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PRSS27 (protease, serine 27)

Identity

Alias_symbol (synonym)MPN
CAPH2
Other alias
HGNC (Hugo) PRSS27
LocusID (NCBI) 83886
Atlas_Id 72304
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 2712418 and ends at 2720551 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADCY9 (16p13.3) / PRSS27 (16p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRSS27   15475
Cards
Entrez_Gene (NCBI)PRSS27  83886  protease, serine 27
AliasesCAPH2; MPN
GeneCards (Weizmann)PRSS27
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr16:2712418-2720551 [Contig_View]  PRSS27 [Vega]
TCGA cBioPortalPRSS27
AceView (NCBI)PRSS27
Genatlas (Paris)PRSS27
WikiGenes83886
SOURCE (Princeton)PRSS27
Genetics Home Reference (NIH)PRSS27
Genomic and cartography
GoldenPath hg38 (UCSC)PRSS27  -     chr16:2712418-2720551 -  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRSS27  -     16p13.3   [Description]    (hg19-Feb_2009)
EnsemblPRSS27 - 16p13.3 [CytoView hg19]  PRSS27 - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBIPRSS27 [Mapview hg19]  PRSS27 [Mapview hg38]
OMIM608018   
Gene and transcription
Genbank (Entrez)AB056161 AJ306593 AK055576 AK126510 AK310214
RefSeq transcript (Entrez)NM_001318395 NM_031948
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRSS27
Cluster EST : UnigeneHs.332878 [ NCBI ]
CGAP (NCI)Hs.332878
Gene ExpressionPRSS27 [ NCBI-GEO ]   PRSS27 [ EBI - ARRAY_EXPRESS ]   PRSS27 [ SEEK ]   PRSS27 [ MEM ]
Gene Expression Viewer (FireBrowse)PRSS27 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)83886
GTEX Portal (Tissue expression)PRSS27
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BQR3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BQR3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BQR3
Splice isoforms : SwissVarQ9BQR3
Catalytic activity : Enzyme3.4.21.- [ Enzyme-Expasy ]   3.4.21.-3.4.21.- [ IntEnz-EBI ]   3.4.21.- [ BRENDA ]   3.4.21.- [ KEGG ]   
PhosPhoSitePlusQ9BQR3
Domaine pattern : Prosite (Expaxy)TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
Conserved Domain (NCBI)PRSS27
DMDM Disease mutations83886
Blocks (Seattle)PRSS27
SuperfamilyQ9BQR3
Peptide AtlasQ9BQR3
HPRD07451
IPIIPI00011192   IPI00642635   
Protein Interaction databases
DIP (DOE-UCLA)Q9BQR3
IntAct (EBI)Q9BQR3
BioGRIDPRSS27
STRING (EMBL)PRSS27
ZODIACPRSS27
Ontologies - Pathways
QuickGOQ9BQR3
Ontology : AmiGOserine-type endopeptidase activity  extracellular region  proteolysis  serine-type peptidase activity  extrinsic component of plasma membrane  anchored component of plasma membrane  
Ontology : EGO-EBIserine-type endopeptidase activity  extracellular region  proteolysis  serine-type peptidase activity  extrinsic component of plasma membrane  anchored component of plasma membrane  
NDEx NetworkPRSS27
Atlas of Cancer Signalling NetworkPRSS27
Wikipedia pathwaysPRSS27
Orthology - Evolution
OrthoDB83886
Phylogenetic Trees/Animal Genes : TreeFamPRSS27
HOVERGENQ9BQR3
HOGENOMQ9BQR3
Homologs : HomoloGenePRSS27
Homology/Alignments : Family Browser (UCSC)PRSS27
Gene fusions - Rearrangements
Tumor Fusion PortalPRSS27
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRSS27 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRSS27
dbVarPRSS27
ClinVarPRSS27
1000_GenomesPRSS27 
Exome Variant ServerPRSS27
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP83886
Genomic Variants (DGV)PRSS27 [DGVbeta]
DECIPHERPRSS27 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRSS27 
Mutations
ICGC Data PortalPRSS27 
TCGA Data PortalPRSS27 
Broad Tumor PortalPRSS27
OASIS PortalPRSS27 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRSS27  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRSS27
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRSS27
DgiDB (Drug Gene Interaction Database)PRSS27
DoCM (Curated mutations)PRSS27 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRSS27 (select a term)
intoGenPRSS27
Cancer3DPRSS27(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608018   
Orphanet
DisGeNETPRSS27
MedgenPRSS27
Genetic Testing Registry PRSS27
NextProtQ9BQR3 [Medical]
TSGene83886
GENETestsPRSS27
Target ValidationPRSS27
Huge Navigator PRSS27 [HugePedia]
snp3D : Map Gene to Disease83886
BioCentury BCIQPRSS27
ClinGenPRSS27
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD83886
Chemical/Pharm GKB GenePA33837
Clinical trialPRSS27
Miscellaneous
canSAR (ICR)PRSS27 (select the gene name)
Probes
Litterature
PubMed7 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRSS27
EVEXPRSS27
GoPubMedPRSS27
iHOPPRSS27
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:34:11 CET 2017

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