Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PSMA6 (proteasome subunit alpha 6)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)IOTA
PROS27
p27K
MGC22756
MGC2333
MGC23846
Other alias
HGNC (Hugo) PSMA6
LocusID (NCBI) 5687
Atlas_Id 52053
Location 14q13.2  [Link to chromosome band 14q13]
Location_base_pair Starts at 35292317 and ends at 35317479 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PSMA6 (14q13.2) / KIAA0391 (14q13.2)PSMA6 (14q13.2) / PRKD1 (14q12)VMP1 (17q23.1) / PSMA6 (14q13.2)
PSMA6 14q13.2 / PRKD1 14q12VMP1 17q23.1 / PSMA6 14q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSMA6   9535
Cards
Entrez_Gene (NCBI)PSMA6  5687  proteasome subunit alpha 6
AliasesIOTA; PROS27; p27K
GeneCards (Weizmann)PSMA6
Ensembl hg19 (Hinxton)ENSG00000100902 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100902 [Gene_View]  chr14:35292317-35317479 [Contig_View]  PSMA6 [Vega]
ICGC DataPortalENSG00000100902
TCGA cBioPortalPSMA6
AceView (NCBI)PSMA6
Genatlas (Paris)PSMA6
WikiGenes5687
SOURCE (Princeton)PSMA6
Genetics Home Reference (NIH)PSMA6
Genomic and cartography
GoldenPath hg38 (UCSC)PSMA6  -     chr14:35292317-35317479 +  14q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSMA6  -     14q13.2   [Description]    (hg19-Feb_2009)
EnsemblPSMA6 - 14q13.2 [CytoView hg19]  PSMA6 - 14q13.2 [CytoView hg38]
Mapping of homologs : NCBIPSMA6 [Mapview hg19]  PSMA6 [Mapview hg38]
OMIM602855   608446   
Gene and transcription
Genbank (Entrez)AA090836 AK298920 AK302008 AK313011 AK316223
RefSeq transcript (Entrez)NM_001282232 NM_001282233 NM_001282234 NM_002791
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSMA6
Cluster EST : UnigeneHs.446260 [ NCBI ]
CGAP (NCI)Hs.446260
Alternative Splicing GalleryENSG00000100902
Gene ExpressionPSMA6 [ NCBI-GEO ]   PSMA6 [ EBI - ARRAY_EXPRESS ]   PSMA6 [ SEEK ]   PSMA6 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMA6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5687
GTEX Portal (Tissue expression)PSMA6
Protein : pattern, domain, 3D structure
UniProt/SwissProtP60900   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP60900  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP60900
Splice isoforms : SwissVarP60900
PhosPhoSitePlusP60900
Domaine pattern : Prosite (Expaxy)PROTEASOME_ALPHA_1 (PS00388)    PROTEASOME_ALPHA_2 (PS51475)   
Domains : Interpro (EBI)Ntn_hydrolases_N    Proteasome_asu_N    Proteasome_suA-type    Proteasome_sua/b   
Domain families : Pfam (Sanger)Proteasome (PF00227)    Proteasome_A_N (PF10584)   
Domain families : Pfam (NCBI)pfam00227    pfam10584   
Domain families : Smart (EMBL)Proteasome_A_N (SM00948)  
Conserved Domain (NCBI)PSMA6
DMDM Disease mutations5687
Blocks (Seattle)PSMA6
PDB (SRS)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (PDBSum)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (IMB)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (RSDB)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
Structural Biology KnowledgeBase4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
SCOP (Structural Classification of Proteins)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
CATH (Classification of proteins structures)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
SuperfamilyP60900
Human Protein AtlasENSG00000100902
Peptide AtlasP60900
HPRD04171
IPIIPI00029623   IPI00867679   IPI01026111   IPI01026013   IPI01025425   IPI01025279   IPI01025847   IPI01025632   IPI01025521   IPI01024911   
Protein Interaction databases
DIP (DOE-UCLA)P60900
IntAct (EBI)P60900
FunCoupENSG00000100902
BioGRIDPSMA6
STRING (EMBL)PSMA6
ZODIACPSMA6
Ontologies - Pathways
QuickGOP60900
