Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PSMB2 (proteasome subunit beta 2)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)HC7-I
Other alias
HGNC (Hugo) PSMB2
LocusID (NCBI) 5690
Atlas_Id 54562
Location 1p34.3  [Link to chromosome band 1p34]
Location_base_pair Starts at 35599541 and ends at 35641551 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PSMB2 (1p34.3) / MIDN (19p13.3)PSMB2 (1p34.3) / PSMB2 (1p34.3)PSMB2 (1p34.3) / SLC25A35 (17p13.1)
SRC (20q11.23) / PSMB2 (1p34.3)ZMYM4 (1p34.3) / PSMB2 (1p34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSMB2   9539
Cards
Entrez_Gene (NCBI)PSMB2  5690  proteasome subunit beta 2
AliasesHC7-I
GeneCards (Weizmann)PSMB2
Ensembl hg19 (Hinxton)ENSG00000126067 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126067 [Gene_View]  chr1:35599541-35641551 [Contig_View]  PSMB2 [Vega]
ICGC DataPortalENSG00000126067
TCGA cBioPortalPSMB2
AceView (NCBI)PSMB2
Genatlas (Paris)PSMB2
WikiGenes5690
SOURCE (Princeton)PSMB2
Genetics Home Reference (NIH)PSMB2
Genomic and cartography
GoldenPath hg38 (UCSC)PSMB2  -     chr1:35599541-35641551 -  1p34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSMB2  -     1p34.3   [Description]    (hg19-Feb_2009)
EnsemblPSMB2 - 1p34.3 [CytoView hg19]  PSMB2 - 1p34.3 [CytoView hg38]
Mapping of homologs : NCBIPSMB2 [Mapview hg19]  PSMB2 [Mapview hg38]
OMIM602175   
Gene and transcription
Genbank (Entrez)AB209470 AI025755 AK296956 AK310023 AV762678
RefSeq transcript (Entrez)NM_001199779 NM_001199780 NM_002794
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSMB2
Cluster EST : UnigeneHs.471441 [ NCBI ]
CGAP (NCI)Hs.471441
Alternative Splicing GalleryENSG00000126067
Gene ExpressionPSMB2 [ NCBI-GEO ]   PSMB2 [ EBI - ARRAY_EXPRESS ]   PSMB2 [ SEEK ]   PSMB2 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5690
GTEX Portal (Tissue expression)PSMB2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49721   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49721  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49721
Splice isoforms : SwissVarP49721
PhosPhoSitePlusP49721
Domaine pattern : Prosite (Expaxy)PROTEASOME_BETA_1 (PS00854)    PROTEASOME_BETA_2 (PS51476)   
Domains : Interpro (EBI)Ntn_hydrolases_N    Proteasome_bsu_CS    Proteasome_sua/b    Proteasome_suB-type   
Domain families : Pfam (Sanger)Proteasome (PF00227)   
Domain families : Pfam (NCBI)pfam00227   
Conserved Domain (NCBI)PSMB2
DMDM Disease mutations5690
Blocks (Seattle)PSMB2
PDB (SRS)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (PDBSum)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (IMB)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (RSDB)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
Structural Biology KnowledgeBase4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
SCOP (Structural Classification of Proteins)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
CATH (Classification of proteins structures)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5T0C    5T0G    5T0H    5T0I    5T0J   
SuperfamilyP49721
Human Protein AtlasENSG00000126067
Peptide AtlasP49721
HPRD03708
IPIIPI00028006   IPI00844375   IPI00978288   IPI00980175   
Protein Interaction databases
DIP (DOE-UCLA)P49721
IntAct (EBI)P49721
FunCoupENSG00000126067
BioGRIDPSMB2
STRING (EMBL)PSMB2
ZODIACPSMB2
Ontologies - Pathways
QuickGOP49721
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  threonine-type endopeptidase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytosol  proteasome core complex  regulation of cellular amino acid metabolic process  response to organonitrogen compound  negative regulation of G2/M transition of mitotic cell cycle  response to organic cyclic compound  membrane  viral process  protein deubiquitination  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  threonine-type endopeptidase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytosol  proteasome core complex  regulation of cellular amino acid metabolic process  response to organonitrogen compound  negative regulation of G2/M transition of mitotic cell cycle  response to organic cyclic compound  membrane  viral process  protein deubiquitination  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  
Pathways : KEGGProteasome   
NDEx NetworkPSMB2
Atlas of Cancer Signalling NetworkPSMB2
Wikipedia pathwaysPSMB2
Orthology - Evolution
OrthoDB5690
GeneTree (enSembl)ENSG00000126067
Phylogenetic Trees/Animal Genes : TreeFamPSMB2
HOVERGENP49721
HOGENOMP49721
Homologs : HomoloGenePSMB2
Homology/Alignments : Family Browser (UCSC)PSMB2
Gene fusions - Rearrangements
Fusion : MitelmanZMYM4/PSMB2 [1p34.3/1p34.3]  [t(1;1)(p34;p34)]  
Fusion Cancer (Beijing)PSMB2 [1p34.3]  -  MIDN [19p13.3]  [FUSC001090]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMB2
dbVarPSMB2
ClinVarPSMB2
1000_GenomesPSMB2 
Exome Variant ServerPSMB2
ExAC (Exome Aggregation Consortium)PSMB2 (select the gene name)
Genetic variants : HAPMAP5690
Genomic Variants (DGV)PSMB2 [DGVbeta]
DECIPHERPSMB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSMB2 
Mutations
ICGC Data PortalPSMB2 
TCGA Data PortalPSMB2 
Broad Tumor PortalPSMB2
OASIS PortalPSMB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMB2
DgiDB (Drug Gene Interaction Database)PSMB2
DoCM (Curated mutations)PSMB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMB2 (select a term)
intoGenPSMB2
Cancer3DPSMB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602175   
Orphanet
MedgenPSMB2
Genetic Testing Registry PSMB2
NextProtP49721 [Medical]
TSGene5690
GENETestsPSMB2
Target ValidationPSMB2
Huge Navigator PSMB2 [HugePedia]
snp3D : Map Gene to Disease5690
BioCentury BCIQPSMB2
ClinGenPSMB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5690
Chemical/Pharm GKB GenePA33884
Clinical trialPSMB2
Miscellaneous
canSAR (ICR)PSMB2 (select the gene name)
Probes
Litterature
PubMed95 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMB2
EVEXPSMB2
GoPubMedPSMB2
iHOPPSMB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:51:28 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.