Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PRPS1L1 (phosphoribosyl pyrophosphate synthetase 1-like 1)

Identity

Alias_namesPRPSL
Alias_symbol (synonym)PRPS3
Other aliasPRPS1
PRS-III
HGNC (Hugo) PRPS1L1
LocusID (NCBI) 221823
Atlas_Id 72255
Location 7p21.1  [Link to chromosome band 7p21]
Location_base_pair Starts at 18026776 and ends at 18027863 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRPS1L1   9463
Cards
Entrez_Gene (NCBI)PRPS1L1  221823  phosphoribosyl pyrophosphate synthetase 1-like 1
AliasesPRPS1; PRPS3; PRPSL; PRS-III
GeneCards (Weizmann)PRPS1L1
Ensembl hg19 (Hinxton)ENSG00000229937 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000229937 [Gene_View]  chr7:18026776-18027863 [Contig_View]  PRPS1L1 [Vega]
ICGC DataPortalENSG00000229937
TCGA cBioPortalPRPS1L1
AceView (NCBI)PRPS1L1
Genatlas (Paris)PRPS1L1
WikiGenes221823
SOURCE (Princeton)PRPS1L1
Genetics Home Reference (NIH)PRPS1L1
Genomic and cartography
GoldenPath hg38 (UCSC)PRPS1L1  -     chr7:18026776-18027863 -  7p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRPS1L1  -     7p21.1   [Description]    (hg19-Feb_2009)
EnsemblPRPS1L1 - 7p21.1 [CytoView hg19]  PRPS1L1 - 7p21.1 [CytoView hg38]
Mapping of homologs : NCBIPRPS1L1 [Mapview hg19]  PRPS1L1 [Mapview hg38]
OMIM611566   
Gene and transcription
Genbank (Entrez)BC005309 BC062797 M57423
RefSeq transcript (Entrez)NM_175886
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRPS1L1
Cluster EST : UnigeneHs.169284 [ NCBI ]
CGAP (NCI)Hs.169284
Alternative Splicing GalleryENSG00000229937
Gene ExpressionPRPS1L1 [ NCBI-GEO ]   PRPS1L1 [ EBI - ARRAY_EXPRESS ]   PRPS1L1 [ SEEK ]   PRPS1L1 [ MEM ]
Gene Expression Viewer (FireBrowse)PRPS1L1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)221823
GTEX Portal (Tissue expression)PRPS1L1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP21108   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP21108  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP21108
Splice isoforms : SwissVarP21108
Catalytic activity : Enzyme2.7.6.1 [ Enzyme-Expasy ]   2.7.6.12.7.6.1 [ IntEnz-EBI ]   2.7.6.1 [ BRENDA ]   2.7.6.1 [ KEGG ]   
PhosPhoSitePlusP21108
Domaine pattern : Prosite (Expaxy)PRPP_SYNTHASE (PS00114)   
Domains : Interpro (EBI)PRib_PP_synth_CS    Pribosyltran_N    PRibTrfase_dom    PRTase-like    Rib-P_diPkinase   
Domain families : Pfam (Sanger)Pribosyl_synth (PF14572)    Pribosyltran_N (PF13793)   
Domain families : Pfam (NCBI)pfam14572    pfam13793   
Conserved Domain (NCBI)PRPS1L1
DMDM Disease mutations221823
Blocks (Seattle)PRPS1L1
SuperfamilyP21108
Human Protein AtlasENSG00000229937
Peptide AtlasP21108
HPRD17914
IPIIPI00218371   
Protein Interaction databases
DIP (DOE-UCLA)P21108
IntAct (EBI)P21108
FunCoupENSG00000229937
BioGRIDPRPS1L1
STRING (EMBL)PRPS1L1
ZODIACPRPS1L1
Ontologies - Pathways
QuickGOP21108
Ontology : AmiGOmagnesium ion binding  ribose phosphate diphosphokinase activity  ribose phosphate diphosphokinase activity  ATP binding  cellular_component  5-phosphoribose 1-diphosphate biosynthetic process  nucleoside metabolic process  ribonucleoside monophosphate biosynthetic process  nucleotide biosynthetic process  kinase activity  phosphorylation  protein homodimerization activity  
Ontology : EGO-EBImagnesium ion binding  ribose phosphate diphosphokinase activity  ribose phosphate diphosphokinase activity  ATP binding  cellular_component  5-phosphoribose 1-diphosphate biosynthetic process  nucleoside metabolic process  ribonucleoside monophosphate biosynthetic process  nucleotide biosynthetic process  kinase activity  phosphorylation  protein homodimerization activity  
Pathways : KEGGPentose phosphate pathway    Purine metabolism   
NDEx NetworkPRPS1L1
Atlas of Cancer Signalling NetworkPRPS1L1
Wikipedia pathwaysPRPS1L1
Orthology - Evolution
OrthoDB221823
GeneTree (enSembl)ENSG00000229937
Phylogenetic Trees/Animal Genes : TreeFamPRPS1L1
HOVERGENP21108
HOGENOMP21108
Homologs : HomoloGenePRPS1L1
Homology/Alignments : Family Browser (UCSC)PRPS1L1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRPS1L1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRPS1L1
dbVarPRPS1L1
ClinVarPRPS1L1
1000_GenomesPRPS1L1 
Exome Variant ServerPRPS1L1
ExAC (Exome Aggregation Consortium)PRPS1L1 (select the gene name)
Genetic variants : HAPMAP221823
Genomic Variants (DGV)PRPS1L1 [DGVbeta]
DECIPHERPRPS1L1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRPS1L1 
Mutations
ICGC Data PortalPRPS1L1 
TCGA Data PortalPRPS1L1 
Broad Tumor PortalPRPS1L1
OASIS PortalPRPS1L1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRPS1L1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRPS1L1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRPS1L1
DgiDB (Drug Gene Interaction Database)PRPS1L1
DoCM (Curated mutations)PRPS1L1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRPS1L1 (select a term)
intoGenPRPS1L1
Cancer3DPRPS1L1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611566   
Orphanet
MedgenPRPS1L1
Genetic Testing Registry PRPS1L1
NextProtP21108 [Medical]
TSGene221823
GENETestsPRPS1L1
Target ValidationPRPS1L1
Huge Navigator PRPS1L1 [HugePedia]
snp3D : Map Gene to Disease221823
BioCentury BCIQPRPS1L1
ClinGenPRPS1L1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD221823
Chemical/Pharm GKB GenePA33818
Clinical trialPRPS1L1
Miscellaneous
canSAR (ICR)PRPS1L1 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRPS1L1
EVEXPRPS1L1
GoPubMedPRPS1L1
iHOPPRPS1L1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:37:28 CEST 2017

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