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PRRG2 (proline rich and Gla domain 2)

Identity

Alias_namesproline-rich Gla (G-carboxyglutamic acid) polypeptide 2
Alias_symbol (synonym)PRGP2
Other alias
HGNC (Hugo) PRRG2
LocusID (NCBI) 5639
Atlas_Id 54559
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 49581330 and ends at 49591008 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PRR12 (19q13.33) / PRRG2 (19q13.33)PRRG2 (19q13.33) / CCDC155 (19q13.33)PRRG2 (19q13.33) / FCGRT (19q13.33)
ZNF671 (19q13.43) / PRRG2 (19q13.33)PRR12 19q13.33 / PRRG2 19q13.33PRRG2 19q13.33 / CCDC155 19q13.33
PRRG2 19q13.33 / FCGRT 19q13.33ZNF671 19q13.43 / PRRG2 19q13.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRRG2   9470
Cards
Entrez_Gene (NCBI)PRRG2  5639  proline rich and Gla domain 2
AliasesPRGP2
GeneCards (Weizmann)PRRG2
Ensembl hg19 (Hinxton)ENSG00000126460 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126460 [Gene_View]  chr19:49581330-49591008 [Contig_View]  PRRG2 [Vega]
ICGC DataPortalENSG00000126460
TCGA cBioPortalPRRG2
AceView (NCBI)PRRG2
Genatlas (Paris)PRRG2
WikiGenes5639
SOURCE (Princeton)PRRG2
Genetics Home Reference (NIH)PRRG2
Genomic and cartography
GoldenPath hg38 (UCSC)PRRG2  -     chr19:49581330-49591008 +  19q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRRG2  -     19q13.33   [Description]    (hg19-Feb_2009)
EnsemblPRRG2 - 19q13.33 [CytoView hg19]  PRRG2 - 19q13.33 [CytoView hg38]
Mapping of homologs : NCBIPRRG2 [Mapview hg19]  PRRG2 [Mapview hg38]
OMIM604429   
Gene and transcription
Genbank (Entrez)AF009243 BC026032 CB851486 CD013954 CD609900
RefSeq transcript (Entrez)NM_000951 NM_001316335
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRRG2
Cluster EST : UnigeneHs.35101 [ NCBI ]
CGAP (NCI)Hs.35101
Alternative Splicing GalleryENSG00000126460
Gene ExpressionPRRG2 [ NCBI-GEO ]   PRRG2 [ EBI - ARRAY_EXPRESS ]   PRRG2 [ SEEK ]   PRRG2 [ MEM ]
Gene Expression Viewer (FireBrowse)PRRG2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5639
GTEX Portal (Tissue expression)PRRG2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14669   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14669  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14669
Splice isoforms : SwissVarO14669
PhosPhoSitePlusO14669
Domaine pattern : Prosite (Expaxy)GLA_1 (PS00011)    GLA_2 (PS50998)   
Domains : Interpro (EBI)Coagulation_fac_subgr_Gla_dom    GLA_domain   
Domain families : Pfam (Sanger)Gla (PF00594)   
Domain families : Pfam (NCBI)pfam00594   
Domain families : Smart (EMBL)GLA (SM00069)  
Conserved Domain (NCBI)PRRG2
DMDM Disease mutations5639
Blocks (Seattle)PRRG2
SuperfamilyO14669
Human Protein AtlasENSG00000126460
Peptide AtlasO14669
HPRD09189
IPIIPI00000460   IPI01010063   
Protein Interaction databases
DIP (DOE-UCLA)O14669
IntAct (EBI)O14669
FunCoupENSG00000126460
BioGRIDPRRG2
STRING (EMBL)PRRG2
ZODIACPRRG2
Ontologies - Pathways
QuickGOO14669
Ontology : AmiGOserine-type endopeptidase activity  calcium ion binding  protein binding  extracellular space  integral component of plasma membrane  proteolysis  
Ontology : EGO-EBIserine-type endopeptidase activity  calcium ion binding  protein binding  extracellular space  integral component of plasma membrane  proteolysis  
NDEx NetworkPRRG2
Atlas of Cancer Signalling NetworkPRRG2
Wikipedia pathwaysPRRG2
Orthology - Evolution
OrthoDB5639
GeneTree (enSembl)ENSG00000126460
Phylogenetic Trees/Animal Genes : TreeFamPRRG2
HOVERGENO14669
HOGENOMO14669
Homologs : HomoloGenePRRG2
Homology/Alignments : Family Browser (UCSC)PRRG2
Gene fusions - Rearrangements
Fusion : MitelmanPRR12/PRRG2 [19q13.33/19q13.33]  [t(19;19)(q13;q13)]  
Fusion : MitelmanPRRG2/CCDC155 [19q13.33/19q13.33]  [t(19;19)(q13;q13)]  
Fusion : MitelmanPRRG2/FCGRT [19q13.33/19q13.33]  [t(19;19)(q13;q13)]  
Fusion : MitelmanZNF671/PRRG2 [19q13.43/19q13.33]  [t(19;19)(q13;q13)]  
Fusion: TCGAPRR12 19q13.33 PRRG2 19q13.33 BRCA
Fusion: TCGAPRRG2 19q13.33 CCDC155 19q13.33 BRCA
Fusion: TCGAPRRG2 19q13.33 FCGRT 19q13.33 BRCA
Fusion: TCGAZNF671 19q13.43 PRRG2 19q13.33 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRRG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRRG2
dbVarPRRG2
ClinVarPRRG2
1000_GenomesPRRG2 
Exome Variant ServerPRRG2
ExAC (Exome Aggregation Consortium)PRRG2 (select the gene name)
Genetic variants : HAPMAP5639
Genomic Variants (DGV)PRRG2 [DGVbeta]
DECIPHERPRRG2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRRG2 
Mutations
ICGC Data PortalPRRG2 
TCGA Data PortalPRRG2 
Broad Tumor PortalPRRG2
OASIS PortalPRRG2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRRG2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRRG2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRRG2
DgiDB (Drug Gene Interaction Database)PRRG2
DoCM (Curated mutations)PRRG2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRRG2 (select a term)
intoGenPRRG2
Cancer3DPRRG2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604429   
Orphanet
MedgenPRRG2
Genetic Testing Registry PRRG2
NextProtO14669 [Medical]
TSGene5639
GENETestsPRRG2
Target ValidationPRRG2
Huge Navigator PRRG2 [HugePedia]
snp3D : Map Gene to Disease5639
BioCentury BCIQPRRG2
ClinGenPRRG2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5639
Chemical/Pharm GKB GenePA33825
Clinical trialPRRG2
Miscellaneous
canSAR (ICR)PRRG2 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRRG2
EVEXPRRG2
GoPubMedPRRG2
iHOPPRRG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:11:48 CEST 2017

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