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PROP1 (PROP paired-like homeobox 1)

Identity

Alias_namesprophet of Pit1
Other aliasCPHD2
PROP-1
HGNC (Hugo) PROP1
LocusID (NCBI) 5626
Atlas_Id 41875
Location 5q35.3  [Link to chromosome band 5q35]
Location_base_pair Starts at 177419236 and ends at 177423243 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PROP1   9455
Cards
Entrez_Gene (NCBI)PROP1  5626  PROP paired-like homeobox 1
AliasesCPHD2; PROP-1
GeneCards (Weizmann)PROP1
Ensembl hg19 (Hinxton)ENSG00000175325 [Gene_View]  chr5:177419236-177423243 [Contig_View]  PROP1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000175325 [Gene_View]  chr5:177419236-177423243 [Contig_View]  PROP1 [Vega]
ICGC DataPortalENSG00000175325
TCGA cBioPortalPROP1
AceView (NCBI)PROP1
Genatlas (Paris)PROP1
WikiGenes5626
SOURCE (Princeton)PROP1
Genetics Home Reference (NIH)PROP1
Genomic and cartography
GoldenPath hg19 (UCSC)PROP1  -     chr5:177419236-177423243 -  5q35.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PROP1  -     5q35.3   [Description]    (hg38-Dec_2013)
EnsemblPROP1 - 5q35.3 [CytoView hg19]  PROP1 - 5q35.3 [CytoView hg38]
Mapping of homologs : NCBIPROP1 [Mapview hg19]  PROP1 [Mapview hg38]
OMIM262600   601538   
Gene and transcription
Genbank (Entrez)AF076215 BC069076
RefSeq transcript (Entrez)NM_006261
RefSeq genomic (Entrez)NC_000005 NC_018916 NG_015889 NT_023133 NT_187546 NT_187652 NW_004929325
Consensus coding sequences : CCDS (NCBI)PROP1
Cluster EST : UnigeneHs.158301 [ NCBI ]
CGAP (NCI)Hs.158301
Alternative Splicing GalleryENSG00000175325
Gene ExpressionPROP1 [ NCBI-GEO ]   PROP1 [ EBI - ARRAY_EXPRESS ]   PROP1 [ SEEK ]   PROP1 [ MEM ]
Gene Expression Viewer (FireBrowse)PROP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5626
GTEX Portal (Tissue expression)PROP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75360   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75360  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75360
Splice isoforms : SwissVarO75360
PhosPhoSitePlusO75360
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox_CS    Homeobox_dom    Homeodomain-like    HTH_motif   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)PROP1
DMDM Disease mutations5626
Blocks (Seattle)PROP1
SuperfamilyO75360
Human Protein AtlasENSG00000175325
Peptide AtlasO75360
HPRD03325
IPIIPI00025308   
Protein Interaction databases
DIP (DOE-UCLA)O75360
IntAct (EBI)O75360
FunCoupENSG00000175325
BioGRIDPROP1
STRING (EMBL)PROP1
ZODIACPROP1
Ontologies - Pathways
QuickGOO75360
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II distal enhancer sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding  transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding  blood vessel development  chromatin binding  protein binding  nucleus  transcription factor complex  transcription from RNA polymerase II promoter  central nervous system development  beta-catenin binding  protein C-terminus binding  dorsal/ventral pattern formation  cell migration  hypothalamus cell differentiation  negative regulation of apoptotic process  positive regulation of transcription from RNA polymerase II promoter  hypophysis morphogenesis  canonical Wnt signaling pathway  somatotropin secreting cell differentiation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II distal enhancer sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding  transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding  blood vessel development  chromatin binding  protein binding  nucleus  transcription factor complex  transcription from RNA polymerase II promoter  central nervous system development  beta-catenin binding  protein C-terminus binding  dorsal/ventral pattern formation  cell migration  hypothalamus cell differentiation  negative regulation of apoptotic process  positive regulation of transcription from RNA polymerase II promoter  hypophysis morphogenesis  canonical Wnt signaling pathway  somatotropin secreting cell differentiation  
NDEx NetworkPROP1
Atlas of Cancer Signalling NetworkPROP1
Wikipedia pathwaysPROP1
Orthology - Evolution
OrthoDB5626
GeneTree (enSembl)ENSG00000175325
Phylogenetic Trees/Animal Genes : TreeFamPROP1
HOVERGENO75360
HOGENOMO75360
Homologs : HomoloGenePROP1
Homology/Alignments : Family Browser (UCSC)PROP1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPROP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PROP1
dbVarPROP1
ClinVarPROP1
1000_GenomesPROP1 
Exome Variant ServerPROP1
ExAC (Exome Aggregation Consortium)PROP1 (select the gene name)
Genetic variants : HAPMAP5626
Genomic Variants (DGV)PROP1 [DGVbeta]
DECIPHER (Syndromes)5:177419236-177423243  ENSG00000175325
CONAN: Copy Number AnalysisPROP1 
Mutations
ICGC Data PortalPROP1 
TCGA Data PortalPROP1 
Broad Tumor PortalPROP1
OASIS PortalPROP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPROP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPROP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PROP1
DgiDB (Drug Gene Interaction Database)PROP1
DoCM (Curated mutations)PROP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PROP1 (select a term)
intoGenPROP1
Cancer3DPROP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM262600    601538   
Orphanet19033    12081    12618   
MedgenPROP1
Genetic Testing Registry PROP1
NextProtO75360 [Medical]
TSGene5626
GENETestsPROP1
Huge Navigator PROP1 [HugePedia]
snp3D : Map Gene to Disease5626
BioCentury BCIQPROP1
ClinGenPROP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5626
Chemical/Pharm GKB GenePA33808
Clinical trialPROP1
Miscellaneous
canSAR (ICR)PROP1 (select the gene name)
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePROP1
EVEXPROP1
GoPubMedPROP1
iHOPPROP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:15:47 CEST 2017

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