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PRSS50 (protease, serine 50)

Identity

Alias_symbol (synonym)TSP50
CT20
Other alias
HGNC (Hugo) PRSS50
LocusID (NCBI) 29122
Atlas_Id 51218
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 46753606 and ends at 46759373 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PATJ (1p31.3) / PRSS50 (3p21.31)INADL 1p31.3 / PRSS50 3p21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRSS50   17910
Cards
Entrez_Gene (NCBI)PRSS50  29122  protease, serine 50
AliasesCT20; TSP50
GeneCards (Weizmann)PRSS50
Ensembl hg19 (Hinxton)ENSG00000206549 [Gene_View]  chr3:46753606-46759373 [Contig_View]  PRSS50 [Vega]
Ensembl hg38 (Hinxton)ENSG00000206549 [Gene_View]  chr3:46753606-46759373 [Contig_View]  PRSS50 [Vega]
ICGC DataPortalENSG00000206549
TCGA cBioPortalPRSS50
AceView (NCBI)PRSS50
Genatlas (Paris)PRSS50
WikiGenes29122
SOURCE (Princeton)PRSS50
Genetics Home Reference (NIH)PRSS50
Genomic and cartography
GoldenPath hg19 (UCSC)PRSS50  -     chr3:46753606-46759373 -  3p21.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PRSS50  -     3p21.31   [Description]    (hg38-Dec_2013)
EnsemblPRSS50 - 3p21.31 [CytoView hg19]  PRSS50 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBIPRSS50 [Mapview hg19]  PRSS50 [Mapview hg38]
OMIM607950   
Gene and transcription
Genbank (Entrez)AF100707 BC033016 BC037775 EU176497 HM005523
RefSeq transcript (Entrez)NM_013270
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)PRSS50
Cluster EST : UnigeneHs.120365 [ NCBI ]
CGAP (NCI)Hs.120365
Alternative Splicing GalleryENSG00000206549
Gene ExpressionPRSS50 [ NCBI-GEO ]   PRSS50 [ EBI - ARRAY_EXPRESS ]   PRSS50 [ SEEK ]   PRSS50 [ MEM ]
Gene Expression Viewer (FireBrowse)PRSS50 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29122
GTEX Portal (Tissue expression)PRSS50
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UI38   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UI38  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UI38
Splice isoforms : SwissVarQ9UI38
Catalytic activity : Enzyme3.4.25.- [ Enzyme-Expasy ]   3.4.25.-3.4.25.- [ IntEnz-EBI ]   3.4.25.- [ BRENDA ]   3.4.25.- [ KEGG ]   
PhosPhoSitePlusQ9UI38
Domaine pattern : Prosite (Expaxy)TRYPSIN_DOM (PS50240)   
Domains : Interpro (EBI)Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom   
Domain families : Pfam (Sanger)Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
Conserved Domain (NCBI)PRSS50
DMDM Disease mutations29122
Blocks (Seattle)PRSS50
SuperfamilyQ9UI38
Human Protein AtlasENSG00000206549
Peptide AtlasQ9UI38
HPRD06405
IPIIPI00002279   IPI00791825   IPI00973863   
Protein Interaction databases
DIP (DOE-UCLA)Q9UI38
IntAct (EBI)Q9UI38
FunCoupENSG00000206549
BioGRIDPRSS50
STRING (EMBL)PRSS50
ZODIACPRSS50
Ontologies - Pathways
QuickGOQ9UI38
Ontology : AmiGOserine-type endopeptidase activity  threonine-type endopeptidase activity  cytoplasm  endoplasmic reticulum  proteolysis  
Ontology : EGO-EBIserine-type endopeptidase activity  threonine-type endopeptidase activity  cytoplasm  endoplasmic reticulum  proteolysis  
NDEx NetworkPRSS50
Atlas of Cancer Signalling NetworkPRSS50
Wikipedia pathwaysPRSS50
Orthology - Evolution
OrthoDB29122
GeneTree (enSembl)ENSG00000206549
Phylogenetic Trees/Animal Genes : TreeFamPRSS50
HOVERGENQ9UI38
HOGENOMQ9UI38
Homologs : HomoloGenePRSS50
Homology/Alignments : Family Browser (UCSC)PRSS50
Gene fusions - Rearrangements
Fusion : MitelmanINADL/PRSS50 [1p31.3/3p21.31]  [t(1;3)(p31;p21)]  
Fusion: TCGAINADL 1p31.3 PRSS50 3p21.31 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRSS50 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRSS50
dbVarPRSS50
ClinVarPRSS50
1000_GenomesPRSS50 
Exome Variant ServerPRSS50
ExAC (Exome Aggregation Consortium)PRSS50 (select the gene name)
Genetic variants : HAPMAP29122
Genomic Variants (DGV)PRSS50 [DGVbeta]
DECIPHER (Syndromes)3:46753606-46759373  ENSG00000206549
CONAN: Copy Number AnalysisPRSS50 
Mutations
ICGC Data PortalPRSS50 
TCGA Data PortalPRSS50 
Broad Tumor PortalPRSS50
OASIS PortalPRSS50 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRSS50  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRSS50
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRSS50
DgiDB (Drug Gene Interaction Database)PRSS50
DoCM (Curated mutations)PRSS50 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRSS50 (select a term)
intoGenPRSS50
Cancer3DPRSS50(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607950   
Orphanet
MedgenPRSS50
Genetic Testing Registry PRSS50
NextProtQ9UI38 [Medical]
TSGene29122
GENETestsPRSS50
Huge Navigator PRSS50 [HugePedia]
snp3D : Map Gene to Disease29122
BioCentury BCIQPRSS50
ClinGenPRSS50
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29122
Chemical/Pharm GKB GenePA165698443
Clinical trialPRSS50
Miscellaneous
canSAR (ICR)PRSS50 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRSS50
EVEXPRSS50
GoPubMedPRSS50
iHOPPRSS50
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:15:53 CEST 2017

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