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PSMA4 (proteasome subunit alpha 4)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)HC9
HsT17706
Other aliasPSC9
HGNC (Hugo) PSMA4
LocusID (NCBI) 5685
Atlas_Id 55047
Location 15q25.1  [Link to chromosome band 15q25]
Location_base_pair Starts at 78832747 and ends at 78841563 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PSMA4 (15q25.1) / CHRNA5 (15q25.1)PSMA4 (15q25.1) / PSAP (10q22.1)RAB31 (18p11.22) / PSMA4 (15q25.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSMA4   9533
Cards
Entrez_Gene (NCBI)PSMA4  5685  proteasome subunit alpha 4
AliasesHC9; HsT17706; PSC9
GeneCards (Weizmann)PSMA4
Ensembl hg19 (Hinxton)ENSG00000041357 [Gene_View]  chr15:78832747-78841563 [Contig_View]  PSMA4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000041357 [Gene_View]  chr15:78832747-78841563 [Contig_View]  PSMA4 [Vega]
ICGC DataPortalENSG00000041357
TCGA cBioPortalPSMA4
AceView (NCBI)PSMA4
Genatlas (Paris)PSMA4
WikiGenes5685
SOURCE (Princeton)PSMA4
Genetics Home Reference (NIH)PSMA4
Genomic and cartography
GoldenPath hg19 (UCSC)PSMA4  -     chr15:78832747-78841563 +  15q25.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PSMA4  -     15q25.1   [Description]    (hg38-Dec_2013)
EnsemblPSMA4 - 15q25.1 [CytoView hg19]  PSMA4 - 15q25.1 [CytoView hg38]
Mapping of homologs : NCBIPSMA4 [Mapview hg19]  PSMA4 [Mapview hg38]
OMIM176846   
Gene and transcription
Genbank (Entrez)AK055714 AK315526 AL110100 BC001490 BC005361
RefSeq transcript (Entrez)NM_001102667 NM_001102668 NM_002789
RefSeq genomic (Entrez)NC_000015 NC_018926 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)PSMA4
Cluster EST : UnigeneHs.251531 [ NCBI ]
CGAP (NCI)Hs.251531
Alternative Splicing GalleryENSG00000041357
Gene ExpressionPSMA4 [ NCBI-GEO ]   PSMA4 [ EBI - ARRAY_EXPRESS ]   PSMA4 [ SEEK ]   PSMA4 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMA4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5685
GTEX Portal (Tissue expression)PSMA4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25789   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP25789  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP25789
Splice isoforms : SwissVarP25789
Catalytic activity : Enzyme3.4.25.1 [ Enzyme-Expasy ]   3.4.25.13.4.25.1 [ IntEnz-EBI ]   3.4.25.1 [ BRENDA ]   3.4.25.1 [ KEGG ]   
PhosPhoSitePlusP25789
Domaine pattern : Prosite (Expaxy)PROTEASOME_ALPHA_1 (PS00388)    PROTEASOME_ALPHA_2 (PS51475)   
Domains : Interpro (EBI)Ntn_hydrolases_N    Proteasome_asu_N    Proteasome_bsu_CS    Proteasome_suA-type    Proteasome_sua/b   
Domain families : Pfam (Sanger)Proteasome (PF00227)    Proteasome_A_N (PF10584)   
Domain families : Pfam (NCBI)pfam00227    pfam10584   
Domain families : Smart (EMBL)Proteasome_A_N (SM00948)  
Conserved Domain (NCBI)PSMA4
DMDM Disease mutations5685
Blocks (Seattle)PSMA4
PDB (SRS)4R3O    4R67    5A0Q   
PDB (PDBSum)4R3O    4R67    5A0Q   
PDB (IMB)4R3O    4R67    5A0Q   
PDB (RSDB)4R3O    4R67    5A0Q   
Structural Biology KnowledgeBase4R3O    4R67    5A0Q   
SCOP (Structural Classification of Proteins)4R3O    4R67    5A0Q   
CATH (Classification of proteins structures)4R3O    4R67    5A0Q   
SuperfamilyP25789
Human Protein AtlasENSG00000041357
Peptide AtlasP25789
HPRD10168
IPIIPI00299155   IPI00792218   
Protein Interaction databases
DIP (DOE-UCLA)P25789
IntAct (EBI)P25789
FunCoupENSG00000041357
BioGRIDPSMA4
STRING (EMBL)PSMA4
ZODIACPSMA4
Ontologies - Pathways
QuickGOP25789
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  cytoplasmic mRNA processing body  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  threonine-type endopeptidase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  proteasome core complex  regulation of cellular amino acid metabolic process  viral process  proteasome core complex, alpha-subunit complex  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  intracellular membrane-bounded organelle  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  Wnt signaling pathway, planar cell polarity pathway  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  cytoplasmic mRNA processing body  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  threonine-type endopeptidase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  proteasome core complex  regulation of cellular amino acid metabolic process  viral process  proteasome core complex, alpha-subunit complex  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  intracellular membrane-bounded organelle  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  Wnt signaling pathway, planar cell polarity pathway  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  
Pathways : KEGGProteasome   
NDEx NetworkPSMA4
Atlas of Cancer Signalling NetworkPSMA4
Wikipedia pathwaysPSMA4
Orthology - Evolution
OrthoDB5685
GeneTree (enSembl)ENSG00000041357
Phylogenetic Trees/Animal Genes : TreeFamPSMA4
HOVERGENP25789
HOGENOMP25789
Homologs : HomoloGenePSMA4
Homology/Alignments : Family Browser (UCSC)PSMA4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMA4
dbVarPSMA4
ClinVarPSMA4
1000_GenomesPSMA4 
Exome Variant ServerPSMA4
ExAC (Exome Aggregation Consortium)PSMA4 (select the gene name)
Genetic variants : HAPMAP5685
Genomic Variants (DGV)PSMA4 [DGVbeta]
DECIPHER (Syndromes)15:78832747-78841563  ENSG00000041357
CONAN: Copy Number AnalysisPSMA4 
Mutations
ICGC Data PortalPSMA4 
TCGA Data PortalPSMA4 
Broad Tumor PortalPSMA4
OASIS PortalPSMA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMA4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMA4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMA4
DgiDB (Drug Gene Interaction Database)PSMA4
DoCM (Curated mutations)PSMA4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMA4 (select a term)
intoGenPSMA4
Cancer3DPSMA4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176846   
Orphanet
MedgenPSMA4
Genetic Testing Registry PSMA4
NextProtP25789 [Medical]
TSGene5685
GENETestsPSMA4
Huge Navigator PSMA4 [HugePedia]
snp3D : Map Gene to Disease5685
BioCentury BCIQPSMA4
ClinGenPSMA4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5685
Chemical/Pharm GKB GenePA33878
Clinical trialPSMA4
Miscellaneous
canSAR (ICR)PSMA4 (select the gene name)
Probes
Litterature
PubMed104 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMA4
EVEXPSMA4
GoPubMedPSMA4
iHOPPSMA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:23:17 CET 2017

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