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PROS1 (protein S (alpha))

Identity

Other namesPROS
PS21
PS22
PS23
PS24
PS25
PSA
THPH5
THPH6
HGNC (Hugo) PROS1
LocusID (NCBI) 5627
Atlas_Id 46212
Location 3q11.1
Location_base_pair Starts at 93591881 and ends at 93692934 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PROS1 (3q11.1) / GLUL (1q25.3)SDC1 (2p24.1) / PROS1 (3q11.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PROS1   9456
Cards
Entrez_Gene (NCBI)PROS1  5627  protein S (alpha)
AliasesPROS; PS21; PS22; PS23; 
PS24; PS25; PSA; THPH5; THPH6
GeneCards (Weizmann)PROS1
Ensembl hg19 (Hinxton)ENSG00000184500 [Gene_View]  chr3:93591881-93692934 [Contig_View]  PROS1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000184500 [Gene_View]  chr3:93591881-93692934 [Contig_View]  PROS1 [Vega]
ICGC DataPortalENSG00000184500
TCGA cBioPortalPROS1
AceView (NCBI)PROS1
Genatlas (Paris)PROS1
WikiGenes5627
SOURCE (Princeton)PROS1
Genomic and cartography
GoldenPath hg19 (UCSC)PROS1  -     chr3:93591881-93692934 -  3q11.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PROS1  -     3q11.1   [Description]    (hg38-Dec_2013)
EnsemblPROS1 - 3q11.1 [CytoView hg19]  PROS1 - 3q11.1 [CytoView hg38]
Mapping of homologs : NCBIPROS1 [Mapview hg19]  PROS1 [Mapview hg38]
OMIM176880   612336   614514   
Gene and transcription
Genbank (Entrez)AI139337 AK292994 AK303895 BC015801 BE677834
RefSeq transcript (Entrez)NM_000313 NM_001314077
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_009813 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)PROS1
Cluster EST : UnigeneHs.64016 [ NCBI ]
CGAP (NCI)Hs.64016
Alternative Splicing GalleryENSG00000184500
Gene ExpressionPROS1 [ NCBI-GEO ]   PROS1 [ EBI - ARRAY_EXPRESS ]   PROS1 [ SEEK ]   PROS1 [ MEM ]
Gene Expression Viewer (FireBrowse)PROS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5627
GTEX Portal (Tissue expression)PROS1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07225 (Uniprot)
NextProtP07225  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07225
Splice isoforms : SwissVarP07225 (Swissvar)
PhosPhoSitePlusP07225
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    GLA_1 (PS00011)    GLA_2 (PS50998)    LAM_G_DOMAIN (PS50025)   
Domains : Interpro (EBI)Coagulation_fac_subgr_Gla_dom    ConA-like_dom    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    GLA_domain    Growth_fac_rcpt_    Laminin_G   
Domain families : Pfam (Sanger)EGF (PF00008)    EGF_CA (PF07645)    Gla (PF00594)    Laminin_G_1 (PF00054)    Laminin_G_2 (PF02210)   
Domain families : Pfam (NCBI)pfam00008    pfam07645    pfam00594    pfam00054    pfam02210   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  GLA (SM00069)  LamG (SM00282)  
DMDM Disease mutations5627
Blocks (Seattle)PROS1
PDB (SRS)1Z6C   
PDB (PDBSum)1Z6C   
PDB (IMB)1Z6C   
PDB (RSDB)1Z6C   
Structural Biology KnowledgeBase1Z6C   
SCOP (Structural Classification of Proteins)1Z6C   
CATH (Classification of proteins structures)1Z6C   
SuperfamilyP07225
Human Protein AtlasENSG00000184500
Peptide AtlasP07225
HPRD01473
IPIIPI00294004   IPI00954854   IPI00930047   IPI00878131   IPI00879470   IPI01013520   
Protein Interaction databases
DIP (DOE-UCLA)P07225
IntAct (EBI)P07225
FunCoupENSG00000184500
BioGRIDPROS1
STRING (EMBL)PROS1
ZODIACPROS1
Ontologies - Pathways
QuickGOP07225
Ontology : AmiGOGolgi membrane  platelet degranulation  endopeptidase inhibitor activity  calcium ion binding  extracellular region  extracellular region  extracellular space  endoplasmic reticulum membrane  Golgi lumen  plasma membrane  signal peptide processing  ER to Golgi vesicle-mediated transport  blood coagulation  negative regulation of endopeptidase activity  peptidyl-glutamic acid carboxylation  regulation of complement activation  platelet alpha granule lumen  protein complex binding  response to lipopolysaccharide  fibrinolysis  protein complex  positive regulation of phagocytosis  leukocyte migration  extracellular exosome  blood microparticle  
Ontology : EGO-EBIGolgi membrane  platelet degranulation  endopeptidase inhibitor activity  calcium ion binding  extracellular region  extracellular region  extracellular space  endoplasmic reticulum membrane  Golgi lumen  plasma membrane  signal peptide processing  ER to Golgi vesicle-mediated transport  blood coagulation  negative regulation of endopeptidase activity  peptidyl-glutamic acid carboxylation  regulation of complement activation  platelet alpha granule lumen  protein complex binding  response to lipopolysaccharide  fibrinolysis  protein complex  positive regulation of phagocytosis  leukocyte migration  extracellular exosome  blood microparticle  
Pathways : BIOCARTAIntrinsic Prothrombin Activation Pathway [Genes]    Acute Myocardial Infarction [Genes]    Extrinsic Prothrombin Activation Pathway [Genes]   
Pathways : KEGGComplement and coagulation cascades   
NDEx Network
Atlas of Cancer Signalling NetworkPROS1
Wikipedia pathwaysPROS1
Orthology - Evolution
OrthoDB5627
GeneTree (enSembl)ENSG00000184500
Phylogenetic Trees/Animal Genes : TreeFamPROS1
Homologs : HomoloGenePROS1
Homology/Alignments : Family Browser (UCSC)PROS1
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPROS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PROS1
dbVarPROS1
ClinVarPROS1
1000_GenomesPROS1 
Exome Variant ServerPROS1
ExAC (Exome Aggregation Consortium)PROS1 (select the gene name)
Genetic variants : HAPMAP5627
Genomic Variants (DGV)PROS1 [DGVbeta]
Mutations
ICGC Data PortalPROS1 
TCGA Data PortalPROS1 
Broad Tumor PortalPROS1
OASIS PortalPROS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPROS1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PROS1
DgiDB (Drug Gene Interaction Database)PROS1
DoCM (Curated mutations)PROS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PROS1 (select a term)
intoGenPROS1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)3:93591881-93692934  ENSG00000184500
CONAN: Copy Number AnalysisPROS1 
Mutations and Diseases : HGMDPROS1
OMIM176880    612336    614514   
MedgenPROS1
Genetic Testing Registry PROS1
NextProtP07225 [Medical]
TSGene5627
GENETestsPROS1
Huge Navigator PROS1 [HugePedia]
snp3D : Map Gene to Disease5627
BioCentury BCIQPROS1
ClinGenPROS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5627
Chemical/Pharm GKB GenePA33809
Clinical trialPROS1
Miscellaneous
canSAR (ICR)PROS1 (select the gene name)
Probes
Litterature
PubMed191 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePROS1
EVEXPROS1
GoPubMedPROS1
iHOPPROS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:17:11 CEST 2016

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