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PRPS2 (phosphoribosyl pyrophosphate synthetase 2)

Identity

Other aliasPRSII
HGNC (Hugo) PRPS2
LocusID (NCBI) 5634
Atlas_Id 55367
Location Xp22.2  [Link to chromosome band Xp22]
Location_base_pair Starts at 12791355 and ends at 12824227 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PRPS2 (Xp22.2) / PRPS2 (Xp22.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRPS2   9465
Cards
Entrez_Gene (NCBI)PRPS2  5634  phosphoribosyl pyrophosphate synthetase 2
AliasesPRSII
GeneCards (Weizmann)PRPS2
Ensembl hg19 (Hinxton)ENSG00000101911 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101911 [Gene_View]  chrX:12791355-12824227 [Contig_View]  PRPS2 [Vega]
ICGC DataPortalENSG00000101911
TCGA cBioPortalPRPS2
AceView (NCBI)PRPS2
Genatlas (Paris)PRPS2
WikiGenes5634
SOURCE (Princeton)PRPS2
Genetics Home Reference (NIH)PRPS2
Genomic and cartography
GoldenPath hg38 (UCSC)PRPS2  -     chrX:12791355-12824227 +  Xp22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRPS2  -     Xp22.2   [Description]    (hg19-Feb_2009)
EnsemblPRPS2 - Xp22.2 [CytoView hg19]  PRPS2 - Xp22.2 [CytoView hg38]
Mapping of homologs : NCBIPRPS2 [Mapview hg19]  PRPS2 [Mapview hg38]
OMIM311860   
Gene and transcription
Genbank (Entrez)AK310332 AK313246 BC030019 BC040483 BC110875
RefSeq transcript (Entrez)NM_001039091 NM_002765
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRPS2
Cluster EST : UnigeneHs.654581 [ NCBI ]
CGAP (NCI)Hs.654581
Alternative Splicing GalleryENSG00000101911
Gene ExpressionPRPS2 [ NCBI-GEO ]   PRPS2 [ EBI - ARRAY_EXPRESS ]   PRPS2 [ SEEK ]   PRPS2 [ MEM ]
Gene Expression Viewer (FireBrowse)PRPS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5634
GTEX Portal (Tissue expression)PRPS2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11908   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP11908  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP11908
Splice isoforms : SwissVarP11908
Catalytic activity : Enzyme2.7.6.1 [ Enzyme-Expasy ]   2.7.6.12.7.6.1 [ IntEnz-EBI ]   2.7.6.1 [ BRENDA ]   2.7.6.1 [ KEGG ]   
PhosPhoSitePlusP11908
Domaine pattern : Prosite (Expaxy)PRPP_SYNTHASE (PS00114)   
Domains : Interpro (EBI)PRib_PP_synth_CS    Pribosyltran_N    PRibTrfase_dom    PRTase-like    Rib-P_diPkinase   
Domain families : Pfam (Sanger)Pribosyl_synth (PF14572)    Pribosyltran_N (PF13793)   
Domain families : Pfam (NCBI)pfam14572    pfam13793   
Conserved Domain (NCBI)PRPS2
DMDM Disease mutations5634
Blocks (Seattle)PRPS2
SuperfamilyP11908
Human Protein AtlasENSG00000101911
Peptide AtlasP11908
HPRD02414
IPIIPI00219617   IPI00718888   IPI00642461   IPI00947213   IPI00947377   IPI00947401   
Protein Interaction databases
DIP (DOE-UCLA)P11908
IntAct (EBI)P11908
FunCoupENSG00000101911
BioGRIDPRPS2
STRING (EMBL)PRPS2
ZODIACPRPS2
Ontologies - Pathways
QuickGOP11908
Ontology : AmiGOmagnesium ion binding&~bsp;.n"sp;ribose phosphate diphosphokinase complex  ribose phosphate diphosphokinase activity  protein binding  ATP binding  5-phosphoribose 1-diphosphate biosynthetic process  nucleobase-containing compound metabolic process  AMP biosynthetic process  nucleoside metabolic process  AMP binding  kinase activity  phosphorylation  GDP binding  carbohydrate binding  animal organ regeneration  identical protein binding  protein homodimerization activity  protein complex  ADP binding  extracellular exosome  
Ontology : EGO-EBImagnesium ion binding  ribose phosphate diphosphokinase complex  ribose phosphate diphosphokinase activity  protein binding  ATP binding  5-phosphoribose 1-diphosphate biosynthetic process  nucleobase-containing compound metabolic process  AMP biosynthetic process  nucleoside metabolic process  AMP binding  kinase activity  phosphorylation  GDP binding  carbohydrate binding  animal organ regeneration  identical protein binding  protein homodimerization activity  protein complex  ADP binding  extracellular exosome  
Pathways : KEGGPentose phosphate pathway    Purine metabolism   
NDEx NetworkPRPS2
Atlas of Cancer Signalling NetworkPRPS2
Wikipedia pathwaysPRPS2
Orthology - Evolution
OrthoDB5634
GeneTree (enSembl)ENSG00000101911
Phylogenetic Trees/Animal Genes : TreeFamPRPS2
HOVERGENP11908
HOGENOMP11908
Homologs : HomoloGenePRPS2
Homology/Alignments : Family Browser (UCSC)PRPS2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRPS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRPS2
dbVarPRPS2
ClinVarPRPS2
1000_GenomesPRPS2 
Exome Variant ServerPRPS2
ExAC (Exome Aggregation Consortium)PRPS2 (select the gene name)
Genetic variants : HAPMAP5634
Genomic Variants (DGV)PRPS2 [DGVbeta]
DECIPHERPRPS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRPS2 
Mutations
ICGC Data PortalPRPS2 
TCGA Data PortalPRPS2 
Broad Tumor PortalPRPS2
OASIS PortalPRPS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRPS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRPS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch PRPS2
DgiDB (Drug Gene Interaction Database)PRPS2
DoCM (Curated mutations)PRPS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRPS2 (select a term)
intoGenPRPS2
Cancer3DPRPS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM311860   
Orphanet
MedgenPRPS2
Genetic Testing Registry PRPS2
NextProtP11908 [Medical]
TSGene5634
GENETestsPRPS2
Target ValidationPRPS2
Huge Navigator PRPS2 [HugePedia]
snp3D : Map Gene to Disease5634
BioCentury BCIQPRPS2
ClinGenPRPS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5634
Chemical/Pharm GKB GenePA33820
Clinical trialPRPS2
Miscellaneous
canSAR (ICR)PRPS2 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRPS2
EVEXPRPS2
GoPubMedPRPS2
iHOPPRPS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:26:42 CEST 2017

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