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PRODH (proline dehydrogenase (oxidase) 1)

Identity

Other namesHSPOX2
PIG6
POX
PRODH1
PRODH2
TP53I6
HGNC (Hugo) PRODH
LocusID (NCBI) 5625
Location 22q11.21
Location_base_pair Starts at 18900287 and ends at 18923964 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PRODH   9453
Cards
Entrez_Gene (NCBI)PRODH  5625  proline dehydrogenase (oxidase) 1
GeneCards (Weizmann)PRODH
Ensembl (Hinxton)ENSG00000100033 [Gene_View]  chr22:18900287-18923964 [Contig_View]  PRODH [Vega]
AceView (NCBI)PRODH
Genatlas (Paris)PRODH
WikiGenes5625
SOURCE (Princeton)NM_001195226 NM_016335
Genomic and cartography
GoldenPath (UCSC)PRODH  -  22q11.21   chr22:18900287-18923964 -  22q11.21   [Description]    (hg19-Feb_2009)
EnsemblPRODH - 22q11.21 [CytoView]
Mapping of homologs : NCBIPRODH [Mapview]
OMIM239500   600850   606810   
Gene and transcription
Genbank (Entrez)AA322439 AB209472 AF010310 AK001359 AK091063
RefSeq transcript (Entrez)NM_001195226 NM_016335
RefSeq genomic (Entrez)AC_000154 NC_000022 NC_018933 NG_008226 NT_011519 NW_001838737 NW_004929429
Consensus coding sequences : CCDS (NCBI)PRODH
Cluster EST : UnigeneHs.517352 [ NCBI ]
CGAP (NCI)Hs.517352
Alternative Splicing : Fast-db (Paris)GSHG0020177
Alternative Splicing GalleryENSG00000100033
Gene ExpressionPRODH [ NCBI-GEO ]     PRODH [ SEEK ]   PRODH [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43272 (Uniprot)
NextProtO43272  [Medical]
With graphics : InterProO43272
Splice isoforms : SwissVarO43272 (Swissvar)
Catalytic activity : Enzyme1.5.99.8 [ Enzyme-Expasy ]   1.5.99.81.5.99.8 [ IntEnz-EBI ]   1.5.99.8 [ BRENDA ]   1.5.99.8 [ KEGG ]   
Domains : Interpro (EBI)Proline_DH    Proline_oxidase   
Related proteins : CluSTrO43272
Domain families : Pfam (Sanger)Pro_dh (PF01619)   
Domain families : Pfam (NCBI)pfam01619   
DMDM Disease mutations5625
Blocks (Seattle)O43272
Human Protein AtlasENSG00000100033
Peptide AtlasO43272
HPRD08433
IPIIPI00816398   IPI00816668   IPI00383798   IPI00853430   IPI00177725   IPI00797839   IPI00853114   IPI00953330   IPI00798307   IPI00797607   
Protein Interaction databases
DIP (DOE-UCLA)O43272
IntAct (EBI)O43272
FunCoupENSG00000100033
BioGRIDPRODH
InParanoidO43272
Interologous Interaction database O43272
IntegromeDBPRODH
STRING (EMBL)PRODH
Ontologies - Pathways
Ontology : AmiGOproline dehydrogenase activity  mitochondrial inner membrane  mitochondrial matrix  glutamate biosynthetic process  proline metabolic process  proline catabolic process  intrinsic apoptotic signaling pathway in response to oxidative stress  proline catabolic process to glutamate  4-hydroxyproline catabolic process  cellular nitrogen compound metabolic process  small molecule metabolic process  FAD binding  
Ontology : EGO-EBIproline dehydrogenase activity  mitochondrial inner membrane  mitochondrial matrix  glutamate biosynthetic process  proline metabolic process  proline catabolic process  intrinsic apoptotic signaling pathway in response to oxidative stress  proline catabolic process to glutamate  4-hydroxyproline catabolic process  cellular nitrogen compound metabolic process  small molecule metabolic process  FAD binding  
Pathways : KEGGArginine and proline metabolism   
REACTOMEPRODH
Protein Interaction DatabasePRODH
Wikipedia pathwaysPRODH
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PRODH
SNP (GeneSNP Utah)PRODH
SNP : HGBasePRODH
Genetic variants : HAPMAPPRODH
1000_GenomesPRODH 
ICGC programENSG00000100033 
Somatic Mutations in Cancer : COSMICPRODH 
CONAN: Copy Number AnalysisPRODH 
Mutations and Diseases : HGMDPRODH
OMIM239500    600850    606810   
GENETestsPRODH
Disease Genetic AssociationPRODH
Huge Navigator PRODH [HugePedia]  PRODH [HugeCancerGEM]
Genomic VariantsPRODH  PRODH [DGVbeta]
Exome VariantPRODH
dbVarPRODH
ClinVarPRODH
snp3D : Map Gene to Disease5625
General knowledge
Homologs : HomoloGenePRODH
Homology/Alignments : Family Browser (UCSC)PRODH
Phylogenetic Trees/Animal Genes : TreeFamPRODH
Chemical/Protein Interactions : CTD5625
Chemical/Pharm GKB GenePA33801
Clinical trialPRODH
Cancer Resource (Charite)ENSG00000100033
Other databases
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
CoreMinePRODH
iHOPPRODH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 17:03:59 CEST 2014

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