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PRPF4B (pre-mRNA processing factor 4B)

Identity

Alias_namesPRP4 pre-mRNA processing factor 4 homolog B (yeast)
Alias_symbol (synonym)Prp4
PR4H
KIAA0536
Other aliasPRP4
PRP4H
PRP4K
dJ1013A10.1
HGNC (Hugo) PRPF4B
LocusID (NCBI) 8899
Atlas_Id 43431
Location 6p25.2  [Link to chromosome band 6p25]
Location_base_pair Starts at 4021335 and ends at 4064983 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PHC3 (3q26.2) / PRPF4B (6p25.2)PRPF4B (6p25.2) / SEC63 (6q21)PTPRG (3p14.2) / PRPF4B (6p25.2)
RD3 (1q32.3) / PRPF4B (6p25.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRPF4B   17346
Cards
Entrez_Gene (NCBI)PRPF4B  8899  pre-mRNA processing factor 4B
AliasesPR4H; PRP4; PRP4H; PRP4K; 
dJ1013A10.1
GeneCards (Weizmann)PRPF4B
Ensembl hg19 (Hinxton)ENSG00000112739 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112739 [Gene_View]  ENSG00000112739 [Sequence]  chr6:4021335-4064983 [Contig_View]  PRPF4B [Vega]
ICGC DataPortalENSG00000112739
TCGA cBioPortalPRPF4B
AceView (NCBI)PRPF4B
Genatlas (Paris)PRPF4B
WikiGenes8899
SOURCE (Princeton)PRPF4B
Genetics Home Reference (NIH)PRPF4B
Genomic and cartography
GoldenPath hg38 (UCSC)PRPF4B  -     chr6:4021335-4064983 +  6p25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRPF4B  -     6p25.2   [Description]    (hg19-Feb_2009)
EnsemblPRPF4B - 6p25.2 [CytoView hg19]  PRPF4B - 6p25.2 [CytoView hg38]
Mapping of homologs : NCBIPRPF4B [Mapview hg19]  PRPF4B [Mapview hg38]
OMIM602338   
Gene and transcription
Genbank (Entrez)AB011108 AF283465 AK291244 AK303047 AY029347
RefSeq transcript (Entrez)NM_003913 NM_176800
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRPF4B
Cluster EST : UnigeneHs.159014 [ NCBI ]
CGAP (NCI)Hs.159014
Alternative Splicing GalleryENSG00000112739
Gene ExpressionPRPF4B [ NCBI-GEO ]   PRPF4B [ EBI - ARRAY_EXPRESS ]   PRPF4B [ SEEK ]   PRPF4B [ MEM ]
Gene Expression Viewer (FireBrowse)PRPF4B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8899
GTEX Portal (Tissue expression)PRPF4B
Human Protein AtlasENSG00000112739-PRPF4B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13523   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13523  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13523
Splice isoforms : SwissVarQ13523
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ13523
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)PRPF4B
DMDM Disease mutations8899
Blocks (Seattle)PRPF4B
PDB (SRS)4IAN    4IFC    4IIR    4IJP   
PDB (PDBSum)4IAN    4IFC    4IIR    4IJP   
PDB (IMB)4IAN    4IFC    4IIR    4IJP   
PDB (RSDB)4IAN    4IFC    4IIR    4IJP   
Structural Biology KnowledgeBase4IAN    4IFC    4IIR    4IJP   
SCOP (Structural Classification of Proteins)4IAN    4IFC    4IIR    4IJP   
CATH (Classification of proteins structures)4IAN    4IFC    4IIR    4IJP   
SuperfamilyQ13523
Human Protein Atlas [tissue]ENSG00000112739-PRPF4B [tissue]
Peptide AtlasQ13523
HPRD09087
IPIIPI00013721   IPI00976830   IPI00976263   
Protein Interaction databases
DIP (DOE-UCLA)Q13523
IntAct (EBI)Q13523
FunCoupENSG00000112739
BioGRIDPRPF4B
STRING (EMBL)PRPF4B
ZODIACPRPF4B
Ontologies - Pathways
QuickGOQ13523
Ontology : AmiGOmRNA splicing, via spliceosome  RNA binding  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  chromosome  protein phosphorylation  RNA splicing  nuclear speck  catalytic step 2 spliceosome  
Ontology : EGO-EBImRNA splicing, via spliceosome  RNA binding  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  chromosome  protein phosphorylation  RNA splicing  nuclear speck  catalytic step 2 spliceosome  
NDEx NetworkPRPF4B
Atlas of Cancer Signalling NetworkPRPF4B
Wikipedia pathwaysPRPF4B
Orthology - Evolution
OrthoDB8899
GeneTree (enSembl)ENSG00000112739
Phylogenetic Trees/Animal Genes : TreeFamPRPF4B
HOVERGENQ13523
HOGENOMQ13523
Homologs : HomoloGenePRPF4B
Homology/Alignments : Family Browser (UCSC)PRPF4B
Gene fusions - Rearrangements
Fusion : QuiverPRPF4B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRPF4B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRPF4B
dbVarPRPF4B
ClinVarPRPF4B
1000_GenomesPRPF4B 
Exome Variant ServerPRPF4B
ExAC (Exome Aggregation Consortium)ENSG00000112739
GNOMAD BrowserENSG00000112739
Varsome BrowserPRPF4B
Genetic variants : HAPMAP8899
Genomic Variants (DGV)PRPF4B [DGVbeta]
DECIPHERPRPF4B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRPF4B 
Mutations
ICGC Data PortalPRPF4B 
TCGA Data PortalPRPF4B 
Broad Tumor PortalPRPF4B
OASIS PortalPRPF4B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRPF4B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRPF4B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRPF4B
DgiDB (Drug Gene Interaction Database)PRPF4B
DoCM (Curated mutations)PRPF4B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRPF4B (select a term)
intoGenPRPF4B
Cancer3DPRPF4B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602338   
Orphanet
DisGeNETPRPF4B
MedgenPRPF4B
Genetic Testing Registry PRPF4B
NextProtQ13523 [Medical]
TSGene8899
GENETestsPRPF4B
Target ValidationPRPF4B
Huge Navigator PRPF4B [HugePedia]
snp3D : Map Gene to Disease8899
BioCentury BCIQPRPF4B
ClinGenPRPF4B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8899
Chemical/Pharm GKB GenePA38447
Clinical trialPRPF4B
Miscellaneous
canSAR (ICR)PRPF4B (select the gene name)
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRPF4B
EVEXPRPF4B
GoPubMedPRPF4B
iHOPPRPF4B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:32:35 CET 2018

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