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PRSS21 (serine protease 21)

Identity

Alias (NCBI)ESP-1
ESP1
TEST1
TESTISIN
HGNC (Hugo) PRSS21
HGNC Alias symbESP-1
TEST1
HGNC Alias nametestisin
HGNC Previous nameprotease, serine 21
LocusID (NCBI) 10942
Atlas_Id 41878
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 2817237 and ends at 2821717 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAM20B (1q25.2) / PRSS21 (16p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PRSS21   9485
Cards
Entrez_Gene (NCBI)PRSS21    serine protease 21
AliasesESP-1; ESP1; TEST1; TESTISIN
GeneCards (Weizmann)PRSS21
Ensembl hg19 (Hinxton)ENSG00000007038 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000007038 [Gene_View]  ENSG00000007038 [Sequence]  chr16:2817237-2821717 [Contig_View]  PRSS21 [Vega]
ICGC DataPortalENSG00000007038
TCGA cBioPortalPRSS21
AceView (NCBI)PRSS21
Genatlas (Paris)PRSS21
SOURCE (Princeton)PRSS21
Genetics Home Reference (NIH)PRSS21
Genomic and cartography
GoldenPath hg38 (UCSC)PRSS21  -     chr16:2817237-2821717 +  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRSS21  -     16p13.3   [Description]    (hg19-Feb_2009)
GoldenPathPRSS21 - 16p13.3 [CytoView hg19]  PRSS21 - 16p13.3 [CytoView hg38]
ImmunoBaseENSG00000007038
Genome Data Viewer NCBIPRSS21 [Mapview hg19]  
OMIM608159   
Gene and transcription
Genbank (Entrez)AA860356 AB031329 AB031330 AB031331 AF058300
RefSeq transcript (Entrez)NM_001270452 NM_006799 NM_144956 NM_144957
Consensus coding sequences : CCDS (NCBI)PRSS21
Gene ExpressionPRSS21 [ NCBI-GEO ]   PRSS21 [ EBI - ARRAY_EXPRESS ]   PRSS21 [ SEEK ]   PRSS21 [ MEM ]
Gene Expression Viewer (FireBrowse)PRSS21 [ Firebrowse - Broad ]
GenevisibleExpression of PRSS21 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10942
GTEX Portal (Tissue expression)PRSS21
Human Protein AtlasENSG00000007038-PRSS21 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6M0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6M0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6M0
Catalytic activity : Enzyme3.4.21.- [ Enzyme-Expasy ]   3.4.21.-3.4.21.- [ IntEnz-EBI ]   3.4.21.- [ BRENDA ]   3.4.21.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9Y6M0
Domaine pattern : Prosite (Expaxy)TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Peptidase_S1_PA    Peptidase_S1_PA_chymotrypsin    Peptidase_S1A    Testisin    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
Conserved Domain (NCBI)PRSS21
SuperfamilyQ9Y6M0
AlphaFold pdb e-kbQ9Y6M0   
Human Protein Atlas [tissue]ENSG00000007038-PRSS21 [tissue]
HPRD07082
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6M0
IntAct (EBI)Q9Y6M0
BioGRIDPRSS21
STRING (EMBL)PRSS21
ZODIACPRSS21
Ontologies - Pathways
QuickGOQ9Y6M0
Ontology : AmiGOserine-type endopeptidase activity  protein binding  extracellular region  extracellular space  cytoplasm  plasma membrane  proteolysis  spermatogenesis  serine-type peptidase activity  membrane  anchored component of membrane  
Ontology : EGO-EBIserine-type endopeptidase activity  protein binding  extracellular region  extracellular space  cytoplasm  plasma membrane  proteolysis  spermatogenesis  serine-type peptidase activity  membrane  anchored component of membrane  
NDEx NetworkPRSS21
Atlas of Cancer Signalling NetworkPRSS21
Wikipedia pathwaysPRSS21
Orthology - Evolution
OrthoDB10942
GeneTree (enSembl)ENSG00000007038
Phylogenetic Trees/Animal Genes : TreeFamPRSS21
Homologs : HomoloGenePRSS21
Homology/Alignments : Family Browser (UCSC)PRSS21
Gene fusions - Rearrangements
Fusion : QuiverPRSS21
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRSS21 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRSS21
dbVarPRSS21
ClinVarPRSS21
MonarchPRSS21
1000_GenomesPRSS21 
Exome Variant ServerPRSS21
GNOMAD BrowserENSG00000007038
Varsome BrowserPRSS21
ACMGPRSS21 variants
VarityQ9Y6M0
Genomic Variants (DGV)PRSS21 [DGVbeta]
DECIPHERPRSS21 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRSS21 
Mutations
ICGC Data PortalPRSS21 
TCGA Data PortalPRSS21 
Broad Tumor PortalPRSS21
OASIS PortalPRSS21 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRSS21  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPRSS21
Mutations and Diseases : HGMDPRSS21
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPRSS21
DgiDB (Drug Gene Interaction Database)PRSS21
DoCM (Curated mutations)PRSS21
CIViC (Clinical Interpretations of Variants in Cancer)PRSS21
Cancer3DPRSS21
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608159   
Orphanet
DisGeNETPRSS21
MedgenPRSS21
Genetic Testing Registry PRSS21
NextProtQ9Y6M0 [Medical]
GENETestsPRSS21
Target ValidationPRSS21
Huge Navigator PRSS21 [HugePedia]
ClinGenPRSS21
Clinical trials, drugs, therapy
MyCancerGenomePRSS21
Protein Interactions : CTDPRSS21
Pharm GKB GenePA33834
PharosQ9Y6M0
Clinical trialPRSS21
Miscellaneous
canSAR (ICR)PRSS21
HarmonizomePRSS21
DataMed IndexPRSS21
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPRSS21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:27:05 CEST 2021

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