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PROX2 (prospero homeobox 2)

Identity

Alias_symbol (synonym)FLJ36749
Other aliasPROX-2
HGNC (Hugo) PROX2
LocusID (NCBI) 283571
Atlas_Id 72249
Location 14q24.3  [Link to chromosome band 14q24]
Location_base_pair Starts at 74853033 and ends at 74863834 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PROX2   26715
Cards
Entrez_Gene (NCBI)PROX2  283571  prospero homeobox 2
AliasesPROX-2
GeneCards (Weizmann)PROX2
Ensembl hg19 (Hinxton)ENSG00000119608 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119608 [Gene_View]  chr14:74853033-74863834 [Contig_View]  PROX2 [Vega]
ICGC DataPortalENSG00000119608
TCGA cBioPortalPROX2
AceView (NCBI)PROX2
Genatlas (Paris)PROX2
WikiGenes283571
SOURCE (Princeton)PROX2
Genetics Home Reference (NIH)PROX2
Genomic and cartography
GoldenPath hg38 (UCSC)PROX2  -     chr14:74853033-74863834 -  14q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PROX2  -     14q24.3   [Description]    (hg19-Feb_2009)
EnsemblPROX2 - 14q24.3 [CytoView hg19]  PROX2 - 14q24.3 [CytoView hg38]
Mapping of homologs : NCBIPROX2 [Mapview hg19]  PROX2 [Mapview hg38]
OMIM615094   
Gene and transcription
Genbank (Entrez)AK094068 BC105720 BC105721 BC105927
RefSeq transcript (Entrez)NM_001080408 NM_001243007
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PROX2
Cluster EST : UnigeneHs.675293 [ NCBI ]
CGAP (NCI)Hs.675293
Alternative Splicing GalleryENSG00000119608
Gene ExpressionPROX2 [ NCBI-GEO ]   PROX2 [ EBI - ARRAY_EXPRESS ]   PROX2 [ SEEK ]   PROX2 [ MEM ]
Gene Expression Viewer (FireBrowse)PROX2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)283571
GTEX Portal (Tissue expression)PROX2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ3B8N5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ3B8N5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ3B8N5
Splice isoforms : SwissVarQ3B8N5
PhosPhoSitePlusQ3B8N5
Domaine pattern : Prosite (Expaxy)HOMEO_PROSPERO (PS51818)   
Domains : Interpro (EBI)Homeo_prospero_dom    Homeobox-like   
Domain families : Pfam (Sanger)HPD (PF05044)   
Domain families : Pfam (NCBI)pfam05044   
Conserved Domain (NCBI)PROX2
DMDM Disease mutations283571
Blocks (Seattle)PROX2
SuperfamilyQ3B8N5
Human Protein AtlasENSG00000119608
Peptide AtlasQ3B8N5
IPIIPI00737875   IPI00896404   IPI00018590   IPI01024778   IPI01026245   IPI00964895   
Protein Interaction databases
DIP (DOE-UCLA)Q3B8N5
IntAct (EBI)Q3B8N5
FunCoupENSG00000119608
BioGRIDPROX2
STRING (EMBL)PROX2
ZODIACPROX2
Ontologies - Pathways
QuickGOQ3B8N5
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  lymphangiogenesis  DNA binding  nucleus  transcription, DNA-templated  neuron differentiation  positive regulation of transcription from RNA polymerase II promoter  cardiac muscle cell differentiation  lymphatic endothelial cell differentiation  lens fiber cell morphogenesis  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  lymphangiogenesis  DNA binding  nucleus  transcription, DNA-templated  neuron differentiation  positive regulation of transcription from RNA polymerase II promoter  cardiac muscle cell differentiation  lymphatic endothelial cell differentiation  lens fiber cell morphogenesis  
NDEx NetworkPROX2
Atlas of Cancer Signalling NetworkPROX2
Wikipedia pathwaysPROX2
Orthology - Evolution
OrthoDB283571
GeneTree (enSembl)ENSG00000119608
Phylogenetic Trees/Animal Genes : TreeFamPROX2
HOVERGENQ3B8N5
HOGENOMQ3B8N5
Homologs : HomoloGenePROX2
Homology/Alignments : Family Browser (UCSC)PROX2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPROX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PROX2
dbVarPROX2
ClinVarPROX2
1000_GenomesPROX2 
Exome Variant ServerPROX2
ExAC (Exome Aggregation Consortium)PROX2 (select the gene name)
Genetic variants : HAPMAP283571
Genomic Variants (DGV)PROX2 [DGVbeta]
DECIPHERPROX2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPROX2 
Mutations
ICGC Data PortalPROX2 
TCGA Data PortalPROX2 
Broad Tumor PortalPROX2
OASIS PortalPROX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPROX2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPROX2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PROX2
DgiDB (Drug Gene Interaction Database)PROX2
DoCM (Curated mutations)PROX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PROX2 (select a term)
intoGenPROX2
Cancer3DPROX2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615094   
Orphanet
MedgenPROX2
Genetic Testing Registry PROX2
NextProtQ3B8N5 [Medical]
TSGene283571
GENETestsPROX2
Target ValidationPROX2
Huge Navigator PROX2 [HugePedia]
snp3D : Map Gene to Disease283571
BioCentury BCIQPROX2
ClinGenPROX2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD283571
Chemical/Pharm GKB GenePA162400142
Clinical trialPROX2
Miscellaneous
canSAR (ICR)PROX2 (select the gene name)
Probes
Litterature
PubMed4 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePROX2
EVEXPROX2
GoPubMedPROX2
iHOPPROX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:35:20 CEST 2017

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