Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PSMA3 (proteasome subunit alpha 3)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)HC8
Other aliasPSC3
HGNC (Hugo) PSMA3
LocusID (NCBI) 5684
Atlas_Id 54560
Location 7p14.1  [Link to chromosome band 7p14]
Location_base_pair Starts at 58244805 and ends at 58272009 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CTAGE5 (14q21.1) / PSMA3 (14q23.1)PSMA3 (14q23.1) / ACTR10 (14q23.1)PSMA3 (14q23.1) / ZNFX1 (20q13.13)
PSMA3 14q23.1 / ZNFX1 20q13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(14;20)(q23;q13) PSMA3/ZNFX1


External links

Nomenclature
HGNC (Hugo)PSMA3   9532
Cards
Entrez_Gene (NCBI)PSMA3  5684  proteasome subunit alpha 3
AliasesHC8; PSC3
GeneCards (Weizmann)PSMA3
Ensembl hg19 (Hinxton)ENSG00000100567 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100567 [Gene_View]  ENSG00000100567 [Sequence]  chr14:58244805-58272009 [Contig_View]  PSMA3 [Vega]
ICGC DataPortalENSG00000100567
TCGA cBioPortalPSMA3
AceView (NCBI)PSMA3
Genatlas (Paris)PSMA3
WikiGenes5684
SOURCE (Princeton)PSMA3
Genetics Home Reference (NIH)PSMA3
Genomic and cartography
GoldenPath hg38 (UCSC)PSMA3  -     chr14:58244805-58272009 +  7p14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSMA3  -     7p14.1   [Description]    (hg19-Feb_2009)
EnsemblPSMA3 - 7p14.1 [CytoView hg19]  PSMA3 - 7p14.1 [CytoView hg38]
Mapping of homologs : NCBIPSMA3 [Mapview hg19]  PSMA3 [Mapview hg38]
OMIM176843   
Gene and transcription
Genbank (Entrez)AK315158 BC005265 BC029402 BC038990 BG703488
RefSeq transcript (Entrez)NM_002788 NM_152132
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSMA3
Cluster EST : UnigeneHs.558799 [ NCBI ]
CGAP (NCI)Hs.558799
Alternative Splicing GalleryENSG00000100567
Gene ExpressionPSMA3 [ NCBI-GEO ]   PSMA3 [ EBI - ARRAY_EXPRESS ]   PSMA3 [ SEEK ]   PSMA3 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMA3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5684
GTEX Portal (Tissue expression)PSMA3
Human Protein AtlasENSG00000100567-PSMA3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25788   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP25788  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP25788
Splice isoforms : SwissVarP25788
PhosPhoSitePlusP25788
Domaine pattern : Prosite (Expaxy)PROTEASOME_ALPHA_1 (PS00388)    PROTEASOME_ALPHA_2 (PS51475)   
Domains : Interpro (EBI)Ntn_hydrolases_N    Proteasome_alpha-type    Proteasome_alpha_3    Proteasome_asu_N    Proteasome_sua/b   
Domain families : Pfam (Sanger)Proteasome (PF00227)    Proteasome_A_N (PF10584)   
Domain families : Pfam (NCBI)pfam00227    pfam10584   
Domain families : Smart (EMBL)Proteasome_A_N (SM00948)  
Conserved Domain (NCBI)PSMA3
DMDM Disease mutations5684
Blocks (Seattle)PSMA3
PDB (SRS)4R3O    4R67    5A0Q    5DSV    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    6AVO   
PDB (PDBSum)4R3O    4R67    5A0Q    5DSV    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    6AVO   
PDB (IMB)4R3O    4R67    5A0Q    5DSV    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    6AVO   
PDB (RSDB)4R3O    4R67    5A0Q    5DSV    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    6AVO   
Structural Biology KnowledgeBase4R3O    4R67    5A0Q    5DSV    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    6AVO   
SCOP (Structural Classification of Proteins)4R3O    4R67    5A0Q    5DSV    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    6AVO   
CATH (Classification of proteins structures)4R3O    4R67    5A0Q    5DSV    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    6AVO   
SuperfamilyP25788
Human Protein Atlas [tissue]ENSG00000100567-PSMA3 [tissue]
Peptide AtlasP25788
HPRD01463
IPIIPI00419249   IPI00171199   IPI01025990   IPI01026074   IPI01025741   IPI01025628   
