Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5629
MIM: 601546
HGNC: 9459
Ensembl: ENSG00000117707
Variants:
dbSNP: 5629
ClinVar: 5629
TCGA: ENSG00000117707
COSMIC: PROX1
RNA/Proteins
Expression (GTEx)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA444552 | Hypertension | Disease | ClinicalAnnotation | associated | PD | ||
| PA448499 | atenolol | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38244581 | 2024 | PROX1 interaction with α-SMA-rich cancer-associated fibroblasts facilitates colorectal cancer progression and correlates with poor clinical outcomes and therapeutic resistance. | 0 |
| 38277016 | 2024 | Prox1 Suppresses Proliferation and Drug Resistance of Retinoblastoma Cells via Targeting Notch1. | 0 |
| 38244581 | 2024 | PROX1 interaction with α-SMA-rich cancer-associated fibroblasts facilitates colorectal cancer progression and correlates with poor clinical outcomes and therapeutic resistance. | 0 |
| 38277016 | 2024 | Prox1 Suppresses Proliferation and Drug Resistance of Retinoblastoma Cells via Targeting Notch1. | 0 |
| 36803975 | 2023 | Exosomal circ_0026611 contributes to lymphangiogenesis by reducing PROX1 acetylation and ubiquitination in human lymphatic endothelial cells (HLECs). | 10 |
| 36815375 | 2023 | PROX1 restrains ferroptosis via SCD transcription activation in colorectal cancer. | 1 |
| 37072887 | 2023 | Defects in vein valve PROX1/FOXC2 antithrombotic pathway in endothelial cells drive the hypercoagulable state induced by trauma and critical illness. | 0 |
| 37224811 | 2023 | PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway. | 1 |
| 37508533 | 2023 | Prox1 Suppresses the Proliferation of Breast Cancer Cells via Direct Inhibition of c-Myc Gene Expression. | 0 |
| 38206773 | 2023 | Homeobox Protein PROX1 Expression is Negatively Regulated by Histone Deacetylase 1 and c-JUN Complex in MDA-MB-231 Human Breast Cancer Cells. | 0 |
| 36803975 | 2023 | Exosomal circ_0026611 contributes to lymphangiogenesis by reducing PROX1 acetylation and ubiquitination in human lymphatic endothelial cells (HLECs). | 10 |
| 36815375 | 2023 | PROX1 restrains ferroptosis via SCD transcription activation in colorectal cancer. | 1 |
| 37072887 | 2023 | Defects in vein valve PROX1/FOXC2 antithrombotic pathway in endothelial cells drive the hypercoagulable state induced by trauma and critical illness. | 0 |
| 37224811 | 2023 | PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway. | 1 |
| 37508533 | 2023 | Prox1 Suppresses the Proliferation of Breast Cancer Cells via Direct Inhibition of c-Myc Gene Expression. | 0 |
Citation
Dessen P
PROX1 (prospero homeobox 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46057/prox1
