Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PSMA1 (proteasome subunit alpha 1)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)HC2
NU
PROS30
MGC14542
MGC14575
MGC14751
MGC1667
MGC21459
MGC22853
MGC23915
Other aliasHEL-S-275
HGNC (Hugo) PSMA1
LocusID (NCBI) 5682
Atlas_Id 54076
Location 11p15.2  [Link to chromosome band 11p15]
Location_base_pair Starts at 14513966 and ends at 14520445 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PSMA1 (11p15.2) / MYH9 (22q12.3)PSMA1 (11p15.2) / PKP4 (2q24.1)RRAS2 (11p15.2) / PSMA1 (11p15.2)
SSR1 (6p24.3) / PSMA1 (11p15.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSMA1   9530
Cards
Entrez_Gene (NCBI)PSMA1  5682  proteasome subunit alpha 1
AliasesHC2; HEL-S-275; NU; PROS30
GeneCards (Weizmann)PSMA1
Ensembl hg19 (Hinxton)ENSG00000129084 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000129084 [Gene_View]  chr11:14513966-14520445 [Contig_View]  PSMA1 [Vega]
ICGC DataPortalENSG00000129084
TCGA cBioPortalPSMA1
AceView (NCBI)PSMA1
Genatlas (Paris)PSMA1
WikiGenes5682
SOURCE (Princeton)PSMA1
Genetics Home Reference (NIH)PSMA1
Genomic and cartography
GoldenPath hg38 (UCSC)PSMA1  -     chr11:14513966-14520445 -  11p15.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSMA1  -     11p15.2   [Description]    (hg19-Feb_2009)
EnsemblPSMA1 - 11p15.2 [CytoView hg19]  PSMA1 - 11p15.2 [CytoView hg38]
Mapping of homologs : NCBIPSMA1 [Mapview hg19]  PSMA1 [Mapview hg38]
OMIM602854   
Gene and transcription
Genbank (Entrez)AK290765 AK303565 AW015660 BC002577 BC005932
RefSeq transcript (Entrez)NM_001143937 NM_002786 NM_148976
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSMA1
Cluster EST : UnigeneHs.102798 [ NCBI ]
CGAP (NCI)Hs.102798
Alternative Splicing GalleryENSG00000129084
Gene ExpressionPSMA1 [ NCBI-GEO ]   PSMA1 [ EBI - ARRAY_EXPRESS ]   PSMA1 [ SEEK ]   PSMA1 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMA1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5682
GTEX Portal (Tissue expression)PSMA1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25786   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP25786  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP25786
Splice isoforms : SwissVarP25786
PhosPhoSitePlusP25786
Domaine pattern : Prosite (Expaxy)PROTEASOME_ALPHA_1 (PS00388)    PROTEASOME_ALPHA_2 (PS51475)   
Domains : Interpro (EBI)Ntn_hydrolases_N    Proteasome_asu_N    Proteasome_suA-type    Proteasome_sua/b   
Domain families : Pfam (Sanger)Proteasome (PF00227)    Proteasome_A_N (PF10584)   
Domain families : Pfam (NCBI)pfam00227    pfam10584   
Domain families : Smart (EMBL)Proteasome_A_N (SM00948)  
Conserved Domain (NCBI)PSMA1
DMDM Disease mutations5682
Blocks (Seattle)PSMA1
PDB (SRS)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (PDBSum)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (IMB)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (RSDB)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
Structural Biology KnowledgeBase4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
SCOP (Structural Classification of Proteins)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
CATH (Classification of proteins structures)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
SuperfamilyP25786
Human Protein AtlasENSG00000129084
Peptide AtlasP25786
HPRD04170
IPIIPI00016832   IPI00472442   IPI00910408   IPI01012065   IPI01012975   
Protein Interaction databases
DIP (DOE-UCLA)P25786
IntAct (EBI)P25786
FunCoupENSG00000129084
BioGRIDPSMA1
STRING (EMBL)PSMA1
ZODIACPSMA1
Ontologies - Pathways
QuickGOP25786
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  RNA binding  threonine-type endopeptidase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  centrosome  cytosol  proteasome core complex  polysome  regulation of cellular amino acid metabolic process  negative regulation of G2/M transition of mitotic cell cycle  protein deubiquitination  proteasome core complex, alpha-subunit complex  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  RNA binding  threonine-type endopeptidase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  centrosome  cytosol  proteasome core complex  polysome  regulation of cellular amino acid metabolic process  negative regulation of G2/M transition of mitotic cell cycle  protein deubiquitination  proteasome core complex, alpha-subunit complex  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  
Pathways : KEGGProteasome   
NDEx NetworkPSMA1
Atlas of Cancer Signalling NetworkPSMA1
Wikipedia pathwaysPSMA1
Orthology - Evolution
OrthoDB5682
GeneTree (enSembl)ENSG00000129084
Phylogenetic Trees/Animal Genes : TreeFamPSMA1
HOVERGENP25786
HOGENOMP25786
Homologs : HomoloGenePSMA1
Homology/Alignments : Family Browser (UCSC)PSMA1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMA1
dbVarPSMA1
ClinVarPSMA1
1000_GenomesPSMA1 
Exome Variant ServerPSMA1
ExAC (Exome Aggregation Consortium)PSMA1 (select the gene name)
Genetic variants : HAPMAP5682
Genomic Variants (DGV)PSMA1 [DGVbeta]
DECIPHERPSMA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSMA1 
Mutations
ICGC Data PortalPSMA1 
TCGA Data PortalPSMA1 
Broad Tumor PortalPSMA1
OASIS PortalPSMA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMA1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMA1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMA1
DgiDB (Drug Gene Interaction Database)PSMA1
DoCM (Curated mutations)PSMA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMA1 (select a term)
intoGenPSMA1
Cancer3DPSMA1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602854   
Orphanet
MedgenPSMA1
Genetic Testing Registry PSMA1
NextProtP25786 [Medical]
TSGene5682
GENETestsPSMA1
Target ValidationPSMA1
Huge Navigator PSMA1 [HugePedia]
snp3D : Map Gene to Disease5682
BioCentury BCIQPSMA1
ClinGenPSMA1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5682
Chemical/Pharm GKB GenePA33875
Clinical trialPSMA1
Miscellaneous
canSAR (ICR)PSMA1 (select the gene name)
Probes
Litterature
PubMed123 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMA1
EVEXPSMA1
GoPubMedPSMA1
iHOPPSMA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:11:52 CEST 2017

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