Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PSMB6 (proteasome subunit beta 6)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)Y
DELTA
Other aliasLMPY
HGNC (Hugo) PSMB6
LocusID (NCBI) 5694
Atlas_Id 55420
Location 14q11.2  [Link to chromosome band 14q11]
Location_base_pair Starts at 4796144 and ends at 4798503 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PSMB6 (17p13.2) / ANKRD27 (19q13.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PSMB6   9543
Cards
Entrez_Gene (NCBI)PSMB6  5694  proteasome subunit beta 6
AliasesDELTA; LMPY; Y
GeneCards (Weizmann)PSMB6
Ensembl hg19 (Hinxton)ENSG00000142507 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142507 [Gene_View]  ENSG00000142507 [Sequence]  chr17:4796144-4798503 [Contig_View]  PSMB6 [Vega]
ICGC DataPortalENSG00000142507
TCGA cBioPortalPSMB6
AceView (NCBI)PSMB6
Genatlas (Paris)PSMB6
WikiGenes5694
SOURCE (Princeton)PSMB6
Genetics Home Reference (NIH)PSMB6
Genomic and cartography
GoldenPath hg38 (UCSC)PSMB6  -     chr17:4796144-4798503 +  14q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSMB6  -     14q11.2   [Description]    (hg19-Feb_2009)
EnsemblPSMB6 - 14q11.2 [CytoView hg19]  PSMB6 - 14q11.2 [CytoView hg38]
Mapping of homologs : NCBIPSMB6 [Mapview hg19]  PSMB6 [Mapview hg38]
OMIM600307   
Gene and transcription
Genbank (Entrez)AK311768 BC000835 BF671774 BM553399 BQ691763
RefSeq transcript (Entrez)NM_001270481 NM_002798
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSMB6
Cluster EST : UnigeneHs.77060 [ NCBI ]
CGAP (NCI)Hs.77060
Alternative Splicing GalleryENSG00000142507
Gene ExpressionPSMB6 [ NCBI-GEO ]   PSMB6 [ EBI - ARRAY_EXPRESS ]   PSMB6 [ SEEK ]   PSMB6 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMB6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5694
GTEX Portal (Tissue expression)PSMB6
Human Protein AtlasENSG00000142507-PSMB6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP28072   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP28072  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP28072
Splice isoforms : SwissVarP28072
PhosPhoSitePlusP28072
Domaine pattern : Prosite (Expaxy)PROTEASOME_BETA_1 (PS00854)    PROTEASOME_BETA_2 (PS51476)   
Domains : Interpro (EBI)Ntn_hydrolases_N    Pept_T1A_subB    Proteasome_beta6    Proteasome_bsu_CS    Proteasome_sua/b    Proteasome_suB-type   
Domain families : Pfam (Sanger)Proteasome (PF00227)   
Domain families : Pfam (NCBI)pfam00227   
Conserved Domain (NCBI)PSMB6
DMDM Disease mutations5694
Blocks (Seattle)PSMB6
PDB (SRS)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (PDBSum)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (IMB)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (RSDB)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J   
Structural Biology KnowledgeBase4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J   
SCOP (Structural Classification of Proteins)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J   
CATH (Classification of proteins structures)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J   
SuperfamilyP28072
Human Protein Atlas [tissue]ENSG00000142507-PSMB6 [tissue]
Peptide AtlasP28072
HPRD02630
IPIIPI00000811   
Protein Interaction databases
DIP (DOE-UCLA)P28072
IntAct (EBI)P28072
FunCoupENSG00000142507
BioGRIDPSMB6
STRING (EMBL)PSMB6
ZODIACPSMB6
Ontologies - Pathways
QuickGOP28072
Ontology : AmiGOproteasome complex  endopeptidase activity  endopeptidase activity  threonine-type endopeptidase activity  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  proteasome core complex  proteasome core complex  proteasomal protein catabolic process  proteasomal ubiquitin-independent protein catabolic process  viral process  protein deubiquitination  proteasome core complex, beta-subunit complex  proteasome-mediated ubiquitin-dependent protein catabolic process  post-translational protein modification  cadherin binding  proteolysis involved in cellular protein catabolic process  extracellular exosome  
Ontology : EGO-EBIproteasome complex  endopeptidase activity  endopeptidase activity  threonine-type endopeptidase activity  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  proteasome core complex  proteasome core complex  proteasomal protein catabolic process  proteasomal ubiquitin-independent protein catabolic process  viral process  protein deubiquitination  proteasome core complex, beta-subunit complex  proteasome-mediated ubiquitin-dependent protein catabolic process  post-translational protein modification  cadherin binding  proteolysis involved in cellular protein catabolic process  extracellular exosome  
Pathways : KEGGProteasome   
NDEx NetworkPSMB6
Atlas of Cancer Signalling NetworkPSMB6
Wikipedia pathwaysPSMB6
Orthology - Evolution
OrthoDB5694
GeneTree (enSembl)ENSG00000142507
Phylogenetic Trees/Animal Genes : TreeFamPSMB6
HOVERGENP28072
HOGENOMP28072
Homologs : HomoloGenePSMB6
Homology/Alignments : Family Browser (UCSC)PSMB6
Gene fusions - Rearrangements
Fusion : QuiverPSMB6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMB6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMB6
dbVarPSMB6
ClinVarPSMB6
1000_GenomesPSMB6 
Exome Variant ServerPSMB6
ExAC (Exome Aggregation Consortium)ENSG00000142507
GNOMAD BrowserENSG00000142507
Varsome BrowserPSMB6
Genetic variants : HAPMAP5694
Genomic Variants (DGV)PSMB6 [DGVbeta]
DECIPHERPSMB6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSMB6 
Mutations
ICGC Data PortalPSMB6 
TCGA Data PortalPSMB6 
Broad Tumor PortalPSMB6
OASIS PortalPSMB6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMB6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMB6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMB6
DgiDB (Drug Gene Interaction Database)PSMB6
DoCM (Curated mutations)PSMB6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMB6 (select a term)
intoGenPSMB6
Cancer3DPSMB6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600307   
Orphanet
DisGeNETPSMB6
MedgenPSMB6
Genetic Testing Registry PSMB6
NextProtP28072 [Medical]
TSGene5694
GENETestsPSMB6
Target ValidationPSMB6
Huge Navigator PSMB6 [HugePedia]
snp3D : Map Gene to Disease5694
BioCentury BCIQPSMB6
ClinGenPSMB6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5694
Chemical/Pharm GKB GenePA33888
Clinical trialPSMB6
Miscellaneous
canSAR (ICR)PSMB6 (select the gene name)
Probes
Litterature
PubMed92 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMB6
EVEXPSMB6
GoPubMedPSMB6
iHOPPSMB6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Aug 16 11:25:58 CEST 2018
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