Identity
HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
ACPA,AGP7,C-ANCA,CANCA,MBN,MBT,NP-4,NP4,P29,PR-3,PR3
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5657
MIM: 177020
HGNC: 9495
Ensembl: ENSG00000196415
Variants:
dbSNP: 5657
ClinVar: 5657
TCGA: ENSG00000196415
COSMIC: PRTN3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000196415 | ENST00000234347 | P24158 |
| ENSG00000196415 | ENST00000544537 | U3KPS2 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38167145 | 2024 | Elevated first-trimester neutrophil elastase and proteinase 3 increase the risk of gestational diabetes mellitus and adverse fetal outcomes. | 1 |
| 38167145 | 2024 | Elevated first-trimester neutrophil elastase and proteinase 3 increase the risk of gestational diabetes mellitus and adverse fetal outcomes. | 1 |
| 36626226 | 2023 | PRTN3 variant correlates with increased autoantigen levels and relapse risk in PR3-ANCA versus MPO-ANCA disease. | 2 |
| 36801813 | 2023 | Proteinase 3 promotes formation of multinucleated giant cells and granuloma-like structures in patients with granulomatosis with polyangiitis. | 3 |
| 36804380 | 2023 | Identification of proteinase 3 autoreactive CD4(+)T cells and their T-cell receptor repertoires in antineutrophil cytoplasmic antibody-associated vasculitis. | 1 |
| 36804624 | 2023 | Identification of PRTN3 as a novel biomarker for the diagnosis of early gastric cance. | 0 |
| 36944270 | 2023 | N-glycan in the variable region of monoclonal ACPA (CCP-Ab1) promotes the exacerbation of experimental arthritis. | 0 |
| 36990659 | 2023 | Risk of relapse of ANCA-associated vasculitis among patients homozygous for the proteinase 3 gene Val119Ile polymorphism. | 1 |
| 36626226 | 2023 | PRTN3 variant correlates with increased autoantigen levels and relapse risk in PR3-ANCA versus MPO-ANCA disease. | 2 |
| 36801813 | 2023 | Proteinase 3 promotes formation of multinucleated giant cells and granuloma-like structures in patients with granulomatosis with polyangiitis. | 3 |
| 36804380 | 2023 | Identification of proteinase 3 autoreactive CD4(+)T cells and their T-cell receptor repertoires in antineutrophil cytoplasmic antibody-associated vasculitis. | 1 |
| 36804624 | 2023 | Identification of PRTN3 as a novel biomarker for the diagnosis of early gastric cance. | 0 |
| 36944270 | 2023 | N-glycan in the variable region of monoclonal ACPA (CCP-Ab1) promotes the exacerbation of experimental arthritis. | 0 |
| 36990659 | 2023 | Risk of relapse of ANCA-associated vasculitis among patients homozygous for the proteinase 3 gene Val119Ile polymorphism. | 1 |
| 35063507 | 2022 | Competitively disrupting the neutrophil-specific receptor-autoantigen CD177:proteinase 3 membrane complex reduces anti-PR3 antibody-induced neutrophil activation. | 2 |
Citation
Dessen P
PRTN3 (proteinase 3)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46246/prtn3
