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PRRG4 (proline rich and Gla domain 4)

Identity

Alias_namesproline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
Alias_symbol (synonym)TMG4
Other aliasPRGP4
HGNC (Hugo) PRRG4
LocusID (NCBI) 79056
Atlas_Id 72295
Location 11p13  [Link to chromosome band 11p13]
Location_base_pair Starts at 32829935 and ends at 32858123 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PRRG4 (11p13) / RAPGEFL1 (17q21.1)QSER1 (11p13) / PRRG4 (11p13)TM7SF2 (11q13.1) / PRRG4 (11p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(11;11)(p13;q13) TM7SF2/PRRG4
t(11;17)(p13;q21) PRRG4/RAPGEFL1

External links

Nomenclature
HGNC (Hugo)PRRG4   30799
Cards
Entrez_Gene (NCBI)PRRG4  79056  proline rich and Gla domain 4
AliasesPRGP4; TMG4
GeneCards (Weizmann)PRRG4
Ensembl hg19 (Hinxton)ENSG00000135378 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135378 [Gene_View]  chr11:32829935-32858123 [Contig_View]  PRRG4 [Vega]
ICGC DataPortalENSG00000135378
TCGA cBioPortalPRRG4
AceView (NCBI)PRRG4
Genatlas (Paris)PRRG4
WikiGenes79056
SOURCE (Princeton)PRRG4
Genetics Home Reference (NIH)PRRG4
Genomic and cartography
GoldenPath hg38 (UCSC)PRRG4  -     chr11:32829935-32858123 +  11p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRRG4  -     11p13   [Description]    (hg19-Feb_2009)
EnsemblPRRG4 - 11p13 [CytoView hg19]  PRRG4 - 11p13 [CytoView hg38]
Mapping of homologs : NCBIPRRG4 [Mapview hg19]  PRRG4 [Mapview hg38]
OMIM611690   
Gene and transcription
Genbank (Entrez)AF326351 BC010052 BC063393 DQ892884 DQ896133
RefSeq transcript (Entrez)NM_024081
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRRG4
Cluster EST : UnigeneHs.471695 [ NCBI ]
CGAP (NCI)Hs.471695
Alternative Splicing GalleryENSG00000135378
Gene ExpressionPRRG4 [ NCBI-GEO ]   PRRG4 [ EBI - ARRAY_EXPRESS ]   PRRG4 [ SEEK ]   PRRG4 [ MEM ]
Gene Expression Viewer (FireBrowse)PRRG4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79056
GTEX Portal (Tissue expression)PRRG4
Human Protein AtlasENSG00000135378-PRRG4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BZD6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BZD6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BZD6
Splice isoforms : SwissVarQ9BZD6
PhosPhoSitePlusQ9BZD6
Domaine pattern : Prosite (Expaxy)GLA_1 (PS00011)    GLA_2 (PS50998)   
Domains : Interpro (EBI)Coagulation_fac_subgr_Gla_dom    GLA_domain   
Domain families : Pfam (Sanger)Gla (PF00594)   
Domain families : Pfam (NCBI)pfam00594   
Domain families : Smart (EMBL)GLA (SM00069)  
Conserved Domain (NCBI)PRRG4
DMDM Disease mutations79056
Blocks (Seattle)PRRG4
SuperfamilyQ9BZD6
Human Protein Atlas [tissue]ENSG00000135378-PRRG4 [tissue]
Peptide AtlasQ9BZD6
HPRD15187
IPIIPI00031663   
Protein Interaction databases
DIP (DOE-UCLA)Q9BZD6
IntAct (EBI)Q9BZD6
FunCoupENSG00000135378
BioGRIDPRRG4
STRING (EMBL)PRRG4
ZODIACPRRG4
Ontologies - Pathways
QuickGOQ9BZD6
Ontology : AmiGOmolecular_function  calcium ion binding  extracellular region  biological_process  integral component of membrane  
Ontology : EGO-EBImolecular_function  calcium ion binding  extracellular region  biological_process  integral component of membrane  
NDEx NetworkPRRG4
Atlas of Cancer Signalling NetworkPRRG4
Wikipedia pathwaysPRRG4
Orthology - Evolution
OrthoDB79056
GeneTree (enSembl)ENSG00000135378
Phylogenetic Trees/Animal Genes : TreeFamPRRG4
HOVERGENQ9BZD6
HOGENOMQ9BZD6
Homologs : HomoloGenePRRG4
Homology/Alignments : Family Browser (UCSC)PRRG4
Gene fusions - Rearrangements
Fusion : QuiverPRRG4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRRG4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRRG4
dbVarPRRG4
ClinVarPRRG4
1000_GenomesPRRG4 
Exome Variant ServerPRRG4
ExAC (Exome Aggregation Consortium)ENSG00000135378
GNOMAD BrowserENSG00000135378
Genetic variants : HAPMAP79056
Genomic Variants (DGV)PRRG4 [DGVbeta]
DECIPHERPRRG4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRRG4 
Mutations
ICGC Data PortalPRRG4 
TCGA Data PortalPRRG4 
Broad Tumor PortalPRRG4
OASIS PortalPRRG4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRRG4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRRG4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRRG4
DgiDB (Drug Gene Interaction Database)PRRG4
DoCM (Curated mutations)PRRG4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRRG4 (select a term)
intoGenPRRG4
Cancer3DPRRG4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611690   
Orphanet
DisGeNETPRRG4
MedgenPRRG4
Genetic Testing Registry PRRG4
NextProtQ9BZD6 [Medical]
TSGene79056
GENETestsPRRG4
Target ValidationPRRG4
Huge Navigator PRRG4 [HugePedia]
snp3D : Map Gene to Disease79056
BioCentury BCIQPRRG4
ClinGenPRRG4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79056
Chemical/Pharm GKB GenePA134974592
Clinical trialPRRG4
Miscellaneous
canSAR (ICR)PRRG4 (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRRG4
EVEXPRRG4
GoPubMedPRRG4
iHOPPRRG4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Feb 23 18:48:34 CET 2018
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