Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PSMB3 (proteasome subunit beta 3)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)HC10-II
MGC4147
Other alias
HGNC (Hugo) PSMB3
LocusID (NCBI) 5691
Atlas_Id 55445
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 36908966 and ends at 36920484 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DEXI (16p13.13) / PSMB3 (17q12)HLA-B (6p21.33) / PSMB3 (17q12)PSMB3 (17q12) / PSMB3 (17q12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSMB3   9540
Cards
Entrez_Gene (NCBI)PSMB3  5691  proteasome subunit beta 3
AliasesHC10-II
GeneCards (Weizmann)PSMB3
Ensembl hg19 (Hinxton)ENSG00000277791 [Gene_View]  chr17:36908966-36920484 [Contig_View]  PSMB3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000277791 [Gene_View]  chr17:36908966-36920484 [Contig_View]  PSMB3 [Vega]
ICGC DataPortalENSG00000277791
TCGA cBioPortalPSMB3
AceView (NCBI)PSMB3
Genatlas (Paris)PSMB3
WikiGenes5691
SOURCE (Princeton)PSMB3
Genetics Home Reference (NIH)PSMB3
Genomic and cartography
GoldenPath hg19 (UCSC)PSMB3  -     chr17:36908966-36920484 +  17q12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PSMB3  -     17q12   [Description]    (hg38-Dec_2013)
EnsemblPSMB3 - 17q12 [CytoView hg19]  PSMB3 - 17q12 [CytoView hg38]
Mapping of homologs : NCBIPSMB3 [Mapview hg19]  PSMB3 [Mapview hg38]
OMIM602176   
Gene and transcription
Genbank (Entrez)BC013008 BG184666 BG942618 BQ428285 CN412852
RefSeq transcript (Entrez)NM_002795
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NT_187614 NW_004929407
Consensus coding sequences : CCDS (NCBI)PSMB3
Cluster EST : UnigeneHs.82793 [ NCBI ]
CGAP (NCI)Hs.82793
Alternative Splicing GalleryENSG00000277791
Gene ExpressionPSMB3 [ NCBI-GEO ]   PSMB3 [ EBI - ARRAY_EXPRESS ]   PSMB3 [ SEEK ]   PSMB3 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMB3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5691
GTEX Portal (Tissue expression)PSMB3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49720   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49720  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49720
Splice isoforms : SwissVarP49720
Catalytic activity : Enzyme3.4.25.1 [ Enzyme-Expasy ]   3.4.25.13.4.25.1 [ IntEnz-EBI ]   3.4.25.1 [ BRENDA ]   3.4.25.1 [ KEGG ]   
PhosPhoSitePlusP49720
Domaine pattern : Prosite (Expaxy)PROTEASOME_BETA_1 (PS00854)    PROTEASOME_BETA_2 (PS51476)   
Domains : Interpro (EBI)Ntn_hydrolases_N    Proteasome_bsu_CS    Proteasome_sua/b    Proteasome_suB-type   
Domain families : Pfam (Sanger)Proteasome (PF00227)   
Domain families : Pfam (NCBI)pfam00227   
Conserved Domain (NCBI)PSMB3
DMDM Disease mutations5691
Blocks (Seattle)PSMB3
PDB (SRS)4R3O    4R67    5A0Q   
PDB (PDBSum)4R3O    4R67    5A0Q   
PDB (IMB)4R3O    4R67    5A0Q   
PDB (RSDB)4R3O    4R67    5A0Q   
Structural Biology KnowledgeBase4R3O    4R67    5A0Q   
SCOP (Structural Classification of Proteins)4R3O    4R67    5A0Q   
CATH (Classification of proteins structures)4R3O    4R67    5A0Q   
SuperfamilyP49720
Human Protein AtlasENSG00000277791
Peptide AtlasP49720
HPRD03709
IPIIPI00028004   
Protein Interaction databases
DIP (DOE-UCLA)P49720
IntAct (EBI)P49720
FunCoupENSG00000277791
BioGRIDPSMB3
STRING (EMBL)PSMB3
ZODIACPSMB3
Ontologies - Pathways
QuickGOP49720
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  threonine-type endopeptidase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  mitochondrion  Golgi apparatus  cytosol  proteasome core complex  regulation of cellular amino acid metabolic process  actin cytoskeleton  viral process  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  Wnt signaling pathway, planar cell polarity pathway  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  threonine-type endopeptidase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  mitochondrion  Golgi apparatus  cytosol  proteasome core complex  regulation of cellular amino acid metabolic process  actin cytoskeleton  viral process  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  Wnt signaling pathway, planar cell polarity pathway  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  
Pathways : KEGGProteasome   
NDEx NetworkPSMB3
Atlas of Cancer Signalling NetworkPSMB3
Wikipedia pathwaysPSMB3
Orthology - Evolution
OrthoDB5691
GeneTree (enSembl)ENSG00000277791
Phylogenetic Trees/Animal Genes : TreeFamPSMB3
HOVERGENP49720
HOGENOMP49720
Homologs : HomoloGenePSMB3
Homology/Alignments : Family Browser (UCSC)PSMB3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMB3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMB3
dbVarPSMB3
ClinVarPSMB3
1000_GenomesPSMB3 
Exome Variant ServerPSMB3
ExAC (Exome Aggregation Consortium)PSMB3 (select the gene name)
Genetic variants : HAPMAP5691
Genomic Variants (DGV)PSMB3 [DGVbeta]
DECIPHER (Syndromes)17:36908966-36920484  ENSG00000277791
CONAN: Copy Number AnalysisPSMB3 
Mutations
ICGC Data PortalPSMB3 
TCGA Data PortalPSMB3 
Broad Tumor PortalPSMB3
OASIS PortalPSMB3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMB3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMB3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMB3
DgiDB (Drug Gene Interaction Database)PSMB3
DoCM (Curated mutations)PSMB3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMB3 (select a term)
intoGenPSMB3
Cancer3DPSMB3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602176   
Orphanet
MedgenPSMB3
Genetic Testing Registry PSMB3
NextProtP49720 [Medical]
TSGene5691
GENETestsPSMB3
Huge Navigator PSMB3 [HugePedia]
snp3D : Map Gene to Disease5691
BioCentury BCIQPSMB3
ClinGenPSMB3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5691
Chemical/Pharm GKB GenePA33885
Clinical trialPSMB3
Miscellaneous
canSAR (ICR)PSMB3 (select the gene name)
Probes
Litterature
PubMed84 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMB3
EVEXPSMB3
GoPubMedPSMB3
iHOPPSMB3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:23:19 CET 2017

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