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PROX1 (prospero homeobox 1)

Identity

Alias_namesprospero-related homeobox 1
Other alias-
HGNC (Hugo) PROX1
LocusID (NCBI) 5629
Atlas_Id 46057
Location 1q32.3  [Link to chromosome band 1q32]
Location_base_pair Starts at 214161278 and ends at 214214847 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
C1orf132 () / PROX1 (1q32.3)FBXL4 (6q16.1) / PROX1 (1q32.3)PROX1 (1q32.3) / DAB2IP (9q33.2)
C1orf132 1q32.2 / PROX1 1q32.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PROX1   9459
Cards
Entrez_Gene (NCBI)PROX1  5629  prospero homeobox 1
Aliases
GeneCards (Weizmann)PROX1
Ensembl hg19 (Hinxton)ENSG00000117707 [Gene_View]  chr1:214161278-214214847 [Contig_View]  PROX1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000117707 [Gene_View]  chr1:214161278-214214847 [Contig_View]  PROX1 [Vega]
ICGC DataPortalENSG00000117707
TCGA cBioPortalPROX1
AceView (NCBI)PROX1
Genatlas (Paris)PROX1
WikiGenes5629
SOURCE (Princeton)PROX1
Genetics Home Reference (NIH)PROX1
Genomic and cartography
GoldenPath hg19 (UCSC)PROX1  -     chr1:214161278-214214847 +  1q32.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PROX1  -     1q32.3   [Description]    (hg38-Dec_2013)
EnsemblPROX1 - 1q32.3 [CytoView hg19]  PROX1 - 1q32.3 [CytoView hg38]
Mapping of homologs : NCBIPROX1 [Mapview hg19]  PROX1 [Mapview hg38]
OMIM601546   
Gene and transcription
Genbank (Entrez)AK025453 AK298182 BC024201 DA743374 DA802102
RefSeq transcript (Entrez)NM_001270616 NM_002763
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_004487 NW_004929294
Consensus coding sequences : CCDS (NCBI)PROX1
Cluster EST : UnigeneHs.744931 [ NCBI ]
CGAP (NCI)Hs.744931
Alternative Splicing GalleryENSG00000117707
Gene ExpressionPROX1 [ NCBI-GEO ]   PROX1 [ EBI - ARRAY_EXPRESS ]   PROX1 [ SEEK ]   PROX1 [ MEM ]
Gene Expression Viewer (FireBrowse)PROX1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5629
GTEX Portal (Tissue expression)PROX1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92786   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92786  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92786
Splice isoforms : SwissVarQ92786
PhosPhoSitePlusQ92786
Domains : Interpro (EBI)Homeo_prospero_dom    Homeodomain-like   
Domain families : Pfam (Sanger)HPD (PF05044)   
Domain families : Pfam (NCBI)pfam05044   
Conserved Domain (NCBI)PROX1
DMDM Disease mutations5629
Blocks (Seattle)PROX1
PDB (SRS)2LMD   
PDB (PDBSum)2LMD   
PDB (IMB)2LMD   
PDB (RSDB)2LMD   
Structural Biology KnowledgeBase2LMD   
SCOP (Structural Classification of Proteins)2LMD   
CATH (Classification of proteins structures)2LMD   
SuperfamilyQ92786
Human Protein AtlasENSG00000117707
Peptide AtlasQ92786
HPRD03330
IPIIPI00152167   IPI01012673   IPI00947005   
Protein Interaction databases
DIP (DOE-UCLA)Q92786
IntAct (EBI)Q92786
FunCoupENSG00000117707
BioGRIDPROX1
STRING (EMBL)PROX1
ZODIACPROX1
Ontologies - Pathways
QuickGOQ92786
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  core promoter sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  cell fate determination  kidney development  liver development  positive regulation of endothelial cell proliferation  lymphangiogenesis  lens development in camera-type eye  hepatocyte cell migration  DNA binding  transcription factor activity, sequence-specific DNA binding  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  transcription corepressor activity  protein binding  nucleus  nucleus  cytoplasm  transcription, DNA-templated  brain development  circadian rhythm  positive regulation of cell proliferation  negative regulation of cell proliferation  regulation of gene expression  positive regulation of endothelial cell migration  ligand-dependent nuclear receptor binding  dorsal spinal cord development  dentate gyrus development  cerebellar granule cell differentiation  neural tube development  neuron differentiation  skeletal muscle thin filament assembly  lung development  olfactory placode formation  pancreas development  response to nutrient levels  regulation of circadian rhythm  otic placode formation  negative regulation of sequence-specific DNA binding transcription factor activity  transcription regulatory region DNA binding  negative regulation of viral genome replication  positive regulation of cyclin-dependent protein serine/threonine kinase activity  positive regulation of cell cycle  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  optic placode formation involved in camera-type eye formation  venous blood vessel morphogenesis  DBD domain binding  LBD domain binding  ventricular cardiac myofibril assembly  cardiac muscle cell differentiation  atrial cardiac muscle tissue morphogenesis  ventricular cardiac muscle tissue morphogenesis  retina morphogenesis in camera-type eye  embryonic retina morphogenesis in camera-type eye  endocardium formation  positive regulation of sarcomere organization  ventricular septum morphogenesis  aorta smooth muscle tissue morphogenesis  positive regulation of heart growth  lymphatic endothelial cell differentiation  regulation