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PSMA6 (proteasome subunit alpha 6)

Identity

Other namesIOTA
PROS27
p27K
HGNC (Hugo) PSMA6
LocusID (NCBI) 5687
Atlas_Id 52053
Location 14q13.2
Location_base_pair Starts at 35761523 and ends at 35786685 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PSMA6 (14q13.2) / KIAA0391 (14q13.2)PSMA6 (14q13.2) / PRKD1 (14q12)VMP1 (17q23.1) / PSMA6 (14q13.2)
PSMA6 14q13.2 / PRKD1 14q12VMP1 17q23.1 / PSMA6 14q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSMA6   9535
Cards
Entrez_Gene (NCBI)PSMA6  5687  proteasome subunit alpha 6
AliasesIOTA; PROS27; p27K
GeneCards (Weizmann)PSMA6
Ensembl hg19 (Hinxton)ENSG00000100902 [Gene_View]  chr14:35761523-35786685 [Contig_View]  PSMA6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000100902 [Gene_View]  chr14:35761523-35786685 [Contig_View]  PSMA6 [Vega]
ICGC DataPortalENSG00000100902
TCGA cBioPortalPSMA6
AceView (NCBI)PSMA6
Genatlas (Paris)PSMA6
WikiGenes5687
SOURCE (Princeton)PSMA6
Genomic and cartography
GoldenPath hg19 (UCSC)PSMA6  -     chr14:35761523-35786685 +  14q13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PSMA6  -     14q13.2   [Description]    (hg38-Dec_2013)
EnsemblPSMA6 - 14q13.2 [CytoView hg19]  PSMA6 - 14q13.2 [CytoView hg38]
Mapping of homologs : NCBIPSMA6 [Mapview hg19]  PSMA6 [Mapview hg38]
OMIM602855   608446   
Gene and transcription
Genbank (Entrez)AA090836 AK298920 AK302008 AK313011 AK316223
RefSeq transcript (Entrez)NM_001282232 NM_001282233 NM_001282234 NM_002791
RefSeq genomic (Entrez)NC_000014 NC_018925 NG_011703 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)PSMA6
Cluster EST : UnigeneHs.446260 [ NCBI ]
CGAP (NCI)Hs.446260
Alternative Splicing GalleryENSG00000100902
Gene ExpressionPSMA6 [ NCBI-GEO ]   PSMA6 [ EBI - ARRAY_EXPRESS ]   PSMA6 [ SEEK ]   PSMA6 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMA6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5687
GTEX Portal (Tissue expression)PSMA6
Protein : pattern, domain, 3D structure
UniProt/SwissProtP60900 (Uniprot)
NextProtP60900  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP60900
Splice isoforms : SwissVarP60900 (Swissvar)
Catalytic activity : Enzyme3.4.25.1 [ Enzyme-Expasy ]   3.4.25.13.4.25.1 [ IntEnz-EBI ]   3.4.25.1 [ BRENDA ]   3.4.25.1 [ KEGG ]   
PhosPhoSitePlusP60900
Domaine pattern : Prosite (Expaxy)PROTEASOME_ALPHA_1 (PS00388)    PROTEASOME_ALPHA_2 (PS51475)   
Domains : Interpro (EBI)Ntn_hydrolases_N    Proteasome_asu_N    Proteasome_suA-type    Proteasome_sua/b   
Domain families : Pfam (Sanger)Proteasome (PF00227)    Proteasome_A_N (PF10584)   
Domain families : Pfam (NCBI)pfam00227    pfam10584   
Domain families : Smart (EMBL)Proteasome_A_N (SM00948)  
DMDM Disease mutations5687
Blocks (Seattle)PSMA6
PDB (SRS)4R3O    4R67    5A0Q   
PDB (PDBSum)4R3O    4R67    5A0Q   
PDB (IMB)4R3O    4R67    5A0Q   
PDB (RSDB)4R3O    4R67    5A0Q   
Structural Biology KnowledgeBase4R3O    4R67    5A0Q   
SCOP (Structural Classification of Proteins)4R3O    4R67    5A0Q   
CATH (Classification of proteins structures)4R3O    4R67    5A0Q   
SuperfamilyP60900
Human Protein AtlasENSG00000100902
Peptide AtlasP60900
HPRD04171
IPIIPI00029623   IPI00867679   IPI01026111   IPI01026013   IPI01025425   IPI01025279   IPI01025847   IPI01025632   IPI01025521   IPI01024911   
Protein Interaction databases
DIP (DOE-UCLA)P60900
IntAct (EBI)P60900
FunCoupENSG00000100902
BioGRIDPSMA6
STRING (EMBL)PSMA6
ZODIACPSMA6
Ontologies - Pathways
QuickGOP60900
