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PSMB8 (proteasome subunit beta 8)

Identity

Other namesALDD
D6S216
D6S216E
JMP
LMP7
NKJO
PSMB5i
RING10
HGNC (Hugo) PSMB8
LocusID (NCBI) 5696
Atlas_Id 43865
Location 6p21.32  [Link to chromosome band 6p21]
Location_base_pair Starts at 32808494 and ends at 32812712 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
SERPINF1 (17p13.3) / PSMB8 (6p21.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSMB8   9545
Cards
Entrez_Gene (NCBI)PSMB8  5696  proteasome subunit beta 8
AliasesALDD; D6S216; D6S216E; JMP; 
LMP7; NKJO; PSMB5i; RING10
GeneCards (Weizmann)PSMB8
Ensembl hg19 (Hinxton)ENSG00000204264 [Gene_View]  chr6:32808494-32812712 [Contig_View]  PSMB8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000204264 [Gene_View]  chr6:32808494-32812712 [Contig_View]  PSMB8 [Vega]
ICGC DataPortalENSG00000204264
TCGA cBioPortalPSMB8
AceView (NCBI)PSMB8
Genatlas (Paris)PSMB8
WikiGenes5696
SOURCE (Princeton)PSMB8
Genomic and cartography
GoldenPath hg19 (UCSC)PSMB8  -     chr6:32808494-32812712 -  6p21.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PSMB8  -     6p21.32   [Description]    (hg38-Dec_2013)
EnsemblPSMB8 - 6p21.32 [CytoView hg19]  PSMB8 - 6p21.32 [CytoView hg38]
Mapping of homologs : NCBIPSMB8 [Mapview hg19]  PSMB8 [Mapview hg38]
OMIM177046   256040   
Gene and transcription
Genbank (Entrez)AA807046 AK300962 AW242683 BC001114 BG547344
RefSeq transcript (Entrez)NM_004159 NM_148919
RefSeq genomic (Entrez)NC_000006 NC_018917 NG_028165 NT_007592 NT_113891 NT_167244 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249 NW_004929326
Consensus coding sequences : CCDS (NCBI)PSMB8
Cluster EST : UnigeneHs.180062 [ NCBI ]
CGAP (NCI)Hs.180062
Alternative Splicing GalleryENSG00000204264
Gene ExpressionPSMB8 [ NCBI-GEO ]   PSMB8 [ EBI - ARRAY_EXPRESS ]   PSMB8 [ SEEK ]   PSMB8 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMB8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5696
GTEX Portal (Tissue expression)PSMB8
Protein : pattern, domain, 3D structure
UniProt/SwissProtP28062 (Uniprot)
NextProtP28062  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP28062
Splice isoforms : SwissVarP28062 (Swissvar)
Catalytic activity : Enzyme3.4.25.1 [ Enzyme-Expasy ]   3.4.25.13.4.25.1 [ IntEnz-EBI ]   3.4.25.1 [ BRENDA ]   3.4.25.1 [ KEGG ]   
PhosPhoSitePlusP28062
Domaine pattern : Prosite (Expaxy)PROTEASOME_BETA_1 (PS00854)    PROTEASOME_BETA_2 (PS51476)   
Domains : Interpro (EBI)Ntn_hydrolases_N    Pept_T1A_subB    Proteasome_bsu_CS    Proteasome_sua/b    Proteasome_suB-type   
Domain families : Pfam (Sanger)Proteasome (PF00227)   
Domain families : Pfam (NCBI)pfam00227   
DMDM Disease mutations5696
Blocks (Seattle)PSMB8
SuperfamilyP28062
Human Protein AtlasENSG00000204264
Peptide AtlasP28062
HPRD01515
IPIIPI00000783   IPI00215824   IPI01017933   IPI00893032   IPI00552984   
Protein Interaction databases
DIP (DOE-UCLA)P28062
IntAct (EBI)P28062
FunCoupENSG00000204264
BioGRIDPSMB8
STRING (EMBL)PSMB8
ZODIACPSMB8
Ontologies - Pathways
QuickGOP28062
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  threonine-type endopeptidase activity  protein binding  nucleoplasm  cytosol  proteasome core complex  regulation of cellular amino acid metabolic process  viral process  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  fat cell differentiation  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  regulation of endopeptidase activity  Wnt signaling pathway, planar cell polarity pathway  type I interferon signaling pathway  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  spermatoproteasome complex  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  threonine-type endopeptidase activity  protein binding  nucleoplasm  cytosol  proteasome core complex  regulation of cellular amino acid metabolic process  viral process  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  fat cell differentiation  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  regulation of endopeptidase activity  Wnt signaling pathway, planar cell polarity pathway  type I interferon signaling pathway  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  spermatoproteasome complex  
Pathways : BIOCARTAAntigen Processing and Presentation [Genes]   
Pathways : KEGGProteasome   
NDEx NetworkPSMB8
Atlas of Cancer Signalling NetworkPSMB8
Wikipedia pathwaysPSMB8
Orthology - Evolution
OrthoDB5696
GeneTree (enSembl)ENSG00000204264
Phylogenetic Trees/Animal Genes : TreeFamPSMB8
Homologs : HomoloGenePSMB8
Homology/Alignments : Family Browser (UCSC)PSMB8
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPSMB8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMB8
dbVarPSMB8
ClinVarPSMB8
1000_GenomesPSMB8 
Exome Variant ServerPSMB8
ExAC (Exome Aggregation Consortium)PSMB8 (select the gene name)
Genetic variants : HAPMAP5696
Genomic Variants (DGV)PSMB8 [DGVbeta]
Mutations
ICGC Data PortalPSMB8 
TCGA Data PortalPSMB8 
Broad Tumor PortalPSMB8
OASIS PortalPSMB8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMB8 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch PSMB8
DgiDB (Drug Gene Interaction Database)PSMB8
DoCM (Curated mutations)PSMB8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMB8 (select a term)
intoGenPSMB8
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)6:32808494-32812712  ENSG00000204264
CONAN: Copy Number AnalysisPSMB8 
Mutations and Diseases : HGMDPSMB8
OMIM177046    256040   
MedgenPSMB8
Genetic Testing Registry PSMB8
NextProtP28062 [Medical]
TSGene5696
GENETestsPSMB8
Huge Navigator PSMB8 [HugePedia]
snp3D : Map Gene to Disease5696
BioCentury BCIQPSMB8
ClinGenPSMB8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5696
Chemical/Pharm GKB GenePA33890
Clinical trialPSMB8
Miscellaneous
canSAR (ICR)PSMB8 (select the gene name)
Probes
Litterature
PubMed126 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMB8
EVEXPSMB8
GoPubMedPSMB8
iHOPPSMB8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 19 19:08:58 CEST 2016

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