homology/Alignments : Family Browser (UCSC)PRODH
Gene fusions - Rearrangements
Fusion : MitelmanPI4KA/PRODH [22q11.21/22q11.21]  
Fusion : MitelmanTHAP7/PRODH [22q11.21/22q11.21]  
Fusion Cancer (Beijing)ST5 [11p15.4]  -  PRODH [22q11.21]  [FUSC003118]
Fusion : QuiverPRODH
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRODH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRODH
dbVarPRODH
ClinVarPRODH
MonarchPRODH
1000_GenomesPRODH 
Exome Variant ServerPRODH
GNOMAD BrowserENSG00000100033
Varsome BrowserPRODH
ACMGPRODH variants
VarityO43272
Genomic Variants (DGV)PRODH [DGVbeta]
DECIPHERPRODH [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRODH 
Mutations
ICGC Data PortalPRODH 
TCGA Data PortalPRODH 
Broad Tumor PortalPRODH
OASIS PortalPRODH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRODH  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPRODH
Mutations and Diseases : HGMDPRODH
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPRODH
DgiDB (Drug Gene Interaction Database)PRODH
DoCM (Curated mutations)PRODH
CIViC (Clinical Interpretations of Variants in Cancer)PRODH
Cancer3DPRODH
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM239500    600850    606810   
Orphanet3729   
DisGeNETPRODH
MedgenPRODH
Genetic Testing Registry PRODH
NextProtO43272 [Medical]
GENETestsPRODH
Target ValidationPRODH
Huge Navigator PRODH [HugePedia]
ClinGenPRODH
Clinical trials, drugs, therapy
MyCancerGenomePRODH
Protein Interactions : CTDPRODH
Pharm GKB GenePA33801
PharosO43272
Clinical trialPRODH
Miscellaneous
canSAR (ICR)PRODH
HarmonizomePRODH
DataMed IndexPRODH
Probes
Litterature
PubMed88 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPRODH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:26:57 CEST 2021

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