PROP1 (PROP paired-like homeobox 1)

2003-02-01  

Identity

HGNC
LOCATION
5q35.3
LOCUSID
ALIAS
CPHD2,PROP-1

Other Information

Locus ID:

NCBI: 5626
MIM: 601538
HGNC: 9455
Ensembl: ENSG00000175325

Variants:

dbSNP: 5626
ClinVar: 5626
TCGA: ENSG00000175325
COSMIC: PROP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175325ENST00000308304O75360

Expression (GTEx)

0
1
2
3

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
154722322004PROP1 mutations cause progressive deterioration of anterior pituitary function including adrenal insufficiency: a longitudinal analysis.26
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
159630552005Mutations within the transcription factor PROP1 are rare in a cohort of patients with sporadic combined pituitary hormone deficiency (CPHD).13
201817232010Corepressors TLE1 and TLE3 interact with HESX1 and PROP1.13
205347632010Mutation and gene copy number analyses of six pituitary transcription factor genes in 71 patients with combined pituitary hormone deficiency: identification of a single patient with LHX4 deletion.12
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
268121622016All Hormone-Producing Cell Types of the Pituitary Intermediate and Anterior Lobes Derive From Prop1-Expressing Progenitors.11
151265422004Pituitary magnetic resonance imaging in 15 patients with Prop1 gene mutations: pituitary enlargement may originate from the intermediate lobe.9
191283662009Molecular analysis of novel PROP1 mutations associated with combined pituitary hormone deficiency (CPHD).9

Citation

Dessen P

PROP1 (PROP paired-like homeobox 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41875/prop1