Protein Interaction databases
DIP (DOE-UCLA)P25788
IntAct (EBI)P25788
FunCoupENSG00000100567
BioGRIDPSMA3
STRING (EMBL)PSMA3
ZODIACPSMA3
Ontologies - Pathways
QuickGOP25788
Ontology : AmiGOproteasome complex  endopeptidase activity  threonine-type endopeptidase activity  protein binding  nucleus  nucleus  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  proteasome core complex  proteasome core complex  ubiquitin-dependent protein catabolic process  proteasomal protein catabolic process  proteasomal ubiquitin-independent protein catabolic process  viral process  protein deubiquitination  proteasome core complex, alpha-subunit complex  proteasome core complex, alpha-subunit complex  ubiquitin protein ligase binding  proteasome-mediated ubiquitin-dependent protein catabolic process  post-translational protein modification  synapse  synapse  regulation of endopeptidase activity  extracellular exosome  
Ontology : EGO-EBIproteasome complex  endopeptidase activity  threonine-type endopeptidase activity  protein binding  nucleus  nucleus  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  proteasome core complex  proteasome core complex  ubiquitin-dependent protein catabolic process  proteasomal protein catabolic process  proteasomal ubiquitin-independent protein catabolic process  viral process  protein deubiquitination  proteasome core complex, alpha-subunit complex  proteasome core complex, alpha-subunit complex  ubiquitin protein ligase binding  proteasome-mediated ubiquitin-dependent protein catabolic process  post-translational protein modification  synapse  synapse  regulation of endopeptidase activity  extracellular exosome  
Pathways : KEGGProteasome   
NDEx NetworkPSMA3
Atlas of Cancer Signalling NetworkPSMA3
Wikipedia pathwaysPSMA3
Orthology - Evolution
OrthoDB5684
GeneTree (enSembl)ENSG00000100567
Phylogenetic Trees/Animal Genes : TreeFamPSMA3
HOVERGENP25788
HOGENOMP25788
Homologs : HomoloGenePSMA3
Homology/Alignments : Family Browser (UCSC)PSMA3
Gene fusions - Rearrangements
Fusion : MitelmanCTAGE5/PSMA3 [14q21.1/14q23.1]  [t(14;14)(q21;q23)]  
Fusion : MitelmanPSMA3/ZNFX1 [14q23.1/20q13.13]  [t(14;20)(q23;q13)]  
Fusion PortalPSMA3 14q23.1 ZNFX1 20q13.13 BRCA
Fusion : QuiverPSMA3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMA3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMA3
dbVarPSMA3
ClinVarPSMA3
1000_GenomesPSMA3 
Exome Variant ServerPSMA3
ExAC (Exome Aggregation Consortium)ENSG00000100567
GNOMAD BrowserENSG00000100567
Varsome BrowserPSMA3
Genetic variants : HAPMAP5684
Genomic Variants (DGV)PSMA3 [DGVbeta]
DECIPHERPSMA3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSMA3 
Mutations
ICGC Data PortalPSMA3 
TCGA Data PortalPSMA3 
Broad Tumor PortalPSMA3
OASIS PortalPSMA3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMA3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMA3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMA3
DgiDB (Drug Gene Interaction Database)PSMA3
DoCM (Curated mutations)PSMA3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMA3 (select a term)
intoGenPSMA3
Cancer3DPSMA3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176843   
Orphanet
DisGeNETPSMA3
MedgenPSMA3
Genetic Testing Registry PSMA3
NextProtP25788 [Medical]
TSGene5684
GENETestsPSMA3
Target ValidationPSMA3
Huge Navigator PSMA3 [HugePedia]
snp3D : Map Gene to Disease5684
BioCentury BCIQPSMA3
ClinGenPSMA3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5684
Chemical/Pharm GKB GenePA33877
Clinical trialPSMA3
Miscellaneous
canSAR (ICR)PSMA3 (select the gene name)
Probes
Litterature
PubMed153 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMA3
EVEXPSMA3
GoPubMedPSMA3
iHOPPSMA3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Jul 30 15:11:18 CEST 2018

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