Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PSMC1 (proteasome 26S subunit, ATPase 1)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)S4
p56
Other aliasP26S4
HGNC (Hugo) PSMC1
LocusID (NCBI) 5700
Atlas_Id 55432
Location 14q32.11  [Link to chromosome band 14q32]
Location_base_pair Starts at 90722894 and ends at 90738966 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PSMC1 (14q32.11) / SYTL1 (1p36.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSMC1   9547
Cards
Entrez_Gene (NCBI)PSMC1  5700  proteasome 26S subunit, ATPase 1
AliasesP26S4; S4; p56
GeneCards (Weizmann)PSMC1
Ensembl hg19 (Hinxton)ENSG00000100764 [Gene_View]  chr14:90722894-90738966 [Contig_View]  PSMC1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000100764 [Gene_View]  chr14:90722894-90738966 [Contig_View]  PSMC1 [Vega]
ICGC DataPortalENSG00000100764
TCGA cBioPortalPSMC1
AceView (NCBI)PSMC1
Genatlas (Paris)PSMC1
WikiGenes5700
SOURCE (Princeton)PSMC1
Genetics Home Reference (NIH)PSMC1
Genomic and cartography
GoldenPath hg19 (UCSC)PSMC1  -     chr14:90722894-90738966 +  14q32.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PSMC1  -     14q32.11   [Description]    (hg38-Dec_2013)
EnsemblPSMC1 - 14q32.11 [CytoView hg19]  PSMC1 - 14q32.11 [CytoView hg38]
Mapping of homologs : NCBIPSMC1 [Mapview hg19]  PSMC1 [Mapview hg38]
OMIM602706   
Gene and transcription
Genbank (Entrez)AB451311 AB451441 AF401213 AK124201 AK222668
RefSeq transcript (Entrez)NM_002802
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)PSMC1
Cluster EST : UnigeneHs.476697 [ NCBI ]
CGAP (NCI)Hs.476697
Alternative Splicing GalleryENSG00000100764
Gene ExpressionPSMC1 [ NCBI-GEO ]   PSMC1 [ EBI - ARRAY_EXPRESS ]   PSMC1 [ SEEK ]   PSMC1 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5700
GTEX Portal (Tissue expression)PSMC1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62191   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62191  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62191
Splice isoforms : SwissVarP62191
PhosPhoSitePlusP62191
Domaine pattern : Prosite (Expaxy)AAA (PS00674)   
Domains : Interpro (EBI)26S_Psome_P45    AAA+_ATPase    ATPase_AAA_core    ATPase_AAA_CS    P-loop_NTPase   
Domain families : Pfam (Sanger)AAA (PF00004)   
Domain families : Pfam (NCBI)pfam00004   
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)PSMC1
DMDM Disease mutations5700
Blocks (Seattle)PSMC1
SuperfamilyP62191
Human Protein AtlasENSG00000100764
Peptide AtlasP62191
HPRD04084
IPIIPI00011126   IPI01015427   IPI00895901   
Protein Interaction databases
DIP (DOE-UCLA)P62191
IntAct (EBI)P62191
FunCoupENSG00000100764
BioGRIDPSMC1
STRING (EMBL)PSMC1
ZODIACPSMC1
Ontologies - Pathways
QuickGOP62191
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  regulation of cellular amino acid metabolic process  proteasome regulatory particle, base subcomplex  membrane  ATPase activity  TBP-class protein binding  proteasome accessory complex  ER-associated ubiquitin-dependent protein catabolic process  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  nuclear proteasome complex  cytosolic proteasome complex  tumor necrosis factor-mediated signaling pathway  proteasome-activating ATPase activity  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  poly(A) RNA binding  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  Wnt signaling pathway, planar cell polarity pathway  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  negative regulation of neuron death  positive regulation of proteasomal protein catabolic process  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  regulation of cellular amino acid metabolic process  proteasome regulatory particle, base subcomplex  membrane  ATPase activity  TBP-class protein binding  proteasome accessory complex  ER-associated ubiquitin-dependent protein catabolic process  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  nuclear proteasome complex  cytosolic proteasome complex  tumor necrosis factor-mediated signaling pathway  proteasome-activating ATPase activity  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  poly(A) RNA binding  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  Wnt signaling pathway, planar cell polarity pathway  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  negative regulation of neuron death  positive regulation of proteasomal protein catabolic process  
Pathways : KEGGProteasome    Epstein-Barr virus infection    Viral carcinogenesis   
NDEx NetworkPSMC1
Atlas of Cancer Signalling NetworkPSMC1
Wikipedia pathwaysPSMC1
Orthology - Evolution
OrthoDB5700
GeneTree (enSembl)ENSG00000100764
Phylogenetic Trees/Animal Genes : TreeFamPSMC1
HOVERGENP62191
HOGENOMP62191
Homologs : HomoloGenePSMC1
Homology/Alignments : Family Browser (UCSC)PSMC1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMC1
dbVarPSMC1
ClinVarPSMC1
1000_GenomesPSMC1 
Exome Variant ServerPSMC1
ExAC (Exome Aggregation Consortium)PSMC1 (select the gene name)
Genetic variants : HAPMAP5700
Genomic Variants (DGV)PSMC1 [DGVbeta]
DECIPHER (Syndromes)14:90722894-90738966  ENSG00000100764
CONAN: Copy Number AnalysisPSMC1 
Mutations
ICGC Data PortalPSMC1 
TCGA Data PortalPSMC1 
Broad Tumor PortalPSMC1
OASIS PortalPSMC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMC1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMC1
DgiDB (Drug Gene Interaction Database)PSMC1
DoCM (Curated mutations)PSMC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMC1 (select a term)
intoGenPSMC1
Cancer3DPSMC1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602706   
Orphanet
MedgenPSMC1
Genetic Testing Registry PSMC1
NextProtP62191 [Medical]
TSGene5700
GENETestsPSMC1
Huge Navigator PSMC1 [HugePedia]
snp3D : Map Gene to Disease5700
BioCentury BCIQPSMC1
ClinGenPSMC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5700
Chemical/Pharm GKB GenePA33892
Clinical trialPSMC1
Miscellaneous
canSAR (ICR)PSMC1 (select the gene name)
Probes
Litterature
PubMed114 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMC1
EVEXPSMC1
GoPubMedPSMC1
iHOPPSMC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:16:00 CEST 2017

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