Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PSMB10 (proteasome subunit beta 10)

Identity

Alias_namesMECL1
proteasome (prosome
Alias_symbol (synonym)LMP10
MGC1665
beta2i
Other alias
HGNC (Hugo) PSMB10
LocusID (NCBI) 5699
Atlas_Id 43821
Location 16q22.1  [Link to chromosome band 16q22]
Location_base_pair Starts at 67934504 and ends at 67936877 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FBXW5 (9q34.3) / PSMB10 (16q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSMB10   9538
Cards
Entrez_Gene (NCBI)PSMB10  5699  proteasome subunit beta 10
AliasesLMP10; MECL1; beta2i
GeneCards (Weizmann)PSMB10
Ensembl hg19 (Hinxton)ENSG00000205220 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000205220 [Gene_View]  chr16:67934504-67936877 [Contig_View]  PSMB10 [Vega]
ICGC DataPortalENSG00000205220
TCGA cBioPortalPSMB10
AceView (NCBI)PSMB10
Genatlas (Paris)PSMB10
WikiGenes5699
SOURCE (Princeton)PSMB10
Genetics Home Reference (NIH)PSMB10
Genomic and cartography
GoldenPath hg38 (UCSC)PSMB10  -     chr16:67934504-67936877 -  16q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSMB10  -     16q22.1   [Description]    (hg19-Feb_2009)
EnsemblPSMB10 - 16q22.1 [CytoView hg19]  PSMB10 - 16q22.1 [CytoView hg38]
Mapping of homologs : NCBIPSMB10 [Mapview hg19]  PSMB10 [Mapview hg38]
OMIM176847   
Gene and transcription
Genbank (Entrez)AK225658 AK298012 AK312208 BC017198 BC052369
RefSeq transcript (Entrez)NM_002801
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSMB10
Cluster EST : UnigeneHs.9661 [ NCBI ]
CGAP (NCI)Hs.9661
Alternative Splicing GalleryENSG00000205220
Gene ExpressionPSMB10 [ NCBI-GEO ]   PSMB10 [ EBI - ARRAY_EXPRESS ]   PSMB10 [ SEEK ]   PSMB10 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMB10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5699
GTEX Portal (Tissue expression)PSMB10
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40306   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP40306  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP40306
Splice isoforms : SwissVarP40306
Catalytic activity : Enzyme3.4.25.1 [ Enzyme-Expasy ]   3.4.25.13.4.25.1 [ IntEnz-EBI ]   3.4.25.1 [ BRENDA ]   3.4.25.1 [ KEGG ]   
PhosPhoSitePlusP40306
Domaine pattern : Prosite (Expaxy)PROTEASOME_BETA_1 (PS00854)    PROTEASOME_BETA_2 (PS51476)   
Domains : Interpro (EBI)Ntn_hydrolases_N    Pept_T1A_subB    Proteasome_bsu_C    Proteasome_bsu_CS    Proteasome_sua/b    Proteasome_suB-type   
Domain families : Pfam (Sanger)Pr_beta_C (PF12465)    Proteasome (PF00227)   
Domain families : Pfam (NCBI)pfam12465    pfam00227   
Conserved Domain (NCBI)PSMB10
DMDM Disease mutations5699
Blocks (Seattle)PSMB10
SuperfamilyP40306
Human Protein AtlasENSG00000205220
Peptide AtlasP40306
HPRD01465
IPIIPI00027933   IPI00909032   
Protein Interaction databases
DIP (DOE-UCLA)P40306
IntAct (EBI)P40306
FunCoupENSG00000205220
BioGRIDPSMB10
STRING (EMBL)PSMB10
ZODIACPSMB10
Ontologies - Pathways
QuickGOP40306
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  threonine-type endopeptidase activity  protein binding  nucleoplasm  cytosol  proteasome core complex  regulation of cellular amino acid metabolic process  humoral immune response  negative regulation of G2/M transition of mitotic cell cycle  viral process  protein deubiquitination  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  spermatoproteasome complex  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  threonine-type endopeptidase activity  protein binding  nucleoplasm  cytosol  proteasome core complex  regulation of cellular amino acid metabolic process  humoral immune response  negative regulation of G2/M transition of mitotic cell cycle  viral process  protein deubiquitination  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  spermatoproteasome complex  
Pathways : KEGGProteasome   
NDEx NetworkPSMB10
Atlas of Cancer Signalling NetworkPSMB10
Wikipedia pathwaysPSMB10
Orthology - Evolution
OrthoDB5699
GeneTree (enSembl)ENSG00000205220
Phylogenetic Trees/Animal Genes : TreeFamPSMB10
HOVERGENP40306
HOGENOMP40306
Homologs : HomoloGenePSMB10
Homology/Alignments : Family Browser (UCSC)PSMB10
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMB10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMB10
dbVarPSMB10
ClinVarPSMB10
1000_GenomesPSMB10 
Exome Variant ServerPSMB10
ExAC (Exome Aggregation Consortium)PSMB10 (select the gene name)
Genetic variants : HAPMAP5699
Genomic Variants (DGV)PSMB10 [DGVbeta]
DECIPHERPSMB10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSMB10 
Mutations
ICGC Data PortalPSMB10 
TCGA Data PortalPSMB10 
Broad Tumor PortalPSMB10
OASIS PortalPSMB10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMB10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMB10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMB10
DgiDB (Drug Gene Interaction Database)PSMB10
DoCM (Curated mutations)PSMB10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMB10 (select a term)
intoGenPSMB10
Cancer3DPSMB10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176847   
Orphanet
MedgenPSMB10
Genetic Testing Registry PSMB10
NextProtP40306 [Medical]
TSGene5699
GENETestsPSMB10
Target ValidationPSMB10
Huge Navigator PSMB10 [HugePedia]
snp3D : Map Gene to Disease5699
BioCentury BCIQPSMB10
ClinGenPSMB10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5699
Chemical/Pharm GKB GenePA33883
Clinical trialPSMB10
Miscellaneous
canSAR (ICR)PSMB10 (select the gene name)
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMB10
EVEXPSMB10
GoPubMedPSMB10
iHOPPSMB10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:51:28 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.