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PROK2 (prokineticin 2)

Identity

Alias_symbol (synonym)PK2
BV8
MIT1
KAL4
HGNC (Hugo) PROK2
LocusID (NCBI) 60675
Atlas_Id 50357
Location 3p13  [Link to chromosome band 3p13]
Location_base_pair Starts at 71820806 and ends at 71834357 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PROK2   18455
Cards
Entrez_Gene (NCBI)PROK2  60675  prokineticin 2
AliasesBV8; HH4; KAL4; MIT1; 
PK2
GeneCards (Weizmann)PROK2
Ensembl hg19 (Hinxton)ENSG00000163421 [Gene_View]  chr3:71820806-71834357 [Contig_View]  PROK2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000163421 [Gene_View]  chr3:71820806-71834357 [Contig_View]  PROK2 [Vega]
ICGC DataPortalENSG00000163421
TCGA cBioPortalPROK2
AceView (NCBI)PROK2
Genatlas (Paris)PROK2
WikiGenes60675
SOURCE (Princeton)PROK2
Genetics Home Reference (NIH)PROK2
Genomic and cartography
GoldenPath hg19 (UCSC)PROK2  -     chr3:71820806-71834357 -  3p13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PROK2  -     3p13   [Description]    (hg38-Dec_2013)
EnsemblPROK2 - 3p13 [CytoView hg19]  PROK2 - 3p13 [CytoView hg38]
Mapping of homologs : NCBIPROK2 [Mapview hg19]  PROK2 [Mapview hg38]
OMIM607002   610628   
Gene and transcription
Genbank (Entrez)AF182069 AF333025 AY349131 BC069395 BC096695
RefSeq transcript (Entrez)NM_001126128 NM_021935
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_008275 NT_022517 NW_004929310
Consensus coding sequences : CCDS (NCBI)PROK2
Cluster EST : UnigeneHs.528665 [ NCBI ]
CGAP (NCI)Hs.528665
Alternative Splicing GalleryENSG00000163421
Gene ExpressionPROK2 [ NCBI-GEO ]   PROK2 [ EBI - ARRAY_EXPRESS ]   PROK2 [ SEEK ]   PROK2 [ MEM ]
Gene Expression Viewer (FireBrowse)PROK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)60675
GTEX Portal (Tissue expression)PROK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HC23   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HC23  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HC23
Splice isoforms : SwissVarQ9HC23
PhosPhoSitePlusQ9HC23
Domains : Interpro (EBI)Prokineticin    Prokineticin_domain   
Domain families : Pfam (Sanger)Prokineticin (PF06607)   
Domain families : Pfam (NCBI)pfam06607   
Domain structure : Prodom (Prabi Lyon)Prokineticin (PD059788)   
Conserved Domain (NCBI)PROK2
DMDM Disease mutations60675
Blocks (Seattle)PROK2
SuperfamilyQ9HC23
Human Protein AtlasENSG00000163421
Peptide AtlasQ9HC23
HPRD08446
IPIIPI00030045   IPI00220189   
Protein Interaction databases
DIP (DOE-UCLA)Q9HC23
IntAct (EBI)Q9HC23
FunCoupENSG00000163421
BioGRIDPROK2
STRING (EMBL)PROK2
ZODIACPROK2
Ontologies - Pathways
QuickGOQ9HC23
Ontology : AmiGOactivation of MAPK activity  angiogenesis  G-protein coupled receptor binding  extracellular region  cell  chemotaxis  inflammatory response  G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  neuropeptide signaling pathway  spermatogenesis  circadian rhythm  cell proliferation  positive regulation of cell proliferation  sensory perception of pain  negative regulation of apoptotic process  regulation of angiogenesis  positive regulation of smooth muscle contraction  
Ontology : EGO-EBIactivation of MAPK activity  angiogenesis  G-protein coupled receptor binding  extracellular region  cell  chemotaxis  inflammatory response  G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  neuropeptide signaling pathway  spermatogenesis  circadian rhythm  cell proliferation  positive regulation of cell proliferation  sensory perception of pain  negative regulation of apoptotic process  regulation of angiogenesis  positive regulation of smooth muscle contraction  
NDEx NetworkPROK2
Atlas of Cancer Signalling NetworkPROK2
Wikipedia pathwaysPROK2
Orthology - Evolution
OrthoDB60675
GeneTree (enSembl)ENSG00000163421
Phylogenetic Trees/Animal Genes : TreeFamPROK2
HOVERGENQ9HC23
HOGENOMQ9HC23
Homologs : HomoloGenePROK2
Homology/Alignments : Family Browser (UCSC)PROK2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPROK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PROK2
dbVarPROK2
ClinVarPROK2
1000_GenomesPROK2 
Exome Variant ServerPROK2
ExAC (Exome Aggregation Consortium)PROK2 (select the gene name)
Genetic variants : HAPMAP60675
Genomic Variants (DGV)PROK2 [DGVbeta]
DECIPHER (Syndromes)3:71820806-71834357  ENSG00000163421
CONAN: Copy Number AnalysisPROK2 
Mutations
ICGC Data PortalPROK2 
TCGA Data PortalPROK2 
Broad Tumor PortalPROK2
OASIS PortalPROK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPROK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPROK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PROK2
DgiDB (Drug Gene Interaction Database)PROK2
DoCM (Curated mutations)PROK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PROK2 (select a term)
intoGenPROK2
Cancer3DPROK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607002    610628   
Orphanet3249    8668   
MedgenPROK2
Genetic Testing Registry PROK2
NextProtQ9HC23 [Medical]
TSGene60675
GENETestsPROK2
Huge Navigator PROK2 [HugePedia]
snp3D : Map Gene to Disease60675
BioCentury BCIQPROK2
ClinGenPROK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD60675
Chemical/Pharm GKB GenePA38540
Clinical trialPROK2
Miscellaneous
canSAR (ICR)PROK2 (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePROK2
EVEXPROK2
GoPubMedPROK2
iHOPPROK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Nov 18 19:48:37 CET 2016

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