Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PSMA4 (proteasome subunit alpha 4)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)HC9
HsT17706
Other aliasPSC9
HGNC (Hugo) PSMA4
LocusID (NCBI) 5685
Atlas_Id 55047
Location 15q25.1  [Link to chromosome band 15q25]
Location_base_pair Starts at 78540405 and ends at 78549262 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PSMA4 (15q25.1) / CHRNA5 (15q25.1)PSMA4 (15q25.1) / PSAP (10q22.1)RAB31 (18p11.22) / PSMA4 (15q25.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSMA4   9533
Cards
Entrez_Gene (NCBI)PSMA4  5685  proteasome subunit alpha 4
AliasesHC9; HsT17706; PSC9
GeneCards (Weizmann)PSMA4
Ensembl hg19 (Hinxton)ENSG00000041357 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000041357 [Gene_View]  chr15:78540405-78549262 [Contig_View]  PSMA4 [Vega]
ICGC DataPortalENSG00000041357
TCGA cBioPortalPSMA4
AceView (NCBI)PSMA4
Genatlas (Paris)PSMA4
WikiGenes5685
SOURCE (Princeton)PSMA4
Genetics Home Reference (NIH)PSMA4
Genomic and cartography
GoldenPath hg38 (UCSC)PSMA4  -     chr15:78540405-78549262 +  15q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSMA4  -     15q25.1   [Description]    (hg19-Feb_2009)
EnsemblPSMA4 - 15q25.1 [CytoView hg19]  PSMA4 - 15q25.1 [CytoView hg38]
Mapping of homologs : NCBIPSMA4 [Mapview hg19]  PSMA4 [Mapview hg38]
OMIM176846   
Gene and transcription
Genbank (Entrez)AK055714 AK315526 AL110100 BC001490 BC005361
RefSeq transcript (Entrez)NM_001102667 NM_001102668 NM_001330673 NM_001330675 NM_001330676 NM_002789
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSMA4
Cluster EST : UnigeneHs.251531 [ NCBI ]
CGAP (NCI)Hs.251531
Alternative Splicing GalleryENSG00000041357
Gene ExpressionPSMA4 [ NCBI-GEO ]   PSMA4 [ EBI - ARRAY_EXPRESS ]   PSMA4 [ SEEK ]   PSMA4 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMA4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5685
GTEX Portal (Tissue expression)PSMA4
Human Protein AtlasENSG00000041357-PSMA4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25789   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP25789  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP25789
Splice isoforms : SwissVarP25789
PhosPhoSitePlusP25789
Domaine pattern : Prosite (Expaxy)PROTEASOME_ALPHA_1 (PS00388)    PROTEASOME_ALPHA_2 (PS51475)   
Domains : Interpro (EBI)Ntn_hydrolases_N    Proteasome_asu_N    Proteasome_bsu_CS    Proteasome_suA-type    Proteasome_sua/b   
Domain families : Pfam (Sanger)Proteasome (PF00227)    Proteasome_A_N (PF10584)   
Domain families : Pfam (NCBI)pfam00227    pfam10584   
Domain families : Smart (EMBL)Proteasome_A_N (SM00948)  
Conserved Domain (NCBI)PSMA4
DMDM Disease mutations5685
Blocks (Seattle)PSMA4
PDB (SRS)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (PDBSum)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (IMB)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (RSDB)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
Structural Biology KnowledgeBase4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
SCOP (Structural Classification of Proteins)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
CATH (Classification of proteins structures)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
SuperfamilyP25789
Human Protein Atlas [tissue]ENSG00000041357-PSMA4 [tissue]
Peptide AtlasP25789
HPRD10168
IPIIPI00299155   IPI00792218   
Protein Interaction databases
DIP (DOE-UCLA)P25789
IntAct (EBI)P25789
FunCoupENSG00000041357
BioGRIDPSMA4
STRING (EMBL)PSMA4
ZODIACPSMA4
Ontologies - Pathways
QuickGOP25789
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  P-body  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  threonine-type endopeptidase activity  protein binding  nucleus  nucleoplasm  cytosol  cytosol  proteasome core complex  regulation of cellular amino acid metabolic process  negative regulation of G2/M transition of mitotic cell cycle  viral process  protein deubiquitination  proteasome core complex, alpha-subunit complex  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  intracellular membrane-bounded organelle  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  P-body  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  threonine-type endopeptidase activity  protein binding  nucleus  nucleoplasm  cytosol  cytosol  proteasome core complex  regulation of cellular amino acid metabolic process  negative regulation of G2/M transition of mitotic cell cycle  viral process  protein deubiquitination  proteasome core complex, alpha-subunit complex  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  intracellular membrane-bounded organelle  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  
Pathways : KEGGProteasome   
NDEx NetworkPSMA4
Atlas of Cancer Signalling NetworkPSMA4
Wikipedia pathwaysPSMA4
Orthology - Evolution
OrthoDB5685
GeneTree (enSembl)ENSG00000041357
Phylogenetic Trees/Animal Genes : TreeFamPSMA4
HOVERGENP25789
HOGENOMP25789
Homologs : HomoloGenePSMA4
Homology/Alignments : Family Browser (UCSC)PSMA4
Gene fusions - Rearrangements
Tumor Fusion PortalPSMA4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMA4
dbVarPSMA4
ClinVarPSMA4
1000_GenomesPSMA4 
Exome Variant ServerPSMA4
ExAC (Exome Aggregation Consortium)ENSG00000041357
GNOMAD BrowserENSG00000041357
Genetic variants : HAPMAP5685
Genomic Variants (DGV)PSMA4 [DGVbeta]
DECIPHERPSMA4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSMA4 
Mutations
ICGC Data PortalPSMA4 
TCGA Data PortalPSMA4 
Broad Tumor PortalPSMA4
OASIS PortalPSMA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMA4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMA4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMA4
DgiDB (Drug Gene Interaction Database)PSMA4
DoCM (Curated mutations)PSMA4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMA4 (select a term)
intoGenPSMA4
Cancer3DPSMA4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176846   
Orphanet
DisGeNETPSMA4
MedgenPSMA4
Genetic Testing Registry PSMA4
NextProtP25789 [Medical]
TSGene5685
GENETestsPSMA4
Target ValidationPSMA4
Huge Navigator PSMA4 [HugePedia]
snp3D : Map Gene to Disease5685
BioCentury BCIQPSMA4
ClinGenPSMA4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5685
Chemical/Pharm GKB GenePA33878
Clinical trialPSMA4
Miscellaneous
canSAR (ICR)PSMA4 (select the gene name)
Probes
Litterature
PubMed108 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMA4
EVEXPSMA4
GoPubMedPSMA4
iHOPPSMA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:30:40 CET 2017

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