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PRSS2 (protease, serine 2)

Identity

Alias_symbol (synonym)TRY2
Other aliasTRY8
TRYP2
HGNC (Hugo) PRSS2
LocusID (NCBI) 5645
Atlas_Id 46254
Location 7q34  [Link to chromosome band 7q34]
Location_base_pair Starts at 142479909 and ends at 142481884 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)PRSS2   9483
Cards
Entrez_Gene (NCBI)PRSS2  5645  protease, serine 2
AliasesTRY2; TRY8; TRYP2
GeneCards (Weizmann)PRSS2
Ensembl hg19 (Hinxton)ENSG00000275896 [Gene_View]  chr7:142479909-142481884 [Contig_View]  PRSS2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000275896 [Gene_View]  chr7:142479909-142481884 [Contig_View]  PRSS2 [Vega]
ICGC DataPortalENSG00000275896
TCGA cBioPortalPRSS2
AceView (NCBI)PRSS2
Genatlas (Paris)PRSS2
WikiGenes5645
SOURCE (Princeton)PRSS2
Genetics Home Reference (NIH)PRSS2
Genomic and cartography
GoldenPath hg19 (UCSC)PRSS2  -     chr7:142479909-142481884 +  7q34   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PRSS2  -     7q34   [Description]    (hg38-Dec_2013)
EnsemblPRSS2 - 7q34 [CytoView hg19]  PRSS2 - 7q34 [CytoView hg38]
Mapping of homologs : NCBIPRSS2 [Mapview hg19]  PRSS2 [Mapview hg38]
OMIM167800   601564   
Gene and transcription
Genbank (Entrez)BC005814 BC030260 BC103997 BC103998 BC107784
RefSeq transcript (Entrez)NM_001303414 NM_002770
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_001333 NG_008322 NT_007933 NT_187562 NW_004929333
Consensus coding sequences : CCDS (NCBI)PRSS2
Cluster EST : UnigeneHs.728780 [ NCBI ]
CGAP (NCI)Hs.728780
Alternative Splicing GalleryENSG00000275896
Gene ExpressionPRSS2 [ NCBI-GEO ]   PRSS2 [ EBI - ARRAY_EXPRESS ]   PRSS2 [ SEEK ]   PRSS2 [ MEM ]
Gene Expression Viewer (FireBrowse)PRSS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5645
GTEX Portal (Tissue expression)PRSS2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07478   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07478  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07478
Splice isoforms : SwissVarP07478
Catalytic activity : Enzyme3.4.21.4 [ Enzyme-Expasy ]   3.4.21.43.4.21.4 [ IntEnz-EBI ]   3.4.21.4 [ BRENDA ]   3.4.21.4 [ KEGG ]   
PhosPhoSitePlusP07478
Domaine pattern : Prosite (Expaxy)TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
Conserved Domain (NCBI)PRSS2
DMDM Disease mutations5645
Blocks (Seattle)PRSS2
SuperfamilyP07478
Human Protein AtlasENSG00000275896
Peptide AtlasP07478
HPRD03335
Protein Interaction databases
DIP (DOE-UCLA)P07478
IntAct (EBI)P07478
FunCoupENSG00000275896
BioGRIDPRSS2
STRING (EMBL)PRSS2
ZODIACPRSS2
Ontologies - Pathways
QuickGOP07478
Ontology : AmiGOserine-type endopeptidase activity  serine-type endopeptidase activity  calcium ion binding  protein binding  extracellular region  extracellular region  extracellular space  proteolysis  digestion  serine-type peptidase activity  extracellular matrix disassembly  positive regulation of cell growth  collagen catabolic process  collagen catabolic process  collagen catabolic process  extracellular matrix  positive regulation of cell adhesion  
Ontology : EGO-EBIserine-type endopeptidase activity  serine-type endopeptidase activity  calcium ion binding  protein binding  extracellular region  extracellular region  extracellular space  proteolysis  digestion  serine-type peptidase activity  extracellular matrix disassembly  positive regulation of cell growth  collagen catabolic process  collagen catabolic process  collagen catabolic process  extracellular matrix  positive regulation of cell adhesion  
Pathways : KEGGNeuroactive ligand-receptor interaction    Pancreatic secretion    Protein digestion and absorption    Influenza A   
NDEx NetworkPRSS2
Atlas of Cancer Signalling NetworkPRSS2
Wikipedia pathwaysPRSS2
Orthology - Evolution
OrthoDB5645
GeneTree (enSembl)ENSG00000275896
Phylogenetic Trees/Animal Genes : TreeFamPRSS2
HOVERGENP07478
HOGENOMP07478
Homologs : HomoloGenePRSS2
Homology/Alignments : Family Browser (UCSC)PRSS2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRSS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRSS2
dbVarPRSS2
ClinVarPRSS2
1000_GenomesPRSS2 
Exome Variant ServerPRSS2
ExAC (Exome Aggregation Consortium)PRSS2 (select the gene name)
Genetic variants : HAPMAP5645
Genomic Variants (DGV)PRSS2 [DGVbeta]
DECIPHER (Syndromes)7:142479909-142481884  ENSG00000275896
CONAN: Copy Number AnalysisPRSS2 
Mutations
ICGC Data PortalPRSS2 
TCGA Data PortalPRSS2 
Broad Tumor PortalPRSS2
OASIS PortalPRSS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRSS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRSS2
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch PRSS2
DgiDB (Drug Gene Interaction Database)PRSS2
DoCM (Curated mutations)PRSS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRSS2 (select a term)
intoGenPRSS2
Cancer3DPRSS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM167800    601564   
Orphanet937   
MedgenPRSS2
Genetic Testing Registry PRSS2
NextProtP07478 [Medical]
TSGene5645
GENETestsPRSS2
Huge Navigator PRSS2 [HugePedia]
snp3D : Map Gene to Disease5645
BioCentury BCIQPRSS2
ClinGenPRSS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5645
Chemical/Pharm GKB GenePA33833
Clinical trialPRSS2
Miscellaneous
canSAR (ICR)PRSS2 (select the gene name)
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRSS2
EVEXPRSS2
GoPubMedPRSS2
iHOPPRSS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:23:11 CET 2017

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