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PRODH2 (proline dehydrogenase 2)

Identity

Alias_namesproline dehydrogenase (oxidase) 2
Alias_symbol (synonym)HSPOX1
Other aliasHYPDH
HGNC (Hugo) PRODH2
LocusID (NCBI) 58510
Atlas_Id 72238
Location 19q13.12  [Link to chromosome band 19q13]
Location_base_pair Starts at 35799990 and ends at 35813299 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRODH2   17325
Cards
Entrez_Gene (NCBI)PRODH2  58510  proline dehydrogenase 2
AliasesHSPOX1; HYPDH
GeneCards (Weizmann)PRODH2
Ensembl hg19 (Hinxton)ENSG00000250799 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000250799 [Gene_View]  chr19:35799990-35813299 [Contig_View]  PRODH2 [Vega]
ICGC DataPortalENSG00000250799
TCGA cBioPortalPRODH2
AceView (NCBI)PRODH2
Genatlas (Paris)PRODH2
WikiGenes58510
SOURCE (Princeton)PRODH2
Genetics Home Reference (NIH)PRODH2
Genomic and cartography
GoldenPath hg38 (UCSC)PRODH2  -     chr19:35799990-35813299 -  19q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRODH2  -     19q13.12   [Description]    (hg19-Feb_2009)
EnsemblPRODH2 - 19q13.12 [CytoView hg19]  PRODH2 - 19q13.12 [CytoView hg38]
Mapping of homologs : NCBIPRODH2 [Mapview hg19]  PRODH2 [Mapview hg38]
OMIM616377   
Gene and transcription
Genbank (Entrez)BC038853 BC039710 BC166629 U80018
RefSeq transcript (Entrez)NM_021232
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRODH2
Cluster EST : UnigeneHs.515366 [ NCBI ]
CGAP (NCI)Hs.515366
Alternative Splicing GalleryENSG00000250799
Gene ExpressionPRODH2 [ NCBI-GEO ]   PRODH2 [ EBI - ARRAY_EXPRESS ]   PRODH2 [ SEEK ]   PRODH2 [ MEM ]
Gene Expression Viewer (FireBrowse)PRODH2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)58510
GTEX Portal (Tissue expression)PRODH2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UF12   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UF12  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UF12
Splice isoforms : SwissVarQ9UF12
Catalytic activity : Enzyme1.5.5.2 [ Enzyme-Expasy ]   1.5.5.21.5.5.2 [ IntEnz-EBI ]   1.5.5.2 [ BRENDA ]   1.5.5.2 [ KEGG ]   
PhosPhoSitePlusQ9UF12
Domains : Interpro (EBI)FAD-linked_oxidoreductase-like    Proline_DH_dom    Proline_oxidase   
Domain families : Pfam (Sanger)Pro_dh (PF01619)   
Domain families : Pfam (NCBI)pfam01619   
Conserved Domain (NCBI)PRODH2
DMDM Disease mutations58510
Blocks (Seattle)PRODH2
SuperfamilyQ9UF12
Human Protein AtlasENSG00000250799
Peptide AtlasQ9UF12
HPRD17911
IPIIPI00009704   IPI00956219   
Protein Interaction databases
DIP (DOE-UCLA)Q9UF12
IntAct (EBI)Q9UF12
FunCoupENSG00000250799
BioGRIDPRODH2
STRING (EMBL)PRODH2
ZODIACPRODH2
Ontologies - Pathways
QuickGOQ9UF12
Ontology : AmiGOproline dehydrogenase activity  mitochondrion  mitochondrial inner membrane  proline catabolic process to glutamate  proline catabolic process to glutamate  oxidoreductase activity, acting on the CH-NH group of donors  oxidation-reduction process  FAD binding  
Ontology : EGO-EBIproline dehydrogenase activity  mitochondrion  mitochondrial inner membrane  proline catabolic process to glutamate  proline catabolic process to glutamate  oxidoreductase activity, acting on the CH-NH group of donors  oxidation-reduction process  FAD binding  
Pathways : KEGGArginine and proline metabolism   
NDEx NetworkPRODH2
Atlas of Cancer Signalling NetworkPRODH2
Wikipedia pathwaysPRODH2
Orthology - Evolution
OrthoDB58510
GeneTree (enSembl)ENSG00000250799
Phylogenetic Trees/Animal Genes : TreeFamPRODH2
HOVERGENQ9UF12
HOGENOMQ9UF12
Homologs : HomoloGenePRODH2
Homology/Alignments : Family Browser (UCSC)PRODH2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRODH2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRODH2
dbVarPRODH2
ClinVarPRODH2
1000_GenomesPRODH2 
Exome Variant ServerPRODH2
ExAC (Exome Aggregation Consortium)PRODH2 (select the gene name)
Genetic variants : HAPMAP58510
Genomic Variants (DGV)PRODH2 [DGVbeta]
DECIPHERPRODH2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRODH2 
Mutations
ICGC Data PortalPRODH2 
TCGA Data PortalPRODH2 
Broad Tumor PortalPRODH2
OASIS PortalPRODH2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRODH2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRODH2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PRODH2
DgiDB (Drug Gene Interaction Database)PRODH2
DoCM (Curated mutations)PRODH2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRODH2 (select a term)
intoGenPRODH2
Cancer3DPRODH2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616377   
Orphanet
MedgenPRODH2
Genetic Testing Registry PRODH2
NextProtQ9UF12 [Medical]
TSGene58510
GENETestsPRODH2
Target ValidationPRODH2
Huge Navigator PRODH2 [HugePedia]
snp3D : Map Gene to Disease58510
BioCentury BCIQPRODH2
ClinGenPRODH2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD58510
Chemical/Pharm GKB GenePA33802
Clinical trialPRODH2
Miscellaneous
canSAR (ICR)PRODH2 (select the gene name)
Probes
Litterature
PubMed5 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRODH2
EVEXPRODH2
GoPubMedPRODH2
iHOPPRODH2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:37:25 CEST 2017

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