of transcription involved in lymphatic endothelial cell fate commitment  branching involved in pancreas morphogenesis  lens fiber cell morphogenesis  hepatocyte differentiation  negative regulation of bile acid biosynthetic process  hepatocyte proliferation  acinar cell differentiation  neuronal stem cell population maintenance  positive regulation of cell cycle checkpoint  positive regulation of neural precursor cell proliferation  positive regulation of forebrain neuron differentiation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  core promoter sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  cell fate determination  kidney development  liver development  positive regulation of endothelial cell proliferation  lymphangiogenesis  lens development in camera-type eye  hepatocyte cell migration  DNA binding  transcription factor activity, sequence-specific DNA binding  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  transcription corepressor activity  protein binding  nucleus  nucleus  cytoplasm  transcription, DNA-templated  brain development  circadian rhythm  positive regulation of cell proliferation  negative regulation of cell proliferation  regulation of gene expression  positive regulation of endothelial cell migration  ligand-dependent nuclear receptor binding  dorsal spinal cord development  dentate gyrus development  cerebellar granule cell differentiation  neural tube development  neuron differentiation  skeletal muscle thin filament assembly  lung development  olfactory placode formation  pancreas development  response to nutrient levels  regulation of circadian rhythm  otic placode formation  negative regulation of sequence-specific DNA binding transcription factor activity  transcription regulatory region DNA binding  negative regulation of viral genome replication  positive regulation of cyclin-dependent protein serine/threonine kinase activity  positive regulation of cell cycle  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  optic placode formation involved in camera-type eye formation  venous blood vessel morphogenesis  DBD domain binding  LBD domain binding  ventricular cardiac myofibril assembly  cardiac muscle cell differentiation  atrial cardiac muscle tissue morphogenesis  ventricular cardiac muscle tissue morphogenesis  retina morphogenesis in camera-type eye  embryonic retina morphogenesis in camera-type eye  endocardium formation  positive regulation of sarcomere organization  ventricular septum morphogenesis  aorta smooth muscle tissue morphogenesis  positive regulation of heart growth  lymphatic endothelial cell differentiation  regulation of transcription involved in lymphatic endothelial cell fate commitment  branching involved in pancreas morphogenesis  lens fiber cell morphogenesis  hepatocyte differentiation  negative regulation of bile acid biosynthetic process  hepatocyte proliferation  acinar cell differentiation  neuronal stem cell population maintenance  positive regulation of cell cycle checkpoint  positive regulation of neural precursor cell proliferation  positive regulation of forebrain neuron differentiation  
NDEx NetworkPROX1
Atlas of Cancer Signalling NetworkPROX1
Wikipedia pathwaysPROX1
Orthology - Evolution
OrthoDB5629
GeneTree (enSembl)ENSG00000117707
Phylogenetic Trees/Animal Genes : TreeFamPROX1
HOVERGENQ92786
HOGENOMQ92786
Homologs : HomoloGenePROX1
Homology/Alignments : Family Browser (UCSC)PROX1
Gene fusions - Rearrangements
Fusion : MitelmanC1orf132/PROX1 [1q32.2/1q32.3]  [t(1;1)(q32;q32)]  
Fusion: TCGAC1orf132 1q32.2 PROX1 1q32.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPROX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PROX1
dbVarPROX1
ClinVarPROX1
1000_GenomesPROX1 
Exome Variant ServerPROX1
ExAC (Exome Aggregation Consortium)PROX1 (select the gene name)
Genetic variants : HAPMAP5629
Genomic Variants (DGV)PROX1 [DGVbeta]
DECIPHER (Syndromes)1:214161278-214214847  ENSG00000117707
CONAN: Copy Number AnalysisPROX1 
Mutations
ICGC Data PortalPROX1 
TCGA Data PortalPROX1 
Broad Tumor PortalPROX1
OASIS PortalPROX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPROX1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPROX1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PROX1
DgiDB (Drug Gene Interaction Database)PROX1
DoCM (Curated mutations)PROX1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PROX1 (select a term)
intoGenPROX1
Cancer3DPROX1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601546   
Orphanet
MedgenPROX1
Genetic Testing Registry PROX1
NextProtQ92786 [Medical]
TSGene5629
GENETestsPROX1
Huge Navigator PROX1 [HugePedia]
snp3D : Map Gene to Disease5629
BioCentury BCIQPROX1
ClinGenPROX1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5629
Chemical/Pharm GKB GenePA33812
Clinical trialPROX1
Miscellaneous
canSAR (ICR)PROX1 (select the gene name)
Probes
Litterature
PubMed99 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePROX1
EVEXPROX1
GoPubMedPROX1
iHOPPROX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:15:47 CEST 2017

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