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  cytoplasmic mRNA processing body  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  RNA binding  RNA binding  endopeptidase activity  threonine-type endopeptidase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  proteasome core complex  proteasome core complex  polysome  regulation of cellular amino acid metabolic process  nuclear matrix  proteasome core complex, alpha-subunit complex  proteasome core complex, alpha-subunit complex  myofibril  sarcomere  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  purine ribonucleoside triphosphate binding  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  regulation of inflammatory response  T cell receptor signaling pathway  NF-kappaB binding  positive regulation of NF-kappaB transcription factor activity  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  proteolysis involved in cellular protein catabolic process  Wnt signaling pathway, planar cell polarity pathway  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  cytoplasmic mRNA processing body  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  RNA binding  RNA binding  endopeptidase activity  threonine-type endopeptidase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  proteasome core complex  proteasome core complex  polysome  regulation of cellular amino acid metabolic process  nuclear matrix  proteasome core complex, alpha-subunit complex  proteasome core complex, alpha-subunit complex  myofibril  sarcomere  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  purine ribonucleoside triphosphate binding  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  regulation of inflammatory response  T cell receptor signaling pathway  NF-kappaB binding  positive regulation of NF-kappaB transcription factor activity  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  proteolysis involved in cellular protein catabolic process  Wnt signaling pathway, planar cell polarity pathway  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  
Pathways : KEGGProteasome   
NDEx Network
Atlas of Cancer Signalling NetworkPSMA6
Wikipedia pathwaysPSMA6
Orthology - Evolution
OrthoDB5687
GeneTree (enSembl)ENSG00000100902
Phylogenetic Trees/Animal Genes : TreeFamPSMA6
Homologs : HomoloGenePSMA6
Homology/Alignments : Family Browser (UCSC)PSMA6
Gene fusions - Rearrangements
Fusion: TCGAPSMA6 14q13.2 PRKD1 14q12 LGG
Fusion: TCGAVMP1 17q23.1 PSMA6 14q13.2 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerPSMA6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMA6
dbVarPSMA6
ClinVarPSMA6
1000_GenomesPSMA6 
Exome Variant ServerPSMA6
ExAC (Exome Aggregation Consortium)PSMA6 (select the gene name)
Genetic variants : HAPMAP5687
Genomic Variants (DGV)PSMA6 [DGVbeta]
Mutations
ICGC Data PortalPSMA6 
TCGA Data PortalPSMA6 
Broad Tumor PortalPSMA6
OASIS PortalPSMA6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMA6 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMA6
DgiDB (Drug Gene Interaction Database)PSMA6
DoCM (Curated mutations)PSMA6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMA6 (select a term)
intoGenPSMA6
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)14:35761523-35786685  ENSG00000100902
CONAN: Copy Number AnalysisPSMA6 
Mutations and Diseases : HGMDPSMA6
OMIM602855    608446   
MedgenPSMA6
Genetic Testing Registry PSMA6
NextProtP60900 [Medical]
TSGene5687
GENETestsPSMA6
Huge Navigator PSMA6 [HugePedia]
snp3D : Map Gene to Disease5687
BioCentury BCIQPSMA6
ClinGenPSMA6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5687
Chemical/Pharm GKB GenePA33880
Clinical trialPSMA6
Miscellaneous
canSAR (ICR)PSMA6 (select the gene name)
Probes
Litterature
PubMed147 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMA6
EVEXPSMA6
GoPubMedPSMA6
iHOPPSMA6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:17:23 CEST 2016

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