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PRR4 (proline rich 4 (lacrimal))

Identity

Alias_namesPROL4
Alias_symbol (synonym)LPRP
Other alias
HGNC (Hugo) PRR4
LocusID (NCBI) 11272
Atlas_Id 72287
Location 12p13.2  [Link to chromosome band 12p13]
Location_base_pair Starts at 10845849 and ends at 10849476 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DIP2A (21q22.3) / PRR4 (12p13.2)EXOSC7 (3p21.31) / PRR4 (12p13.2)FBXW7 (4q31.3) / PRR4 (12p13.2)
FRYL (4p11) / PRR4 (12p13.2)PRR4 (12p13.2) / FRYL (4p11)PRR4 (12p13.2) / GIGYF2 (2q37.1)
PRR4 (12p13.2) / LTF (3p21.31)PRR4 (12p13.2) / MYH11 (16p13.11)PRR4 (12p13.2) / NR2C2 (3p25.1)
PRR4 (12p13.2) / RNPEP (1q32.1)PRR4 (12p13.2) / ULK1 (12q24.33)TSPAN9 (12p13.33) / PRR4 (12p13.2)
TSPAN9 PRR4DIP2A PRR4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRR4   18020
Cards
Entrez_Gene (NCBI)PRR4  11272  proline rich 4 (lacrimal)
AliasesLPRP; PROL4
GeneCards (Weizmann)PRR4
Ensembl hg19 (Hinxton)ENSG00000111215 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111215 [Gene_View]  chr12:10845849-10849476 [Contig_View]  PRR4 [Vega]
ICGC DataPortalENSG00000111215
TCGA cBioPortalPRR4
AceView (NCBI)PRR4
Genatlas (Paris)PRR4
WikiGenes11272
SOURCE (Princeton)PRR4
Genetics Home Reference (NIH)PRR4
Genomic and cartography
GoldenPath hg38 (UCSC)PRR4  -     chr12:10845849-10849476 -  12p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRR4  -     12p13.2   [Description]    (hg19-Feb_2009)
EnsemblPRR4 - 12p13.2 [CytoView hg19]  PRR4 - 12p13.2 [CytoView hg38]
Mapping of homologs : NCBIPRR4 [Mapview hg19]  PRR4 [Mapview hg38]
OMIM605359   
Gene and transcription
Genbank (Entrez)AF530472 AK292934 AK292991 AK304321 AK311715
RefSeq transcript (Entrez)NM_001098538 NM_007244
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_187658 NW_003571050
Consensus coding sequences : CCDS (NCBI)PRR4
Cluster EST : UnigeneHs.732031 [ NCBI ]
CGAP (NCI)Hs.732031
Alternative Splicing GalleryENSG00000111215
Gene ExpressionPRR4 [ NCBI-GEO ]   PRR4 [ EBI - ARRAY_EXPRESS ]   PRR4 [ SEEK ]   PRR4 [ MEM ]
Gene Expression Viewer (FireBrowse)PRR4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11272
GTEX Portal (Tissue expression)PRR4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16378   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16378  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16378
Splice isoforms : SwissVarQ16378
PhosPhoSitePlusQ16378
Domains : Interpro (EBI)Pro-rich   
Domain families : Pfam (Sanger)Pro-rich (PF15240)   
Domain families : Pfam (NCBI)pfam15240   
Domain families : Smart (EMBL)Pro-rich (SM01412)  
Conserved Domain (NCBI)PRR4
DMDM Disease mutations11272
Blocks (Seattle)PRR4
SuperfamilyQ16378
Human Protein AtlasENSG00000111215
Peptide AtlasQ16378
HPRD09248
IPIIPI00027019   IPI00856018   IPI01009909   IPI01014441   
Protein Interaction databases
DIP (DOE-UCLA)Q16378
IntAct (EBI)Q16378
FunCoupENSG00000111215
BioGRIDPRR4
STRING (EMBL)PRR4
ZODIACPRR4
Ontologies - Pathways
QuickGOQ16378
Ontology : AmiGOretina homeostasis  extracellular space  visual perception  
Ontology : EGO-EBIretina homeostasis  extracellular space  visual perception  
NDEx NetworkPRR4
Atlas of Cancer Signalling NetworkPRR4
Wikipedia pathwaysPRR4
Orthology - Evolution
OrthoDB11272
GeneTree (enSembl)ENSG00000111215
Phylogenetic Trees/Animal Genes : TreeFamPRR4
HOVERGENQ16378
HOGENOMQ16378
Homologs : HomoloGenePRR4
Homology/Alignments : Family Browser (UCSC)PRR4
Gene fusions - Rearrangements
Fusion: TCGATSPAN9 PRR4
Fusion: TCGADIP2A PRR4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRR4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRR4
dbVarPRR4
ClinVarPRR4
1000_GenomesPRR4 
Exome Variant ServerPRR4
ExAC (Exome Aggregation Consortium)PRR4 (select the gene name)
Genetic variants : HAPMAP11272
Genomic Variants (DGV)PRR4 [DGVbeta]
DECIPHERPRR4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRR4 
Mutations
ICGC Data PortalPRR4 
TCGA Data PortalPRR4 
Broad Tumor PortalPRR4
OASIS PortalPRR4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRR4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRR4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRR4
DgiDB (Drug Gene Interaction Database)PRR4
DoCM (Curated mutations)PRR4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRR4 (select a term)
intoGenPRR4
Cancer3DPRR4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605359   
Orphanet
MedgenPRR4
Genetic Testing Registry PRR4
NextProtQ16378 [Medical]
TSGene11272
GENETestsPRR4
Target ValidationPRR4
Huge Navigator PRR4 [HugePedia]
snp3D : Map Gene to Disease11272
BioCentury BCIQPRR4
ClinGenPRR4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11272
Chemical/Pharm GKB GenePA33806
Clinical trialPRR4
Miscellaneous
canSAR (ICR)PRR4 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRR4
EVEXPRR4
GoPubMedPRR4
iHOPPRR4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:37:35 CEST 2017

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