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PRRC2A (proline rich coiled-coil 2A)

Identity

Alias_namesBAT2
HLA-B associated transcript 2
proline-rich coiled-coil 2A
Alias_symbol (synonym)G2
D6S51E
Other aliasD6S51
HGNC (Hugo) PRRC2A
LocusID (NCBI) 7916
Atlas_Id 53192
Location 6p21.33  [Link to chromosome band 6p21]
Location_base_pair Starts at 31620673 and ends at 31637777 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AMFR (16q12.2) / PRRC2A (6p21.33)NRBP1 (2p23.3) / PRRC2A (6p21.33)PRRC2A (6p21.33) / AIF1 (6p21.33)
PRRC2A (6p21.33) / AMFR (16q12.2)PRRC2A (6p21.33) / NCR3 (6p21.33)PRRC2A (6p21.33) / RASA4 (7q22.1)
PRRC2A (6p21.33) / SFN (1p36.11)PRRC2A (6p21.33) / SHISA5 (3p21.31)PRRC2A (6p21.33) / USP44 (12q22)
ZACN (17q25.1) / PRRC2A (6p21.33)PRRC2A 6p21.33 / AIF1 6p21.33PRRC2A 6p21.33 / NCR3 6p21.33
PRRC2A 6p21.33 / SFN 1p36.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(1;6)(p36;p21) PRRC2A/SFN
t(6;6)(p21;p21) PRRC2A/AIF1
t(6;6)(p21;p21) PRRC2A/NCR3


