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PROS1 (protein S (alpha))

Identity

Other namesPROS
PS21
PS22
PS23
PS24
PS25
PSA
THPH5
THPH6
HGNC (Hugo) PROS1
LocusID (NCBI) 5627
Location 3q11.1
Location_base_pair Starts at 93591881 and ends at 93692934 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PROS1   9456
Cards
Entrez_Gene (NCBI)PROS1  5627  protein S (alpha)
GeneCards (Weizmann)PROS1
Ensembl (Hinxton)ENSG00000184500 [Gene_View]  chr3:93591881-93692934 [Contig_View]  PROS1 [Vega]
ICGC DataPortalENSG00000184500
cBioPortalPROS1
AceView (NCBI)PROS1
Genatlas (Paris)PROS1
WikiGenes5627
SOURCE (Princeton)NM_000313
Genomic and cartography
GoldenPath (UCSC)PROS1  -  3q11.1   chr3:93591881-93692934 -  3q11.1   [Description]    (hg19-Feb_2009)
EnsemblPROS1 - 3q11.1 [CytoView]
Mapping of homologs : NCBIPROS1 [Mapview]
OMIM176880   612336   614514   
Gene and transcription
Genbank (Entrez)AI139337 AK292994 AK303895 BC015801 BE677834
RefSeq transcript (Entrez)NM_000313
RefSeq genomic (Entrez)AC_000135 NC_000003 NC_018914 NG_009813 NT_005612 NW_001838880 NW_004929311
Consensus coding sequences : CCDS (NCBI)PROS1
Cluster EST : UnigeneHs.64016 [ NCBI ]
CGAP (NCI)Hs.64016
Alternative Splicing : Fast-db (Paris)GSHG0021885
Alternative Splicing GalleryENSG00000184500
Gene ExpressionPROS1 [ NCBI-GEO ]     PROS1 [ SEEK ]   PROS1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07225 (Uniprot)
NextProtP07225  [Medical]
With graphics : InterProP07225
Splice isoforms : SwissVarP07225 (Swissvar)
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    GLA_1 (PS00011)    GLA_2 (PS50998)    LAM_G_DOMAIN (PS50025)   
Domains : Interpro (EBI)Coagulation_fac_subgr_Gla_dom [organisation]   ConA-like_lec_gl_sf [organisation]   ConA-like_subgrp [organisation]   EG-like_dom [organisation]   EGF-like_Ca-bd_dom [organisation]   EGF-like_CS [organisation]   EGF-type_Asp/Asn_hydroxyl_site [organisation]   EGF_Ca-bd_CS [organisation]   GLA_domain [organisation]   Growth_fac_rcpt_N_dom [organisation]   Laminin_G [organisation]  
Related proteins : CluSTrP07225
Domain families : Pfam (Sanger)EGF (PF00008)    EGF_CA (PF07645)    Gla (PF00594)    Laminin_G_1 (PF00054)    Laminin_G_2 (PF02210)   
Domain families : Pfam (NCBI)pfam00008    pfam07645    pfam00594    pfam00054    pfam02210   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  GLA (SM00069)  LamG (SM00282)  
DMDM Disease mutations5627
Blocks (Seattle)P07225
PDB (SRS)1Z6C   
PDB (PDBSum)1Z6C   
PDB (IMB)1Z6C   
PDB (RSDB)1Z6C   
Human Protein AtlasENSG00000184500 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP07225
HPRD01473
IPIIPI00294004   IPI00954854   IPI00930047   IPI00878131   IPI00879470   IPI01013520   
Protein Interaction databases
DIP (DOE-UCLA)P07225
IntAct (EBI)P07225
FunCoupENSG00000184500
BioGRIDPROS1
InParanoidP07225
Interologous Interaction database P07225
IntegromeDBPROS1
STRING (EMBL)PROS1
Ontologies - Pathways
Ontology : AmiGOGolgi membrane  platelet degranulation  endopeptidase inhibitor activity  calcium ion binding  extracellular region  extracellular region  extracellular space  endoplasmic reticulum membrane  Golgi lumen  proteolysis  blood coagulation  negative regulation of endopeptidase activity  peptidyl-glutamic acid carboxylation  platelet activation  regulation of complement activation  platelet alpha granule lumen  fibrinolysis  post-translational protein modification  cellular protein metabolic process  innate immune response  leukocyte migration  blood microparticle  
Ontology : EGO-EBIGolgi membrane  platelet degranulation  endopeptidase inhibitor activity  calcium ion binding  extracellular region  extracellular region  extracellular space  endoplasmic reticulum membrane  Golgi lumen  proteolysis  blood coagulation  negative regulation of endopeptidase activity  peptidyl-glutamic acid carboxylation  platelet activation  regulation of complement activation  platelet alpha granule lumen  fibrinolysis  post-translational protein modification  cellular protein metabolic process  innate immune response  leukocyte migration  blood microparticle  
Pathways : BIOCARTAIntrinsic Prothrombin Activation Pathway [Genes]    Acute Myocardial Infarction [Genes]    Extrinsic Prothrombin Activation Pathway [Genes]   
Pathways : KEGGComplement and coagulation cascades   
Protein Interaction DatabasePROS1
Wikipedia pathwaysPROS1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PROS1
snp3D : Map Gene to Disease5627
SNP (GeneSNP Utah)PROS1
SNP : HGBasePROS1
Genetic variants : HAPMAPPROS1
Exome VariantPROS1
1000_GenomesPROS1 
ICGC programENSG00000184500 
Somatic Mutations in Cancer : COSMICPROS1 
CONAN: Copy Number AnalysisPROS1 
Mutations and Diseases : HGMDPROS1
Mutations and Diseases : intOGenPROS1
Genomic VariantsPROS1  PROS1 [DGVbeta]
dbVarPROS1
ClinVarPROS1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM176880    612336    614514   
MedgenPROS1
GENETestsPROS1
Disease Genetic AssociationPROS1
Huge Navigator PROS1 [HugePedia]  PROS1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGenePROS1
Homology/Alignments : Family Browser (UCSC)PROS1
Phylogenetic Trees/Animal Genes : TreeFamPROS1
Chemical/Protein Interactions : CTD5627
Chemical/Pharm GKB GenePA33809
Clinical trialPROS1
Cancer Resource (Charite)ENSG00000184500
Other databases
Probes
Litterature
PubMed176 Pubmed reference(s) in Entrez
CoreMinePROS1
iHOPPROS1
OncoSearchPROS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 17:01:17 CEST 2014

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