PRSS21 (serine protease 21)

2003-06-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
ESP-1,ESP1,TEST1,TESTISIN
FUSION GENES

Other Information

Locus ID:

NCBI: 10942
MIM: 608159
HGNC: 9485
Ensembl: ENSG00000007038

Variants:

dbSNP: 10942
ClinVar: 10942
TCGA: ENSG00000007038
COSMIC: PRSS21

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000007038ENST00000005995Q9Y6M0
ENSG00000007038ENST00000450020Q9Y6M0
ENSG00000007038ENST00000570594I3L2G7
ENSG00000007038ENST00000570629I3L3F7
ENSG00000007038ENST00000574265I3L3C7
ENSG00000007038ENST00000574813I3L0U2

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195712642009The glycosylphosphatidylinositol-anchored serine protease PRSS21 (testisin) imparts murine epididymal sperm cell maturation and fertilizing ability.24
255199082015Proteolytic activation of the protease-activated receptor (PAR)-2 by the glycosylphosphatidylinositol-anchored serine protease testisin.15
156852342005Hypermethylation of the 5' CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis.13
168105012006Epigenetic silencing of the putative tumor suppressor gene testisin in testicular germ cell tumors.9
202116232010Interaction of testisin with maspin and its impact on invasion and cell death resistance of cervical cancer cells.4

Citation

Dessen P

PRSS21 (serine protease 21)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41878/prss21