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PRTN3 (proteinase 3)

Identity

Alias_symbol (synonym)PR-3
ACPA
C-ANCA
AGP7
MBT
P29
Other aliasCANCA
MBN
NP-4
NP4
PR3
HGNC (Hugo) PRTN3
LocusID (NCBI) 5657
Atlas_Id 46246
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 840985 and ends at 848175 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRTN3   9495
Cards
Entrez_Gene (NCBI)PRTN3  5657  proteinase 3
AliasesACPA; AGP7; C-ANCA; CANCA; 
MBN; MBT; NP-4; NP4; P29; PR-3; PR3
GeneCards (Weizmann)PRTN3
Ensembl hg19 (Hinxton)ENSG00000196415 [Gene_View]  chr19:840985-848175 [Contig_View]  PRTN3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000196415 [Gene_View]  chr19:840985-848175 [Contig_View]  PRTN3 [Vega]
ICGC DataPortalENSG00000196415
TCGA cBioPortalPRTN3
AceView (NCBI)PRTN3
Genatlas (Paris)PRTN3
WikiGenes5657
SOURCE (Princeton)PRTN3
Genetics Home Reference (NIH)PRTN3
Genomic and cartography
GoldenPath hg19 (UCSC)PRTN3  -     chr19:840985-848175 +  19p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PRTN3  -     19p13.3   [Description]    (hg38-Dec_2013)
EnsemblPRTN3 - 19p13.3 [CytoView hg19]  PRTN3 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIPRTN3 [Mapview hg19]  PRTN3 [Mapview hg38]
OMIM177020   
Gene and transcription
Genbank (Entrez)BC096183 BC096184 BC096185 BC096186 FN647680
RefSeq transcript (Entrez)NM_002777
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011295 NT_187622 NW_004929412
Consensus coding sequences : CCDS (NCBI)PRTN3
Cluster EST : UnigeneHs.928 [ NCBI ]
CGAP (NCI)Hs.928
Alternative Splicing GalleryENSG00000196415
Gene ExpressionPRTN3 [ NCBI-GEO ]   PRTN3 [ EBI - ARRAY_EXPRESS ]   PRTN3 [ SEEK ]   PRTN3 [ MEM ]
Gene Expression Viewer (FireBrowse)PRTN3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5657
GTEX Portal (Tissue expression)PRTN3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP24158   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP24158  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP24158
Splice isoforms : SwissVarP24158
Catalytic activity : Enzyme3.4.21.76 [ Enzyme-Expasy ]   3.4.21.763.4.21.76 [ IntEnz-EBI ]   3.4.21.76 [ BRENDA ]   3.4.21.76 [ KEGG ]   
PhosPhoSitePlusP24158
Domaine pattern : Prosite (Expaxy)TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
Conserved Domain (NCBI)PRTN3
DMDM Disease mutations5657
Blocks (Seattle)PRTN3
PDB (SRS)1FUJ   
PDB (PDBSum)1FUJ   
PDB (IMB)1FUJ   
PDB (RSDB)1FUJ   
Structural Biology KnowledgeBase1FUJ   
SCOP (Structural Classification of Proteins)1FUJ   
CATH (Classification of proteins structures)1FUJ   
SuperfamilyP24158
Human Protein AtlasENSG00000196415
Peptide AtlasP24158
HPRD01512
IPIIPI00027409   IPI01013441   
Protein Interaction databases
DIP (DOE-UCLA)P24158
IntAct (EBI)P24158
FunCoupENSG00000196415
BioGRIDPRTN3
STRING (EMBL)PRTN3
ZODIACPRTN3
Ontologies - Pathways
QuickGOP24158
Ontology : AmiGOserine-type endopeptidase activity  extracellular space  cytosol  cytosol  plasma membrane  plasma membrane  proteolysis  blood coagulation  serine-type peptidase activity  positive regulation of cell proliferation  enzyme binding  collagen catabolic process  extracellular matrix  negative regulation of phagocytosis  extracellular exosome  mature conventional dendritic cell differentiation  
Ontology : EGO-EBIserine-type endopeptidase activity  extracellular space  cytosol  cytosol  plasma membrane  plasma membrane  proteolysis  blood coagulation  serine-type peptidase activity  positive regulation of cell proliferation  enzyme binding  collagen catabolic process  extracellular matrix  negative regulation of phagocytosis  extracellular exosome  mature conventional dendritic cell differentiation  
NDEx NetworkPRTN3
Atlas of Cancer Signalling NetworkPRTN3
Wikipedia pathwaysPRTN3
Orthology - Evolution
OrthoDB5657
GeneTree (enSembl)ENSG00000196415
Phylogenetic Trees/Animal Genes : TreeFamPRTN3
HOVERGENP24158
HOGENOMP24158
Homologs : HomoloGenePRTN3
Homology/Alignments : Family Browser (UCSC)PRTN3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRTN3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRTN3
dbVarPRTN3
ClinVarPRTN3
1000_GenomesPRTN3 
Exome Variant ServerPRTN3
ExAC (Exome Aggregation Consortium)PRTN3 (select the gene name)
Genetic variants : HAPMAP5657
Genomic Variants (DGV)PRTN3 [DGVbeta]
DECIPHER (Syndromes)19:840985-848175  ENSG00000196415
CONAN: Copy Number AnalysisPRTN3 
Mutations
ICGC Data PortalPRTN3 
TCGA Data PortalPRTN3 
Broad Tumor PortalPRTN3
OASIS PortalPRTN3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRTN3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRTN3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRTN3
DgiDB (Drug Gene Interaction Database)PRTN3
DoCM (Curated mutations)PRTN3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRTN3 (select a term)
intoGenPRTN3
Cancer3DPRTN3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM177020   
Orphanet759   
MedgenPRTN3
Genetic Testing Registry PRTN3
NextProtP24158 [Medical]
TSGene5657
GENETestsPRTN3
Huge Navigator PRTN3 [HugePedia]
snp3D : Map Gene to Disease5657
BioCentury BCIQPRTN3
ClinGenPRTN3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5657
Chemical/Pharm GKB GenePA33842
Clinical trialPRTN3
Miscellaneous
canSAR (ICR)PRTN3 (select the gene name)
Probes
Litterature
PubMed128 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRTN3
EVEXPRTN3
GoPubMedPRTN3
iHOPPRTN3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:15:54 CEST 2017

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