Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PSMA8 (proteasome subunit alpha 8)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)MGC26605
PSMA7L
Other alias
HGNC (Hugo) PSMA8
LocusID (NCBI) 143471
Atlas_Id 54561
Location 18q11.2  [Link to chromosome band 18q11]
Location_base_pair Starts at 26133852 and ends at 26193355 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KLHL29 (2p24.1) / PSMA8 (18q11.2)LAMA3 (18q11.2) / PSMA8 (18q11.2)LAMA3 18q11.2 / PSMA8 18q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)PSMA8   22985
Cards
Entrez_Gene (NCBI)PSMA8  143471  proteasome subunit alpha 8
AliasesPSMA7L
GeneCards (Weizmann)PSMA8
Ensembl hg19 (Hinxton)ENSG00000154611 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000154611 [Gene_View]  chr18:26133852-26193355 [Contig_View]  PSMA8 [Vega]
ICGC DataPortalENSG00000154611
TCGA cBioPortalPSMA8
AceView (NCBI)PSMA8
Genatlas (Paris)PSMA8
WikiGenes143471
SOURCE (Princeton)PSMA8
Genetics Home Reference (NIH)PSMA8
Genomic and cartography
GoldenPath hg38 (UCSC)PSMA8  -     chr18:26133852-26193355 +  18q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSMA8  -     18q11.2   [Description]    (hg19-Feb_2009)
EnsemblPSMA8 - 18q11.2 [CytoView hg19]  PSMA8 - 18q11.2 [CytoView hg38]
Mapping of homologs : NCBIPSMA8 [Mapview hg19]  PSMA8 [Mapview hg38]
Gene and transcription
Genbank (Entrez)BC021713 BC025389 BC025393 BC028371 BC028686
RefSeq transcript (Entrez)NM_001025096 NM_001025097 NM_001308188 NM_144662
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSMA8
Cluster EST : UnigeneHs.464813 [ NCBI ]
CGAP (NCI)Hs.464813
Alternative Splicing GalleryENSG00000154611
Gene ExpressionPSMA8 [ NCBI-GEO ]   PSMA8 [ EBI - ARRAY_EXPRESS ]   PSMA8 [ SEEK ]   PSMA8 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMA8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)143471
GTEX Portal (Tissue expression)PSMA8
Human Protein AtlasENSG00000154611-PSMA8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TAA3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TAA3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TAA3
Splice isoforms : SwissVarQ8TAA3
PhosPhoSitePlusQ8TAA3
Domaine pattern : Prosite (Expaxy)PROTEASOME_ALPHA_1 (PS00388)    PROTEASOME_ALPHA_2 (PS51475)   
Domains : Interpro (EBI)Ntn_hydrolases_N    Proteasome_asu_N    Proteasome_suA-type    Proteasome_sua/b   
Domain families : Pfam (Sanger)Proteasome (PF00227)    Proteasome_A_N (PF10584)   
Domain families : Pfam (NCBI)pfam00227    pfam10584   
Domain families : Smart (EMBL)Proteasome_A_N (SM00948)  
Conserved Domain (NCBI)PSMA8
DMDM Disease mutations143471
Blocks (Seattle)PSMA8
SuperfamilyQ8TAA3
Human Protein Atlas [tissue]ENSG00000154611-PSMA8 [tissue]
Peptide AtlasQ8TAA3
HPRD11322
IPIIPI00154509   IPI00219950   IPI00748423   IPI01012067   IPI01009874   
Protein Interaction databases
DIP (DOE-UCLA)Q8TAA3
IntAct (EBI)Q8TAA3
FunCoupENSG00000154611
BioGRIDPSMA8
STRING (EMBL)PSMA8
ZODIACPSMA8
Ontologies - Pathways
QuickGOQ8TAA3
Ontology : AmiGOMAPK cascade  protein polyubiquitination  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  threonine-type endopeptidase activity  nucleus  cytosol  regulation of cellular amino acid metabolic process  negative regulation of G2/M transition of mitotic cell cycle  protein deubiquitination  proteasome core complex, alpha-subunit complex  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  T cell receptor signaling pathway  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  spermatoproteasome complex  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  threonine-type endopeptidase activity  nucleus  cytosol  regulation of cellular amino acid metabolic process  negative regulation of G2/M transition of mitotic cell cycle  protein deubiquitination  proteasome core complex, alpha-subunit complex  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  T cell receptor signaling pathway  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  spermatoproteasome complex  
Pathways : KEGGProteasome   
NDEx NetworkPSMA8
Atlas of Cancer Signalling NetworkPSMA8
Wikipedia pathwaysPSMA8
Orthology - Evolution
OrthoDB143471
GeneTree (enSembl)ENSG00000154611
Phylogenetic Trees/Animal Genes : TreeFamPSMA8
HOVERGENQ8TAA3
HOGENOMQ8TAA3
Homologs : HomoloGenePSMA8
Homology/Alignments : Family Browser (UCSC)PSMA8
Gene fusions - Rearrangements
Fusion : MitelmanKLHL29/PSMA8 [2p24.1/18q11.2]  [t(2;18)(p24;q11)]  
Fusion : MitelmanLAMA3/PSMA8 [18q11.2/18q11.2]  [t(18;18)(q11;q11)]  
Fusion: TCGA_MDACCLAMA3 18q11.2 PSMA8 18q11.2 BRCA
Tumor Fusion PortalPSMA8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMA8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMA8
dbVarPSMA8
ClinVarPSMA8
1000_GenomesPSMA8 
Exome Variant ServerPSMA8
ExAC (Exome Aggregation Consortium)ENSG00000154611
GNOMAD BrowserENSG00000154611
Genetic variants : HAPMAP143471
Genomic Variants (DGV)PSMA8 [DGVbeta]
DECIPHERPSMA8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSMA8 
Mutations
ICGC Data PortalPSMA8 
TCGA Data PortalPSMA8 
Broad Tumor PortalPSMA8
OASIS PortalPSMA8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMA8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMA8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMA8
DgiDB (Drug Gene Interaction Database)PSMA8
DoCM (Curated mutations)PSMA8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMA8 (select a term)
intoGenPSMA8
Cancer3DPSMA8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETPSMA8
MedgenPSMA8
Genetic Testing Registry PSMA8
NextProtQ8TAA3 [Medical]
TSGene143471
GENETestsPSMA8
Target ValidationPSMA8
Huge Navigator PSMA8 [HugePedia]
snp3D : Map Gene to Disease143471
BioCentury BCIQPSMA8
ClinGenPSMA8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD143471
Chemical/Pharm GKB GenePA134969470
Clinical trialPSMA8
Miscellaneous
canSAR (ICR)PSMA8 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMA8
EVEXPSMA8
GoPubMedPSMA8
iHOPPSMA8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:30:41 CET 2017

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