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PSMB8 (proteasome (prosome, macropain) subunit, beta type, 8)

Identity

Other namesALDD
D6S216
D6S216E
JMP
LMP7
NKJO
PSMB5i
RING10
HGNC (Hugo) PSMB8
LocusID (NCBI) 5696
Location 6p21.32
Location_base_pair Starts at 32808494 and ends at 32812712 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PSMB8   9545
Cards
Entrez_Gene (NCBI)PSMB8  5696  proteasome (prosome, macropain) subunit, beta type, 8
GeneCards (Weizmann)PSMB8
Ensembl (Hinxton)ENSG00000204264 [Gene_View]  chr6:32808494-32812712 [Contig_View]  PSMB8 [Vega]
ICGC DataPortalENSG00000204264
AceView (NCBI)PSMB8
Genatlas (Paris)PSMB8
WikiGenes5696
SOURCE (Princeton)NM_004159 NM_148919
Genomic and cartography
GoldenPath (UCSC)PSMB8  -  6p21.32   chr6:32808494-32812712 -  6p21.32   [Description]    (hg19-Feb_2009)
EnsemblPSMB8 - 6p21.32 [CytoView]
Mapping of homologs : NCBIPSMB8 [Mapview]
OMIM177046   256040   
Gene and transcription
Genbank (Entrez)AA807046 AK300962 AW242683 BC001114 BG547344
RefSeq transcript (Entrez)NM_004159 NM_148919
RefSeq genomic (Entrez)AC_000138 NC_000006 NC_018917 NG_028165 NT_007592 NT_113891 NT_167244 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249 NW_001838980 NW_004929326
Consensus coding sequences : CCDS (NCBI)PSMB8
Cluster EST : UnigeneHs.180062 [ NCBI ]
CGAP (NCI)Hs.180062
Alternative Splicing : Fast-db (Paris)GSHG0026504
Alternative Splicing GalleryENSG00000204264
Gene ExpressionPSMB8 [ NCBI-GEO ]     PSMB8 [ SEEK ]   PSMB8 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP28062 (Uniprot)
NextProtP28062  [Medical]
With graphics : InterProP28062
Splice isoforms : SwissVarP28062 (Swissvar)
Catalytic activity : Enzyme3.4.25.1 [ Enzyme-Expasy ]   3.4.25.13.4.25.1 [ IntEnz-EBI ]   3.4.25.1 [ BRENDA ]   3.4.25.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEASOME_BETA_1 (PS00854)    PROTEASOME_BETA_2 (PS51476)   
Domains : Interpro (EBI)Ntn_hydrolases_N    Pept_T1A_subB    Proteasome_bsu_CS    Proteasome_sua/b    Proteasome_suB-type   
Related proteins : CluSTrP28062
Domain families : Pfam (Sanger)Proteasome (PF00227)   
Domain families : Pfam (NCBI)pfam00227   
DMDM Disease mutations5696
Blocks (Seattle)P28062
Human Protein AtlasENSG00000204264
Peptide AtlasP28062
HPRD01515
IPIIPI00000783   IPI00215824   IPI01017933   IPI00893032   IPI00552984   
Protein Interaction databases
DIP (DOE-UCLA)P28062
IntAct (EBI)P28062
FunCoupENSG00000204264
BioGRIDPSMB8
IntegromeDBPSMB8
STRING (EMBL)PSMB8
Ontologies - Pathways
QuickGOP28062
Ontology : AmiGOG1/S transition of mitotic cell cycle  protein polyubiquitination  mitotic cell cycle  proteasome complex  antigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  threonine-type endopeptidase activity  protein binding  nucleoplasm  cytosol  proteasome core complex  regulation of cellular amino acid metabolic process  apoptotic process  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  gene expression  viral process  RNA metabolic process  mRNA metabolic process  cytokine-mediated signaling pathway  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  cellular nitrogen compound metabolic process  antigen processing and presentation of exogenous peptide antigen via MHC class I  regulation of apoptotic process  negative regulation of apoptotic process  small molecule metabolic process  fat cell differentiation  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  type I interferon signaling pathway  extracellular vesicular exosome  spermatoproteasome complex  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  protein polyubiquitination  mitotic cell cycle  proteasome complex  antigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  threonine-type endopeptidase activity  protein binding  nucleoplasm  cytosol  proteasome core complex  regulation of cellular amino acid metabolic process  apoptotic process  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  gene expression  viral process  RNA metabolic process  mRNA metabolic process  cytokine-mediated signaling pathway  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  cellular nitrogen compound metabolic process  antigen processing and presentation of exogenous peptide antigen via MHC class I  regulation of apoptotic process  negative regulation of apoptotic process  small molecule metabolic process  fat cell differentiation  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  type I interferon signaling pathway  extracellular vesicular exosome  spermatoproteasome complex  
Pathways : BIOCARTAAntigen Processing and Presentation [Genes]   
Pathways : KEGGProteasome   
Protein Interaction DatabasePSMB8
Wikipedia pathwaysPSMB8
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PSMB8
SNP (GeneSNP Utah)PSMB8
SNP : HGBasePSMB8
Genetic variants : HAPMAPPSMB8
1000_GenomesPSMB8 
ICGC programENSG00000204264 
CONAN: Copy Number AnalysisPSMB8 
Somatic Mutations in Cancer : COSMICPSMB8 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
DECIPHER (Syndromes)6:32808494-32812712
Mutations and Diseases : HGMDPSMB8
OMIM177046    256040   
MedgenPSMB8
GENETestsPSMB8
Disease Genetic AssociationPSMB8
Huge Navigator PSMB8 [HugePedia]  PSMB8 [HugeCancerGEM]
Genomic VariantsPSMB8  PSMB8 [DGVbeta]
Exome VariantPSMB8
dbVarPSMB8
ClinVarPSMB8
snp3D : Map Gene to Disease5696
General knowledge
Homologs : HomoloGenePSMB8
Homology/Alignments : Family Browser (UCSC)PSMB8
Phylogenetic Trees/Animal Genes : TreeFamPSMB8
Chemical/Protein Interactions : CTD5696
Chemical/Pharm GKB GenePA33890
Clinical trialPSMB8
Cancer Resource (Charite)ENSG00000204264
Other databases
Probes
Litterature
PubMed123 Pubmed reference(s) in Entrez
CoreMinePSMB8
GoPubMedPSMB8
iHOPPSMB8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Nov 8 17:51:10 CET 2014

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