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PRXL2A (peroxiredoxin like 2A)

Identity

Alias (NCBI)Adrx
C10orf58
FAM213A
PAMM
HGNC (Hugo) PRXL2A
HGNC Alias symbMGC4248
PAMM
Adrx
HGNC Alias nameperoxiredoxin-like 2 activated in M-CSF stimulated monocytes
 Adiporedoxin
HGNC Previous nameC10orf58
 FAM213A
HGNC Previous namechromosome 10 open reading frame 58
 family with sequence similarity 213, member A
LocusID (NCBI) 84293
Atlas_Id 58325
Location 10q23.1  [Link to chromosome band 10q23]
Location_base_pair Starts at 80408551 and ends at 80437115 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



External links

 

Nomenclature
HGNC (Hugo)PRXL2A   28651
Cards
Entrez_Gene (NCBI)PRXL2A    peroxiredoxin like 2A
AliasesAdrx; C10orf58; FAM213A; PAMM
GeneCards (Weizmann)PRXL2A
Ensembl hg19 (Hinxton)ENSG00000122378 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000122378 [Gene_View]  ENSG00000122378 [Sequence]  chr10:80408551-80437115 [Contig_View]  PRXL2A [Vega]
ICGC DataPortalENSG00000122378
TCGA cBioPortalPRXL2A
AceView (NCBI)PRXL2A
Genatlas (Paris)PRXL2A
SOURCE (Princeton)PRXL2A
Genetics Home Reference (NIH)PRXL2A
Genomic and cartography
GoldenPath hg38 (UCSC)PRXL2A  -     chr10:80408551-80437115 +  10q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRXL2A  -     10q23.1   [Description]    (hg19-Feb_2009)
GoldenPathPRXL2A - 10q23.1 [CytoView hg19]  PRXL2A - 10q23.1 [CytoView hg38]
ImmunoBaseENSG00000122378
Genome Data Viewer NCBIPRXL2A [Mapview hg19]  
OMIM617165   
Gene and transcription
Genbank (Entrez)AA829725 AF086462 AF305824 AI589570 AK022598
RefSeq transcript (Entrez)NM_001243778 NM_001243779 NM_001243780 NM_001243781 NM_001243782 NM_032333
Consensus coding sequences : CCDS (NCBI)PRXL2A
Gene ExpressionPRXL2A [ NCBI-GEO ]   PRXL2A [ EBI - ARRAY_EXPRESS ]   PRXL2A [ SEEK ]   PRXL2A [ MEM ]
Gene Expression Viewer (FireBrowse)PRXL2A [ Firebrowse - Broad ]
GenevisibleExpression of PRXL2A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84293
GTEX Portal (Tissue expression)PRXL2A
Human Protein AtlasENSG00000122378-PRXL2A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BRX8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BRX8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BRX8
PhosPhoSitePlusQ9BRX8
Domains : Interpro (EBI)PRXL2A    PXL2A/B/C   
Domain families : Pfam (Sanger)AhpC-TSA_2 (PF13911)   
Domain families : Pfam (NCBI)pfam13911   
Conserved Domain (NCBI)PRXL2A
SuperfamilyQ9BRX8
AlphaFold pdb e-kbQ9BRX8   
Human Protein Atlas [tissue]ENSG00000122378-PRXL2A [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q9BRX8
IntAct (EBI)Q9BRX8
BioGRIDPRXL2A
STRING (EMBL)PRXL2A
ZODIACPRXL2A
Ontologies - Pathways
QuickGOQ9BRX8
Ontology : AmiGOextracellular region  cytoplasm  cytoplasm  antioxidant activity  antioxidant activity  regulation of osteoclast differentiation  cellular oxidant detoxification  
Ontology : EGO-EBIextracellular region  cytoplasm  cytoplasm  antioxidant activity  antioxidant activity  regulation of osteoclast differentiation  cellular oxidant detoxification  
NDEx NetworkPRXL2A
Atlas of Cancer Signalling NetworkPRXL2A
Wikipedia pathwaysPRXL2A
Orthology - Evolution
OrthoDB84293
GeneTree (enSembl)ENSG00000122378
Phylogenetic Trees/Animal Genes : TreeFamPRXL2A
Homologs : HomoloGenePRXL2A
Homology/Alignments : Family Browser (UCSC)PRXL2A
Gene fusions - Rearrangements
Fusion : QuiverPRXL2A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRXL2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRXL2A
dbVarPRXL2A
ClinVarPRXL2A
MonarchPRXL2A
1000_GenomesPRXL2A 
Exome Variant ServerPRXL2A
GNOMAD BrowserENSG00000122378
Varsome BrowserPRXL2A
ACMGPRXL2A variants
VarityQ9BRX8
Genomic Variants (DGV)PRXL2A [DGVbeta]
DECIPHERPRXL2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRXL2A 
Mutations
ICGC Data PortalPRXL2A 
TCGA Data PortalPRXL2A 
Broad Tumor PortalPRXL2A
OASIS PortalPRXL2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRXL2A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPRXL2A
Mutations and Diseases : HGMDPRXL2A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPRXL2A
DgiDB (Drug Gene Interaction Database)PRXL2A
DoCM (Curated mutations)PRXL2A
CIViC (Clinical Interpretations of Variants in Cancer)PRXL2A
Cancer3DPRXL2A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617165   
Orphanet
DisGeNETPRXL2A
MedgenPRXL2A
Genetic Testing Registry PRXL2A
NextProtQ9BRX8 [Medical]
GENETestsPRXL2A
Target ValidationPRXL2A
Huge Navigator PRXL2A [HugePedia]
ClinGenPRXL2A
Clinical trials, drugs, therapy
MyCancerGenomePRXL2A
Protein Interactions : CTDPRXL2A
PharosQ9BRX8
Clinical trialPRXL2A
Miscellaneous
canSAR (ICR)PRXL2A
HarmonizomePRXL2A
DataMed IndexPRXL2A
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPRXL2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:27:07 CEST 2021

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