Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PRR5L (proline rich 5 like)

Identity

Alias (NCBI)PROTOR2
HGNC (Hugo) PRR5L
HGNC Alias symbFLJ14213
PROTOR-2
HGNC Alias nameprotein observed with Rictor-2
LocusID (NCBI) 79899
Atlas_Id 72289
Location 11p13  [Link to chromosome band 11p13]
Location_base_pair Starts at 36375985 and ends at 36465204 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LDLRAD3 (11p13) / PRR5L (11p13)PRR5L (11p13) / TRIM44 (11p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PRR5L   25878
Cards
Entrez_Gene (NCBI)PRR5L    proline rich 5 like
AliasesPROTOR2
GeneCards (Weizmann)PRR5L
Ensembl hg19 (Hinxton)ENSG00000135362 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135362 [Gene_View]  ENSG00000135362 [Sequence]  chr11:36375985-36465204 [Contig_View]  PRR5L [Vega]
ICGC DataPortalENSG00000135362
TCGA cBioPortalPRR5L
AceView (NCBI)PRR5L
Genatlas (Paris)PRR5L
SOURCE (Princeton)PRR5L
Genetics Home Reference (NIH)PRR5L
Genomic and cartography
GoldenPath hg38 (UCSC)PRR5L  -     chr11:36375985-36465204 +  11p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRR5L  -     11p13   [Description]    (hg19-Feb_2009)
GoldenPathPRR5L - 11p13 [CytoView hg19]  PRR5L - 11p13 [CytoView hg38]
ImmunoBaseENSG00000135362
genome Data Viewer NCBIPRR5L [Mapview hg19]  
OMIM611728   
Gene and transcription
Genbank (Entrez)AK024275 AK026283 AK055042 BC008922 BC125122
RefSeq transcript (Entrez)NM_001160167 NM_001160168 NM_001160169 NM_024841
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRR5L
Alternative Splicing GalleryENSG00000135362
Gene ExpressionPRR5L [ NCBI-GEO ]   PRR5L [ EBI - ARRAY_EXPRESS ]   PRR5L [ SEEK ]   PRR5L [ MEM ]
Gene Expression Viewer (FireBrowse)PRR5L [ Firebrowse - Broad ]
GenevisibleExpression of PRR5L in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79899
GTEX Portal (Tissue expression)PRR5L
Human Protein AtlasENSG00000135362-PRR5L [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6MZQ0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6MZQ0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6MZQ0
Splice isoforms : SwissVarQ6MZQ0
PhosPhoSitePlusQ6MZQ0
Domains : Interpro (EBI)Bit61/PRR5   
Domain families : Pfam (Sanger)HbrB (PF08539)   
Domain families : Pfam (NCBI)pfam08539   
Conserved Domain (NCBI)PRR5L
Blocks (Seattle)PRR5L
SuperfamilyQ6MZQ0
Human Protein Atlas [tissue]ENSG00000135362-PRR5L [tissue]
Peptide AtlasQ6MZQ0
HPRD07854
IPIIPI00784461   IPI00411757   IPI00646619   IPI00978928   IPI00981256   IPI00984339   IPI00976892   IPI00983343   IPI00982322   IPI00983937   IPI00984947   IPI00979231   IPI00930157   
Protein Interaction databases
DIP (DOE-UCLA)Q6MZQ0
IntAct (EBI)Q6MZQ0
BioGRIDPRR5L
STRING (EMBL)PRR5L
ZODIACPRR5L
Ontologies - Pathways
QuickGOQ6MZQ0
Ontology : AmiGOnegative regulation of protein phosphorylation  positive regulation of protein phosphorylation  protein binding  negative regulation of signal transduction  regulation of fibroblast migration  positive regulation of phosphatidylinositol 3-kinase signaling  ubiquitin protein ligase binding  TORC2 complex  TORC2 complex  cellular response to oxidative stress  TORC2 signaling  TORC2 signaling  positive regulation of mRNA catabolic process  positive regulation of intracellular protein transport  
Ontology : EGO-EBInegative regulation of protein phosphorylation  positive regulation of protein phosphorylation  protein binding  negative regulation of signal transduction  regulation of fibroblast migration  positive regulation of phosphatidylinositol 3-kinase signaling  ubiquitin protein ligase binding  TORC2 complex  TORC2 complex  cellular response to oxidative stress  TORC2 signaling  TORC2 signaling  positive regulation of mRNA catabolic process  positive regulation of intracellular protein transport  
NDEx NetworkPRR5L
Atlas of Cancer Signalling NetworkPRR5L
Wikipedia pathwaysPRR5L
Orthology - Evolution
OrthoDB79899
GeneTree (enSembl)ENSG00000135362
Phylogenetic Trees/Animal Genes : TreeFamPRR5L
HOGENOMQ6MZQ0
Homologs : HomoloGenePRR5L
Homology/Alignments : Family Browser (UCSC)PRR5L
Gene fusions - Rearrangements
Fusion : QuiverPRR5L
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRR5L [hg38]
dbVarPRR5L
ClinVarPRR5L
MonarchPRR5L
1000_GenomesPRR5L 
Exome Variant ServerPRR5L
GNOMAD BrowserENSG00000135362
Varsome BrowserPRR5L
Genomic Variants (DGV)PRR5L [DGVbeta]
DECIPHERPRR5L [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRR5L 
Mutations
ICGC Data PortalPRR5L 
TCGA Data PortalPRR5L 
Broad Tumor PortalPRR5L
OASIS PortalPRR5L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRR5L  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPRR5L
Mutations and Diseases : HGMDPRR5L
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRR5L
DgiDB (Drug Gene Interaction Database)PRR5L
DoCM (Curated mutations)PRR5L (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRR5L (select a term)
intoGenPRR5L
Cancer3DPRR5L(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611728   
Orphanet
DisGeNETPRR5L
MedgenPRR5L
Genetic Testing Registry PRR5L
NextProtQ6MZQ0 [Medical]
GENETestsPRR5L
Target ValidationPRR5L
Huge Navigator PRR5L [HugePedia]
ClinGenPRR5L
Clinical trials, drugs, therapy
MyCancerGenomePRR5L
Protein Interactions : CTD
Pharm GKB GenePA165543593
Clinical trialPRR5L
Miscellaneous
canSAR (ICR)PRR5L (select the gene name)
HarmonizomePRR5L
DataMed IndexPRR5L
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRR5L
EVEXPRR5L
GoPubMedPRR5L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Dec 5 17:23:40 CET 2020
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