Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PSMA2 (proteasome subunit alpha 2)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)MU
HC3
PMSA2
Other aliasPSC2
HGNC (Hugo) PSMA2
LocusID (NCBI) 5683
Atlas_Id 55442
Location 7p14.1  [Link to chromosome band 7p14]
Location_base_pair Starts at 42956462 and ends at 42971805 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSMA2   9531
Cards
Entrez_Gene (NCBI)PSMA2  5683  proteasome subunit alpha 2
AliasesHC3; MU; PMSA2; PSC2
GeneCards (Weizmann)PSMA2
Ensembl hg19 (Hinxton)ENSG00000106588 [Gene_View]  chr7:42956462-42971805 [Contig_View]  PSMA2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000106588 [Gene_View]  chr7:42956462-42971805 [Contig_View]  PSMA2 [Vega]
ICGC DataPortalENSG00000106588
TCGA cBioPortalPSMA2
AceView (NCBI)PSMA2
Genatlas (Paris)PSMA2
WikiGenes5683
SOURCE (Princeton)PSMA2
Genetics Home Reference (NIH)PSMA2
Genomic and cartography
GoldenPath hg19 (UCSC)PSMA2  -     chr7:42956462-42971805 -  7p14.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PSMA2  -     7p14.1   [Description]    (hg38-Dec_2013)
EnsemblPSMA2 - 7p14.1 [CytoView hg19]  PSMA2 - 7p14.1 [CytoView hg38]
Mapping of homologs : NCBIPSMA2 [Mapview hg19]  PSMA2 [Mapview hg38]
OMIM176842   
Gene and transcription
Genbank (Entrez)AK222976 AK290654 AU120930 BC002900 BC047697
RefSeq transcript (Entrez)NM_002787
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007819 NW_004929329
Consensus coding sequences : CCDS (NCBI)PSMA2
Cluster EST : UnigeneHs.333786 [ NCBI ]
CGAP (NCI)Hs.333786
Alternative Splicing GalleryENSG00000106588
Gene ExpressionPSMA2 [ NCBI-GEO ]   PSMA2 [ EBI - ARRAY_EXPRESS ]   PSMA2 [ SEEK ]   PSMA2 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5683
GTEX Portal (Tissue expression)PSMA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25787   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP25787  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP25787
Splice isoforms : SwissVarP25787
Catalytic activity : Enzyme3.4.25.1 [ Enzyme-Expasy ]   3.4.25.13.4.25.1 [ IntEnz-EBI ]   3.4.25.1 [ BRENDA ]   3.4.25.1 [ KEGG ]   
PhosPhoSitePlusP25787
Domaine pattern : Prosite (Expaxy)PROTEASOME_ALPHA_1 (PS00388)    PROTEASOME_ALPHA_2 (PS51475)   
Domains : Interpro (EBI)Ntn_hydrolases_N    Proteasome_asu_N    Proteasome_suA-type    Proteasome_sua/b   
Domain families : Pfam (Sanger)Proteasome (PF00227)    Proteasome_A_N (PF10584)   
Domain families : Pfam (NCBI)pfam00227    pfam10584   
Domain families : Smart (EMBL)Proteasome_A_N (SM00948)  
Conserved Domain (NCBI)PSMA2
DMDM Disease mutations5683
Blocks (Seattle)PSMA2
PDB (SRS)4R3O    4R67    5A0Q   
PDB (PDBSum)4R3O    4R67    5A0Q   
PDB (IMB)4R3O    4R67    5A0Q   
PDB (RSDB)4R3O    4R67    5A0Q   
Structural Biology KnowledgeBase4R3O    4R67    5A0Q   
SCOP (Structural Classification of Proteins)4R3O    4R67    5A0Q   
CATH (Classification of proteins structures)4R3O    4R67    5A0Q   
SuperfamilyP25787
Human Protein AtlasENSG00000106588
Peptide AtlasP25787
HPRD08907
IPIIPI00219622   IPI00925799   IPI01009356   IPI00925664   IPI00926198   IPI00927830   
Protein Interaction databases
DIP (DOE-UCLA)P25787
IntAct (EBI)P25787
FunCoupENSG00000106588
BioGRIDPSMA2
STRING (EMBL)PSMA2
ZODIACPSMA2
Ontologies - Pathways
QuickGOP25787
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  cytoplasmic mRNA processing body  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  threonine-type endopeptidase activity  protein binding  nucleus  nucleoplasm  cytosol  proteasome core complex  regulation of cellular amino acid metabolic process  response to virus  proteasome core complex, alpha-subunit complex  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  Wnt signaling pathway, planar cell polarity pathway  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  cytoplasmic mRNA processing body  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  threonine-type endopeptidase activity  protein binding  nucleus  nucleoplasm  cytosol  proteasome core complex  regulation of cellular amino acid metabolic process  response to virus  proteasome core complex, alpha-subunit complex  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  Wnt signaling pathway, planar cell polarity pathway  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  
Pathways : KEGGProteasome   
NDEx NetworkPSMA2
Atlas of Cancer Signalling NetworkPSMA2
Wikipedia pathwaysPSMA2
Orthology - Evolution
OrthoDB5683
GeneTree (enSembl)ENSG00000106588
Phylogenetic Trees/Animal Genes : TreeFamPSMA2
HOVERGENP25787
HOGENOMP25787
Homologs : HomoloGenePSMA2
Homology/Alignments : Family Browser (UCSC)PSMA2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMA2
dbVarPSMA2
ClinVarPSMA2
1000_GenomesPSMA2 
Exome Variant ServerPSMA2
ExAC (Exome Aggregation Consortium)PSMA2 (select the gene name)
Genetic variants : HAPMAP5683
Genomic Variants (DGV)PSMA2 [DGVbeta]
DECIPHER (Syndromes)7:42956462-42971805  ENSG00000106588
CONAN: Copy Number AnalysisPSMA2 
Mutations
ICGC Data PortalPSMA2 
TCGA Data PortalPSMA2 
Broad Tumor PortalPSMA2
OASIS PortalPSMA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMA2
DgiDB (Drug Gene Interaction Database)PSMA2
DoCM (Curated mutations)PSMA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMA2 (select a term)
intoGenPSMA2
Cancer3DPSMA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176842   
Orphanet
MedgenPSMA2
Genetic Testing Registry PSMA2
NextProtP25787 [Medical]
TSGene5683
GENETestsPSMA2
Huge Navigator PSMA2 [HugePedia]
snp3D : Map Gene to Disease5683
BioCentury BCIQPSMA2
ClinGenPSMA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5683
Chemical/Pharm GKB GenePA33876
Clinical trialPSMA2
Miscellaneous
canSAR (ICR)PSMA2 (select the gene name)
Probes
Litterature
PubMed119 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMA2
EVEXPSMA2
GoPubMedPSMA2
iHOPPSMA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:23:17 CET 2017

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