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  P-body  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  RNA binding  RNA binding  endopeptidase activity  threonine-type endopeptidase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytosol  cytosol  proteasome core complex  proteasome core complex  polysome  regulation of cellular amino acid metabolic process  negative regulation of G2/M transition of mitotic cell cycle  nuclear matrix  protein deubiquitination  proteasome core complex, alpha-subunit complex  proteasome core complex, alpha-subunit complex  myofibril  sarcomere  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  purine ribonucleoside triphosphate binding  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  regulation of inflammatory response  T cell receptor signaling pathway  NF-kappaB binding  positive regulation of NF-kappaB transcription factor activity  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  proteolysis involved in cellular protein catabolic process  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  P-body  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  RNA binding  RNA binding  endopeptidase activity  threonine-type endopeptidase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytosol  cytosol  proteasome core complex  proteasome core complex  polysome  regulation of cellular amino acid metabolic process  negative regulation of G2/M transition of mitotic cell cycle  nuclear matrix  protein deubiquitination  proteasome core complex, alpha-subunit complex  proteasome core complex, alpha-subunit complex  myofibril  sarcomere  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  purine ribonucleoside triphosphate binding  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  regulation of inflammatory response  T cell receptor signaling pathway  NF-kappaB binding  positive regulation of NF-kappaB transcription factor activity  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  proteolysis involved in cellular protein catabolic process  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  
Pathways : KEGGProteasome   
NDEx NetworkPSMA6
Atlas of Cancer Signalling NetworkPSMA6
Wikipedia pathwaysPSMA6
Orthology - Evolution
OrthoDB5687
GeneTree (enSembl)ENSG00000100902
Phylogenetic Trees/Animal Genes : TreeFamPSMA6
HOVERGENP60900
HOGENOMP60900
Homologs : HomoloGenePSMA6
Homology/Alignments : Family Browser (UCSC)PSMA6
Gene fusions - Rearrangements
Fusion : MitelmanPSMA6/PRKD1 [14q13.2/14q12]  
Fusion : MitelmanVMP1/PSMA6 [17q23.1/14q13.2]  [t(14;17)(q13;q23)]  
Fusion: TCGAPSMA6 14q13.2 PRKD1 14q12 LGG
Fusion: TCGAVMP1 17q23.1 PSMA6 14q13.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMA6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMA6
dbVarPSMA6
ClinVarPSMA6
1000_GenomesPSMA6 
Exome Variant ServerPSMA6
ExAC (Exome Aggregation Consortium)PSMA6 (select the gene name)
Genetic variants : HAPMAP5687
Genomic Variants (DGV)PSMA6 [DGVbeta]
DECIPHERPSMA6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSMA6 
Mutations
ICGC Data PortalPSMA6 
TCGA Data PortalPSMA6 
Broad Tumor PortalPSMA6
OASIS PortalPSMA6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMA6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMA6
intOGen PortalPSMA6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMA6
DgiDB (Drug Gene Interaction Database)PSMA6
DoCM (Curated mutations)PSMA6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMA6 (select a term)
intoGenPSMA6
Cancer3DPSMA6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602855    608446   
Orphanet
MedgenPSMA6
Genetic Testing Registry PSMA6
NextProtP60900 [Medical]
TSGene5687
GENETestsPSMA6
Huge Navigator PSMA6 [HugePedia]
snp3D : Map Gene to Disease5687
BioCentury BCIQPSMA6
ClinGenPSMA6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5687
Chemical/Pharm GKB GenePA33880
Clinical trialPSMA6
Miscellaneous
canSAR (ICR)PSMA6 (select the gene name)
Probes
Litterature
PubMed154 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMA6
EVEXPSMA6
GoPubMedPSMA6
iHOPPSMA6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:33:10 CEST 2017

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