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PRRC1 (proline rich coiled-coil 1)

Identity

Alias (NCBI)-
HGNC (Hugo) PRRC1
HGNC Alias symbFLJ32875
HGNC Previous nameproline-rich coiled-coil 1
LocusID (NCBI) 133619
Atlas_Id 54557
Location 5q23.2  [Link to chromosome band 5q23]
Location_base_pair Starts at 127517640 and ends at 127555085 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CUL3 (2q36.2) / PRRC1 (5q23.2)KMT2A (11q23.3) / PRRC1 (5q23.2)PRRC1 (5q23.2) / PRRC1 (5q23.2)
RUNX1 (21q22.12) / PRRC1 (5q23.2)KMT2A 11q23.3 / PRRC1 5q23.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(5;11)(q23;q23) KMT2A/PRRC1
t(5;21)(q23;q22) RUNX1/PRRC1


External links

 

Nomenclature
HGNC (Hugo)PRRC1   28164
Cards
Entrez_Gene (NCBI)PRRC1    proline rich coiled-coil 1
Aliases
GeneCards (Weizmann)PRRC1
Ensembl hg19 (Hinxton)ENSG00000164244 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164244 [Gene_View]  ENSG00000164244 [Sequence]  chr5:127517640-127555085 [Contig_View]  PRRC1 [Vega]
ICGC DataPortalENSG00000164244
TCGA cBioPortalPRRC1
AceView (NCBI)PRRC1
Genatlas (Paris)PRRC1
SOURCE (Princeton)PRRC1
Genetics Home Reference (NIH)PRRC1
Genomic and cartography
GoldenPath hg38 (UCSC)PRRC1  -     chr5:127517640-127555085 +  5q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRRC1  -     5q23.2   [Description]    (hg19-Feb_2009)
GoldenPathPRRC1 - 5q23.2 [CytoView hg19]  PRRC1 - 5q23.2 [CytoView hg38]
ImmunoBaseENSG00000164244
Genome Data Viewer NCBIPRRC1 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AJ427339 AJ441110 AJ496322 AJ515158 AJ515428
RefSeq transcript (Entrez)NM_001286808 NM_130809
Consensus coding sequences : CCDS (NCBI)PRRC1
Gene ExpressionPRRC1 [ NCBI-GEO ]   PRRC1 [ EBI - ARRAY_EXPRESS ]   PRRC1 [ SEEK ]   PRRC1 [ MEM ]
Gene Expression Viewer (FireBrowse)PRRC1 [ Firebrowse - Broad ]
GenevisibleExpression of PRRC1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)133619
GTEX Portal (Tissue expression)PRRC1
Human Protein AtlasENSG00000164244-PRRC1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96M27   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96M27  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96M27
PhosPhoSitePlusQ96M27
Domains : Interpro (EBI)ITPase-like_fam    NTPase/PRRC1    PRRC1   
Domain families : Pfam (Sanger)NTPase_I-T (PF01931)   
Domain families : Pfam (NCBI)pfam01931   
Conserved Domain (NCBI)PRRC1
SuperfamilyQ96M27
AlphaFold pdb e-kbQ96M27   
Human Protein Atlas [tissue]ENSG00000164244-PRRC1 [tissue]
HPRD14052
Protein Interaction databases
DIP (DOE-UCLA)Q96M27
IntAct (EBI)Q96M27
BioGRIDPRRC1
STRING (EMBL)PRRC1
ZODIACPRRC1
Ontologies - Pathways
QuickGOQ96M27
Ontology : AmiGOprotein binding  cytoplasm  Golgi apparatus  activation of protein kinase A activity  protein kinase A regulatory subunit binding  
Ontology : EGO-EBIprotein binding  cytoplasm  Golgi apparatus  activation of protein kinase A activity  protein kinase A regulatory subunit binding  
NDEx NetworkPRRC1
Atlas of Cancer Signalling NetworkPRRC1
Wikipedia pathwaysPRRC1
Orthology - Evolution
OrthoDB133619
GeneTree (enSembl)ENSG00000164244
Phylogenetic Trees/Animal Genes : TreeFamPRRC1
Homologs : HomoloGenePRRC1
Homology/Alignments : Family Browser (UCSC)PRRC1
Gene fusions - Rearrangements
Fusion : MitelmanRUNX1/PRRC1 [21q22.12/5q23.2]  
Fusion : QuiverPRRC1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRRC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRRC1
dbVarPRRC1
ClinVarPRRC1
MonarchPRRC1
1000_GenomesPRRC1 
Exome Variant ServerPRRC1
GNOMAD BrowserENSG00000164244
Varsome BrowserPRRC1
ACMGPRRC1 variants
VarityQ96M27
Genomic Variants (DGV)PRRC1 [DGVbeta]
DECIPHERPRRC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRRC1 
Mutations
ICGC Data PortalPRRC1 
TCGA Data PortalPRRC1 
Broad Tumor PortalPRRC1
OASIS PortalPRRC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRRC1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPRRC1
Mutations and Diseases : HGMDPRRC1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPRRC1
DgiDB (Drug Gene Interaction Database)PRRC1
DoCM (Curated mutations)PRRC1
CIViC (Clinical Interpretations of Variants in Cancer)PRRC1
Cancer3DPRRC1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETPRRC1
MedgenPRRC1
Genetic Testing Registry PRRC1
NextProtQ96M27 [Medical]
GENETestsPRRC1
Target ValidationPRRC1
Huge Navigator PRRC1 [HugePedia]
ClinGenPRRC1
Clinical trials, drugs, therapy
MyCancerGenomePRRC1
Protein Interactions : CTDPRRC1
Pharm GKB GenePA162400175
PharosQ96M27
Clinical trialPRRC1
Miscellaneous
canSAR (ICR)PRRC1
HarmonizomePRRC1
DataMed IndexPRRC1
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPRRC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:27:03 CEST 2021

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