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PRSS58 (serine protease 58)

Identity

Alias (NCBI)PRSS1
TRY1
TRYX3
UNQ2540
HGNC (Hugo) PRSS58
HGNC Alias symbTRYX3
HGNC Alias nametrypsin X3
LocusID (NCBI) 136541
Atlas_Id 72320
Location 7q34  [Link to chromosome band 7q34]
Location_base_pair Starts at 142252143 and ends at 142258058 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PRSS58   39125
Cards
Entrez_Gene (NCBI)PRSS58    serine protease 58
AliasesPRSS1; TRY1; TRYX3; UNQ2540
GeneCards (Weizmann)PRSS58
Ensembl hg19 (Hinxton)ENSG00000258223 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000258223 [Gene_View]  ENSG00000258223 [Sequence]  chr7:142252143-142258058 [Contig_View]  PRSS58 [Vega]
ICGC DataPortalENSG00000258223
TCGA cBioPortalPRSS58
AceView (NCBI)PRSS58
Genatlas (Paris)PRSS58
SOURCE (Princeton)PRSS58
Genetics Home Reference (NIH)PRSS58
Genomic and cartography
GoldenPath hg38 (UCSC)PRSS58  -     chr7:142252143-142258058 -  7q34   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRSS58  -     7q34   [Description]    (hg19-Feb_2009)
GoldenPathPRSS58 - 7q34 [CytoView hg19]  PRSS58 - 7q34 [CytoView hg38]
ImmunoBaseENSG00000258223
Genome Data Viewer NCBIPRSS58 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AA625766 AK122940 AY358487 BC035384
RefSeq transcript (Entrez)NM_001001317
Consensus coding sequences : CCDS (NCBI)PRSS58
Gene ExpressionPRSS58 [ NCBI-GEO ]   PRSS58 [ EBI - ARRAY_EXPRESS ]   PRSS58 [ SEEK ]   PRSS58 [ MEM ]
Gene Expression Viewer (FireBrowse)PRSS58 [ Firebrowse - Broad ]
GenevisibleExpression of PRSS58 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)136541
GTEX Portal (Tissue expression)PRSS58
Human Protein AtlasENSG00000258223-PRSS58 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IYP2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IYP2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IYP2
Catalytic activity : Enzyme3.4.21.4 [ Enzyme-Expasy ]   3.4.21.43.4.21.4 [ IntEnz-EBI ]   3.4.21.4 [ BRENDA ]   3.4.21.4 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ8IYP2
Domaine pattern : Prosite (Expaxy)TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)   
Domains : Interpro (EBI)Peptidase_S1_PA    Peptidase_S1_PA_chymotrypsin    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS   
Domain families : Pfam (Sanger)Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
Conserved Domain (NCBI)PRSS58
SuperfamilyQ8IYP2
AlphaFold pdb e-kbQ8IYP2   
Human Protein Atlas [tissue]ENSG00000258223-PRSS58 [tissue]
HPRD15572
Protein Interaction databases
DIP (DOE-UCLA)Q8IYP2
IntAct (EBI)Q8IYP2
BioGRIDPRSS58
STRING (EMBL)PRSS58
ZODIACPRSS58
Ontologies - Pathways
QuickGOQ8IYP2
Ontology : AmiGOserine-type endopeptidase activity  extracellular region  proteolysis  secretory granule  
Ontology : EGO-EBIserine-type endopeptidase activity  extracellular region  proteolysis  secretory granule  
NDEx NetworkPRSS58
Atlas of Cancer Signalling NetworkPRSS58
Wikipedia pathwaysPRSS58
Orthology - Evolution
OrthoDB136541
GeneTree (enSembl)ENSG00000258223
Phylogenetic Trees/Animal Genes : TreeFamPRSS58
Homologs : HomoloGenePRSS58
Homology/Alignments : Family Browser (UCSC)PRSS58
Gene fusions - Rearrangements
Fusion : QuiverPRSS58
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRSS58 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRSS58
dbVarPRSS58
ClinVarPRSS58
MonarchPRSS58
1000_GenomesPRSS58 
Exome Variant ServerPRSS58
GNOMAD BrowserENSG00000258223
Varsome BrowserPRSS58
ACMGPRSS58 variants
VarityQ8IYP2
Genomic Variants (DGV)PRSS58 [DGVbeta]
DECIPHERPRSS58 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRSS58 
Mutations
ICGC Data PortalPRSS58 
TCGA Data PortalPRSS58 
Broad Tumor PortalPRSS58
OASIS PortalPRSS58 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRSS58  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPRSS58
Mutations and Diseases : HGMDPRSS58
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPRSS58
DgiDB (Drug Gene Interaction Database)PRSS58
DoCM (Curated mutations)PRSS58
CIViC (Clinical Interpretations of Variants in Cancer)PRSS58
Cancer3DPRSS58
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETPRSS58
MedgenPRSS58
Genetic Testing Registry PRSS58
NextProtQ8IYP2 [Medical]
GENETestsPRSS58
Target ValidationPRSS58
Huge Navigator PRSS58 [HugePedia]
ClinGenPRSS58
Clinical trials, drugs, therapy
MyCancerGenomePRSS58
Protein Interactions : CTDPRSS58
Pharm GKB GenePA166049038
PharosQ8IYP2
Clinical trialPRSS58
Miscellaneous
canSAR (ICR)PRSS58
HarmonizomePRSS58
DataMed IndexPRSS58
Probes
Litterature
PubMed7 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPRSS58
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:17:28 CEST 2021

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