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PSMA6 (proteasome (prosome, macropain) subunit, alpha type, 6)

Identity

Other namesIOTA
PROS27
p27K
HGNC (Hugo) PSMA6
LocusID (NCBI) 5687
Location 14q13.2
Location_base_pair Starts at 35761523 and ends at 35786685 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)PSMA6   9535
Cards
Entrez_Gene (NCBI)PSMA6  5687  proteasome (prosome, macropain) subunit, alpha type, 6
GeneCards (Weizmann)PSMA6
Ensembl (Hinxton)ENSG00000100902 [Gene_View]  chr14:35761523-35786685 [Contig_View]  PSMA6 [Vega]
ICGC DataPortalENSG00000100902
cBioPortalPSMA6
AceView (NCBI)PSMA6
Genatlas (Paris)PSMA6
WikiGenes5687
SOURCE (Princeton)NM_001282232 NM_001282233 NM_001282234 NM_002791
Genomic and cartography
GoldenPath (UCSC)PSMA6  -  14q13.2   chr14:35761523-35786685 +  14q13.2   [Description]    (hg19-Feb_2009)
EnsemblPSMA6 - 14q13.2 [CytoView]
Mapping of homologs : NCBIPSMA6 [Mapview]
OMIM602855   608446   
Gene and transcription
Genbank (Entrez)AA090836 AK298920 AK302008 AK313011 AK316223
RefSeq transcript (Entrez)NM_001282232 NM_001282233 NM_001282234 NM_002791
RefSeq genomic (Entrez)AC_000146 NC_000014 NC_018925 NG_011703 NT_026437 NW_001838110 NW_004929393
Consensus coding sequences : CCDS (NCBI)PSMA6
Cluster EST : UnigeneHs.446260 [ NCBI ]
CGAP (NCI)Hs.446260
Alternative Splicing : Fast-db (Paris)GSHG0008788
Alternative Splicing GalleryENSG00000100902
Gene ExpressionPSMA6 [ NCBI-GEO ]     PSMA6 [ SEEK ]   PSMA6 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP60900 (Uniprot)
NextProtP60900  [Medical]
With graphics : InterProP60900
Splice isoforms : SwissVarP60900 (Swissvar)
Catalytic activity : Enzyme3.4.25.1 [ Enzyme-Expasy ]   3.4.25.13.4.25.1 [ IntEnz-EBI ]   3.4.25.1 [ BRENDA ]   3.4.25.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEASOME_ALPHA_1 (PS00388)    PROTEASOME_ALPHA_2 (PS51475)   
Domains : Interpro (EBI)Ntn_hydrolases_N [organisation]   Proteasome_asu_N [organisation]   Proteasome_suA-type [organisation]   Proteasome_sua/b [organisation]  
Related proteins : CluSTrP60900
Domain families : Pfam (Sanger)Proteasome (PF00227)    Proteasome_A_N (PF10584)   
Domain families : Pfam (NCBI)pfam00227    pfam10584   
Domain families : Smart (EMBL)Proteasome_A_N (SM00948)  
DMDM Disease mutations5687
Blocks (Seattle)P60900
Human Protein AtlasENSG00000100902 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP60900
HPRD04171
IPIIPI00029623   IPI00867679   IPI01026111   IPI01026013   IPI01025425   IPI01025279   IPI01025847   IPI01025632   IPI01025521   IPI01024911   
Protein Interaction databases
DIP (DOE-UCLA)P60900
IntAct (EBI)P60900
FunCoupENSG00000100902
BioGRIDPSMA6
InParanoidP60900
Interologous Interaction database P60900
IntegromeDBPSMA6
STRING (EMBL)PSMA6
Ontologies - Pathways
Ontology : AmiGOG1/S transition of mitotic cell cycle  protein polyubiquitination  mitotic cell cycle  cytoplasmic mRNA processing body  antigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  RNA binding  RNA binding  endopeptidase activity  threonine-type endopeptidase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  proteasome core complex  proteasome core complex  polysome  regulation of cellular amino acid metabolic process  apoptotic process  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  gene expression  viral process  RNA metabolic process  mRNA metabolic process  nuclear matrix  proteasome core complex, alpha-subunit complex  proteasome core complex, alpha-subunit complex  myofibril  sarcomere  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  cellular nitrogen compound metabolic process  purine ribonucleoside triphosphate binding  antigen processing and presentation of exogenous peptide antigen via MHC class I  regulation of apoptotic process  negative regulation of apoptotic process  small molecule metabolic process  regulation of inflammatory response  NF-kappaB binding  positive regulation of NF-kappaB transcription factor activity  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  proteolysis involved in cellular protein catabolic process  extracellular vesicular exosome  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  protein polyubiquitination  mitotic cell cycle  cytoplasmic mRNA processing body  antigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  RNA binding  RNA binding  endopeptidase activity  threonine-type endopeptidase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  proteasome core complex  proteasome core complex  polysome  regulation of cellular amino acid metabolic process  apoptotic process  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  gene expression  viral process  RNA metabolic process  mRNA metabolic process  nuclear matrix  proteasome core complex, alpha-subunit complex  proteasome core complex, alpha-subunit complex  myofibril  sarcomere  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  cellular nitrogen compound metabolic process  purine ribonucleoside triphosphate binding  antigen processing and presentation of exogenous peptide antigen via MHC class I  regulation of apoptotic process  negative regulation of apoptotic process  small molecule metabolic process  regulation of inflammatory response  NF-kappaB binding  positive regulation of NF-kappaB transcription factor activity  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  proteolysis involved in cellular protein catabolic process  extracellular vesicular exosome  
Pathways : KEGGProteasome   
Protein Interaction DatabasePSMA6
Wikipedia pathwaysPSMA6
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PSMA6
snp3D : Map Gene to Disease5687
SNP (GeneSNP Utah)PSMA6
SNP : HGBasePSMA6
Genetic variants : HAPMAPPSMA6
Exome VariantPSMA6
1000_GenomesPSMA6 
ICGC programENSG00000100902 
Somatic Mutations in Cancer : COSMICPSMA6 
CONAN: Copy Number AnalysisPSMA6 
Mutations and Diseases : HGMDPSMA6
Mutations and Diseases : intOGenPSMA6
Genomic VariantsPSMA6  PSMA6 [DGVbeta]
dbVarPSMA6
ClinVarPSMA6
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM602855    608446   
MedgenPSMA6
GENETestsPSMA6
Disease Genetic AssociationPSMA6
Huge Navigator PSMA6 [HugePedia]  PSMA6 [HugeCancerGEM]
General knowledge
Homologs : HomoloGenePSMA6
Homology/Alignments : Family Browser (UCSC)PSMA6
Phylogenetic Trees/Animal Genes : TreeFamPSMA6
Chemical/Protein Interactions : CTD5687
Chemical/Pharm GKB GenePA33880
Clinical trialPSMA6
Cancer Resource (Charite)ENSG00000100902
Other databases
Probes
Litterature
PubMed129 Pubmed reference(s) in Entrez
CoreMinePSMA6
iHOPPSMA6
OncoSearchPSMA6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 17:01:27 CEST 2014

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