Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PSMA3 (proteasome subunit alpha 3)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)HC8
Other aliasPSC3
HGNC (Hugo) PSMA3
LocusID (NCBI) 5684
Atlas_Id 54560
Location 14q23.1  [Link to chromosome band 14q23]
Location_base_pair Starts at 58711523 and ends at 58738727 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CTAGE5 (14q21.1) / PSMA3 (14q23.1)PSMA3 (14q23.1) / ACTR10 (14q23.1)PSMA3 (14q23.1) / ZNFX1 (20q13.13)
PSMA3 14q23.1 / ZNFX1 20q13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSMA3   9532
Cards
Entrez_Gene (NCBI)PSMA3  5684  proteasome subunit alpha 3
AliasesHC8; PSC3
GeneCards (Weizmann)PSMA3
Ensembl hg19 (Hinxton)ENSG00000100567 [Gene_View]  chr14:58711523-58738727 [Contig_View]  PSMA3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000100567 [Gene_View]  chr14:58711523-58738727 [Contig_View]  PSMA3 [Vega]
ICGC DataPortalENSG00000100567
TCGA cBioPortalPSMA3
AceView (NCBI)PSMA3
Genatlas (Paris)PSMA3
WikiGenes5684
SOURCE (Princeton)PSMA3
Genetics Home Reference (NIH)PSMA3
Genomic and cartography
GoldenPath hg19 (UCSC)PSMA3  -     chr14:58711523-58738727 +  14q23.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PSMA3  -     14q23.1   [Description]    (hg38-Dec_2013)
EnsemblPSMA3 - 14q23.1 [CytoView hg19]  PSMA3 - 14q23.1 [CytoView hg38]
Mapping of homologs : NCBIPSMA3 [Mapview hg19]  PSMA3 [Mapview hg38]
OMIM176843   
Gene and transcription
Genbank (Entrez)AK315158 BC005265 BC029402 BC038990 BG703488
RefSeq transcript (Entrez)NM_002788 NM_152132
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)PSMA3
Cluster EST : UnigeneHs.558799 [ NCBI ]
CGAP (NCI)Hs.558799
Alternative Splicing GalleryENSG00000100567
Gene ExpressionPSMA3 [ NCBI-GEO ]   PSMA3 [ EBI - ARRAY_EXPRESS ]   PSMA3 [ SEEK ]   PSMA3 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMA3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5684
GTEX Portal (Tissue expression)PSMA3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25788   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP25788  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP25788
Splice isoforms : SwissVarP25788
Catalytic activity : Enzyme3.4.25.1 [ Enzyme-Expasy ]   3.4.25.13.4.25.1 [ IntEnz-EBI ]   3.4.25.1 [ BRENDA ]   3.4.25.1 [ KEGG ]   
PhosPhoSitePlusP25788
Domaine pattern : Prosite (Expaxy)PROTEASOME_ALPHA_1 (PS00388)    PROTEASOME_ALPHA_2 (PS51475)   
Domains : Interpro (EBI)Ntn_hydrolases_N    Proteasome_asu_N    Proteasome_suA-type    Proteasome_sua/b   
Domain families : Pfam (Sanger)Proteasome (PF00227)    Proteasome_A_N (PF10584)   
Domain families : Pfam (NCBI)pfam00227    pfam10584   
Domain families : Smart (EMBL)Proteasome_A_N (SM00948)  
Conserved Domain (NCBI)PSMA3
DMDM Disease mutations5684
Blocks (Seattle)PSMA3
PDB (SRS)4R3O    4R67    5A0Q    5DSV   
PDB (PDBSum)4R3O    4R67    5A0Q    5DSV   
PDB (IMB)4R3O    4R67    5A0Q    5DSV   
PDB (RSDB)4R3O    4R67    5A0Q    5DSV   
Structural Biology KnowledgeBase4R3O    4R67    5A0Q    5DSV   
SCOP (Structural Classification of Proteins)4R3O    4R67    5A0Q    5DSV   
CATH (Classification of proteins structures)4R3O    4R67    5A0Q    5DSV   
SuperfamilyP25788
Human Protein AtlasENSG00000100567
Peptide AtlasP25788
HPRD01463
IPIIPI00419249   IPI00171199   IPI01025990   IPI01026074   IPI01025741   IPI01025628   
Protein Interaction databases
DIP (DOE-UCLA)P25788
IntAct (EBI)P25788
FunCoupENSG00000100567
BioGRIDPSMA3
STRING (EMBL)PSMA3
ZODIACPSMA3
Ontologies - Pathways
QuickGOP25788
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  threonine-type endopeptidase activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  proteasome core complex  regulation of cellular amino acid metabolic process  viral process  proteasome core complex, alpha-subunit complex  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  regulation of endopeptidase activity  Wnt signaling pathway, planar cell polarity pathway  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  threonine-type endopeptidase activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  proteasome core complex  regulation of cellular amino acid metabolic process  viral process  proteasome core complex, alpha-subunit complex  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  regulation of endopeptidase activity  Wnt signaling pathway, planar cell polarity pathway  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  
Pathways : KEGGProteasome   
NDEx NetworkPSMA3
Atlas of Cancer Signalling NetworkPSMA3
Wikipedia pathwaysPSMA3
Orthology - Evolution
OrthoDB5684
GeneTree (enSembl)ENSG00000100567
Phylogenetic Trees/Animal Genes : TreeFamPSMA3
HOVERGENP25788
HOGENOMP25788
Homologs : HomoloGenePSMA3
Homology/Alignments : Family Browser (UCSC)PSMA3
Gene fusions - Rearrangements
Fusion : MitelmanCTAGE5/PSMA3 [14q21.1/14q23.1]  [t(14;14)(q21;q23)]  
Fusion : MitelmanPSMA3/ZNFX1 [14q23.1/20q13.13]  [t(14;20)(q23;q13)]  
Fusion: TCGAPSMA3 14q23.1 ZNFX1 20q13.13 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMA3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMA3
dbVarPSMA3
ClinVarPSMA3
1000_GenomesPSMA3 
Exome Variant ServerPSMA3
ExAC (Exome Aggregation Consortium)PSMA3 (select the gene name)
Genetic variants : HAPMAP5684
Genomic Variants (DGV)PSMA3 [DGVbeta]
DECIPHER (Syndromes)14:58711523-58738727  ENSG00000100567
CONAN: Copy Number AnalysisPSMA3 
Mutations
ICGC Data PortalPSMA3 
TCGA Data PortalPSMA3 
Broad Tumor PortalPSMA3
OASIS PortalPSMA3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMA3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMA3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMA3
DgiDB (Drug Gene Interaction Database)PSMA3
DoCM (Curated mutations)PSMA3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMA3 (select a term)
intoGenPSMA3
Cancer3DPSMA3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176843   
Orphanet
MedgenPSMA3
Genetic Testing Registry PSMA3
NextProtP25788 [Medical]
TSGene5684
GENETestsPSMA3
Huge Navigator PSMA3 [HugePedia]
snp3D : Map Gene to Disease5684
BioCentury BCIQPSMA3
ClinGenPSMA3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5684
Chemical/Pharm GKB GenePA33877
Clinical trialPSMA3
Miscellaneous
canSAR (ICR)PSMA3 (select the gene name)
Probes
Litterature
PubMed139 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMA3
EVEXPSMA3
GoPubMedPSMA3
iHOPPSMA3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:15:57 CEST 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.