PROX1 (prospero homeobox 1)

2007-02-01  

Identity

HGNC
LOCATION
1q32.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 5629
MIM: 601546
HGNC: 9459
Ensembl: ENSG00000117707

Variants:

dbSNP: 5629
ClinVar: 5629
TCGA: ENSG00000117707
COSMIC: PROX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117707ENST00000261454Q92786
ENSG00000117707ENST00000366958Q92786
ENSG00000117707ENST00000435016Q92786
ENSG00000117707ENST00000471129C9JU29
ENSG00000117707ENST00000498508Q92786
ENSG00000117707ENST00000607425U3KPY6

Expression (GTEx)

0
5
10
15
20
25
30
35

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD
PA448499atenololChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
200818582010New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.925
121981612002Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor.179
124120202002Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate.144
126925512003Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina.121
201858072010Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans.101
117194312001LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis.91
117194312001LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis.91
184551242008Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype.73
199012622010Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1.71
208898532011Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.65

Citation

Dessen P

PROX1 (prospero homeobox 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46057/prox1