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PRSS12 (protease, serine, 12 (neurotrypsin, motopsin))

Identity

Alias_symbol (synonym)BSSP-3
MRT1
Other aliasBSSP3
HGNC (Hugo) PRSS12
LocusID (NCBI) 8492
Atlas_Id 72301
Location 4q26  [Link to chromosome band 4q26]
Location_base_pair Starts at 119201193 and ends at 119273922 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PRSS12 (4q26) / PRSS12 (4q26)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRSS12   9477
Cards
Entrez_Gene (NCBI)PRSS12  8492  protease, serine, 12 (neurotrypsin, motopsin)
AliasesBSSP-3; BSSP3; MRT1
GeneCards (Weizmann)PRSS12
Ensembl hg19 (Hinxton)ENSG00000164099 [Gene_View]  chr4:119201193-119273922 [Contig_View]  PRSS12 [Vega]
Ensembl hg38 (Hinxton)ENSG00000164099 [Gene_View]  chr4:119201193-119273922 [Contig_View]  PRSS12 [Vega]
ICGC DataPortalENSG00000164099
TCGA cBioPortalPRSS12
AceView (NCBI)PRSS12
Genatlas (Paris)PRSS12
WikiGenes8492
SOURCE (Princeton)PRSS12
Genetics Home Reference (NIH)PRSS12
Genomic and cartography
GoldenPath hg19 (UCSC)PRSS12  -     chr4:119201193-119273922 -  4q26   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PRSS12  -     4q26   [Description]    (hg38-Dec_2013)
EnsemblPRSS12 - 4q26 [CytoView hg19]  PRSS12 - 4q26 [CytoView hg38]
Mapping of homologs : NCBIPRSS12 [Mapview hg19]  PRSS12 [Mapview hg38]
OMIM249500   606709   
Gene and transcription
Genbank (Entrez)AF077298 AJ001531 BC007761 BG386264
RefSeq transcript (Entrez)NM_003619
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_023350 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)PRSS12
Cluster EST : UnigeneHs.445857 [ NCBI ]
CGAP (NCI)Hs.445857
Alternative Splicing GalleryENSG00000164099
Gene ExpressionPRSS12 [ NCBI-GEO ]   PRSS12 [ EBI - ARRAY_EXPRESS ]   PRSS12 [ SEEK ]   PRSS12 [ MEM ]
Gene Expression Viewer (FireBrowse)PRSS12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8492
GTEX Portal (Tissue expression)PRSS12
Protein : pattern, domain, 3D structure
UniProt/SwissProtP56730   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP56730  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP56730
Splice isoforms : SwissVarP56730
Catalytic activity : Enzyme3.4.21.- [ Enzyme-Expasy ]   3.4.21.-3.4.21.- [ IntEnz-EBI ]   3.4.21.- [ BRENDA ]   3.4.21.- [ KEGG ]   
PhosPhoSitePlusP56730
Domaine pattern : Prosite (Expaxy)KRINGLE_1 (PS00021)    KRINGLE_2 (PS50070)    SRCR_1 (PS00420)    SRCR_2 (PS50287)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Kringle    Kringle-like    Kringle_CS    Peptidase_S1    Peptidase_S1_AS    Peptidase_S1A    SRCR    SRCR-like_dom    Trypsin-like_Pept_dom   
Domain families : Pfam (Sanger)Kringle (PF00051)    SRCR (PF00530)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00051    pfam00530    pfam00089   
Domain families : Smart (EMBL)KR (SM00130)  SR (SM00202)  Tryp_SPc (SM00020)  
Conserved Domain (NCBI)PRSS12
DMDM Disease mutations8492
Blocks (Seattle)PRSS12
SuperfamilyP56730
Human Protein AtlasENSG00000164099
Peptide AtlasP56730
HPRD05989
IPIIPI00011063   
Protein Interaction databases
DIP (DOE-UCLA)P56730
IntAct (EBI)P56730
FunCoupENSG00000164099
BioGRIDPRSS12
STRING (EMBL)PRSS12
ZODIACPRSS12
Ontologies - Pathways
QuickGOP56730
Ontology : AmiGOserine-type endopeptidase activity  scavenger receptor activity  extracellular region  plasma membrane  exocytosis  receptor-mediated endocytosis  serine-type peptidase activity  axon  dendrite  cytoplasmic vesicle  zymogen activation  synaptic cleft  terminal bouton  
Ontology : EGO-EBIserine-type endopeptidase activity  scavenger receptor activity  extracellular region  plasma membrane  exocytosis  receptor-mediated endocytosis  serine-type peptidase activity  axon  dendrite  cytoplasmic vesicle  zymogen activation  synaptic cleft  terminal bouton  
NDEx NetworkPRSS12
Atlas of Cancer Signalling NetworkPRSS12
Wikipedia pathwaysPRSS12
Orthology - Evolution
OrthoDB8492
GeneTree (enSembl)ENSG00000164099
Phylogenetic Trees/Animal Genes : TreeFamPRSS12
HOVERGENP56730
HOGENOMP56730
Homologs : HomoloGenePRSS12
Homology/Alignments : Family Browser (UCSC)PRSS12
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRSS12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRSS12
dbVarPRSS12
ClinVarPRSS12
1000_GenomesPRSS12 
Exome Variant ServerPRSS12
ExAC (Exome Aggregation Consortium)PRSS12 (select the gene name)
Genetic variants : HAPMAP8492
Genomic Variants (DGV)PRSS12 [DGVbeta]
DECIPHER (Syndromes)4:119201193-119273922  ENSG00000164099
CONAN: Copy Number AnalysisPRSS12 
Mutations
ICGC Data PortalPRSS12 
TCGA Data PortalPRSS12 
Broad Tumor PortalPRSS12
OASIS PortalPRSS12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRSS12  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRSS12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRSS12
DgiDB (Drug Gene Interaction Database)PRSS12
DoCM (Curated mutations)PRSS12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRSS12 (select a term)
intoGenPRSS12
Cancer3DPRSS12(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM249500    606709   
Orphanet11804   
MedgenPRSS12
Genetic Testing Registry PRSS12
NextProtP56730 [Medical]
TSGene8492
GENETestsPRSS12
Huge Navigator PRSS12 [HugePedia]
snp3D : Map Gene to Disease8492
BioCentury BCIQPRSS12
ClinGenPRSS12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8492
Chemical/Pharm GKB GenePA33830
Clinical trialPRSS12
Miscellaneous
canSAR (ICR)PRSS12 (select the gene name)
Probes
Litterature
PubMed7 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRSS12
EVEXPRSS12
GoPubMedPRSS12
iHOPPRSS12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:39:57 CET 2017

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