External links

Nomenclature
HGNC (Hugo)PRRC2A   13918
Cards
Entrez_Gene (NCBI)PRRC2A  7916  proline rich coiled-coil 2A
AliasesBAT2; D6S51; D6S51E; G2
GeneCards (Weizmann)PRRC2A
Ensembl hg19 (Hinxton)ENSG00000204469 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204469 [Gene_View]  ENSG00000204469 [Sequence]  chr6:31620673-31637777 [Contig_View]  PRRC2A [Vega]
ICGC DataPortalENSG00000204469
TCGA cBioPortalPRRC2A
AceView (NCBI)PRRC2A
Genatlas (Paris)PRRC2A
WikiGenes7916
SOURCE (Princeton)PRRC2A
Genetics Home Reference (NIH)PRRC2A
Genomic and cartography
GoldenPath hg38 (UCSC)PRRC2A  -     chr6:31620673-31637777 +  6p21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRRC2A  -     6p21.33   [Description]    (hg19-Feb_2009)
EnsemblPRRC2A - 6p21.33 [CytoView hg19]  PRRC2A - 6p21.33 [CytoView hg38]
Mapping of homologs : NCBIPRRC2A [Mapview hg19]  PRRC2A [Mapview hg38]
OMIM142580   
Gene and transcription
Genbank (Entrez)AA909001 AA969275 AB210034 AF075059 AI383939
RefSeq transcript (Entrez)NM_004638 NM_080686
RefSeq genomic (Entrez)NC_000006 NC_018917 NT_113891 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249
Consensus coding sequences : CCDS (NCBI)PRRC2A
Cluster EST : UnigeneHs.436093 [ NCBI ]
CGAP (NCI)Hs.436093
Alternative Splicing GalleryENSG00000204469
Gene ExpressionPRRC2A [ NCBI-GEO ]   PRRC2A [ EBI - ARRAY_EXPRESS ]   PRRC2A [ SEEK ]   PRRC2A [ MEM ]
Gene Expression Viewer (FireBrowse)PRRC2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7916
GTEX Portal (Tissue expression)PRRC2A
Human Protein AtlasENSG00000204469-PRRC2A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48634   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48634  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48634
Splice isoforms : SwissVarP48634
PhosPhoSitePlusP48634
Domains : Interpro (EBI)BAT2_N    PRRC2   
Domain families : Pfam (Sanger)BAT2_N (PF07001)   
Domain families : Pfam (NCBI)pfam07001   
Conserved Domain (NCBI)PRRC2A
DMDM Disease mutations7916
Blocks (Seattle)PRRC2A
SuperfamilyP48634
Human Protein Atlas [tissue]ENSG00000204469-PRRC2A [tissue]
Peptide AtlasP48634
HPRD00807
IPIIPI00010700   IPI00084746   IPI00642817   IPI00885161   IPI01022761   IPI00941514   IPI01023032   IPI01021424   IPI01021070   IPI01022086   IPI01018665   IPI01021248   IPI01021294   IPI01022288   IPI01021167   IPI01020756   IPI00941298   IPI01021410   IPI01021184   IPI01022146   
Protein Interaction databases
DIP (DOE-UCLA)P48634
IntAct (EBI)P48634
FunCoupENSG00000204469
BioGRIDPRRC2A
STRING (EMBL)PRRC2A
ZODIACPRRC2A
Ontologies - Pathways
QuickGOP48634
Ontology : AmiGORNA binding  protein binding  nucleoplasm  cytosol  plasma membrane  membrane  cell differentiation  extracellular exosome  
Ontology : EGO-EBIRNA binding  protein binding  nucleoplasm  cytosol  plasma membrane  membrane  cell differentiation  extracellular exosome  
NDEx NetworkPRRC2A
Atlas of Cancer Signalling NetworkPRRC2A
Wikipedia pathwaysPRRC2A
Orthology - Evolution
OrthoDB7916
GeneTree (enSembl)ENSG00000204469
Phylogenetic Trees/Animal Genes : TreeFamPRRC2A
HOVERGENP48634
HOGENOMP48634
Homologs : HomoloGenePRRC2A
Homology/Alignments : Family Browser (UCSC)PRRC2A
Gene fusions - Rearrangements
Fusion : MitelmanPRRC2A/AIF1 [6p21.33/6p21.33]  
Fusion : MitelmanPRRC2A/NCR3 [6p21.33/6p21.33]  [t(6;6)(p21;p21)]  
Fusion : MitelmanPRRC2A/SFN [6p21.33/1p36.11]  [t(1;6)(p36;p21)]  
Fusion PortalPRRC2A 6p21.33 AIF1 6p21.33 BRCA
Fusion PortalPRRC2A 6p21.33 NCR3 6p21.33 BRCA
Fusion PortalPRRC2A 6p21.33 SFN 1p36.11 HNSC
Fusion Cancer (Beijing)NRBP1 [2p23.3]  -  PRRC2A [6p21.33]  [FUSC002232]  [FUSC002232]
Fusion : QuiverPRRC2A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRRC2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRRC2A
dbVarPRRC2A
ClinVarPRRC2A
1000_GenomesPRRC2A 
Exome Variant ServerPRRC2A
ExAC (Exome Aggregation Consortium)ENSG00000204469
GNOMAD BrowserENSG00000204469
Genetic variants : HAPMAP7916
Genomic Variants (DGV)PRRC2A [DGVbeta]
DECIPHERPRRC2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRRC2A 
Mutations
ICGC Data PortalPRRC2A 
TCGA Data PortalPRRC2A 
Broad Tumor PortalPRRC2A
OASIS PortalPRRC2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRRC2A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRRC2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRRC2A
DgiDB (Drug Gene Interaction Database)PRRC2A
DoCM (Curated mutations)PRRC2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRRC2A (select a term)
intoGenPRRC2A
Cancer3DPRRC2A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142580   
Orphanet
DisGeNETPRRC2A
MedgenPRRC2A
Genetic Testing Registry PRRC2A
NextProtP48634 [Medical]
TSGene7916
GENETestsPRRC2A
Target ValidationPRRC2A
Huge Navigator PRRC2A [HugePedia]
snp3D : Map Gene to Disease7916
BioCentury BCIQPRRC2A
ClinGenPRRC2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7916
Chemical/Pharm GKB GenePA25263
Clinical trialPRRC2A
Miscellaneous
canSAR (ICR)PRRC2A (select the gene name)
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRRC2A
EVEXPRRC2A
GoPubMedPRRC2A
iHOPPRRC2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:45:00 CEST 2018

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