Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PSMB4 (proteasome subunit beta 4)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)HN3
PROS26
Other aliasHsN3
PRAAS3
PROS-26
HGNC (Hugo) PSMB4
LocusID (NCBI) 5692
Atlas_Id 55428
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 151399565 and ends at 151401936 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PSMB4 (1q21.3) / IGFN1 (1q32.1)PSMB4 (1q21.3) / PSMB4 (1q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSMB4   9541
Cards
Entrez_Gene (NCBI)PSMB4  5692  proteasome subunit beta 4
AliasesHN3; HsN3; PRAAS3; PROS-26; 
PROS26
GeneCards (Weizmann)PSMB4
Ensembl hg19 (Hinxton)ENSG00000159377 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000159377 [Gene_View]  ENSG00000159377 [Sequence]  chr1:151399565-151401936 [Contig_View]  PSMB4 [Vega]
ICGC DataPortalENSG00000159377
TCGA cBioPortalPSMB4
AceView (NCBI)PSMB4
Genatlas (Paris)PSMB4
WikiGenes5692
SOURCE (Princeton)PSMB4
Genetics Home Reference (NIH)PSMB4
Genomic and cartography
GoldenPath hg38 (UCSC)PSMB4  -     chr1:151399565-151401936 +  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSMB4  -     1q21.3   [Description]    (hg19-Feb_2009)
GoldenPathPSMB4 - 1q21.3 [CytoView hg19]  PSMB4 - 1q21.3 [CytoView hg38]
ImmunoBaseENSG00000159377
Mapping of homologs : NCBIPSMB4 [Mapview hg19]  PSMB4 [Mapview hg38]
OMIM602177   617591   
Gene and transcription
Genbank (Entrez)AK294149 AK313825 BC000331 BC008314 BC010088
RefSeq transcript (Entrez)NM_002796
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSMB4
Cluster EST : UnigeneHs.89545 [ NCBI ]
CGAP (NCI)Hs.89545
Alternative Splicing GalleryENSG00000159377
Gene ExpressionPSMB4 [ NCBI-GEO ]   PSMB4 [ EBI - ARRAY_EXPRESS ]   PSMB4 [ SEEK ]   PSMB4 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMB4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5692
GTEX Portal (Tissue expression)PSMB4
Human Protein AtlasENSG00000159377-PSMB4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP28070   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP28070  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP28070
Splice isoforms : SwissVarP28070
PhosPhoSitePlusP28070
Domaine pattern : Prosite (Expaxy)PROTEASOME_BETA_1 (PS00854)    PROTEASOME_BETA_2 (PS51476)   
Domains : Interpro (EBI)Ntn_hydrolases_N    Proteasome_bsu_CS    Proteasome_endopept_cplx_B    Proteasome_sua/b    Proteasome_suB-type   
Domain families : Pfam (Sanger)Proteasome (PF00227)   
Domain families : Pfam (NCBI)pfam00227   
Conserved Domain (NCBI)PSMB4
DMDM Disease mutations5692
Blocks (Seattle)PSMB4
PDB (RSDB)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    6AVO   
PDB Europe4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    6AVO   
PDB (PDBSum)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    6AVO   
PDB (IMB)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    6AVO   
Structural Biology KnowledgeBase4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    6AVO   
SCOP (Structural Classification of Proteins)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    6AVO   
CATH (Classification of proteins structures)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    6AVO   
SuperfamilyP28070
Human Protein Atlas [tissue]ENSG00000159377-PSMB4 [tissue]
Peptide AtlasP28070
HPRD03710
IPIIPI00555956   
Protein Interaction databases
DIP (DOE-UCLA)P28070
IntAct (EBI)P28070
FunCoupENSG00000159377
BioGRIDPSMB4
STRING (EMBL)PSMB4
ZODIACPSMB4
Ontologies - Pathways
QuickGOP28070
Ontology : AmiGOproteasome complex  lipopolysaccharide binding  negative regulation of inflammatory response to antigenic stimulus  endopeptidase activity  threonine-type endopeptidase activity  protein binding  nucleus  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  proteasome core complex  proteasome core complex  proteasomal protein catabolic process  proteasomal ubiquitin-independent protein catabolic process  viral process  protein deubiquitination  proteasome core complex, beta-subunit complex  proteasome-mediated ubiquitin-dependent protein catabolic process  post-translational protein modification  extracellular exosome  
Ontology : EGO-EBIproteasome complex  lipopolysaccharide binding  negative regulation of inflammatory response to antigenic stimulus  endopeptidase activity  threonine-type endopeptidase activity  protein binding  nucleus  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  proteasome core complex  proteasome core complex  proteasomal protein catabolic process  proteasomal ubiquitin-independent protein catabolic process  viral process  protein deubiquitination  proteasome core complex, beta-subunit complex  proteasome-mediated ubiquitin-dependent protein catabolic process  post-translational protein modification  extracellular exosome  
Pathways : KEGGProteasome   
NDEx NetworkPSMB4
Atlas of Cancer Signalling NetworkPSMB4
Wikipedia pathwaysPSMB4
Orthology - Evolution
OrthoDB5692
GeneTree (enSembl)ENSG00000159377
Phylogenetic Trees/Animal Genes : TreeFamPSMB4
HOGENOMP28070
Homologs : HomoloGenePSMB4
Homology/Alignments : Family Browser (UCSC)PSMB4
Gene fusions - Rearrangements
Fusion : QuiverPSMB4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMB4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMB4
dbVarPSMB4
ClinVarPSMB4
1000_GenomesPSMB4 
Exome Variant ServerPSMB4
ExAC (Exome Aggregation Consortium)ENSG00000159377
GNOMAD BrowserENSG00000159377
Varsome BrowserPSMB4
Genetic variants : HAPMAP5692
Genomic Variants (DGV)PSMB4 [DGVbeta]
DECIPHERPSMB4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSMB4 
Mutations
ICGC Data PortalPSMB4 
TCGA Data PortalPSMB4 
Broad Tumor PortalPSMB4
OASIS PortalPSMB4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMB4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMB4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMB4
DgiDB (Drug Gene Interaction Database)PSMB4
DoCM (Curated mutations)PSMB4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMB4 (select a term)
intoGenPSMB4
Cancer3DPSMB4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602177    617591   
Orphanet
DisGeNETPSMB4
MedgenPSMB4
Genetic Testing Registry PSMB4
NextProtP28070 [Medical]
TSGene5692
GENETestsPSMB4
Target ValidationPSMB4
Huge Navigator PSMB4 [HugePedia]
snp3D : Map Gene to Disease5692
BioCentury BCIQPSMB4
ClinGenPSMB4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5692
Chemical/Pharm GKB GenePA33886
Clinical trialPSMB4
Miscellaneous
canSAR (ICR)PSMB4 (select the gene name)
DataMed IndexPSMB4
Probes
Litterature
PubMed115 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMB4
EVEXPSMB4
GoPubMedPSMB4
iHOPPSMB4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 7 18:14:16 CEST 2019

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